Dendrobium officinale PDRN fermentation liquor with moisturizing, anti-wrinkle and soothing effects
Fermentation of Dendrobium officinale by Lactobacillus plantarum FBL002 has solved the problems of limited PDRN sources and low content, achieving efficient and low-cost PDRN production. It has significant moisturizing, anti-wrinkle and soothing effects, making it suitable for cosmetic applications.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- WUXI YINGHUAMENG BEAUTY PROD CO LTD
- Filing Date
- 2026-06-01
- Publication Date
- 2026-07-21
AI Technical Summary
Existing technologies suffer from limited PDRN sources, low PDRN content in Dendrobium officinale, lack of specificity in product detection, and low fermentation yield and high cost of existing strains, which cannot meet the needs of cosmetic industrialization.
Lactobacillus plantarum FBL002 was used to ferment Dendrobium officinale. The optimal process parameters were determined by dynamic monitoring of the fermentation process. A high-efficiency method for converting Dendrobium officinale into PDRN was screened. Combined with the cell's own synthesis, the efficient, low-cost and large-scale production of PDRN was achieved. PDRN with a molecular weight distribution of 1000-30000 Da was obtained by DEAE cellulose column chromatography purification.
The PDRN content in the fermentation broth increased by 112 times, significantly higher than other strains. It has high safety, no risk of animal-derived disease transmission, and has moisturizing, anti-wrinkle and soothing effects. It significantly promotes the expression of AQP3 gene in keratinocytes and the synthesis of type I collagen in fibroblasts, significantly inhibits elastase, and significantly inhibits LPS-induced release of TNF-α and NO from macrophages. It is suitable for large-scale industrial production.
Smart Images
Figure CN122428007A_ABST