Real-time non-invasive bilirubin monitoring system for newborns based on near-infrared spectroscopy

By using a non-invasive monitoring system based on near-infrared spectroscopy, combined with multi-wavelength sensors and the PLSR algorithm, non-invasive, real-time, and continuous high-precision monitoring of neonatal bilirubin has been achieved. This solves the problems of pain, large errors, and cross-infection associated with existing technologies, and improves monitoring efficiency and safety.

CN122440184APending Publication Date: 2026-07-24ZHEJIANG XIAOSHAN HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG XIAOSHAN HOSPITAL
Filing Date
2026-04-15
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Current neonatal bilirubin monitoring technologies cannot achieve non-invasive, real-time, and continuous high-precision monitoring. They are painful, have large errors, are inconvenient, and pose a risk of cross-infection, making it difficult to meet the clinical need for continuous monitoring of neonatal jaundice.

Method used

A non-invasive monitoring system based on near-infrared spectroscopy is adopted, including a multi-wavelength near-infrared sensor module, a signal acquisition and preprocessing module, a control and processing module, a wireless communication module, and a power supply module. Combined with the PLSR algorithm and low-power design, it realizes real-time wireless transmission of bilirubin concentration and personalized early warning.

Benefits of technology

It achieves non-invasive, real-time, and continuous high-precision bilirubin monitoring, reducing the measurement error to ±0.5 mg/dl, lowering the risk of kernicterus, improving medical efficiency and parental satisfaction, and meeting infection control requirements.

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Abstract

The present application provides a kind of newborn noninvasive bilirubin real-time monitoring system based on near infrared spectroscopy, comprising: monitoring bracelet, mobile terminal and / or hospital monitoring system, bracelet integrates multi-wavelength near infrared sensor and AI algorithm, noninvasive, continuously monitor the concentration change of bilirubin through wrist skin, and real-time wireless transmission to terminal, realize jaundice dynamic management.Using near infrared spectroscopy technology, without blood sampling, noninvasive monitoring, 24 hours continuous tracking of bilirubin concentration dynamic change, avoid the pain and infection risk of invasive operation, can be used as a substitute or supplementary means for serum detection.According to the day age of newborn, set personalized threshold according to weight, combined with concentration change rate dynamic early warning, early signs of pathological jaundice are found, early warning response time ≤1 minute, the incidence of kernicterus is reduced by 25%, effectively guarantee the life and health of newborn.
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