A method for the continuous synthesis of methyl 2-methylacetoacetate

By conducting continuous synthesis in a fixed-bed reactor with microchannels and supported catalysts, the problems of difficult solvent separation, low catalyst efficiency, and low yield in existing technologies have been solved, enabling the industrial production of methyl 2-methylacetoacetate with high purity and high yield.

CN122444594APending Publication Date: 2026-07-24HUNAN CHEM RES INST
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUNAN CHEM RES INST
Filing Date
2026-05-09
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing methods for synthesizing methyl 2-methylacetoacetate suffer from problems such as difficulty in solvent separation, low catalyst efficiency, low yield, and impurities affecting product quality, and are not suitable for industrial production.

Method used

A continuous synthesis process is adopted, in which raw materials are reacted in a microchannel continuous reactor, a liquid-liquid separator and a fixed-bed reactor with a supported catalyst. Through precise feeding and step-by-step reaction by microchannels, combined with hydrogenation reduction, a highly efficient continuous synthesis process is formed.

Benefits of technology

It improves product purity and yield, reduces equipment investment and operational complexity, is suitable for industrial production, and has good economic benefits and safety.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The application discloses a method for continuously synthesizing 2-methyl acetoacetate, which comprises the following steps: continuously synthesizing 2-methyl acetoacetate by sequentially feeding raw materials into a micro-channel continuous reactor, a liquid-liquid separator and a fixed bed reactor with a catalyst, wherein the raw materials comprise material A composed of methyl acetoacetate and acetic acid, and material B composed of formaldehyde and an alkaline catalyst. In the method, the continuous double-feeding mode is used, the characteristics of precise dosing of the micro-channel, step-by-step promotion without back mixing and fast reaction are combined, and hydrogenation is carried out after the reaction of the raw materials is completed, so that the problem of reduction of formaldehyde can be effectively solved, the possibility of generation of impurities is reduced from the source, and then the product content and the yield can be improved. The method has the advantages of simple operation, safety and convenience, suitability for industrial production, small equipment investment, high product purity, high yield and the like. The content of the obtained product is more than 98%, the yield is more than 97%, and the product has good market competitiveness.
Need to check novelty before this filing date? Find Prior Art