A compound preparation with the effect of improving blood deficiency
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG SHUANGYINGZHIJIA HEALTH MANAGEMENT CO LTD
- Filing Date
- 2026-05-19
- Publication Date
- 2026-08-07
AI Technical Summary
一是配方单一，多以阿胶、红枣等少数几种原料为主，功效局限，难以全面调理气血；二是原料未经特殊处理，有效成分多为大分子物质，人体吸收率低，见效缓慢；三是部分产品添加了大量蔗糖、防腐剂、人工色素等添加剂，长期服用可能增加身体负担；四是单纯依靠中药调理，缺乏直接补充造血原料的成分，对于中重度气血亏虚患者改善效果不佳
1.本发明提供了一种具有改善气血亏虚功效的复方制剂，本发明将红参、阿胶、黄精、当归等传统补气养血中药与黑枸杞、桑椹、龙眼肉等滋阴补肾原料，以及血蛋白多肽、甘氨酸亚铁、阿胶蛋白肽等现代生物活性成分科学配伍。其中红参大补元气，阿胶滋阴补血，二者共为君药；黄精、枸杞子、杜仲雄花等滋补肝肾，桑椹、龙眼肉等养血安神，共为臣药；山楂健脾开胃，促进消化吸收，为佐药；生姜、肉桂温通经脉，调和诸药，为使药，同时添加的血蛋白多肽和甘氨酸亚铁直接补充人体造血所需的铁元素和蛋白质，与中药成分协同作用，实现补气与养血同步，调理与补充结合，全面改善气血亏虚症状。
Abstract
Description
Technical Field
[0001] This invention relates to the field of health functional food technology, specifically a compound preparation with the effect of improving qi and blood deficiency. Background Technology
[0002] Qi and blood deficiency is one of the most common syndromes in Traditional Chinese Medicine (TCM) clinical practice, mainly manifested as pale or sallow complexion, dizziness, fatigue, palpitations, shortness of breath, insomnia, scanty and pale menstrual flow, and numbness in the limbs. With the fast pace of modern life, increased work pressure, late nights, irregular eating habits, and lack of exercise, the number of people suffering from qi and blood deficiency is increasing year by year, showing a significant trend towards affecting younger people. This seriously impacts people's quality of life and health. Currently, there are many products on the market for improving qi and blood deficiency, but they generally suffer from the following problems: First, the formulas are simple, mainly consisting of a few ingredients such as donkey-hide gelatin and red dates, resulting in limited efficacy and difficulty in comprehensively regulating qi and blood. Second, the raw materials are not specially processed, and the effective components are mostly large molecules, which have low absorption rates and slow effects. Third, some products contain large amounts of sucrose, preservatives, artificial colors, and other additives, which may increase the burden on the body with long-term use. Fourth, relying solely on traditional Chinese medicine for conditioning lacks components that directly replenish hematopoietic raw materials, resulting in poor improvement effects for patients with moderate to severe qi and blood deficiency.
[0003] Therefore, this invention proposes a compound preparation with a scientifically comprehensive formula, high absorption rate of effective ingredients, rapid effect, good safety, and suitable for long-term use, which has the effect of improving qi and blood deficiency, thereby effectively solving the above-mentioned problems and difficulties. Summary of the Invention
[0004] To address the shortcomings of existing technologies, this invention provides a compound preparation that improves qi and blood deficiency. This preparation uses food-grade medicinal materials and modern bioactive ingredients in a scientific combination. It improves the bioavailability of the active ingredients through probiotic fermentation technology, while directly supplementing hematopoietic raw materials. This achieves simultaneous replenishment of qi and blood, and combines conditioning with supplementation, thus rapidly and comprehensively improving the symptoms of qi and blood deficiency.
[0005] To achieve the above objectives, the present invention provides the following technical solution: A compound preparation for improving qi and blood deficiency, by weight percentage, is composed of the following ingredients: Birch water 30%-50%, red ginseng and donkey-hide gelatin fermentation liquid 20%-35%, fructooligosaccharides 5%-10%, black goji berry puree 3%-8%, honey 2%-6%, hawthorn concentrated juice 1%-4%, blood protein polypeptide 0.5%-2%, ferrous glycine 0.1%-0.5%, donkey-hide gelatin protein peptide powder 0.5%-2%, white tomato concentrated powder 0.3%-1%, golden oyster mushroom concentrated powder 0.3%-1%, snow lotus culture 0.1%-0.5%, oyster peptide powder 0.2%-0.8%, sea cucumber peptide powder 0.2%-0.8%, tremella polysaccharide 0.1%-0.5%, flaxseed concentrated powder 0.2%-0.8%, pectin 0.1%-0.3%, steviol glycosides 0.01%-0.1%; The red ginseng and donkey-hide gelatin fermentation liquid is composed of the following raw materials by weight percentage: Birch water 60%-75%, five-year-old artificially cultivated red ginseng 2%-5%, mulberry 3%-6%, double-petaled red rose 1%-3%, wolfberry 2%-5%, polygonatum 2%-4%, raspberry 1%-3%, black wolfberry 1%-3%, donkey-hide gelatin 1%-3%, eucommia male flower 0.5%-2%, cordyceps militaris 0.5%-2%, jujube seed 1%-3%, longan pulp 2%-4%, angelica 0.5%-1.5%, poria cocos 1%-3%, cinnamon 0.3%-1%, red date 3%-6%, ginger 0.5%-2%, compound probiotics 0.1%-0.5%; The compound probiotics are composed of *Lactobacillus plantarum*, *Lactobacillus fermentum*, and *Lactococcus lactis* subsp. JYLL-60 in a mass ratio of 1:1:1.
[0006] Furthermore, the preparation method of the red ginseng and donkey-hide gelatin fermentation liquid includes the following steps: Step S1: Raw material pretreatment; Wash the red ginseng, mulberry, double-petaled red rose, wolfberry, polygonatum, raspberry, black wolfberry, eucommia male flower, cordyceps militaris, jujube seed, longan pulp, angelica, poria cocos, cinnamon, red dates, and ginger separately, drain the water, and grind them to 20-40 mesh to obtain mixed raw material powder; grind the donkey-hide gelatin to 80-100 mesh to obtain donkey-hide gelatin powder; Step S2: Extraction; Add birch sap to an extraction tank, heat to 40-50℃, add mixed raw material powder and donkey-hide gelatin powder, stir well, keep warm and extract for 2-3 hours, then raise the temperature to 80-90℃ and continue extraction for 1-2 hours, filter to obtain the extract; Step S3: Sterilization; Cool the extract to room temperature, pasteurize at 65-70°C for 30 minutes, and then cool to 37°C. Step S4: Inoculation and fermentation; Inoculate the sterilized extract with compound probiotics, stir well, and ferment at 37°C under anaerobic conditions for 48-72 hours. Step S5: Post-processing After fermentation, the fermentation liquid was sterilized at 85℃ for 15 minutes, cooled to room temperature, and filtered to obtain the red ginseng and donkey-hide gelatin fermentation liquid.
[0007] The preparation process of a compound preparation with the effect of improving qi and blood deficiency is as follows: Step A1: Weigh the raw materials; Weigh each raw material accurately according to its weight percentage; Step A2: Mix and dissolve; Add birch water to the mixing tank and heat to 40-50℃. While stirring, add pectin, steviol glycosides, fructooligosaccharides, hemoprotein polypeptides, ferrous glycine, donkey-hide gelatin peptide powder, white tomato concentrate powder, golden pine ear concentrate powder, snow lotus culture, oyster peptide powder, sea cucumber peptide powder, tremella polysaccharide, and flaxseed concentrate powder in sequence, and stir until completely dissolved. Step A3: Add liquid ingredients; Continue stirring, then add the fermented red ginseng and donkey-hide gelatin liquid, black goji berry puree, honey, and hawthorn concentrate in sequence, and stir well to obtain a mixture; Step A4: Homogenize; The mixture is homogenized using a homogenizer; Step A5: Sterilization; The homogenized mixture was sterilized using an ultra-high temperature instantaneous sterilization method; Step A6: Filling; The sterilized mixture is cooled to room temperature and then filled and sealed under aseptic conditions. Step A7: Inspect the packaging; After passing inspection, the product is labeled and packaged to obtain the finished product.
[0008] Furthermore, during the homogenization process in step A4, the homogenization pressure is 20-30 MPa and the temperature is 40-50℃.
[0009] Furthermore, during the sterilization process in step A5, the ultra-high temperature instantaneous sterilization condition is sterilization at 121°C for 15 seconds; The application of a compound preparation with the effect of improving qi and blood deficiency in the preparation of functional foods that improve qi and blood deficiency, wherein the dosage form of the functional food is an oral liquid.
[0010] This invention provides a compound preparation that improves qi and blood deficiency. It possesses the following beneficial effects: 1. This invention provides a compound preparation with the effect of improving qi and blood deficiency. This invention scientifically combines traditional qi-tonifying and blood-nourishing Chinese herbs such as red ginseng, donkey-hide gelatin, polygonatum, and angelica with yin-nourishing and kidney-tonifying ingredients such as black goji berries, mulberries, and longan pulp, as well as modern bioactive components such as hematin polypeptides, ferrous glycine, and donkey-hide gelatin protein peptides. Red ginseng greatly tonifies vital energy, and donkey-hide gelatin nourishes yin and blood; these two are the principal herbs. Polygonatum, goji berries, and eucommia male flowers nourish the liver and kidneys, while mulberries and longan pulp nourish blood and calm the mind; these are the assistant herbs. Hawthorn strengthens the spleen and stomach, promotes digestion and absorption, and is the adjuvant herb. Ginger and cinnamon warm the meridians and harmonize the other herbs, serving as the guiding herbs. Simultaneously, the added hematin polypeptides and ferrous glycine directly supplement the iron and protein needed for hematopoiesis, working synergistically with the Chinese herbal components to achieve simultaneous qi-tonifying and blood-nourishing effects, combining regulation and supplementation to comprehensively improve symptoms of qi and blood deficiency.
[0011] 2. This invention provides a compound preparation with the effect of improving qi and blood deficiency. It uses a compound probiotic composed of *Lactobacillus plantarum*, *Lactobacillus fermentum*, and *Lactococcus lactis* subsp. *Lactococcus* JYLL-60 to ferment traditional Chinese medicine raw materials such as red ginseng and donkey-hide gelatin. During fermentation, various enzymes produced by the probiotics break down large-molecule polysaccharides and proteins in the traditional Chinese medicine into small-molecule peptides, amino acids, monosaccharides, and other substances that are easily absorbed by the human body. Simultaneously, some glycoside components are converted into more active aglycones, significantly improving the bioavailability of the active ingredients and making the product more effective.
[0012] 3. This invention provides a compound preparation with the effect of improving qi and blood deficiency. All raw materials are medicinal and edible materials or food materials as stipulated by the state, and no sucrose, preservatives, artificial colors, or artificial flavors are added. Stevia glycosides are used as a sweetener, resulting in extremely low calories, making it suitable for diabetic patients and people who need to control their weight. The product is mild in nature, with no side effects from long-term use. Furthermore, the preparation process has clear steps and well-defined parameters, and the required equipment is all commonly used in the food industry, making it easy to achieve large-scale, standardized production, and ensuring stable and controllable product quality. Detailed Implementation
[0013] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention. Example 1:
[0014] This invention provides a compound preparation for improving qi and blood deficiency, which is composed of the following raw materials by weight percentage: Birch water 30%-50%, red ginseng and donkey-hide gelatin fermentation liquid 20%-35%, fructooligosaccharides 5%-10%, black goji berry puree 3%-8%, honey 2%-6%, hawthorn concentrated juice 1%-4%, blood protein polypeptide 0.5%-2%, ferrous glycine 0.1%-0.5%, donkey-hide gelatin protein peptide powder 0.5%-2%, white tomato concentrated powder 0.3%-1%, golden oyster mushroom concentrated powder 0.3%-1%, snow lotus culture 0.1%-0.5%, oyster peptide powder 0.2%-0.8%, sea cucumber peptide powder 0.2%-0.8%, tremella polysaccharide 0.1%-0.5%, flaxseed concentrated powder 0.2%-0.8%, pectin 0.1%-0.3%, steviol glycosides 0.01%-0.1%; The red ginseng and donkey-hide gelatin fermentation liquid is composed of the following raw materials by weight percentage: Birch water 60%-75%, five-year-old artificially cultivated red ginseng 2%-5%, mulberry 3%-6%, double-petaled red rose 1%-3%, wolfberry 2%-5%, polygonatum 2%-4%, raspberry 1%-3%, black wolfberry 1%-3%, donkey-hide gelatin 1%-3%, eucommia male flower 0.5%-2%, cordyceps militaris 0.5%-2%, jujube seed 1%-3%, longan pulp 2%-4%, angelica 0.5%-1.5%, poria cocos 1%-3%, cinnamon 0.3%-1%, red date 3%-6%, ginger 0.5%-2%, compound probiotics 0.1%-0.5%; The compound probiotics are composed of *Lactobacillus plantarum*, *Lactobacillus fermentum*, and *Lactococcus lactis* subsp. JYLL-60 in a mass ratio of 1:1:1. Example 2:
[0015] This invention provides a compound preparation with the effect of improving qi and blood deficiency, wherein the preparation method of red ginseng and donkey-hide gelatin fermentation liquid includes the following steps: Step S1: Raw material pretreatment; Wash the red ginseng, mulberry, double-petaled red rose, wolfberry, polygonatum, raspberry, black wolfberry, eucommia male flower, cordyceps militaris, jujube seed, longan pulp, angelica, poria cocos, cinnamon, red dates, and ginger separately, drain the water, and grind them to 20-40 mesh to obtain mixed raw material powder; grind the donkey-hide gelatin to 80-100 mesh to obtain donkey-hide gelatin powder; Step S2: Extraction; Add birch sap to an extraction tank, heat to 40-50℃, add mixed raw material powder and donkey-hide gelatin powder, stir well, keep warm and extract for 2-3 hours, then raise the temperature to 80-90℃ and continue extraction for 1-2 hours, filter to obtain the extract; Step S3: Sterilization; Cool the extract to room temperature, pasteurize at 65-70°C for 30 minutes, and then cool to 37°C. Step S4: Inoculation and fermentation; Inoculate the sterilized extract with compound probiotics, stir well, and ferment at 37°C under anaerobic conditions for 48-72 hours. Step S5: Post-processing After fermentation, the fermentation liquid was sterilized at 85℃ for 15 minutes, cooled to room temperature, and filtered to obtain the red ginseng and donkey-hide gelatin fermentation liquid. Example 3:
[0016] This invention provides a compound preparation that improves qi and blood deficiency, and its detailed steps are as follows: Step A1: Weigh the raw materials; Weigh each raw material accurately according to its weight percentage; Step A2: Mix and dissolve; Add birch water to the mixing tank and heat to 40-50℃. While stirring, add pectin, steviol glycosides, fructooligosaccharides, hemoprotein polypeptides, ferrous glycine, donkey-hide gelatin peptide powder, white tomato concentrate powder, golden pine ear concentrate powder, snow lotus culture, oyster peptide powder, sea cucumber peptide powder, tremella polysaccharide, and flaxseed concentrate powder in sequence, and stir until completely dissolved. Step A3: Add liquid ingredients; Continue stirring, then add the fermented red ginseng and donkey-hide gelatin liquid, black goji berry puree, honey, and hawthorn concentrate in sequence, and stir well to obtain a mixture; Step A4: Homogenize; The mixture is homogenized using a homogenizer; Step A5: Sterilization; The homogenized mixture was sterilized using an ultra-high temperature instantaneous sterilization method; Step A6: Filling; The sterilized mixture is cooled to room temperature and then filled and sealed under aseptic conditions. Step A7: Inspect the packaging; After passing inspection, the product is labeled and packaged to obtain the finished product. During the homogenization process in step A4, the homogenization pressure is 20-30 MPa and the temperature is 40-50℃. During the sterilization process in step A5, the ultra-high temperature instantaneous sterilization condition is sterilization at 121℃ for 15 seconds.
[0017] The compound preparation with the effect of improving qi and blood deficiency provided in this embodiment is used in the preparation of functional food for improving qi and blood deficiency, wherein the dosage form of the functional food is an oral liquid.
[0018] The following points should be noted in this article: 1. The embodiments disclosed herein only relate to the structures involved in the embodiments disclosed herein; other structures may refer to general designs.
[0019] 2. Where there is no conflict, the embodiments of this disclosure and the features in the embodiments can be combined with each other to obtain new embodiments.
[0020] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.
Claims
1. A compound preparation for improving qi and blood deficiency, characterized in that: By weight percentage, it consists of the following raw materials: Birch water 30%-50%, red ginseng and donkey-hide gelatin fermentation liquid 20%-35%, fructooligosaccharides 5%-10%, black goji berry puree 3%-8%, honey 2%-6%, hawthorn concentrated juice 1%-4%, blood protein polypeptide 0.5%-2%, ferrous glycine 0.1%-0.5%, donkey-hide gelatin protein peptide powder 0.5%-2%, white tomato concentrated powder 0.3%-1%, golden oyster mushroom concentrated powder 0.3%-1%, snow lotus culture 0.1%-0.5%, oyster peptide powder 0.2%-0.8%, sea cucumber peptide powder 0.2%-0.8%, tremella polysaccharide 0.1%-0.5%, flaxseed concentrated powder 0.2%-0.8%, pectin 0.1%-0.3%, steviol glycosides 0.01%-0.1%; The red ginseng and donkey-hide gelatin fermentation liquid is composed of the following raw materials by weight percentage: Birch water 60%-75%, five-year-old artificially cultivated red ginseng 2%-5%, mulberry 3%-6%, double-petaled red rose 1%-3%, wolfberry 2%-5%, polygonatum 2%-4%, raspberry 1%-3%, black wolfberry 1%-3%, donkey-hide gelatin 1%-3%, eucommia male flower 0.5%-2%, cordyceps militaris 0.5%-2%, jujube seed 1%-3%, longan pulp 2%-4%, angelica 0.5%-1.5%, poria cocos 1%-3%, cinnamon 0.3%-1%, red date 3%-6%, ginger 0.5%-2%, compound probiotics 0.1%-0.5%; The compound probiotics are composed of *Lactobacillus plantarum*, *Lactobacillus fermentum*, and *Lactococcus lactis* subsp. JYLL-60 in a mass ratio of 1:1:
1.
2. The compound preparation according to claim 1, characterized in that: The preparation method of the red ginseng and donkey-hide gelatin fermentation liquid includes the following steps: Step S1: Raw material pretreatment; Wash the red ginseng, mulberry, double-petaled red rose, wolfberry, polygonatum, raspberry, black wolfberry, eucommia male flower, cordyceps militaris, jujube seed, longan pulp, angelica, poria cocos, cinnamon, red dates, and ginger separately, drain the water, and grind them to 20-40 mesh to obtain mixed raw material powder; grind the donkey-hide gelatin to 80-100 mesh to obtain donkey-hide gelatin powder; Step S2: Extraction; Add birch sap to an extraction tank, heat to 40-50℃, add mixed raw material powder and donkey-hide gelatin powder, stir well, keep warm and extract for 2-3 hours, then raise the temperature to 80-90℃ and continue extraction for 1-2 hours, filter to obtain the extract; Step S3: Sterilization; Cool the extract to room temperature, pasteurize at 65-70°C for 30 minutes, and then cool to 37°C. Step S4: Inoculation and fermentation; Inoculate the sterilized extract with compound probiotics, stir well, and ferment at 37°C under anaerobic conditions for 48-72 hours. Step S5: Post-processing After fermentation, the fermentation liquid was sterilized at 85℃ for 15 minutes, cooled to room temperature, and filtered to obtain the red ginseng and donkey-hide gelatin fermentation liquid.
3. A preparation process for a compound preparation with the effect of improving qi and blood deficiency, characterized in that: The preparation process achieves the compound preparation with the effect of improving qi and blood deficiency as described in any one of claims 1-2, and its detailed steps are as follows: Step A1: Weigh the raw materials; Weigh each raw material accurately according to its weight percentage; Step A2: Mix and dissolve; Add birch water to the mixing tank and heat to 40-50℃. While stirring, add pectin, steviol glycosides, fructooligosaccharides, hemoprotein polypeptides, ferrous glycine, donkey-hide gelatin peptide powder, white tomato concentrate powder, golden pine ear concentrate powder, snow lotus culture, oyster peptide powder, sea cucumber peptide powder, tremella polysaccharide, and flaxseed concentrate powder in sequence, and stir until completely dissolved. Step A3: Add liquid ingredients; Continue stirring, then add the fermented red ginseng and donkey-hide gelatin liquid, black goji berry puree, honey, and hawthorn concentrate in sequence, and stir well to obtain a mixture; Step A4: Homogenize; The mixture is homogenized using a homogenizer; Step A5: Sterilization; The homogenized mixture was sterilized using an ultra-high temperature instantaneous sterilization method; Step A6: Filling; The sterilized mixture is cooled to room temperature and then filled and sealed under aseptic conditions. Step A7: Inspect the packaging; After passing inspection, the product is labeled and packaged to obtain the finished product.
4. The preparation process of a compound preparation with the effect of improving qi and blood deficiency according to claim 3, characterized in that: During the homogenization process in step A4, the homogenization pressure is 20-30 MPa and the temperature is 40-50℃.
5. The preparation process of a compound preparation with the effect of improving qi and blood deficiency according to claim 3, characterized in that: During the sterilization process in step A5, the ultra-high temperature instantaneous sterilization condition is sterilization at 121°C for 15 seconds.
6. The application of the compound preparation with the effect of improving qi and blood deficiency according to claim 1 in the preparation of functional foods for improving qi and blood deficiency, characterized in that: The functional food is in the form of an oral liquid.