A hair follicle cell hair growth technology formulation

Abstract

The application discloses a kind of hair follicle cell hair growth technology formula, comprising: cypress leaf extract, ginseng root extract, radix polygoni multiflori extract, ginger root extract, acetyl tetrapeptide-3, biotin tripeptide-1, lactobacillus fermentation lysate product and pharmaceutically or cosmetically acceptable carrier;Wherein, with weight parts, the total weight parts of cypress leaf extract, ginseng root extract and radix polygoni multiflori extract is 10-30 parts, and the weight ratio of acetyl tetrapeptide-3 and biotin tripeptide-1 is 0.5-5:1.The application forms a multi-dimensional synergistic activation system by combining specific peptides that stimulate hair follicle signals and improve the microenvironment with fermentation products that regulate the microecosystem in a specific ratio, achieving efficient and stereoscopic synergistic activation of hair follicle cell proliferation.

Description

Technical Field

[0001] This invention relates to the technical field of cosmetics, and more particularly to a formula for hair follicle cell hair growth technology. Background Technology

[0002] Currently, in the field of hair growth and hair follicle repair, single-dimensional active ingredients are typically used to stimulate hair follicle growth. For example, existing technologies often focus on using plant extracts to improve the scalp microenvironment or using single peptides to directly stimulate hair follicle signaling pathways. However, the proliferation and activation of hair follicle cells is a complex physiological process regulated by multiple factors, including the microenvironment, signaling pathways, and microecology. Existing solutions that use single-dimensional stimulation or simply combine multiple ingredients lack a synergistic ratio between the components, making it difficult to create a synergistic mechanism between microenvironment improvement, signaling pathway activation, and microecological regulation. This results in limited activation of hair follicle cell proliferation and a high relapse rate, failing to achieve efficient, three-dimensional, and synergistic activation of hair follicle cells. Summary of the Invention

[0003] The present invention aims to at least partially solve one of the technical problems in the related art.

[0004] Therefore, the purpose of this invention is to propose a formula for hair follicle cell growth technology, which combines plant extracts that improve the microenvironment, specific peptides that directly stimulate hair follicle signals, and fermentation products that regulate the microecology in a specific ratio to form a multi-dimensional synergistic activation system, thereby achieving efficient and three-dimensional synergistic activation of hair follicle cell proliferation.

[0005] To achieve the above objectives, the present invention provides a composition for activating hair follicle cell proliferation, comprising the following components: Platycladus orientalis leaf extract, ginseng root extract, Polygonum multiflorum extract, ginger root extract, acetyl tetrapeptide-3, biotin tripeptide-1, Lactobacillus fermentation lysate, and a pharmaceutically or cosmetically acceptable carrier; wherein, by weight, the total weight of Platycladus orientalis leaf extract, ginseng root extract, and Polygonum multiflorum extract is 10-30 parts, and the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 is 0.5-5:1.

[0006] The above scheme establishes a core proportional relationship between microenvironment-improving components, signal-stimulating components, and microecological-regulating components by limiting the total weight of plant extract combinations and the weight ratio of specific peptide combinations. This enables the components in each dimension to produce an irreplaceable three-dimensional synergistic effect under specific ratios, rather than a simple additive effect, thereby achieving highly efficient activation of hair follicle cell proliferation.

[0007] In addition, the hair follicle cell hair growth technology formula proposed above according to the present invention may also have the following additional technical features:

[0008] Specifically, by weight, the Platycladus orientalis leaf extract is 3-15 parts, the ginseng root extract is 2-10 parts, the Polygonum multiflorum extract is 2-10 parts, the ginger root extract is 1-8 parts, the acetyl tetrapeptide-3 is 0.1-2 parts, the biotin tripeptide-1 is 0.05-1 parts, and the lactobacillus fermentation lysate is 0.5-5 parts.

[0009] Specifically, by weight, the Platycladus orientalis leaf extract is 5-12 parts, the ginseng root extract is 3-8 parts, the Polygonum multiflorum extract is 3-8 parts, the ginger root extract is 2-6 parts, the acetyl tetrapeptide-3 is 0.2-1.5 parts, the biotin tripeptide-1 is 0.1-0.8 parts, and the lactobacillus fermentation lysate is 1-4 parts.

[0010] Specifically, by weight, the Platycladus orientalis leaf extract is 8 parts, the ginseng root extract is 5 parts, the Polygonum multiflorum extract is 5 parts, the ginger root extract is 3 parts, the acetyl tetrapeptide-3 is 0.5 parts, the biotin tripeptide-1 is 0.3 parts, and the lactobacillus fermentation lysate is 2 parts.

[0011] Specifically, the pharmaceutically or cosmetically acceptable carrier includes at least one of water, ethanol, glycerin, propylene glycol, butylene glycol, sodium hyaluronate, carbomer, or polysorbate-80.

[0012] Specifically, the extracts of Platycladus orientalis leaves, ginseng root, Polygonum multiflorum, and ginger root are water extracts or alcohol extracts, with an extraction temperature of 60-90℃ and a material-to-liquid ratio of 1:8-1:20.

[0013] Specifically, the amount of the lactobacillus fermentation lysate is 0.5 to 5 parts by weight.

[0014] Furthermore, the present invention also provides a method for preparing a composition for activating hair follicle cell proliferation, the composition comprising Platycladus orientalis leaf extract, ginseng root extract, Polygonum multiflorum extract, ginger root extract, acetyl tetrapeptide-3, biotin tripeptide-1, Lactobacillus fermentation lysate, and a pharmaceutically or cosmetically acceptable carrier; wherein, by weight, the total weight of Platycladus orientalis leaf extract, ginseng root extract, and Polygonum multiflorum extract is 10-30 parts, and the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 is 0.5-5:1; the preparation method comprises: mixing Platycladus orientalis leaf extract, ginseng root extract, Polygonum multiflorum extract, and ginger root extract to obtain a plant extract mixture; mixing acetyl tetrapeptide-3, biotin tripeptide-1, and Lactobacillus fermentation lysate to obtain an active mixture; mixing the active mixture with the plant extract mixture; adding a pharmaceutically or cosmetically acceptable carrier; homogenizing, filtering, and sterilizing to obtain the composition. The above scheme, through a step-by-step mixing logic, first prepares plant extract mixtures and active mixtures separately and then combines them, avoiding mutual interference and degradation of active ingredients of different dimensions during the mixing process, and ensuring the retention of the activity of each component and the stability of the system in the multidimensional synergistic system.

[0015] Specifically, the homogenization conditions are: homogenization speed of 5000-10000 rpm and homogenization time of 5-15 min; the filtration is performed using a 0.22-0.45 μm microporous filter membrane.

[0016] Compared with existing technologies, the technical solution provided by this invention has the following beneficial effects: By combining plant extracts that improve the scalp microenvironment with specific peptides that directly stimulate hair follicle signaling pathways, and fermentation products that regulate the scalp microecology, a multi-dimensional synergistic activation system is formed in a specific ratio. Specifically, the total amount of plant extracts is limited to 10-30 parts, ensuring an effective concentration base for the microenvironment-improving components; the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 is limited to 0.5-5:1, ensuring that the signal-stimulating components are at a critical synergistic point in synergistic activation, avoiding the limitations of single-peptide stimulation. Under the aforementioned specific ratio, these three components provide the basic conditions for signaling pathway activation through microenvironment improvement, and microecological regulation further consolidates the stability of the microenvironment and signal transduction, producing a synergistic effect. This achieves highly efficient and lasting activation of hair follicle cell proliferation, significantly overcoming the problems of limited single-dimensional stimulation and easy recurrence in existing technologies.

[0017] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Detailed Implementation

[0018] The following describes a formula for hair follicle cell hair growth technology according to an embodiment of the present invention.

[0019] Example 1:

[0020] This embodiment provides a composition for activating hair follicle cell proliferation, which constructs the core framework of a multi-dimensional synergistic activation system. The composition includes the following components: Platycladus orientalis leaf extract, ginseng root extract, Polygonum multiflorum extract, ginger root extract, acetyl tetrapeptide-3, biotin tripeptide-1, Lactobacillus fermentation lysate, and a pharmaceutically or cosmetically acceptable carrier. It should be understood that although this embodiment lists the specific plant extracts and peptide components mentioned above, similar synergistic frameworks can be achieved in other embodiments as long as the active substances satisfy the same dimensional positioning. For example, plant extracts that improve the microenvironment are not limited to Platycladus orientalis leaf extract, but can also be other plant-derived active substances with similar microenvironment conditioning functions. Signal-stimulating components are not limited to acetyl tetrapeptide-3 and biotin tripeptide-1, but can also be other peptide combinations that can directly act on hair follicle signaling pathways.

[0021] In the multidimensional synergistic activation system of this embodiment, the dimensional positioning and functional mechanism of each component are as follows: The extracts of Platycladus orientalis leaves, ginseng root, Polygonum multiflorum, and ginger root serve as microenvironment-improving components. Their core function is to improve the local microenvironment around the hair follicles on the scalp, for example, by promoting local microcirculation and providing a nutrient matrix, thus laying the foundation for subsequent signal transduction and cell proliferation. Acetyl tetrapeptide-3 and biotin tripeptide-1 serve as signal-stimulating components. Their core function is to directly stimulate key signaling pathways for hair follicle cell proliferation, for example, by upregulating the expression of specific growth factors in hair follicle papilla cells, directly triggering cell proliferation and differentiation instructions at the molecular level. Lactobacillus fermentation lysate serves as a microecological regulation component. Its core function is to regulate the microecological balance on the scalp surface, for example, by inhibiting the excessive proliferation of potentially degrading bacteria and promoting the growth of beneficial symbiotic bacteria, thereby consolidating the stability of microenvironment improvement and signaling pathway activation, and preventing microenvironmental deterioration and signal transduction obstruction caused by microecological imbalance.

[0022] The total weight of the extracts from Platycladus orientalis leaves, ginseng root, and Polygonum multiflorum is 10–30 parts, and the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 is 0.5–5:1. This ratio is not a simple numerical additive but a critical point for achieving three-dimensional synergistic effects. Specifically, when the total amount of plant extracts is in the range of 10–30 parts, the microenvironment-improving components can provide a sufficient concentration of nutrients and a circulatory-driving base, avoiding both insufficient concentration (too low to effectively improve the microenvironment) and excessive concentration (too high to cause irritation to the scalp). When the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 is in the range of 0.5–5:1, the two peptides form a precise complementary and relay relationship in stimulating signaling pathways, reaching a critical point of synergistic activation, avoiding the limitations of single peptide stimulation or signal transduction antagonism caused by imbalances in ratios.

[0023] It must be emphasized that the core value of this embodiment lies in the three-dimensional synergistic mechanism among the three types of components, rather than the superposition of the effects of a single dimension. Why can't a single dimension or a simple combination achieve sustained activation? If only the microenvironment-improving component is used, although it can improve local blood circulation and nutrient supply, it lacks the signal instructions to directly drive cell proliferation, and hair follicle cells are often in a dormant state and cannot be effectively awakened; if only the signal-stimulating component is used, although it can directly send proliferation signals, under harsh microenvironment conditions, signal transduction pathways are easily blocked, and even if cells receive the instructions, they are difficult to complete substantial proliferation and division; if only the microecological regulation component is used, although it can maintain the balance of the microbiota, it cannot directly reach the core target of hair follicle cell proliferation. Furthermore, if the above three types of components are simply combined without following specific proportional relationships and synergistic logic, each component often acts independently, and may even interfere with each other at extreme concentrations.

[0024] Only when the microenvironment-improving components provide a smooth transmission basis for signal stimulation, the microecological regulation components provide a stable ecological guarantee for the microenvironment and signal transmission, and the three interact with each other under the core ratio relationship defined in this embodiment, can efficient and lasting activation of hair follicle cell proliferation be achieved, thus laying the logical foundation for subsequent comparative verification.

[0025] Example 2:

[0026] Based on the core framework of the multidimensional synergistic activation system constructed in Example 1, this example further elaborates and verifies the dosage range and core ratio relationship of each component in detail to prove the criticality of specific ratio parameters and the irreplaceable nature of three-dimensional synergy.

[0027] First, by weight, the following components are present: 3-15 parts of Platycladus orientalis leaf extract, 2-10 parts of ginseng root extract, 2-10 parts of Polygonum multiflorum extract, 1-8 parts of ginger root extract, 0.1-2 parts of acetyl tetrapeptide-3, 0.05-1 part of biotin tripeptide-1, and 0.5-5 parts of Lactobacillus fermentation lysate. This wide range provides a basic effective concentration range for the three dimensions of microenvironment improvement, signal stimulation, and microecological regulation, ensuring that each component can exert its localization function within the system without becoming ineffective or antagonistic.

[0028] More preferably, by weight, the Platycladus orientalis leaf extract comprises 5-12 parts, the ginseng root extract comprises 3-8 parts, the Polygonum multiflorum extract comprises 3-8 parts, the ginger root extract comprises 2-6 parts, the acetyl tetrapeptide-3 comprises 0.2-1.5 parts, the biotin tripeptide-1 comprises 0.1-0.8 parts, and the Lactobacillus fermentation lysate comprises 1-4 parts. This narrow range, by narrowing the concentration fluctuations in each dimension, allows for a more precise match between the nutrients provided by the microenvironment-improving components and the circulatory driving substrate, the proliferation instructions triggered by the signal stimulation components, and the microbial balance effect of the microecological regulation components, reducing the loss of synergistic efficiency due to concentration deviations.

[0029] More preferably, by weight, the Platycladus orientalis leaf extract comprises 8 parts, the ginseng root extract comprises 5 parts, the Polygonum multiflorum extract comprises 5 parts, the ginger root extract comprises 3 parts, the acetyl tetrapeptide-3 comprises 0.5 parts, the biotin tripeptide-1 comprises 0.3 parts, and the Lactobacillus fermentation lysate comprises 2 parts. It should be understood that although specific optimal values ​​are given here, this only represents a specific point in the synergistic peak value under the current experimental verification system. In other application scenarios or different carrier systems, this value can be fine-tuned according to actual needs, as long as it does not deviate from the core proportional relationship defined by this invention.

[0030] Example 3:

[0031] Based on the multidimensional synergistic activation system and dosage range constructed in Examples 1 and 2, this example further elaborates on the selection of functional carriers, the preparation details of plant extracts, and the dosage supplementation of microecological regulation components in the system, so as to illustrate how these features support the stable operation and efficient expression of the three-dimensional synergistic mechanism from the bottom up.

[0032] In some embodiments, pharmaceutically or cosmetically acceptable carriers include at least one selected from water, ethanol, glycerin, propylene glycol, butylene glycol, sodium hyaluronate, carbomer, or polysorbate-80. It should be understood that while specific carrier substances are listed above, in other embodiments, any carrier capable of dissolving, dispersing, stabilizing, and transdermal delivering the active ingredients can also be used in the composition system of the present invention. Specifically, water, glycerin, propylene glycol, and butylene glycol primarily serve as base solvents, providing a liquid dispersion medium for the multidimensional synergistic system; ethanol not only acts as a solvent but also provides a cooling sensation and slightly promotes local microcirculation through its transient volatility when applied to the scalp; polysorbate-80, as an emulsifier, helps improve the uniform dispersion of the active components in the system and prevents stratification or precipitation due to differences in component polarity. More importantly, sodium hyaluronate and carbomer, as thickeners, play an irreplaceable role in the stability of the multidimensional synergistic system. Because the composition of this invention simultaneously contains high-concentration plant extracts, easily degradable peptide combinations, and macromolecular fermentation lysates, these three types of components are highly susceptible to frequent collisions and physicochemical interferences due to Brownian motion in a low-viscosity aqueous system. This can even lead to peptide chain breakage or oxidative polymerization of polyphenols in the plant extracts. Sodium hyaluronate or carbomer significantly reduces the collision frequency and diffusion rate of active molecules in each dimension by increasing the macroscopic viscosity of the system. This provides a physical buffer layer for each component, effectively preventing the degradation and inactivation of signaling and microecological regulating components during storage, and ensuring the long-term stability of the three-dimensional synergistic mechanism throughout the product lifecycle. As another optional implementation, when the composition is designed as a leave-in scalp serum, a combination of sodium hyaluronate and carbomer is preferred to form a thin gel network, ensuring activity retention while avoiding a heavy and sticky application experience. When the composition is designed as a rinse-out shampoo, thickeners can be reduced or eliminated to meet the application requirements of rapid foaming and rinsing.

[0033] Example 4:

[0034] This embodiment provides a method for preparing a composition for activating hair follicle cell proliferation. This preparation method focuses on a temporal logic that achieves non-destructive mixing of multidimensional components and system stability. Through a specific stepwise mixing sequence, it ensures that the activity of microenvironment-improving components, signal-stimulating components, and microecological-regulating components is preserved and that they synergistically do not interfere with each other during the combination process.

[0035] Step S100 involves mixing the extracts of Platycladus orientalis leaves, ginseng root, Polygonum multiflorum, and ginger root to obtain a plant extract mixture. Specifically, this step aims to premix the four plant extracts, which fall under the microenvironment improvement dimension, to form mixture A. Because plant extracts are rich in active substances such as flavonoids, saponins, and polyphenols, these substances often exhibit strong physicochemical activity at high concentrations. Direct contact with easily degradable peptides or macromolecular fermentation products can easily trigger unintended interactions. For example, polyphenols in plant extracts may non-specifically bind to peptide chains through hydrogen bonds or hydrophobic interactions, leading to the blocking of peptide-targeted signaling pathways. Simultaneously, high concentrations of plant extract matrix may alter the pH or osmotic pressure of the local microenvironment, damaging fragile metabolites in Lactobacillus fermentation lysates. Therefore, premixing the plant extracts individually not only achieves a preliminary balance of concentration and polarity among the extracts but also establishes a buffer barrier for subsequent contact with sensitive active ingredients.

[0036] In step S200, acetyl tetrapeptide-3, biotin tripeptide-1, and Lactobacillus fermentation lysate are mixed to obtain an active mixture. Specifically, this step premixes two peptides belonging to the signal stimulation dimension with the fermentation product belonging to the microecological regulation dimension to form mixture B. Acetyl tetrapeptide-3 and biotin tripeptide-1, as key instruction molecules that directly act on the hair follicle signaling pathway, have peptide chain structures that are extremely sensitive to the surrounding chemical environment; the Lactobacillus fermentation lysate contains abundant bacteriocins and intracellular enzymes, and also requires a mild chemical environment to maintain its activity. Premixing these two sensitive components allows the peptide combination and fermentation product to complete the initial molecular adaptation and stabilization in a pure environment with low plant extract concentration interference. It should be understood that although this embodiment mixes the peptides and fermentation product simultaneously, in other optional embodiments, the peptides can be dissolved in a specific buffer solution before adding the fermentation product, depending on the solubility requirements of the specific peptides, as long as high concentrations of plant extracts are not introduced in this step.

[0037] Step S300 involves mixing the active mixture with the plant extract mixture. Specifically, this step combines mixture B obtained in step S200 with mixture A obtained in step S100. At this point, since the signaling and regulatory components in mixture B are already in a relatively stable dispersed state, when mixed with mixture A, the plant extract no longer directly impacts the sensitive components in the form of a high-concentration stock solution, but rather undergoes a gentle convergence in the already internally balanced mixture A. This sequential logic significantly reduces the probability of non-specific binding of polyphenols to peptide chains and avoids the destruction of fermentation metabolites by local extreme pH of the plant extract, thus achieving non-destructive mixing of multidimensional components at the chemical level. From a microscopic mechanism perspective, the gentle merging process allows the three types of components to maintain their independent active spatial conformations within the system, preserving a complete molecular functional basis for the subsequent stereosynergistic effect (1+1+1>3) at the hair follicle target.

[0038] Step S400: Add a pharmaceutically or cosmetically acceptable carrier, homogenize, filter, and sterilize to obtain the composition. Specifically, after the non-destructive merging of the core active ingredients, the carrier component is introduced last. The carrier mainly performs physical functions such as dissolution, dispersion, thickening, and transdermal delivery. Its chemical properties are generally inert and will not cause disruptive interference to the established equilibrium active system. Adding the carrier in the last step avoids the problem of thickeners in the carrier potentially causing local gelation under early high-concentration conditions, thus hindering the uniform dispersion of active molecules. It also ensures that the entire multidimensional synergistic system is in the most suitable hydrodynamic state before final homogenization and filtration.

[0039] Through the above-mentioned step-by-step mixing timing logic, the preparation method of this embodiment ensures the survival rate and functional integrity of each active ingredient in the multi-dimensional synergistic system from the process dimension, proving that "why it is step-by-step" is not only a division of the operation process, but also an irreplaceable process defense line to maintain the three-dimensional synergistic mechanism.

[0040] Example 5:

[0041] Based on the stepwise mixing timing logic constructed in Example 4, this example further elaborates on the key process parameters of homogenization and filtration in the final composition preparation process to illustrate how these parameters ensure the physicochemical stability and sterility of the multidimensional synergistic system from the perspective of physical processing, while avoiding structural damage to sensitive active ingredients.

[0042] In some embodiments, the homogenization conditions are: homogenization speed of 5000–10000 rpm and homogenization time of 5–15 min; the filtration is performed using a 0.22–0.45 μm microporous membrane. It should be understood that although specific rotation speed, time, and membrane pore size ranges are listed herein, in other embodiments, any combination of process parameters that can achieve uniform dispersion of active molecules without disrupting their three-dimensional conformation and simultaneously achieve effective sterilization can also be applied to the preparation process of this invention.

[0043] Specifically, the setting of homogenization speed and time directly affects the microscopic dispersion state and activity retention rate of each component in the multidimensional synergistic system. In step S400, after the plant extract mixture A and the active mixture B are combined and the carrier is added, the system simultaneously contains macromolecular fermentation lysate products, easily degradable peptide combinations, and polyphenol-rich plant extracts. These three types of components are often difficult to achieve molecular-level homogeneous miscibility under low shear force, and are prone to local concentration segregation or microscopic aggregation, thereby affecting the targeted delivery efficiency and synergistic consistency during subsequent application. By controlling the homogenization speed at 5000–10000 rpm and the time at 5–15 min, an optimal balance can be achieved between macroscopic fluid dynamics and microscopic molecular forces: this shear force range is sufficient to break the polar barrier between plant extracts and fermentation products, promoting the uniform embedding of peptide combinations in the carrier network and achieving uniform dispersion of the entire system; at the same time, this shear force is below the critical threshold, which will not cause destructive tearing of the fragile peptide chain structure of acetyl tetrapeptide-3 and biotin tripeptide-1, nor will it cause denaturation and inactivation of intracellular enzymes and short-chain fatty acids in the lactobacillus fermentation lysate due to excessive mechanical shearing.

[0044] In the description of this specification, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0045] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0046] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A formula for hair follicle cell hair regrowth technology, characterized in that, It includes the following components: Platycladus orientalis leaf extract, ginseng root extract, Polygonum multiflorum extract, ginger root extract, acetyl tetrapeptide-3, biotin tripeptide-1, Lactobacillus fermentation lysate, and a pharmaceutically or cosmetically acceptable carrier. The total weight of the extracts of Platycladus orientalis leaf, ginseng root and Polygonum multiflorum was 10-30 parts by weight, and the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 was 0.5-5:

1.

2. The formula for hair follicle cell hair growth technology according to claim 1, characterized in that, By weight, the arborvitae leaf extract is 3-15 parts, the ginseng root extract is 2-10 parts, the Polygonum multiflorum extract is 2-10 parts, the ginger root extract is 1-8 parts, the acetyl tetrapeptide-3 is 0.1-2 parts, the biotin tripeptide-1 is 0.05-1 parts, and the lactobacillus fermentation lysate is 0.5-5 parts.

3. The hair follicle cell hair growth formula according to claim 2, characterized in that, By weight, the arborvitae leaf extract is 5-12 parts, the ginseng root extract is 3-8 parts, the Polygonum multiflorum extract is 3-8 parts, the ginger root extract is 2-6 parts, the acetyl tetrapeptide-3 is 0.2-1.5 parts, the biotin tripeptide-1 is 0.1-0.8 parts, and the lactobacillus fermentation lysate is 1-4 parts.

4. The hair follicle cell hair growth formula according to claim 3, wherein, by weight, the Platycladus orientalis leaf extract is 8 parts, the ginseng root extract is 5 parts, the Polygonum multiflorum extract is 5 parts, the ginger root extract is 3 parts, the acetyl tetrapeptide-3 is 0.5 parts, the biotin tripeptide-1 is 0.3 parts, and the lactobacillus fermentation lysate is 2 parts.

5. The hair follicle cell hair growth formula according to claim 1, characterized in that, The pharmaceutically or cosmetically acceptable carriers include at least one of water, ethanol, glycerin, propylene glycol, butylene glycol, sodium hyaluronate, carbomer, or polysorbate-80.

6. The hair follicle cell hair growth technology formula according to claim 1, characterized in that, The extracts of Platycladus orientalis leaves, ginseng root, Polygonum multiflorum, and ginger root are water extracts or alcohol extracts, extracted at a temperature of 60–90°C, with a material-to-liquid ratio of 1:8–1:

20.

7. The hair follicle cell hair growth formula according to claim 1, characterized in that, The amount of the lactobacillus fermentation lysate is 0.5 to 5 parts by weight.

8. A method for preparing a hair follicle cell-based hair growth formula, wherein the composition comprises arborvitae leaf extract, ginseng root extract, Polygonum multiflorum extract, ginger root extract, acetyl tetrapeptide-3, biotin tripeptide-1, Lactobacillus fermentation lysate, and a pharmaceutically or cosmetically acceptable carrier; wherein, The total weight of the arborvitae leaf extract, ginseng root extract, and Polygonum multiflorum extract is 10-30 parts by weight, and the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 is 0.5-5:1; characterized in that the preparation method includes: The extracts of Platycladus orientalis leaves, ginseng root, Polygonum multiflorum, and ginger root were mixed to obtain a mixture of plant extracts. Acetyl tetrapeptide-3, biotin tripeptide-1, and lactobacillus fermentation lysate were mixed to obtain an active mixture. Mix the active mixture with the plant extract mixture; The composition is obtained by adding a pharmaceutically or cosmetically acceptable carrier, homogenizing, filtering, and sterilizing.

9. A formula for hair follicle cell hair growth technology according to claim 8, characterized in that, The homogenization conditions are: homogenization speed of 5000-10000 rpm and homogenization time of 5-15 min; the filtration is performed using a 0.22-0.45 μm microporous filter membrane.

10. The application of a hair follicle cell-based hair growth technology formulation in the preparation of topical products or cosmetics that promote hair growth, reduce hair loss, or repair hair follicles, said composition comprising Platycladus orientalis leaf extract, ginseng root extract, Polygonum multiflorum extract, ginger root extract, acetyl tetrapeptide-3, biotin tripeptide-1, Lactobacillus fermentation lysate, and a pharmaceutically or cosmetically acceptable carrier; wherein, The total weight of the arborvitae leaf extract, ginseng root extract and Polygonum multiflorum extract is 10 to 30 parts by weight, and the weight ratio of acetyl tetrapeptide-3 to biotin tripeptide-1 is 0.5 to 5:1.