Fully automatic intelligent microscopic detection system

Abstract

The application discloses a kind of full-automatic intelligent microscopic detection systems, system includes base, support arm, three-dimensional mobile carrier table, observation seat and high-definition touch screen.Base integration LED light source array light supplementing;Support arm is equipped with Z-axis moving component and drives carrier table to lift focusing, carrier table is built-in X / Y-axis moving component and drives horizontal positioning;Observation seat is built-in common light path imaging module, lower end is configured objective lens, upper end is connected high-definition camera, and touch screen is hung by gimbals to support visual angle adjustment and touch operation.This system replaces manual operation by XYZ-axis automatic positioning, reduces threshold and error, meets high-throughput detection demand;With digital display to replace ocular observation to relieve operation fatigue, and support data storage, collaboration and AI docking;Redundant drive design does not need super-precision feedback module, significantly reduces cost, suitable for cost-sensitive scenarios such as grass-roots medical care and small and medium-sized biological enterprises.

Description

Technical Field

[0001] This invention relates to the field of optical inspection equipment technology, specifically to a fully automated intelligent microscopic inspection system. Background Technology

[0002] In fields such as biological detection, medical diagnostics, and precision instrument manufacturing, microscopic inspection technology is a key means of evaluating the microscopic quality and core performance of products. Existing bio-optical microscopy systems typically consist of a gantry, optical imaging module, stage, and image acquisition and display unit, primarily used for visual observation of microscopic morphology and internal structures. However, as industrial testing standards demand increasingly stringent precision, the limitations of traditional microscopic inspection solutions in terms of automation integration and quantitative detection accuracy are becoming increasingly apparent, making it difficult to meet the quality control requirements of modern high-precision, automated production lines.

[0003] First, existing equipment is highly dependent on manual operation. Sample positioning and focusing are generally adjusted by manual knobs, which has problems such as poor positioning consistency, low repeatability, and fatigue from long-term operation. The manual alignment and focusing process is not only inefficient and has a high learning threshold for operators, but the micro-vibrations generated during operation can also directly introduce imaging and measurement errors, making it completely unsuitable for the needs of high-throughput fully automated continuous detection.

[0004] Secondly, motion control is the core bottleneck for the implementation of existing solutions. Especially in biomedical testing scenarios, general-purpose equipment has not yet formed an automated alternative that balances hardware procurement costs, subsequent maintenance costs, and the entry barriers for small and medium-sized institutions. Manual equipment lacks automatic positioning logic on the X, Y, and Z axes, resulting in significant repeatability errors and failing to meet the stable alignment requirements of conventional microscopic testing. Furthermore, the Z-axis focusing mechanism is often an independent structure separate from the XY stage module, leading to a cumbersome focusing process and insufficient axial stability. Existing commercially available automated microscopy solutions are mostly modified industrial-grade precision motion platforms, redundantly incorporating modules such as grating ruler closed-loop feedback and multi-axis calibration algorithms required for ultra-precision testing. This far exceeds the positioning accuracy requirements of conventional biological testing, not only increasing hardware procurement costs but also raising maintenance difficulty and reliance on professional personnel due to complex control logic, further increasing the usage barriers for primary healthcare institutions and small and medium-sized biotechnology companies.

[0005] Furthermore, the observation and data transfer capabilities of existing systems lag behind the demands of digitalization: commercial microscopy equipment still primarily uses traditional direct eyepiece viewing as the main observation mode. Prolonged direct eyepiece viewing can easily cause visual fatigue for operators and is detrimental to real-time recording, retrospective analysis, and collaborative observation by multiple personnel. This mode also naturally hinders the direct integration of microscopes with machine vision and AI analysis algorithms. While some high-end equipment has added camera modules, the integration of the image processing unit with the overall control system is low, the display terminal is highly coupled with the main control module, the viewing angle adjustment is insufficient, and the human-computer interaction experience is poor, making it unable to adapt to the data transfer requirements of automated inspection processes.

[0006] In summary, there is an urgent need for a fully automated microscopic inspection system that integrates uniform illumination, high-precision multidimensional movement, and intelligent visualization to solve the aforementioned technical problems. Summary of the Invention

[0007] I. Technical problems to be solved The technical problem to be solved by the present invention is the various problems mentioned in the background art above, and a fully automatic intelligent microscopic inspection system is provided.

[0008] II. Technical Solution To solve the above-mentioned technical problems, the technical solution provided by the present invention is: a fully automatic intelligent microscopic inspection system. As an improvement, it includes a device base, on which a supplementary light seat is provided, and on which a supplementary light component is provided. A support arm is provided on the device base at the rear of the supplementary light seat, and a three-dimensional moving stage is provided at the front of the support arm. A moving component is provided at the front of the support arm to drive the three-dimensional moving stage to move up and down in the Z-axis direction. A moving component is also provided at the front of the support arm to drive the three-dimensional moving stage to move in the X-axis and Y-axis directions. An observation seat is connected to the upper end of the support arm. An eyepiece is provided at the front of the observation seat. An objective lens is provided at the lower end of the observation seat above the three-dimensional moving stage. A connecting rod is provided at the upper end of the observation seat, and a high-definition touch imaging display screen is connected to the upper end of the connecting rod.

[0009] As an improvement, the supplementary lighting component includes a uniformly distributed array of LED light sources, the intensity of which can be adjusted by a touch imaging display screen or set in advance according to observation requirements. The base of the device is provided with a supplementary lighting slot to accommodate the LED light source array. The top of the supplementary lighting slot is covered with a multi-level adjustable light-transmitting plate, so that the light shines vertically upward onto the sample to be tested on the three-dimensional moving stage.

[0010] As an improvement, the X-axis and Y-axis moving components include a lead screw and guide rail pair structure, and the bottom of the three-dimensional moving stage is provided with a drive motor that is connected to the X-axis and Y-axis moving components, so that the three-dimensional moving stage can move horizontally in the X-axis and Y-axis directions to adjust the sample position.

[0011] As an improvement, the Z-axis moving component includes an electric push rod structure, the drive motor of which is mounted on one side of the support arm. The electric push rod connects to and drives the three-dimensional moving stage and its planar moving component to move vertically in the Z-axis direction to complete the focusing operation.

[0012] As an improvement, the observation base has a beam-splitting prism structure inside, with a camera sensor connected to the image processing equipment above it. The camera sensor is built into the lower half of the connecting rod. The camera sensor receives the optical image after the light is split by the prism inside the observation base. The camera sensor is connected to the high-definition touch imaging display screen through a data cable to transmit video signals.

[0013] As an improvement, the connecting rod is a universal joint structure, allowing the high-definition touch imaging display to be finely adjusted in angle and height relative to the support arm.

[0014] As an improvement, the three-dimensional moving stage has a specially designed groove at its center for fixing and positioning the glass slide, and a shallow groove on one side of the groove to facilitate the user's placement and removal of the glass slide to be tested. The upper surface of the three-dimensional moving stage has point marks that are easy for the camera sensor above the observation seat to identify, so as to facilitate the rapid and accurate horizontal positioning of the three-dimensional moving stage.

[0015] III. Beneficial Effects The advantages of this invention compared to the prior art are: This fully automated intelligent microscopic inspection system significantly improves the automation level and imaging quality by integrating supplementary lighting components, multi-dimensional movement mechanisms, and intelligent observation units. First, by introducing a three-axis lead screw precision transmission system to replace manual focusing and displacement mechanisms, and combining it with an interactive touch screen to replace traditional eyepieces, a fundamental transformation from "manual visual observation" to "digital automatic imaging" has been achieved. This design significantly improves the system's positioning accuracy and automation, eliminates ergonomic drawbacks, and provides the necessary hardware foundation for building a high-throughput, intelligent, fully automated microscopic inspection platform. Secondly, the X / Y-axis micro-stepping movement achieved through a lead screw guide pair, combined with the Z-axis overall lifting driven by an electric push rod, not only ensures high precision and stability in the positioning of the three-dimensional moving stage but also optimizes the spatial structure, facilitating rapid focusing and field-of-view switching. Finally, the hollow observation seat with a built-in image processing circuit board, along with a universal joint connecting rod with a finely adjustable angle and a built-in high-sensitivity camera sensor, and a high-definition touchscreen imaging display, achieves a closed loop from optical acquisition and real-time image processing to intuitive display. Users can clearly observe through the screen without prolonged viewing of traditional eyepieces, greatly reducing visual fatigue and improving inspection efficiency and operational convenience. Overall, this design constructs a highly efficient microscopic inspection solution integrating precise positioning, uniform illumination, intelligent processing, and human-computer interaction.

[0016] In the fields of high-throughput drug screening and digital pathology diagnosis, this invention has significant application value. For high-throughput screening, this structure, through three-axis automated positioning and motorized focusing, can seamlessly connect to an automated sample loading system, enabling rapid sample scanning, automatic focusing, and batch image acquisition, thus improving detection efficiency several times over. For telemedicine and teaching scenarios, traditional eyepieces limit the sharing of expert resources; this invention utilizes a touchscreen for digital imaging and operation control, not only overcoming the limitations of the observation field of view but also facilitating the real-time transmission of high-definition images to remote locations via 5G / Internet. This supports experts in remote image reading, annotation, and even remote collaborative diagnosis, effectively solving the problem of uneven distribution of high-quality medical resources. Attached Figure Description

[0017] Figure 1 The present invention is a fully automatic intelligent microscopic inspection system for three-dimensional imaging. Figure 1 .

[0018] Figure 2 The present invention is a fully automatic intelligent microscopic inspection system for three-dimensional imaging. Figure 2 .

[0019] Figure 3 The present invention is a fully automatic intelligent microscopic inspection system for three-dimensional imaging. Figure 3 .

[0020] As shown in the figure: 1. Device base; 2. Light source mount; 3. Support arm; 4. Three-dimensional moving stage; 5. Observation mount; 6. Eyepiece; 7. Connecting rod; 8. High-definition touch imaging display screen; 9. Light source slot; 10. Objective lens. Detailed Implementation

[0021] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0022] like Figure 1 — Figure 3As shown, in this embodiment, the basic architecture of the fully automated intelligent microscopic inspection system consists of a stable device base 1, which serves as the mechanical support platform for the entire system, ensuring the stability of the equipment during operation. A supplementary lighting base 2 is fixedly installed at the front end of the device base 1. This base integrates supplementary lighting components to provide an illumination environment for the sample to be tested. A support arm 3 is vertically installed on the device base 1, located behind the supplementary lighting base 2. This support arm 3 not only provides vertical support but also serves as the mounting carrier for various motion modules and optical modules. This basic layout establishes the spatial logical structure of the system as "front illumination, rear support, and sample loading," allowing the functional modules to be arranged in an orderly manner without interference, thus providing a solid physical foundation for subsequent high-precision inspection.

[0023] A Z-axis moving component is mounted on one side of the support arm 3. Specifically, this component is implemented using an electric push rod, with a drive motor mounted on one side of the support arm and connected to the electric push rod. When it is necessary to adjust the observation focal length or field of view height, the high-precision moving component on the support arm 3 drives the three-dimensional moving stage 4 and its planar moving component to move up and down in the Z-axis direction to achieve the focusing effect. This overall high-precision lifting design avoids the accumulation of mechanical errors caused by frequent individual focusing in traditional microscopes, while simplifying the control logic, significantly improving focusing efficiency and repeatability, and ensuring that a clear imaging plane can be quickly obtained during the detection of samples of different thicknesses.

[0024] The front of the support arm 3 extends horizontally and is connected to a three-dimensional moving stage 4. The front of the support arm 3 is equipped with a moving component that drives the three-dimensional moving stage 4 to move horizontally in the X and Y axes. Preferably, the X and Y axis moving components employ a lead screw and guide rail pair structure. The bottom of the three-dimensional moving stage 4 is connected to a drive motor via a transmission connection, enabling the three-dimensional moving stage 4 to perform micro-stepping movements in the X and Y axes. This precision transmission mechanism converts the rotational motion of the motor into high-precision linear motion, eliminating backlash and achieving micron-level precise adjustment of the sample position, meeting the requirements for full-range scanning and high-precision point detection of complex samples.

[0025] In terms of the specific structure of the observation assembly, the upper end of the support arm 3 is rigidly connected to the observation base 5. The observation base 5 is an internally hollow optical mounting shell, which houses a beam splitter prism and matching optical path components. The rigid connection ensures the coaxiality of the optical system and reduces imaging jitter errors during XYZ axis movement. The front side of the observation base 5 is equipped with an eyepiece tube tilted upwards at 30°~45°, and an eyepiece 6 is installed at the front end of the eyepiece tube for direct visual observation by the operator, retaining the operating habits of traditional microscopes. The lower end of the observation base 5 is equipped with an objective lens 10 adapted to biological detection needs through an objective lens converter, supporting quick replacement of objectives with different magnifications. A high-sensitivity image sensor is built into the top of the observation pedestal 5. The beam splitter divides the optical imaging signal collected by the objective lens 10 into two paths according to the ratio suitable for visual observation and imaging needs: one path is projected onto the eyepiece 6 for visual observation, and the other path is imaged onto the photosensitive surface of the image sensor. The image sensor converts the light signal into an analog electrical signal and transmits it to the image processing circuit board. After basic noise reduction, white balance calibration, and analog-to-digital conversion are completed by the onboard circuit, the output is a standard digital image signal, which is transmitted to the high-definition touch imaging display screen 8 suspended from the top of the observation pedestal 5 via the connecting rod 7 for real-time display. The digital signal can also be output to an external terminal through common interfaces such as USB 3.0 / Gigabit Ethernet to realize local image storage, multi-terminal collaborative observation, or integration with AI analysis algorithms.

[0026] The connecting rod 7 is a universal joint structure, supporting multi-degree-of-freedom angle deflection and height fine-tuning of the high-definition touch imaging display screen 8 relative to the support arm 3. This flexible connection method overcomes the drawbacks of traditional microscope eyepieces having fixed fields of view and limited observation posture, allowing operators to adjust the touch screen 8 to the optimal observation angle according to their own posture and operating habits. Simultaneously, the touch screen 8 serves as the system control and interaction hub, integrating real-time observation, object positioning, focusing, and supplementary lighting adjustment—a complete workflow function—achieving synchronous integration of observation and control, eliminating the need for operators to frequently switch eyepieces and manually adjust knobs. This design effectively alleviates visual fatigue and cervical strain caused by prolonged manual inspection, facilitates multi-person collaborative diagnosis and digital archiving of inspection data on-site, significantly lowers the operational threshold, and improves the human-computer interaction experience and batch inspection efficiency.

[0027] The working principle of this fully automated intelligent microscopic inspection system is as follows: First, in the illumination stage, the supplementary lighting component on the base of the device emits light through a uniformly distributed array of LED light sources, which is then vertically upwards through the supplementary lighting slot 9 onto the sample to be tested on the three-dimensional moving stage 4. This vertical and uniform illumination method effectively eliminates surface shadows and high-contrast reflections, providing clear and high-contrast basic light source conditions for subsequent imaging.

[0028] Secondly, in the positioning stage, the control system drives the X-axis, Y-axis, and Y-axis moving component lead screw guides and drive motors, causing the three-dimensional moving stage 4 to perform micron-level precise stepping movements in the horizontal plane, thereby moving a specific area of ​​the sample to the center of the observation field of view. Simultaneously, the Z-axis moving component, according to focusing requirements, drives the three-dimensional moving stage 4 and its planar moving components to achieve high-precision lifting and lowering, realizing rapid and accurate focus adjustment. In terms of control, users can control the three-axis movement via a high-definition touchscreen. As a preferred option, all moving components and lighting intensity can be controlled through automatic program settings or remotely via computer or mobile phone.

[0029] Next, in the imaging stage, the objective lens 10 located at the lower end of the observation seat 5 optically magnifies the illuminated sample, while the high-sensitivity camera sensor above it simultaneously captures high-definition optical images, and performs real-time signal processing and digital conversion through the image processing circuit board.

[0030] Finally, in the display stage, the processed video signal is transmitted to the high-definition touchscreen display 8. Using the universal joint connecting rod 7, the operator can flexibly adjust the angle of the screen 8 for the best viewing experience. At this point, the user can observe directly through the eyepiece 6 or view the real-time image on the touchscreen display. Through an automated sampling process, the device can batch transmit high-quality images to the cloud, forming the first step in intelligent detection and providing a solid foundation for further analysis.

[0031] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A fully automated intelligent microscopic inspection system, characterized in that, The device includes a base (1), a supplementary light seat (2) on the base (1), a supplementary light assembly on the supplementary light seat (2), a support arm (3) on the base (1) located behind the supplementary light seat (2), a three-dimensional moving stage (4) on the front side of the support arm (3), a moving assembly on the front side of the support arm (3) that drives the three-dimensional moving stage (4) to move up and down in the Z-axis direction, a moving assembly on the front side of the support arm (3) that drives the three-dimensional moving stage (4) to move in the X-axis and Y-axis directions, an observation seat (5) connected to the upper end of the support arm (3), an eyepiece (6) on the front side of the observation seat (5), an objective lens (10) on the lower end of the observation seat (5) located above the three-dimensional moving stage (4), a connecting rod (7) on the upper end of the observation seat (5), and a high-definition touch imaging display screen (8) connected to the upper end of the connecting rod (7).

2. The fully automated intelligent microscopic inspection system according to claim 1, characterized in that, The supplementary lighting component (2) includes a uniformly distributed LED light source array, the light intensity of which can be adjusted by the touch imaging display screen (8) or set in advance according to the observation requirements. The device base (1) is provided with a supplementary lighting slot (9) to accommodate the LED light source array. The top of the supplementary lighting slot (9) is covered with a multi-level adjustable light-transmitting plate so that the light shines vertically upward onto the sample to be tested on the three-dimensional moving stage (4).

3. The fully automated intelligent microscopic inspection system according to claim 1, characterized in that, The X-axis and Y-axis moving components include a lead screw and guide rail pair structure. The bottom of the three-dimensional moving stage (4) is provided with a drive motor that is connected to the X-axis and Y-axis moving components, so that the three-dimensional moving stage (4) can move horizontally in the X-axis and Y-axis directions to adjust the sample position.

4. The fully automated intelligent microscopic inspection system according to claim 1, characterized in that, The Z-axis moving component includes an electric push rod structure, whose drive motor is installed on one side of the support arm (3). The electric push rod connects to and drives the three-dimensional moving stage (4) and its planar moving component to move vertically in the Z-axis direction to complete the focusing operation.

5. The fully automated intelligent microscopic inspection system according to claim 1, characterized in that, The observation seat (5) has a beam splitter prism structure inside, and a camera sensor connected to an image processing device is provided above it. The camera sensor is built into the lower half of the connecting rod (7). The camera sensor receives the optical image after the beam is split by the prism inside the observation seat. The camera sensor is connected to the high-definition touch imaging display screen (8) through a data cable to transmit video signals.

6. The fully automated intelligent microscopic inspection system according to claim 1, characterized in that, The connecting rod (7) is a universal joint structure, which allows the high-definition touch imaging display screen (8) to be finely adjusted in angle and height relative to the support arm (3).

7. The fully automated intelligent microscopic inspection system according to claim 1, characterized in that, The three-dimensional moving stage (4) has a special groove at its center for fixing and positioning the glass slide, and a shallow groove on one side of the special groove to facilitate the user to pick up and put in the glass slide to be tested. The upper surface of the three-dimensional moving stage (4) has point marks that are easy for the camera sensor above the observation seat (5) to identify, so as to facilitate the rapid and accurate horizontal positioning of the three-dimensional moving stage (4).

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