Layered extraction equipment

Abstract

The utility model relates to the technical field of ticagrelor production, in particular to layered extraction equipment which comprises a discharge pipe and a reaction kettle body, a feed port is arranged at the front end of the reaction kettle body, a motor and two vacuumizing pumps are arranged on the reaction kettle body, a rotating shaft is arranged at the output end of the motor, a plurality of stirring pieces are arranged on the rotating shaft, and the stirring pieces are arranged on the rotating shaft. A connecting base is arranged on one side of the reaction kettle body, a plurality of containing barrels are connected to the connecting base, the discharging pipe is communicated with the reaction kettle body, the two vacuumizing pumps are arranged, the reaction kettle body is communicated with the corresponding containing barrels, and a vacuum environment is formed in the reaction kettle and the containing barrels through the vacuumizing pumps. By means of the design, ethyl acetate, water and synthetic reaction liquid can be conveniently added in a vacuum state, stirring is conducted through the stirring piece, the equipment has automation due to the design, the layered extraction efficiency is effectively improved, and the specified layered extraction requirement is met.

Description

Technical Field

[0001] The utility model relates to the technical field of ticagrelor production, in particular to a layered extraction device. Background Art

[0002] Ticagrelor, also known as ticagrelor, has a chemical name of (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylthiotriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol, with a molecular formula of C23H28F2N6O4S. It is a platelet aggregation inhibitor.

[0003] However, ticagrelor needs to be subjected to stratified extraction after the synthesis reaction, but the existing stratified extraction equipment has a single structure, low efficiency, and lacks automation, making it difficult to meet the prescribed stratified extraction requirements. Utility Model Content

[0004] The utility model aims to provide a layered extraction device, aiming to solve the technical problem that in the prior art, ticagrelor needs to be subjected to layered extraction after the synthesis reaction, while the existing layered extraction device has a single structure, low efficiency and lacks automation, thus making it difficult to meet the technical problem of the prescribed layered extraction requirements.

[0005] To achieve the above-mentioned purpose, the utility model adopts a layered extraction equipment, including a discharge pipe and a reactor body, a feed port is provided at the front end of the reactor body, a motor and two vacuum pumps are provided on the reactor body, and the motor is located between the two vacuum pumps, a rotating shaft is provided at the output end of the motor, a plurality of stirring members are provided on the rotating shaft, and the rotating shaft is located in the reactor body, a connecting seat is provided on one side of the reactor body, and the connecting seat is connected with the reactor body, a plurality of holding cylinders are connected to the connecting seat, and a vacuum valve is provided below the holding cylinder, a sealing assembly is provided on the upper thread of the holding cylinder, a liquid meter is provided on one side of the holding cylinder, the discharge pipe is connected with the reactor body and is located below the reactor body, and the two vacuum pumps are respectively connected to the other side of the reactor body and the other side of the plurality of holding cylinders.

[0006] Wherein, the discharge pipe includes a control valve and a pipe body, the control valve is arranged on the pipe body, the pipe body is connected with the reactor body and is located below the reactor body.

[0007] Wherein, the sealing assembly includes a sealing gasket and a sealing cover, wherein the sealing gasket is arranged in the sealing cover, and the sealing cover is threadedly connected to the corresponding containing tube and covers the top of the containing tube.

[0008] Wherein, the layered extraction equipment also includes four supporting legs, the four supporting legs are respectively fixedly connected to the reactor body and are located below the reactor body, and the tube body is located between the four supporting legs.

[0009] Among them, the supporting leg includes a first screw, an anti-slip pad and a supporting leg body, the supporting leg body has a first thread groove at the bottom, the first screw is fixedly connected to the anti-slip pad and is located above the anti-slip pad, the first screw is also threadedly connected to the supporting leg body and is located in the first thread groove, the supporting leg body is fixedly connected to the reactor body and is located below the reactor body, and the tube body is located between the four supporting leg bodies.

[0010] Among them, the stirring member includes a second screw and a stirring rod, the rotating shaft has a plurality of second thread grooves, the second screw is fixedly connected to the stirring rod and is located at one end of the stirring rod, the second screw is also threadedly connected to the rotating shaft and is located in the second thread groove.

[0011] The utility model discloses a layered extraction device, comprising a discharge pipe and a reactor body, a feed port is arranged at the front end of the reactor body, a motor and two vacuum pumps are arranged on the reactor body, a rotating shaft is arranged at the output end of the motor, a plurality of stirring members are arranged on the rotating shaft, a connecting seat is arranged on one side of the reactor body, and the connecting seat is communicated with the reactor body, a plurality of containing cylinders are connected to the connecting seat, and a vacuum valve is arranged below the containing cylinders, a sealing assembly is arranged on the upper thread of the containing cylinders, a liquid meter is arranged on one side of the containing cylinders, the discharge pipe is communicated with the reactor body, the two vacuum pumps are communicated with the reactor body respectively, and the two vacuum pumps are also communicated with the corresponding containing cylinders respectively, a vacuum environment is formed in the reactor body and the containing cylinders by the vacuum pumping body, so that ethyl acetate, water and synthetic reaction liquid are added under a vacuum state, and stirred by the stirring members, the design makes the equipment automatic, and effectively improves the efficiency of layered extraction, thereby meeting the requirements of the specified layered extraction. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0013] Figure 1It is a side view of the first embodiment of the utility model.

[0014] Figure 2 The utility model Figure 1 Section view along line AA.

[0015] Figure 3 It is a three-dimensional stereogram of the second embodiment of the utility model.

[0016] Figure 4 It is a side view of the second embodiment of the utility model.

[0017] Figure 5 The utility model Figure 4 Sectional view along line BB.

[0018] Figure 6 The utility model Figure 5 A partial enlarged view of point C in the middle.

[0019] Figure 7 The utility model Figure 5 A partial enlarged view of point D in the middle.

[0020] 101-tube body, 102-reactor body, 103-feed port, 104-motor, 105-vacuum pump, 106-rotating shaft, 107-stirring member, 108-connecting seat, 109-holding cylinder, 110-vacuum valve, 111-liquid meter, 112-control valve, 113-sealing pad, 114-sealing cover, 201-first screw, 202-anti-slip pad, 203-support leg body, 204-first thread groove, 205-second screw, 206-stirring rod, 207-second thread groove. DETAILED DESCRIPTION

[0021] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0022] First embodiment:

[0023] See also Figure 1 to Figure 3 ,in Figure 1 is a side view of the first embodiment of the utility model, Figure 2 The utility model Figure 1 The cross-sectional view along the AA line. Figure 3 It is a three-dimensional stereogram of the second embodiment of the utility model.

[0024] The utility model provides a layered extraction device, including a discharge pipe and a reactor body 102, the discharge pipe including a control valve 112 and a tube body 101, the sealing assembly including a sealing gasket 113 and a sealing cover 114, and the above-mentioned scheme solves the technical problem that the layered extraction of ticagrelor needs to be performed after the synthesis reaction, while the existing layered extraction equipment has a single structure, low efficiency, and lacks automation, thus it is difficult to meet the specified layered extraction requirements. It can be understood that the above-mentioned scheme can be used in the scenario of layered extraction, and can also be used to solve the problem that liquid cannot be added under a vacuum state.

[0025] According to this specific embodiment, a feed port 103 is provided at the front end of the reactor body 102, a motor 104 and two vacuum pumps 105 are provided on the reactor body 102, and the motor 104 is located between the two vacuum pumps 105, a rotating shaft 106 is provided at the output end of the motor 104, a plurality of stirring members 107 are provided on the rotating shaft 106, and the rotating shaft 106 is located in the reactor body 102, a connecting seat 108 is provided on one side of the reactor body 102, and the connecting seat 108 is connected to the reactor body 102, a plurality of holding cylinders 109 are connected to the connecting seat 108, and a vacuum valve 110 is provided below the holding cylinder 109, a sealing assembly is provided on the upper thread of the holding cylinder 109, a liquid meter 111 is provided on one side of the holding cylinder 109, and the discharge pipe is connected to the The reactor body 102 is connected and located below the reactor body 102. The two vacuum pumps 105 are respectively connected to the other side of the reactor body 102 and the other side of the plurality of holding cylinders 109. The vacuum pump 105 can form a vacuum environment in the reactor body 102 and the holding cylinders 109, so as to facilitate the addition of ethyl acetate, water and synthetic reaction liquid. The stirring member 107 can facilitate stirring the raw materials in the reactor body 102, so that the raw materials are mixed more evenly. The holding cylinder 109 can facilitate the holding of ethyl acetate, water and synthetic reaction liquid. The vacuum valve 110 can facilitate the control of the outflow of the liquid in the holding cylinder 109. The liquid meter 111 can facilitate the calculation of the volume of the liquid in the holding cylinder 109, so as to reduce errors and further improve the efficiency of stratified extraction.

[0026] The control valve 112 is disposed on the tube body 101 , the tube body 101 is connected to the reactor body 102 , and is located below the reactor body 102 . The control valve 112 can be used to control the flow rate in the tube body 101 .

[0027] Secondly, the sealing gasket 113 is arranged in the sealing cover 114, and the sealing cover 114 is threadedly connected to the corresponding containing tube 109 and covers the top of the containing tube 109. The sealing gasket 113 can improve the sealing between the sealing cover 114 and the containing tube 109.

[0028] When the device is used in the utility model, the vacuum pump 105 is started to form a vacuum environment in the reactor body 102, and then ethyl acetate, water and synthetic reaction liquid are added into the corresponding containing tubes 109 respectively, and the sealing assembly is covered, and then another vacuum pump 105 is started to form a vacuum environment in multiple containing tubes 109, and then the corresponding vacuum valve 110 is opened to allow ethyl acetate, water and synthetic reaction liquid to enter the reactor body 102, and finally the motor 104 is started to drive the rotating shaft 106 and the stirring member 107 to stir the raw materials in the reactor body 102, and after the stirring is completed, the raw materials are allowed to stand and separate. In this way, the technical problem that ticagrelor needs to be subjected to layered extraction after the synthesis reaction, and the existing layered extraction equipment has a single structure, low efficiency, and lacks automation, and thus it is difficult to meet the requirements of the specified layered extraction is solved.

[0029] The second embodiment is:

[0030] Based on the first embodiment, please refer to Figures 4 to 7 ,in Figure 4 is a side view of the second embodiment of the utility model, Figure 5 The utility model Figure 4 The cross-sectional view of the BB line. Figure 6 The utility model Figure 5 A partial enlarged view of point C in the middle. Figure 7 The utility model Figure 5 A partial enlarged view of point D in the middle.

[0031] The utility model provides a layered extraction device, which also includes four supporting legs. The supporting legs include a first screw 201 , an anti-slip pad 202 and a supporting leg body 203 . The stirring member 107 includes a second screw 205 and a stirring rod 206 .

[0032] According to this specific embodiment, the four supporting legs are respectively fixedly connected to the reactor body 102 and are located below the reactor body 102, and the tube body 101 is located between the four supporting legs. The supporting legs can facilitate the support of the reactor body 102, thereby facilitating the operation of the reactor body 102.

[0033] Among them, there is a first thread groove 204 at the bottom of the support leg body 203, the first screw 201 is fixedly connected to the anti-slip pad 202 and is located above the anti-slip pad 202, the first screw 201 is also threadedly connected to the support leg body 203 and is located in the first thread groove 204, the support leg body 203 is fixedly connected to the reactor body 102 and is located below the reactor body 102, and the tube body 101 is located between the four support leg bodies 203, and the anti-slip pad 202 and the support leg body 203 are connected by the first screw 201, so that the damaged anti-slip pad 202 can be easily replaced.

[0034] Secondly, the rotating shaft 106 is provided with a plurality of second thread grooves 207, the second screw 205 is fixedly connected to the stirring rod 206 and is located at one end of the stirring rod 206, the second screw 205 is also threadedly connected to the rotating shaft 106 and is located in the second thread groove 207, and the stirring can be easily replaced through the second screw 205, thereby improving the stirring efficiency.

[0035] When using a layered extraction device according to the present embodiment, the supporting legs can be used to support the reactor body 102, thereby facilitating the operation of the reactor body 102. The first screw 201 connects the anti-slip pad 202 and the supporting leg body 203, thereby facilitating the replacement of a damaged anti-slip pad 202. The second screw 205 can facilitate the replacement of the stirring, thereby improving the stirring efficiency.

[0036] The above disclosure is only a preferred embodiment of the present invention, and certainly cannot be used to limit the scope of rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiment and equivalent changes made according to the claims of the present invention still fall within the scope covered by the utility model.

Claims

1. A layered extraction device, characterized in that: It includes a discharge pipe and a reactor body, a feed port is provided at the front end of the reactor body, a motor and two vacuum pumps are provided on the reactor body, and the motor is located between the two vacuum pumps, a rotating shaft is provided at the output end of the motor, a plurality of stirring members are provided on the rotating shaft, and the rotating shaft is located in the reactor body, a connecting seat is provided on one side of the reactor body, and the connecting seat is connected with the reactor body, a plurality of holding cylinders are connected to the connecting seat, and a vacuum valve is provided below the holding cylinder, a sealing assembly is provided on the upper thread of the holding cylinder, a liquid meter is provided on one side of the holding cylinder, the discharge pipe is connected with the reactor body and is located below the reactor body, and the two vacuum pumps are respectively connected to the other side of the reactor body and the other side of the plurality of holding cylinders.

2. The layered extraction device according to claim 1, characterized in that: The discharge pipe comprises a control valve and a pipe body, wherein the control valve is arranged on the pipe body, and the pipe body is communicated with the reactor body and is located below the reactor body.

3. The layered extraction device according to claim 2, characterized in that: The sealing assembly comprises a sealing gasket and a sealing cover, wherein the sealing gasket is arranged in the sealing cover, and the sealing cover is threadedly connected with the corresponding containing tube and covers the top of the containing tube.

4. The layered extraction device according to claim 3, characterized in that: The layered extraction equipment further includes four supporting legs, which are respectively fixedly connected to the reactor body and are located below the reactor body, and the tube body is located between the four supporting legs.

5. The layered extraction device according to claim 4, characterized in that: The supporting leg includes a first screw, an anti-slip pad and a supporting leg body. The supporting leg body has a first thread groove at the bottom. The first screw is fixedly connected to the anti-slip pad and is located above the anti-slip pad. The first screw is also threadedly connected to the supporting leg body and is located in the first thread groove. The supporting leg body is fixedly connected to the reactor body and is located below the reactor body, and the tube body is located between the four supporting leg bodies.

6. The layered extraction device according to claim 5, characterized in that: The stirring member includes a second screw and a stirring rod. The rotating shaft is provided with a plurality of second thread grooves. The second screw is fixedly connected to the stirring rod and is located at one end of the stirring rod. The second screw is also threadedly connected to the rotating shaft and is located in the second thread groove.

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