Supporting table and detection system for synchronously detecting back, chest and abdomen of mouse

Abstract

The utility model discloses a supporting table and a detection system for synchronously detecting the back, the chest and the abdomen of a mouse. The detection system comprises a supporting table and a probe clamping assembly, the supporting table comprises a platform; a window and a fixing device are arranged on the surface of the platform; the fixing device comprises a moving groove and a fixing screw; the bottom of the platform is connected with supporting legs. The open window is located in the middle of the platform and is in a long groove shape. The fixing devices are symmetrically arranged on the two sides of the open window. The moving groove is an arc-shaped through groove; the fixing screws are located in the moving grooves. The probe clamping assembly comprises a probe clamping device and a probe, and the probe clamping device is used for fixing the probe. The utility model provides the detection support table and the detection system which can meet the requirements of synchronous measurement and data acquisition of microcirculation functions of the back, the chest and the abdomen of a mouse.

Description

Technical Field

[0001] The utility model belongs to the field of biomedical research, and in particular relates to a support platform and a detection system for synchronous detection of the back, chest and abdomen of a mouse. Background Art

[0002] Under physiological conditions, the microcirculation functions of different tissues and organs of the body may differ. In addition, different diseases or different treatments will also have different effects on the microcirculation functions of different tissues or organs. The body is a complex system that influences each other, and it is necessary to use a holistic and connected perspective to look at changes in the structure or function of different tissues and organs in health and disease. In my country, many major chronic diseases, such as cardiovascular disease, diabetes, obesity and certain types of cancer, will affect the microcirculation functions of multiple organs in animals at the same time. Synchronous detection of the microcirculation functions of these organs can not only more comprehensively evaluate the impact of the disease, but also help evaluate the effectiveness of different treatments in improving microcirculation functions.

[0003] In biomedical research, it is crucial to evaluate the microcirculation function of the back, chest, and abdomen of experimental animals at the same time. The microcirculation function status of the chest, abdomen, and important tissues and organs of mice, including the heart, lungs, liver, pancreas, kidneys, small intestine, large intestine, and reproductive organs, is crucial to the maintenance of normal physiological functions of mice. Therefore, the detection of microcirculation function in the chest and abdomen is one of the important data sources for our microcirculation function evaluation. Secondly, the back is also often used as a microcirculation function detection site. The main target organ for back detection is the skin. The skin is the largest organ in the body, and its microcirculation function is closely related to a variety of diseases and their complications. Therefore, the simultaneous detection of microcirculation function in the back, chest, and abdomen can obtain synchronous microcirculation data of the chest, abdominal organs, and back skin, providing experimental data support for further analysis and interpretation of the microcirculation function of multiple organs in the body under healthy and diseased conditions.

[0004] At present, the fully enclosed experimental support platform for rats and mice cannot simultaneously meet the requirements for synchronous measurement and data collection of the microcirculatory function of the back, chest and abdomen of animals. The fully enclosed design limits the direct contact and observation of the front and back body parts of the animals by the experimenters, resulting in the inability to obtain data of multiple organ tissues at the same time. It not only limits the scientificity and comprehensiveness of the research, but also may affect the accuracy of the experimental results. If only the microcirculatory function of the chest and abdomen is collected, the changes in the microcirculatory function of the back organs and tissues may be ignored or underestimated, resulting in deviations in the experimental results. If the back and chest and abdomen are collected sequentially, the time series will be out of sync, making it impossible to find the correlation between the microcirculatory function data of the back and chest and abdomen and disease events in the same time series, limiting the in-depth understanding of the overall microcirculatory regulation mechanism. At the same time, the experimental support platform for mice used in the prior art is generally made of materials such as stainless steel, hard plastic or aluminum alloy. Poor optical performance may cause light scattering, refraction or absorption, thereby affecting the clarity and accuracy of imaging or detection. In particular, for experiments that require high resolution and high sensitivity detection, such as circulatory function detection, higher requirements are placed on optical performance.

[0005] In order to fully understand the changes in the overall microcirculatory function, further explore the intrinsic connection between the microcirculatory functions of the back, chest and abdomen tissues and organs, and meet the needs of synchronous detection of the microcirculatory functions of the back, chest and abdomen of mice, it is urgent to develop a detection support platform and detection system that can meet the needs of synchronous measurement and data collection of the microcirculatory functions of the back, chest and abdomen of mice. Utility Model Content

[0006] In order to solve the above technical problems, the utility model improves the existing technology and optimizes the material and structure of the support platform. The specific solution is as follows:

[0007] In a first aspect, the utility model provides a support platform for synchronous detection of the mouse back, chest and abdomen, characterized in that it includes a platform; a window and a fixing device are provided on the surface of the platform; the fixing device includes a movable slot and a fixing screw.

[0008] Furthermore, support legs are connected to the bottom of the platform.

[0009] Furthermore, the window is located in the middle of the platform and is in the shape of a long slot, which allows the probe and laser light path signals to pass through and is used to detect the back skin of mice.

[0010] Furthermore, a through hole and a fixing screw are provided on the platform in the extending direction of the window, which can be used to fix the teeth or head of the mouse.

[0011] Furthermore, the fixing devices are located on both sides of the window, and the fixing devices on both sides are distributed in a mirror-symmetrical manner with respect to the window positions.

[0012] Furthermore, the movable groove is an arc-shaped through groove. The arc-shaped structure can better resist the bending force from the side than the straight structure, and the arc-shaped structure usually uses less material when the same bearing capacity is met.

[0013] Furthermore, the fixing screw is located in the movable groove.

[0014] Preferably, the mouse and the fixing screw are connected by a flexible material, and the flexible connecting material can be made of a material with good tensile properties such as a rubber band.

[0015] Furthermore, there are at least two movable grooves, and each movable groove is provided with two fixing screws.

[0016] Preferably, the number of the movable grooves is 4. The 4 movable grooves can satisfy the anatomical position fixation of the body length, upper limbs and lower limbs of mice of different body sizes.

[0017] Furthermore, the opening widths of the window and the movable groove are 1 mm-5 mm.

[0018] Preferably, the opening width is 3 mm, which is compatible with and meets the requirements for smooth movement of different models of probes of mainstream commercially available microcirculation assessment instruments in the slot-shaped opening.

[0019] Furthermore, the support table is made of a transparent material, preferably acrylic. Acrylic has good light transmittance, and the operator can clearly observe the position of the probe during the experimental operation; at the same time, acrylic products are lighter, have high strength, and are not easy to break. It can also be processed into various shapes and sizes by cutting, engraving, thermoforming and other methods to meet different design requirements.

[0020] In a second aspect, the utility model provides a synchronous detection system for the back, chest and abdomen of a mouse, the detection system further comprising a probe clamping assembly; the probe clamping assembly comprises a probe clamp and a probe, the probe clamp being used to fix the probe.

[0021] Furthermore, the probe clamp includes a base, a support rod, a slider, a probe clamp and a locking bolt. The support rod is vertically fixed to the base, the slider is slidably connected to the support rod, the probe clamp and the slider are detachably connected, for example, they can be an interference fit connection or a bolt connection, the locking bolt is threadedly connected to the threaded hole on the slider, and the front end of the locking bolt passes through the threaded hole and abuts against the support rod to fix the slider.

[0022] The probe clamp is provided with a probe sleeve for protecting and supporting the probe and increasing friction.

[0023] Furthermore, at least one set of probe clamping components is provided above the support platform; and at least one set of probe clamping components is provided below the support platform.

[0024] Preferably, the probe clamping assembly is located above the support table, and the probe points vertically downward to the upper plane of the support table.

[0025] Preferably, the probe of the probe clamping assembly located below the support platform is directed vertically upward toward the lower plane of the support platform.

[0026] The upper and lower planes of the support platform are provided with probes, so that the probes can respectively and synchronously collect microcirculation function data of multiple organs or tissues of the back, chest and abdomen of the mouse.

[0027] Furthermore, the number of the probe holders and probes is two or more groups.

[0028] Furthermore, the number of the probe holders and probes is 2 groups, 3 groups, 4 groups or 5 groups.

[0029] Furthermore, the distance between the probe and the mouse tissue on the support platform is about 1 mm.

[0030] The utility model discloses a support platform and a system for simultaneously detecting the back, chest and abdomen of a mouse. The support platform has a long slot-shaped window in the middle and movable slots on both sides, through which different types of commercially available microcirculation evaluation instruments' probes and their optical path signals can pass. Meanwhile, the probe and the probe clamp in the probe clamp assembly cooperate with the support platform to adapt to the microcirculation function detection of two or more organs and tissues of rats and mice.

[0031] Compared with the prior art, the beneficial effects of the utility model include:

[0032] 1. The utility model provides a support platform and a detection system for synchronous detection of the back, chest and abdomen of mice, which solves the problem that the prior art cannot simultaneously meet the needs of synchronous measurement and data collection of the microcirculation functions of the back, chest and abdomen, and provides a more comprehensive experimental platform for researchers.

[0033] 2. The window design of the support platform of the utility model can realize the detection of microcirculation function of back organs and tissues. The design of the window and the movable slot makes it convenient for the experimenter to directly contact and observe the front and back body parts of the mouse, thereby realizing the simultaneous synchronous detection function of two or more probes on non-ipsilateral organs and tissues of mice of different body sizes.

[0034] 3. The arc-shaped structure design of the movable groove of the support platform fixing device of the utility model can adapt to the arc-shaped fixation of the body length, upper limbs and lower limbs of mice of different body types. The position of the fixing screw can also be adjusted according to the specific use of the experimental mouse to ensure a good observation position for the experimental mouse. At the same time, the arc-shaped structure can better disperse and withstand pressure from different directions, reduce the pressure concentration point, and improve the stability of the support platform.

[0035] 4. In the detection system of the utility model, the slotted opening of the support table is adapted to the outer diameter of the probe, so as to be compatible with and satisfy the effect of smooth movement of different types of probes of mainstream microcirculation evaluation instruments on the market within the slotted opening, and at the same time can support the collection of microcirculation function data of different organs and tissues at different positions of mice. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] The present invention will be further described below with reference to the accompanying drawings and embodiments, in which:

[0037] Figure 1 It is a schematic diagram of the overall structure of the support platform;

[0038] Figure 2 A top view of the support platform;

[0039] Figure 3 It is the overall structure diagram of the detection system;

[0040] Figure 4 It is the side view of the detection system;

[0041] Figure 5 A top view of the detection system.

[0042] The reference numerals in the figure are as follows: 1-support table, 2-platform, 3-window, 4-movable slot, 5-fixing screw, 6-probe holder, 7-probe, 8-base, 9-support rod, 10-slider, 11-probe clamp, 12-locking bolt. DETAILED DESCRIPTION

[0043] The present invention will be further described below in conjunction with the accompanying drawings and embodiments. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations on the present invention. It should be noted that the embodiments of the present invention and the features in the embodiments can be combined with each other without conflict.

[0044] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate directions or positional relationships based on the attached Figure 1The orientation or positional relationship shown is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as a limitation on the utility model. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, features defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the utility model, unless otherwise specified, "multiple" means two or more.

[0045] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood by specific circumstances.

[0046] The utility model provides a support platform and a detection system for synchronous detection of the mouse back, chest and abdomen, including a support platform and a probe clamping assembly. The support platform 1 includes a platform 2, and a window 3 and a fixing device are provided on the surface of the platform 2; the fixing device includes a moving groove 4 and a fixing screw 5. The window 3 is located in the middle of the platform 2, and the fixing devices are symmetrically arranged on both sides of the window 3. The bottom of the platform is connected to a support leg. (such as Figure 1 and Figure 2 The support platform is made of acrylic plate. The probe clamping assembly includes a probe clamp 6 and a probe 7. The probe clamp includes a base 8, a support rod 9, a slider 10, a probe clamp 11 and a locking bolt 12.

[0047] In the embodiment, the long slot-shaped window 3 in the middle of the support platform is 3mm wide and 200mm long; the mobile slot 4 is 3mm wide and is provided in two groups, with a number of 4 and 8 fixing screws. The appropriate mobile slot can be selected for fixing according to the body shape of the mouse. This design allows the probe and laser optical path signals to pass through, and can also meet the microcirculation function data collection of the back, chest, and abdominal organs and tissues of rats (body length of about 200mm) and mice (body length of about 100mm). In the embodiment, two groups of probe clamping assemblies are selected to simultaneously and synchronously collect microcirculation function data of the back, chest, and abdominal organs and tissues of the mouse.

[0048] In order to better understand the technical solution of the present invention, specific embodiments are selected below to illustrate the operating steps of the support platform and detection system for synchronous detection of the mouse back, chest and abdomen of the present invention.

[0049] Example 1

[0050] In the embodiment, the flexible connection method uses a rubber band, the support platform has a height of 200 mm, and is used in conjunction with a probe clamping component with a height of less than 200 mm. A rat is selected, and the body length is 200 mm.

[0051] 1) First, the support platform 1 is placed stably on the experimental table, and the rats required for the experiment are selected and placed on the platform 2.

[0052] 2) According to the body length of the rat, select an arc-shaped moving groove corresponding to the length of the rat's limbs. Place the rat in a supine position, then tie the rat's upper limbs with rubber bands, and then fix them to the appropriate positions of the fixing screws 5 on both sides, then slide another fixing screw to make it slide along the moving groove 4 to the corresponding position, adjust the fixing screws 5 and fix the rat's lower limbs. Finally, fix the rat's teeth to the upper fixing screws of the window 3.

[0053] 3) The small intestine tissue to be tested is exposed on the abdomen of the rat, and the tissue to be tested is exposed on the back of the rat skin.

[0054] 4) If Figure 3-Figure 5 As shown, the probes 7 in the two probe clamping assemblies are fixed to the probe clamp 6, and then the placement of the probe clamp 6 and the support platform 1 are adjusted. First, one of the probe clamping assemblies is located above the support platform 1, and the probe is pointed downward to the small intestine and related tissues to be detected in the lower abdomen area of ​​the rat; then the other probe clamping assembly is located below the window 3 of the support platform 1, and the probe is pointed upward to the skin tissue to be detected on the back. After determining the position of the probe, fine-tune the upper and lower probe clamps respectively to keep the probe 1mm away from the tissue or organ to be detected, and tighten the locking bolt 12 to fix the position.

[0055] 5) Finally, turn on the microcirculation function detector to collect microcirculation function data of the rats.

[0056] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structural transformation made using the contents of the present invention specification, or directly or indirectly applied in other related technical fields, is also included in the patent protection scope of the present invention.

Claims

1. A support platform for synchronous detection of mouse back, chest and abdomen, characterized in that: It comprises a platform; a window and a fixing device are arranged on the surface of the platform; the fixing device comprises a movable slot and a fixing screw; the window is located in the middle of the platform and is a long slot type; the fixing devices are symmetrically arranged on both sides of the window; and a supporting leg is connected to the bottom of the platform.

2. The support platform according to claim 1, characterized in that: The movable groove is an arc-shaped through groove; the fixing screw is located in the movable groove.

3. The support platform according to claim 2, characterized in that: There are at least two movable grooves; each movable groove is provided with two fixing screws.

4. The support platform according to claim 1, characterized in that: The opening widths of the window and the movable groove are 1 mm to 5 mm.

5. The support platform according to claim 4, characterized in that: The opening width is 3 mm.

6. The support platform according to any one of claims 1 to 5, characterized in that: The supporting platform is made of transparent material.

7. The support platform according to claim 6, characterized in that: The transparent material is acrylic.

8. A system for synchronously detecting the back, chest and abdomen of a mouse, comprising the support platform according to any one of claims 1 to 7, characterized in that: The detection system also includes a probe clamping assembly; the probe clamping assembly includes a probe clamp and a probe, and the probe clamp is used to fix the probe.

9. The detection system according to claim 8, characterized in that: The probe holder comprises a base, a support rod, a slide block, a probe clamp and a locking bolt.

10. The detection system according to claim 8, characterized in that: At least one set of probe clamping components is arranged above the support platform; and at least one set of probe clamping components is arranged below the support platform.

11. The detection system according to claim 8, characterized in that: The number of the probe holders and probes is 2 sets, 3 sets, 4 sets or 5 sets.

12. The detection system according to claim 8, characterized in that: The distance between the probe and the mouse tissue to be tested on the support platform is 1 mm.

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