Carboxymethyl cellulose freeze-drying sponge mold
By introducing overflow grooves and matching bump structures into the carboxymethyl cellulose lyophilized sponge mold, the apparent unevenness and overflow problems during the lyophilization process are solved, and the uniformity and efficient lyophilization efficiency of the lyophilized sponge are achieved.
Patent Information
- Application Number
- CN202322766109.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2023-10-16
- Publication Date
- 2025-01-14
- Estimated Expiration
- 2033-10-16
AI Technical Summary
The existing carboxymethyl cellulose lyophilized sponge molds lead to uneven appearance structure, and the raw material solution expands or overflows or is uneven during lyophilization, affecting the appearance and performance of the lyophilized sample.
A carboxymethylcellulose sponge freeze-dried mold with overflow tank structure was designed. By setting a gap and overflow tank between the cover plate and the sample tank, the raw material solution is allowed to expand and overflow during freezing, ensuring the appearance of the lyophilized sample is uniform. , and facilitate separation of residual material through matching bumps and overflow groove structures.
The apparent uniformity and lyophilization efficiency of carboxymethyl cellulose lyophilized sponge are improved, ensuring the integrity of the lyophilized shape and appearance uniformity, and simplifying the removal process of residual material.
Smart Images
Figure CN222346337U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to a sponge mould, mainly to a carboxymethyl cellulose freeze-dried sponge mould. Background Art
[0002] Carboxymethyl cellulose (CMC) is derived from cellulose by carboxylmethylation. The aqueous solution of carboxymethyl cellulose has the functions of thickening, film-forming, bonding, water retention, colloid protection, emulsification and suspension. Nowadays, it is widely used in the petroleum, food, medicine, textile and papermaking industries, and is one of the most important ether celluloses. Carboxymethyl cellulose has the advantages of water absorption, thickening, and non-toxicity. It is widely used in petroleum industry treatment agents, washing and printing agents, daily chemical thickeners, pharmaceutical industry thickeners and emulsifiers, food industry thickeners and ceramic industry adhesives. Carboxymethyl cellulose freeze-dried sponge is freeze-dried from carboxymethyl cellulose solution and is often used in biopharmaceutical preparations, but ordinary freeze-drying molds will make the appearance of carboxymethyl cellulose freeze-dried sponge uneven, affecting the appearance and use. The uneven surface structure will affect the performance and use of carboxymethyl cellulose freeze-dried sponge. In addition, if a completely closed container is used for freezing, the raw material solution will expand and overflow or have internal unevenness due to the increase in volume after freezing, making the final freeze-dried sample deformed or uneven in appearance. Therefore, the prior art still needs to be improved and developed. Utility Model Content
[0003] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a carboxymethyl cellulose freeze-dried sponge mold, aiming to solve the problem that the existing sponge mold is not suitable for the carboxymethyl cellulose freeze-dried sponge, resulting in uneven surface structure.
[0004] The technical solution of the utility model is as follows:
[0005] A carboxymethyl cellulose freeze-dried sponge mold, wherein the carboxymethyl cellulose freeze-dried sponge mold comprises a cover plate and a sample slot with an opening at the top, a first convex block protruding toward the cover plate is arranged at the bottom edge of the sample slot, and a second convex block protruding toward the sample slot is arranged on the lower surface of the cover plate;
[0006] When the cover plate covers the sample slot to form a carboxymethyl cellulose freeze-dried sponge mold, a gap for raw materials to pass through is formed between the second protrusion and the first protrusion, the second protrusion and the inner side wall of the sample slot form an overflow slot, and the rest of the cover plate covers the sample slot.
[0007] The utility model provides a carboxymethyl cellulose freeze-dried sponge mold, which can be used to prepare a carboxymethyl cellulose freeze-dried sponge with uniform appearance, shorten the freeze-drying time of the carboxymethyl cellulose freeze-dried sponge while ensuring uniform appearance, improve the freeze-drying efficiency, and ensure the freeze-dried shape.
[0008] Furthermore, the inner side of the second protrusion and the inner side of the first protrusion both match the shape of the sponge contour. The inner side of the second protrusion and the inner side of the first protrusion that match the shape correspond to the shape of the sponge body, which is conducive to sponge molding.
[0009] Furthermore, the gap is arranged horizontally, and the inner edge of the first protrusion is aligned with the inner edge of the second protrusion, so as to ensure that the connection between the residual material part and the sponge body is a regular geometric shape, reduce the influence of the connection part on the sponge body when removing, and facilitate post-processing.
[0010] Furthermore, the protrusion height of the first protrusion is half of the inner height of the sample groove.
[0011] Furthermore, the protrusion height of the second protrusion is greater than or equal to one quarter of the inner height of the sample slot and less than half of the inner height of the sample slot. The protrusion height of the second protrusion can be changed according to the fluidity of the raw material and the ease of separation of the freeze-dried residual material from the sponge body.
[0012] Preferably, the sample slot is a metal sample slot, and the cover plate is a metal cover plate.
[0013] Furthermore, the first protrusions are symmetrically arranged on the bottom surface of the sample slot based on the geometric center of the sample slot.
[0014] Furthermore, the sample slot has a shape of one of square, circle, triangle, trapezoid and irregular shape.
[0015] Furthermore, the sample slot is square in shape, the width of the cover plate is greater than or equal to 2 mm, and the length of the cover plate is less than or equal to 1 to 5 mm.
[0016] Preferably, the width of the cover plate is 2 mm greater than the width of the square sample slot, and the length of the cover plate is 3 mm less than the length of the square sample slot.
[0017] The utility model designs a carboxymethyl cellulose sponge freeze-drying mold with an overflow groove structure, which provides an overflow structure so that the carboxymethyl cellulose solution has space to discharge excess liquid when the volume increases due to freezing, solves the problem that the carboxymethyl cellulose solution raw material overflows in an undirected manner or cannot overflow during the freeze-drying process, resulting in deformation or unevenness of the finished sponge product, and ensures the uniform appearance of the freeze-dried sponge. At the same time, the setting of the overflow groove can make the overflow part form a residual material structure that is easy to separate from the sponge body after freeze-drying molding, and the residual material can be easily removed, ensuring the integrity of the appearance of the freeze-dried sponge. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1This is a front view of the square sample tank of Example 1 of the utility model
[0019] Figure 2 This is a schematic structural diagram of a square sample trough in Example 2 of the utility model.
[0020] Figure 3 This is a front view of the square sample trough of Example 2 of the utility model.
[0021] Figure 4 This is a top view of the square sample tank of Example 2 of the utility model.
[0022] Figure 5 This is a side view of the square sample trough of Example 2 of the present utility model.
[0023] Explanation of reference numerals: 1. sample slot; 2. cover plate; 3. overflow slot; 4. first protrusion; 5. second protrusion. DETAILED DESCRIPTION
[0024] The utility model provides a carboxymethyl cellulose freeze-dried sponge mold. In order to make the purpose, technical solution and effect of the utility model clearer and more specific, the utility model is further described in detail below. It should be understood that the specific embodiments described herein are only used to explain the utility model and are not used to limit the utility model. In the description of the utility model, "inside" means the side facing the inside of the carboxymethyl cellulose freeze-dried sponge mold, and "outside" means the side facing the outside of the carboxymethyl cellulose freeze-dried sponge mold.
[0025] The utility model provides a carboxymethyl cellulose freeze-dried sponge mold, which can be used to prepare a carboxymethyl cellulose freeze-dried sponge with uniform appearance, shorten the freeze-drying time of the carboxymethyl cellulose freeze-dried sponge while ensuring uniform appearance, improve the freeze-drying efficiency, and ensure the freeze-dried shape. Figure 1-Figure 5 As shown, the carboxymethyl cellulose freeze-dried sponge mold includes a cover plate 2 and a sample slot 1 with an opening at the top, a first protrusion 4 protruding toward the cover plate 2 is provided on the bottom edge of the sample slot 1, and a second protrusion 5 protruding toward the sample slot is provided on the lower surface of the cover plate;
[0026] like Figure 1 and Figure 3 As shown, when the cover plate 2 covers the sample slot 1 to form a carboxymethyl cellulose freeze-dried sponge mold, a gap for the raw material to pass through is formed between the second protrusion 5 of the cover plate 2 and the first protrusion 4, and the second protrusion 5 and the inner side wall of the sample slot 1 form an overflow slot 3, and the rest of the cover plate 2 covers the sample slot 1.
[0027] The utility model designs a carboxymethyl cellulose sponge freeze-drying mold with an overflow groove structure, which provides an overflow structure so that the carboxymethyl cellulose solution has space to discharge excess liquid when the volume increases due to freezing, solves the problem that the carboxymethyl cellulose solution raw material overflows in an undirected manner or cannot overflow during the freeze-drying process, resulting in deformation or unevenness of the finished sponge product, and ensures that the appearance of the freeze-dried sponge is uniform. At the same time, the setting of the overflow groove 3 can make the overflow part form a residual material structure that is easily separated from the sponge body after freeze-drying molding, and the residual material can be easily removed, ensuring the appearance integrity of the freeze-dried sponge.
[0028] Furthermore, the inner side of the second protrusion 5 and the inner side of the first protrusion 4 are both matched with the contour shape of the sponge. The second protrusion 5 and the first protrusion 4 are used to form a gap for the raw material to pass through so that the excess material can overflow. The inner side of the second protrusion 5 and the first protrusion 4 are part of the molding mold and can be designed and changed according to the shape of the sponge body. The inner side of the second protrusion 5 and the inner side of the first protrusion 4 that match the shape correspond to the shape of the sponge body so that the sponge is formed.
[0029] Furthermore, the gap is set horizontally, and the inner edge of the first protrusion is aligned with the inner edge of the second protrusion. Part of the raw material overflowing through the gap needs to be removed as residual material after solidification. By setting the gap horizontally and aligning the inner edge of the first protrusion and the inner edge of the second protrusion, it can be ensured that the connection between the residual material part and the sponge body after freeze-drying molding is a regular geometric shape, and the residual material part can be removed by gently breaking it, reducing the impact of the connection part on the sponge body when removing it, which is convenient for post-processing.
[0030] Furthermore, the protruding height of the first protrusion 4 is half of the inner height of the sample tank 1, which can avoid the waste of raw materials due to excessive residual materials overflowing from the tank.
[0031] Furthermore, the protruding height of the second protrusion 5 is greater than or equal to one quarter of the inner height of the sample slot 1 and less than half of the inner height of the sample slot 1. The protruding height of the second protrusion 5 on the cover plate 2 can be changed, and can be determined according to the fluidity of the raw material and the ease of separation of the residual material after freeze-drying from the sponge body. Reducing the protruding height of the second protrusion 5 can allow raw materials with higher viscosity or lower fluidity to pass through the gap smoothly. Properly increasing the height of the second protrusion 5 while ensuring that the raw material can pass through the gap smoothly is conducive to reducing the connection area between the residual material part and the sponge body, and the residual material can be easily separated from the sponge body after freeze-drying.
[0032] During the molding process of carboxymethyl cellulose solution in ordinary freeze-drying molds, the growth rates of ice crystals in the center and around the carboxymethyl cellulose solution are different, with obvious differences, which makes the surface of the carboxymethyl cellulose freeze-dried sponge show a significantly uneven strip structure rather than a uniform fine sand-like crystal structure.
[0033] Furthermore, the material of the sample slot 1 and the cover plate 2 can be a metal material or a non-metallic material that can be separated from the ice cubes formed by freezing the raw material. Preferably, the sample slot 1 and the cover plate 2 are made of metal materials. The utility model uses a non-sealed metal mold for freezing and freeze-drying. Through the excellent thermal conductivity of the metal mold, the surface of the carboxymethyl cellulose solution raw material is evenly cooled during freezing, forming a uniform fine ice crystal structure. Then, when ice crystals are generated from the surface to the inside, they will be restricted by the volume and the ice crystals on the surface, thereby inhibiting their accelerated growth, and will not form large ice crystal structures such as strips and layers inside, thereby making the inside of the freeze-dried sponge also a uniform structure, and then obtaining a freeze-dried sponge with uniform appearance. The metal cover plate can be separated from the ice cubes formed by freezing the raw material without damaging the ice cubes, so that the mold can obtain a larger contact area with the air during freeze-drying, thereby shortening the freeze-drying time and improving the freeze-drying efficiency.
[0034] Furthermore, the first protrusion 4 is symmetrically arranged on the bottom surface of the sample tank 1 based on the geometric center of the sample tank 1. By symmetrically arranging the first protrusion 4 and forming an overflow structure, the excess liquid generated by the expansion during the freeze-drying process can be evenly released to the symmetrical sides of the sample tank 1, timely reducing the stress accumulation caused by the freeze-drying expansion of the sponge, effectively ensuring that the shape of the finished sponge is uniform and wrinkle-free, which is particularly suitable for raw material solutions with low fluidity or high viscosity. Specifically, Figure 3 As shown, first protrusions 4 are symmetrically arranged on both sides of the square sample slot 1 , and second protrusions 5 are symmetrically arranged on both sides of the cover plate, and together with the inner side walls of the sample slot 1 , overflow slots 3 symmetrically arranged on both sides of the square sample slot 1 are formed.
[0035] Further, the shape of the sample slot 1 is one of square, circular, triangular, trapezoidal and irregular, and is set according to the actual shape requirements of the finished sponge product. In some embodiments, the shape of the sample slot is square, and the first bump can be set on one side of the square bottom surface of the square sample slot, or on two opposite sides of the square bottom surface; in some embodiments, the shape of the sample slot is triangular, and the first bump can be set on one side of the triangular bottom surface of the triangular sample slot; in some embodiments, the shape of the sample slot is circular, and the first bump can be set on an arc segment with a central angle of 10°-90° on the edge of the circular bottom surface of the center sample slot, and the first bump can also be symmetrically set based on the center of the circular bottom surface on the edge of the arc segment with a central angle of 10°-60°; in some embodiments, the shape of the sample slot is irregular, and the first bump can be set on the edge of the irregular bottom surface of the irregular sample slot with a length of one-tenth to one-quarter of the circumference.
[0036] Furthermore, the sample slot 1 is in a square shape, and the width of the cover plate 2 is greater than the width of the sample slot 1 by 2 mm or more, so as to facilitate the subsequent separation from the frozen polymer raw material by knocking out, and the length of the cover plate 2 is 1 to 5 mm less than the length of the sample slot 1, which can be determined according to the amount of overflow of the raw material after freezing. Preferably, the width of the cover plate is greater than the width of the square sample slot by 2 mm, and the length of the cover plate is less than the length of the square sample slot by 3 mm.
[0037] The utility model designs a carboxymethyl cellulose sponge freeze-drying mold with an overflow groove structure, which provides an overflow structure so that the carboxymethyl cellulose solution has space to discharge excess liquid when the volume increases due to freezing, solves the problem that the carboxymethyl cellulose solution raw material overflows in an undirected manner or cannot overflow during the freeze-drying process, resulting in deformation or unevenness of the finished sponge product, and ensures the uniform appearance of the freeze-dried sponge. At the same time, the setting of the overflow groove can make the overflow part form a residual material structure that is easy to separate from the sponge body after freeze-drying molding, and the residual material can be easily removed, ensuring the integrity of the appearance of the freeze-dried sponge.
[0038] The following is an explanation through specific examples. Example 1
[0039] The metal mold of Example 1 is as follows Figure 1 As shown, a first protrusion 4 is provided at one end of the square sample tank, and the protrusion height of the first protrusion 4 is one-half of the inner height of the sample tank 1, and the height of the second protrusion 5 of the metal plate is one-quarter of the inner height of the sample tank 1. A carboxymethyl cellulose solution with a concentration of 3% is prepared, and after being completely dissolved, it is slowly added to the metal mold. Under the action of surface tension, the carboxymethyl cellulose solution is added until the liquid level is slightly higher than the top edge of the sample tank 1. Then use a corresponding matching metal plate to cover the upper edge of the mold from above, slightly wipe off the excess liquid overflowing from the overflow tank 3, and place it in a refrigerator at -50°C for 24 hours. After taking out the completely frozen mold, gently knock off the upper metal plate to expose the frozen liquid surface, and then place it in a freeze dryer for freeze drying. After the freeze drying is completed, gently break off the remaining material part at one end to obtain a carboxymethyl cellulose freeze-dried sponge with a uniform surface and a specified shape. Example 2
[0040] The metal mold structure of Example 2 is as follows Figure 2-Figure 5As shown, the first protrusions 4 are symmetrically arranged at both ends of the square sample tank, and the protrusion height of the first protrusion 4 is half of the inner height of the sample tank 1. The height of the second protrusion 5 of the metal plate is one quarter of the inner height of the sample tank 1. A chitosan solution with a concentration of 5% is prepared, and after it is completely dissolved, it is slowly added to the metal mold. Under the action of surface tension, the chitosan solution is added until the liquid level is slightly higher than the top edge of the sample tank 1. Then use a corresponding matching metal plate to cover the upper edge of the mold from above, slightly wipe off the excess liquid overflowing from the overflow tank 3, and place it in a refrigerator at -50°C for 24 hours. After taking out the completely frozen mold, gently knock off the upper metal plate to expose the frozen liquid surface, and then place it in a freeze dryer for freeze drying. After freeze drying, gently break the remaining parts at both ends of the sponge body with force to obtain a chitosan freeze-dried sponge with a uniform surface and a specified shape.
[0041] The utility model takes into account the problem that the separation of the residual material part of the sponge after freeze-drying may cause uneven appearance. The design core is to provide the raw material solution with a proper overflow port in a guiding manner. A non-sealed container is adopted, and an overflow structure is provided so that the carboxymethyl cellulose solution has space to discharge excess liquid when the volume increases due to freezing. After molding, a residual material part that can be easily separated from the sponge body is formed, thereby ensuring the appearance and uniformity of the finished sponge. The provided freeze-drying mold can be designed to obtain a carboxymethyl cellulose freeze-dried sponge of a desired shape and size. The prepared carboxymethyl cellulose freeze-dried sponge has a uniform appearance and can also be extended to other polymer solutions to prepare uniform polymer freeze-dried sponges.
[0042] It should be understood that the application of the present invention is not limited to the above examples. For ordinary technicians in this field, improvements or changes can be made according to the above description, and all these improvements and changes should fall within the protection scope of the present invention.
Claims
1. A carboxymethyl cellulose freeze-dried sponge mold, characterized in that: The carboxymethyl cellulose freeze-dried sponge mold comprises a cover plate and a sample slot with an opening at the top, wherein a first protrusion protruding toward the cover plate is arranged at the bottom edge of the sample slot, and a second protrusion protruding toward the sample slot is arranged at the lower surface of the cover plate; When the cover plate covers the sample slot to form a carboxymethyl cellulose freeze-dried sponge mold, a gap for raw materials to pass through is formed between the second protrusion and the first protrusion, the second protrusion and the inner side wall of the sample slot form an overflow slot, and the rest of the cover plate covers the sample slot.
2. The carboxymethyl cellulose freeze-dried sponge mold according to claim 1, characterized in that The inner side of the second protrusion and the inner side of the first protrusion both match the contour shape of the sponge.
3. The carboxymethyl cellulose freeze-dried sponge mold according to claim 1, characterized in that The gap is arranged horizontally, and the inner edge of the first protrusion is aligned with the inner edge of the second protrusion.
4. The carboxymethyl cellulose freeze-dried sponge mold according to claim 1, characterized in that The protruding height of the first protrusion is half of the inner height of the sample groove.
5. The carboxymethyl cellulose freeze-dried sponge mold according to claim 1, characterized in that The protruding height of the second protrusion is greater than or equal to one quarter of the inner height of the sample groove and less than half of the inner height of the sample groove.
6. The carboxymethyl cellulose freeze-dried sponge mold according to claim 1, characterized in that The sample slot is a metal sample slot, and the cover plate is a metal cover plate.
7. The carboxymethyl cellulose freeze-dried sponge mold according to claim 1, characterized in that The first protrusions are symmetrically arranged on the bottom surface of the sample slot based on the geometric center of the sample slot.
8. The carboxymethyl cellulose freeze-dried sponge mold according to claim 1, characterized in that The shape of the sample slot is one of square, circle, triangle, trapezoid and irregular shape.
9. The carboxymethyl cellulose freeze-dried sponge mold according to claim 8, characterized in that The sample slot is in a square shape, the width of the cover plate is greater than or equal to 2 mm, and the length of the cover plate is less than or equal to 1 to 5 mm.
10. The carboxymethyl cellulose freeze-dried sponge mold according to claim 9, characterized in that: The width of the cover plate is 2 mm greater than the width of the square sample slot, and the length of the cover plate is 3 mm less than the length of the square sample slot.