Automated analyzer

Abstract

The utility model belongs to the technical field of chemiluminescence detection, and discloses an automatic analysis device. The automatic analysis device comprises an incubation disc module, a dispatching disc module, a magnetic separation module, a reagent disc module and a reading station module, wherein the incubation disc module is used for incubating reaction liquid in a reaction cup and transferring the reaction cup to a specified position; the dispatching disc module is used for transferring and dispatching reaction cups; the magnetic separation module is used for cleaning impurities of the reacted magnetic beads; the reagent tray module is used for refrigerating and transferring reagents with different components; the reading station module comprises a first reading station and a second reading station, the first reading station is located among the dispatching disc module, the magnetic separation module and the reagent disc module, and the second reading station is located on the sides, away from the dispatching disc module, of the magnetic separation module and the reagent disc module. And the reading station module can transfer the reaction cup from the first reading station to the second reading station. According to the automatic analysis device provided by the utility model, the scheduling flexibility is improved, and the space is effectively saved.

Description

Technical Field

[0001] The utility model relates to the technical field of chemiluminescence detection, in particular to an automatic analysis device. Background Art

[0002] Immunoassay is a type of highly sensitive and specific analytical instrument, which is often used in clinical laboratories to detect various analytical indicators of blood, urine or other body fluids. Traditional immunoassays have a variety of implementation principles, such as chemiluminescence, electrochemiluminescence, etc. Chemiluminescence immunoassay is an in vitro detection and analysis technology that combines antigen-antibody immune reaction and luminescence reaction. It is based on immunological theory, uses luminescent markers as tracer signals, and detects multiple markers by collecting light signals. It has the advantages of high sensitivity, low nonspecific adsorption, and high accuracy.

[0003] Existing immunoassay analyzers occupy a large area. The incubation plate must take into account the scheduling of adding samples and reagents, as well as the scheduling of the gripper to transport the reaction cup to the mixing component and the magnetic separation plate, and the scheduling of waste suction. The scheduling task is heavy and the scheduling flexibility is poor. In addition, the incubation plate has many control actions, poor temperature control consistency, and low instrument working efficiency.

[0004] Therefore, an automatic analysis device is urgently needed to solve the above technical problems. Utility Model Content

[0005] The purpose of the utility model is to provide an automatic analysis device, aiming to solve the problems that the existing analysis device occupies a large area, has heavy incubation plate scheduling tasks, and has poor scheduling flexibility, resulting in low working efficiency of the analysis device, effectively improving the scheduling flexibility, improving the working efficiency of the automatic analysis device, and saving space.

[0006] To achieve this purpose, the utility model adopts the following technical solutions:

[0007] Automatic analysis device, comprising:

[0008] An incubation tray module, used for incubating the reaction solution in the reaction cup and transporting the reaction cup to a designated location;

[0009] A dispatch tray module, used for transporting and dispatching the reaction cups, wherein the dispatch tray module is independently arranged around the incubation tray module;

[0010] A magnetic separation module, used for cleaning impurities of the magnetic beads after the reaction, wherein the magnetic separation module is arranged at one side of the scheduling disk module;

[0011] A reagent tray module, used for refrigerating and transporting reagents of different components, wherein the reagent tray module is arranged at intervals on the same side of the scheduling tray module and the magnetic separation module;

[0012] A reading station module is used to analyze and test the reaction liquid in the reaction cup. The reading station module includes a first reading station and a second reading station. The first reading station is located between the scheduling disk module, the magnetic separation module and the reagent disk module. The second reading station is located on the side of the magnetic separation module and the reagent disk module away from the scheduling disk module. The reading station module can transfer the reaction cup from the first reading station to the second reading station.

[0013] Optionally, a first gripper is provided between the incubation tray module and the magnetic separation module, and the first gripper is used to transfer the reaction cup between the incubation tray module and the magnetic separation module.

[0014] Optionally, the automatic analysis device further comprises an automatic cup adding module, which is used to screen, correct the postures of and sort the reaction cups in the hopper, and place the reaction cups onto a cup separation plate of the automatic cup adding module.

[0015] Optionally, the automatic analysis device also includes a second gripper and a sample mixing module, the sample mixing module is arranged on one side of the scheduling disk module, the sample mixing module is used to mix the sample and reagent in the reaction cup, the second gripper is arranged between the automatic cup adding module, the sample mixing module and the scheduling disk module, the second gripper is used to transfer the reaction cup between the automatic cup adding module, the scheduling disk module, the sample mixing module and the incubation disk module.

[0016] Optionally, the automatic analysis device also includes a photometric module and a counting module. The photometric module is arranged at the second reading station and is used to collect optical signal data of the reaction liquid in the reaction cup moved to the second reading station. The counting module is arranged at the bottom of the reading station module and is used to process the optical signal data.

[0017] Optionally, the reading station module includes a base, a driving assembly and a cup carrier, the driving assembly includes a first guide rail, a synchronous belt and a driving motor provided on the base, the cup carrier is fixedly provided on the synchronous belt, the cup carrier is used to carry the reaction cup, and the driving motor can drive the synchronous belt to move, so that the synchronous belt drives the cup carrier to move along the first guide rail;

[0018] The base is provided with a cup inlet and outlet and a first shielding component for closing or opening the cup inlet and outlet. The first shielding component is arranged close to the first end of the first guide rail. When the cup carrier moves along the first guide rail, it can push the first shielding component to move so that the cup inlet and outlet is opened.

[0019] Optionally, the first shielding assembly includes a first shielding plate, a first return spring, a first shock-absorbing pad and a second shock-absorbing pad, the first shielding plate is slidably arranged on the second guide rail of the base, the first shock-absorbing pad is arranged on the first shielding plate, and the second shock-absorbing pad is arranged on the base, one end of the first return spring is connected to the base, and the other end of the first return spring is connected to the first shielding plate, the cup carrier contacts the first shock-absorbing pad to push the first shielding plate to slide along the second guide rail, so that the cup inlet and outlet opening is opened, and after the cup carrier is separated from the first shock-absorbing pad, the first return spring drives the first shielding plate to press against the second shock-absorbing pad, so that the cup inlet and outlet opening is closed.

[0020] Optionally, the photometric module is configured as a PMT module, and the reading station module further includes a second shielding assembly. The PMT module is disposed on the base and is disposed close to the second end of the first guide rail, and the second shielding assembly is used to close or open a lens hole corresponding to the lens of the PMT module. A third shock-absorbing pad is disposed on the cup holder, and when the cup holder moves along the first guide rail, the third shock-absorbing pad contacts the second shielding assembly to push the second shielding assembly to move, so that the lens hole of the PMT module opens.

[0021] Optionally, the second shielding assembly includes a second shielding plate, a second return spring and a fourth shock-absorbing pad, the second shielding plate is slidably arranged on the third guide rail of the base, the fourth shock-absorbing pad is arranged on the base, one end of the second return spring is connected to the base, and the other end of the second return spring is connected to the second shielding plate, when the cup carrier moves along the first guide rail, the third shock-absorbing pad contacts the second shielding plate to push the second shielding plate to slide along the third guide rail, so that the lens hole of the PMT module is opened, and after the third shock-absorbing pad is separated from the second shielding plate, the second return spring drives the second shielding plate to slide along the third guide rail to reach the fourth shock-absorbing pad, so that the cup inlet and outlet are closed.

[0022] Optionally, a fifth shock-absorbing pad is provided on the cup carrier, and after the lens hole of the PMT module is opened, the cup carrier abuts against the PMT module through the fifth shock-absorbing pad.

[0023] The beneficial effects of the present invention are as follows: in the automatic analysis device provided by the present invention, the scheduling disk module is independently arranged on the surrounding side of the incubation disk module, and the incubation disk module and the scheduling disk module have relatively independent operation processes, which improves the scheduling flexibility and thus improves the working efficiency of the automatic analysis device; the first reading station of the reading station module is located between the scheduling disk module, the magnetic separation module and the reagent disk module, and the second reading station is located on the side of the magnetic separation module and the reagent disk module away from the scheduling disk module, which effectively saves space. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a functional module diagram of the automatic analysis device provided by the embodiment of the utility model;

[0025] Figure 2 This is a distribution diagram of each workstation of the automatic analysis device provided by the embodiment of the utility model;

[0026] Figure 3 This is a partial structural diagram of the reading station module provided by the embodiment of the utility model Figure 1 ;

[0027] Figure 4 This is a partial structural diagram of the reading station module provided by the embodiment of the utility model Figure 2 ;

[0028] Figure 5 This is a partial structural diagram of the reading station module provided by the embodiment of the utility model Figure 3 ;

[0029] Figure 6 is a cross-sectional view of a reading station module provided by an embodiment of the utility model;

[0030] Figure 7 It is a schematic diagram of the assembly of the cup holder and the first guide rail provided in an embodiment of the utility model;

[0031] Figure 8 is a positional relationship diagram of a calibration component and a photometric module provided in an embodiment of the utility model;

[0032] Fig. 9 It is a structural schematic diagram of a first shielding assembly provided in an embodiment of the utility model;

[0033] Fig.10 is a schematic structural diagram of a second shielding assembly provided in an embodiment of the utility model;

[0034] Fig.11 It is a structural schematic diagram of a cup holder provided by an embodiment of the utility model;

[0035] Fig.12 It is a structural schematic diagram of the excitation liquid filling assembly provided in an embodiment of the utility model.

[0036] In the figure:

[0037] 100, incubation tray module; 110, first incubation position; 120, second incubation position;

[0038] 200, scheduling tray module; 210, third station; 220, sample adding station; 230, reagent adding station; 240, fourth station; 250, fifth station;

[0039] 300, magnetic separation module; 310, magnetic separation station;

[0040] 400. Reagent disk module;

[0041] 500, reading station module; 510, base; 511, cup inlet and outlet; 512, second guide rail; 513, third guide rail; 521, first guide rail; 522, synchronous belt; 523, drive motor; 530, cup carrier; 531, photometric hole; 532, third shock-absorbing pad; 533, fifth shock-absorbing pad; 541, first baffle plate; 542, first return spring; 543, first shock-absorbing pad; 544, second shock-absorbing pad; 551, second baffle plate; 552, second return spring; 553, fourth shock-absorbing pad; 561, exciting liquid filling fixing seat; 562, exciting liquid heating seat; 570, calibration component; 571, calibration light source hole; 581, cup inlet and outlet in place sensor; 582, origin sensor; 583, photometric position in place sensor; 590, baffle; 501, first reading station; 502, second reading station;

[0042] 600, the first grip;

[0043] 700, automatic cup adding module; 710, cup separation plate; 711, first station; 712, second station;

[0044] 800, second grip;

[0045] 900, sample mixing module; 910, sample mixing position;

[0046] 1000, photometry module; 1010, lens;

[0047] 1100, counting module;

[0048] 1200, dilution and mixing module; 1210, dilution position;

[0049] 1310, first waste cup channel module; 1311, discard cup position; 1320, second waste cup channel module; 1400, reagent needle module; 1510, first cleaning pool module; 1511, first cleaning position; 1520, second cleaning pool module; 1521, second cleaning position; 1600, waste liquid needle module; 1700, water tank module; 1800, strong cleaning module; 1900, sampling needle module;

[0050] 2000, track module; 2100, sampling position;

[0051] 3000. Reaction cup. DETAILED DESCRIPTION

[0052] The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for ease of description, only the parts related to the present invention, rather than all structures, are shown in the accompanying drawings.

[0053] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected", and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0054] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0055] In the description of this embodiment, the terms "upper", "lower", "right", etc., are based on the directions or positions shown in the drawings, and are only for the convenience of description and simplified operation, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0056] This embodiment provides an automatic analysis device, which aims to solve the problems of existing analysis devices having a large footprint, heavy incubation plate scheduling tasks, and poor scheduling flexibility, which leads to low working efficiency of the analysis device. It effectively improves the scheduling flexibility, improves the working efficiency of the automatic analysis device, and saves space.

[0057] like Figure 1 and Figure 2As shown, the automatic analysis device includes an incubation tray module 100, a scheduling tray module 200, a magnetic separation module 300, a reagent tray module 400 and a reading station module 500. The incubation tray module 100 is used to incubate the reaction solution in the reaction cup 3000 and transport the reaction cup 3000 to a designated position; the scheduling tray module 200 is used to transport and schedule the reaction cup 3000, and the scheduling tray module 200 is independently arranged around the incubation tray module 100; the magnetic separation module 300 is used to clean impurities of magnetic beads after the reaction, and the magnetic separation module 300 is arranged at intervals on one side of the scheduling tray module 200; the reagent tray module 400 is used to refrigerate and transport reagents of different components, and the reagent tray module 400 is used to refrigerate and transport reagents of different components. The reagent tray module 400 is arranged at intervals on the same side of the scheduling tray module 200 and the magnetic separation module 300; the reading station module 500 is used to analyze and test the reaction liquid in the reaction cup 3000, and the reading station module 500 includes a first reading station 501 and a second reading station 502. The first reading station 501 is located between the scheduling tray module 200, the magnetic separation module 300 and the reagent tray module 400, and the second reading station 502 is located on the side of the magnetic separation module 300 and the reagent tray module 400 away from the scheduling tray module 200. The reading station module 500 can transfer the reaction cup 3000 from the first reading station 501 to the second reading station 502.

[0058] In the automatic analysis device provided by the utility model, the scheduling disk module 200 is independently arranged on the surrounding side of the incubation disk module 100, and the incubation disk module 100 and the scheduling disk module 200 have relatively independent operation processes, which improves the scheduling flexibility and thus improves the working efficiency of the automatic analysis device; the first reading station 501 of the reading station module 500 is located between the scheduling disk module 200, the magnetic separation module 300 and the reagent disk module 400, and the second reading station 502 is located on the side of the magnetic separation module 300 and the reagent disk module 400 away from the scheduling disk module 200, which effectively saves space.

[0059] Preferably, a first gripper 600 is provided between the incubation tray module 100 and the magnetic separation module 300 . The first gripper 600 is used to transfer the reaction cup 3000 between the incubation tray module 100 and the magnetic separation module 300 . The first gripper 600 has a good scheduling function.

[0060] Optionally, the automatic analysis device further comprises an automatic cup adding module 700 , which is used to screen, correct the postures of and sort the reaction cups 3000 in the hopper, and place the reaction cups 3000 onto a cup distribution plate 710 of the automatic cup adding module 700 .

[0061] Furthermore, the automatic analysis device also includes a second gripper 800 and a sample mixing module 900. The sample mixing module 900 is arranged on one side of the scheduling disk module 200. The sample mixing module 900 is used to quickly mix the samples and reagents in the reaction cup 3000. The second gripper 800 is arranged between the automatic cup adding module 700, the sample mixing module 900 and the scheduling disk module 200. The second gripper 800 is used to transport the reaction cup 3000 between the automatic cup adding module 700, the scheduling disk module 200, the sample mixing module 900 and the incubation disk module 100.

[0062] Optionally, the automatic analysis device further includes a dilution and mixing module 1200 , which is disposed on one side of the sample mixing module 900 , and is used to quickly mix the sample, reagent and diluent in the reaction cup 3000 .

[0063] In this embodiment, the automatic analysis device also includes two waste cup channel modules, namely a first waste cup channel module 1310 and a second waste cup channel module 1320. The first waste cup channel module 1310 is arranged between the reagent disk module 400 and the first gripper 600, and is used to provide a waste cup channel for the waste reaction cup 3000 grasped by the first gripper 600. The second waste cup channel module 1320 is arranged between the automatic cup adding module 700 and the scheduling disk module 200, and is used to provide a waste cup channel for the waste reaction cup 3000 grasped by the second gripper 800.

[0064] Optionally, the automatic analysis device also includes a reagent needle module 1400, a first cleaning tank module 1510 and a waste liquid needle module 1600. The reagent needle module 1400 is used to aspirate and discharge a quantitative amount of reagent on the trajectory line between the scheduling disk module 200 and the reagent disk module 400. The first cleaning tank module 1510 is used to clean the inner and outer walls of the reagent needle of the reagent needle module 1400 to reduce contamination and improve the performance of the reagent needle module 1400. The waste liquid needle module 1600 is used to absorb the waste liquid in the reaction cup 3000.

[0065] Optionally, a water tank module 1700 is provided on one side of the reagent disk module 400 for storing coolant and monitoring the content of the coolant.

[0066] The automatic analysis device also includes a track module 2000, a strong cleaning module 1800, a second cleaning tank module 1520 and a sampling needle module 1900. The sampling needle module 1900 is used to aspirate and exhale a quantitative sample on the track line between the track module 2000 and the scheduling disk module 200. The strong cleaning module 1800 is used to provide cleaning liquid for cleaning the inner and outer walls of the sampling needle of the sampling needle module 1900. The second cleaning tank module 1520 is used to clean the inner and outer walls of the sampling needle of the sampling needle module 1900 so as to reduce contamination and improve the performance of the sampling needle module 1900. The track module 2000 is used to transport the sample to be tested to a designated location.

[0067] Preferably, the track module 2000 includes three long tracks and a track change module. The three long tracks are respectively a recovery track A, a conventional track B and an emergency track C. The track module 2000 is located behind the other modules, so that the user can quickly take out and put the reagent kit in the reagent tray module 400, pour the reagent into the reaction cup 3000, and maintain the water tank module 1700, the reagent tray module 400 and the automatic cup adding module 700, thereby improving the user experience and improving the maintainability of the instrument. At the same time, the track module 2000 is located behind the other modules, far away from the staff, which can prevent pollution from harming the staff.

[0068] Optionally, the automatic analysis device also includes a photometric module 1000 and a counting module 1100. The photometric module 1000 is disposed at the second reading station 502 and is used to collect optical signal data of the reaction liquid in the reaction cup 3000 moved to the second reading station 502. The counting module 1100 is disposed at the bottom of the reading station module 500 and is used to process the optical signal data.

[0069] When the automatic analysis device is in operation, the automatic cup adding module 700 is provided with a first station 711 and a second station 712, the track module 2000 is provided with a sampling station 2100, the scheduling disk module 200 is provided with a third station 210, a sample adding station 220, a reagent adding station 230, a fourth station 240 and a fifth station 250, the first cleaning pool module 1510 is provided with a first cleaning station 1511, the second cleaning pool module 1520 is provided with a second cleaning station 1521, the sample mixing module 900 is provided with a sample mixing station 910, the incubation disk module 100 is provided with a first incubation station 110 and a second incubation station 120, the magnetic separation module 300 is provided with a magnetic separation station 310, the first waste cup channel module 1310 is provided with a discard cup station 1311, and the dilution mixing module 1200 is provided with a dilution station 1210.

[0070] The operation process of the automatic analysis device includes:

[0071] The reaction cup 3000 falls to the first station 711, the cup separation plate 710 transfers the reaction cup 3000 to the second station 712, the test tube rack is transported to the sampling position 2100, the second gripper 800 grabs the reaction cup 3000 to the third station 210, the scheduling tray module 200 transports the reaction cup 3000 to the sample adding position 220, the sampling needle of the sampling needle module 1900 is transferred to the sample adding position 220, and the sample is ejected from the reaction cup 3000. After the sample is ejected, the sampling needle is transferred to the second cleaning position 1521 for cleaning, then, the scheduling tray module 200 transports the reaction cup 3000 to the reagent adding position 230, the reagent needle of the reagent needle module 1400 is transferred to the reagent adding position 230 to eject liquid, the scheduling tray module 200 transports the reaction cup 3000 to the third station 210, the second gripper 800 grabs the reaction cup 3000 to the sample mixing station 220, and the sample is ejected from the reaction cup 3000. The first gripper 600 grabs the reaction cup 3000 and moves it from the sample mixing position 910 to the first incubation position 110. The incubation tray module 100 transports the reaction cup 3000 from the first incubation position 110 to the second incubation position 120 for incubation. The first gripper 600 grabs the reaction cup 3000 and moves it to the magnetic separation position 310 for cleaning. The first gripper 600 grabs the reaction cup 3000 and moves it from the magnetic separation position 310 to the fourth position 240. The scheduling tray module 200 rotates the reaction cup 3000 to the fifth position 250. The waste liquid needle module 1600 moves to the fifth position 250 to absorb the waste liquid in the reaction cup 3000. The scheduling tray module 200 transports the reaction cup 3000 from the fifth position 250 to the fourth position 240. The first gripper 600 grabs the reaction cup 3000 and moves it to the discard cup position 1311.

[0072] Alternatively, the operation process of the automatic analysis device includes:

[0073] The reaction cup 3000 falls to the first station 711, the cup separation plate 710 transfers the reaction cup 3000 to the second station 712, the test tube rack is transported to the sampling position 2100, the second gripper 800 grabs the reaction cup 3000 and moves it to the third station 210, the scheduling tray module 200 transports the reaction cup 3000 to the sample adding position 220, the sampling needle of the sampling needle module 1900 moves to the sample adding position 220, spits the sample into the reaction cup 3000, and after spits the sample, the sampling needle moves to the second cleaning position 1521 for cleaning, then the scheduling tray module 200 transports the reaction cup 3000 to the reagent adding position 230, and the reagent needle of the reagent needle module 1400 moves to the sample adding position 220. The reagent adding position 230 is used to discharge the liquid, the scheduling tray module 200 transports the reaction cup 3000 to the third station 210, the second gripper 800 grabs the reaction cup 3000 to the sample mixing position 910, the second gripper 800 grabs the reaction cup 3000 from the sample mixing position 910 to the first incubation position 110, the incubation tray module 100 transports the reaction cup 3000 from the first incubation position 110 to the second incubation position 120 for incubation, the first gripper 600 grabs the reaction cup 3000 to the magnetic separation station 310 for cleaning, the first gripper 600 grabs the reaction cup 3000 from the magnetic separation station 310 to the fourth station 240, and the scheduling tray module 2 00 transports the reaction cup 3000 to the reagent adding position 230, the reagent needle of the reagent needle module 1400 moves to the reagent adding position 230 to spit liquid, the reagent needle of the reagent needle module 1400 moves to the first cleaning position 1511 for cleaning, the scheduling disk module 200 moves the reaction cup 3000 from the reagent adding position 230 to the fourth station 240, the first gripper 600 grabs the reaction cup 3000 to the third incubation position 130 for incubation, the first gripper 600 grabs the reaction cup 3000 to the magnetic separation station 310 for cleaning, then the first gripper 600 grabs the reaction cup 3000 to the first reading station 501 of the reading station module 500, the reading station module Block 500 transports the reaction cup 3000 from the first reading station 501 to the second reading station 502. After reading the data, the reading station module 500 transports the reaction cup 3000 from the second reading station 502 to the first reading station 501. The first gripper 600 grabs the reaction cup 3000 to the fourth station 240. The scheduling tray module 200 transports the reaction cup 3000 to the fifth station 250. The waste liquid needle module 1600 absorbs the waste liquid in the reaction cup 3000. The scheduling tray module 200 transports the reaction cup 3000 to the fourth station 240. The first gripper 600 grabs the reaction cup 3000 to the discard cup position 1311.

[0074] In this embodiment, see Figure 3-Figure 12The reading station module 500 includes a base 510, a driving assembly and a cup carrier 530. The driving assembly includes a first guide rail 521, a synchronous belt 522 and a driving motor 523 arranged on the base 510. The cup carrier 530 is fixedly arranged on the synchronous belt 522. The cup carrier 530 is used to carry the reaction cup 3000. The driving motor 523 can drive the synchronous belt 522 to move, so that the synchronous belt 522 drives the cup carrier 530 to move along the first guide rail 521; the base 510 is provided with a cup inlet and outlet 511 and a first shielding assembly for closing or opening the cup inlet and outlet 511. The first shielding assembly is arranged near the first end of the first guide rail 521. When the cup carrier 530 moves along the first guide rail 521, it can push the first shielding assembly to move so that the cup inlet and outlet 511 is opened. By providing the first shielding component, when the reaction cup 3000 does not reach the position of the cup holder 530, the first shielding component closes the cup inlet and outlet 511 to prevent dust from falling into the cup holder 530, thereby increasing the service life of the cup holder 530. Secondly, when the cup holder 530 moves along the first guide rail 521, it can push the first shielding component to move so that the cup inlet and outlet 511 is opened, thereby improving the degree of automation.

[0075] Specifically, the first shielding assembly includes a first shielding plate 541, a first return spring 542, a first shock-absorbing pad 543 and a second shock-absorbing pad 544. The first shielding plate 541 is slidably arranged on the second guide rail 512 of the base 510, the first shock-absorbing pad 543 is arranged on the first shielding plate 541, and the second shock-absorbing pad 544 is arranged on the base 510. One end of the first return spring 542 is connected to the base 510, and the other end of the first return spring 542 is connected to the first shielding plate 541. The cup holder 530 contacts the first shock-absorbing pad 543 to push the first shielding plate 541 to slide along the second guide rail 512, so that the cup inlet and outlet opening 511 is opened. After the cup holder 530 is separated from the first shock-absorbing pad 543, the first return spring 542 drives the first shielding plate 541 to press against the second shock-absorbing pad 544, so that the cup inlet and outlet opening 511 is closed. By setting the first shock-absorbing pad 543, direct collision between the cup holder 530 and the first shielding plate 541 is effectively avoided, vibration noise is reduced, and service life is extended; by setting the second shock-absorbing pad 544, direct collision between the first shielding plate 541 and the base 510 is effectively avoided, vibration noise is reduced, and service life is extended.

[0076] In this embodiment, the photometric module 1000 is set as a PMT module, and the reading station module 500 also includes a second shielding component. The PMT module is set on the base 510 and is close to the second end of the first guide rail 521. The second shielding component is used to close or open the lens hole corresponding to the lens 1010 of the PMT module. The cup holder 530 is provided with a third shock-absorbing pad 532. When the cup holder 530 moves along the first guide rail 521, the third shock-absorbing pad 532 contacts the second shielding component to push the second shielding component to move, so that the lens hole of the PMT module is opened. By setting the second shielding component, when the cup holder 530 does not reach the position of the PMT module, the second shielding component closes the lens hole to prevent dust from falling into the lens hole, thereby improving the service life of the PMT module. Secondly, when the cup holder 530 moves along the first guide rail 521, it can push the second shielding component to move so that the lens hole is opened, thereby improving the degree of automation. It is easy to understand that the cup inlet and outlet 511 is set at the first reading station 501, and the PMT module is set at the second reading station 502.

[0077] Specifically, the second shielding assembly includes a second shielding plate 551, a second return spring 552 and a fourth shock absorbing pad 553. The second shielding plate 551 is slidably arranged on the third guide rail 513 of the base 510. The fourth shock absorbing pad 553 is arranged on the base 510. One end of the second return spring 552 is connected to the base 510, and the other end of the second return spring 552 is connected to the second shielding plate 551. When the cup holder 530 moves along the first guide rail 521, the third shock absorbing pad 532 contacts the second shielding plate 551 to push the second shielding plate 551 to slide along the third guide rail 513, so that the lens hole of the PMT module is opened. After the third shock absorbing pad 532 is separated from the second shielding plate 551, the second return spring 552 drives the second shielding plate 551 to slide along the third guide rail 513 to reach the fourth shock absorbing pad 553, so that the lens hole is closed. By providing the third shock-absorbing pad 532, direct collision between the cup holder 530 and the second shielding plate 551 is effectively avoided, vibration noise is reduced, and service life is extended. By providing the fourth shock-absorbing pad 553, direct collision between the second shielding plate 551 and the base 510 is effectively avoided, vibration noise is reduced, and service life is extended.

[0078] Preferably, a fifth shock-absorbing pad 533 is provided on the cup holder 530. After the lens hole of the PMT module is opened, the cup holder 530 abuts against the PMT module through the fifth shock-absorbing pad 533, thereby effectively avoiding direct collision between the cup holder 530 and the PMT module, reducing vibration noise, and extending service life.

[0079] Optionally, the reading station module 500 also includes an excitation liquid filling assembly disposed on the base 510, the excitation liquid filling assembly including an excitation liquid filling fixing seat 561 and an excitation liquid heating seat 562, the excitation liquid filling fixing seat 561 is disposed on the top surface of the base 510 and directly faces the PMT module, the excitation liquid heating seat 562 is disposed on the side of the base 510, and the cup holder 530 moves along the first guide rail 521, driving the reaction cup 3000 to move to the photometric position of the PMT module, the excitation liquid is injected into the excitation liquid filling fixing seat 561 and is heated by the excitation liquid heating seat 562 and then injected into the reaction cup 3000, the excitation liquid reacts chemically with the reactant in the reaction cup 3000 and emits light, the emitted photons enter the PMT module through the photometric hole 531 on the cup holder 530 and the lens hole of the PMT module, the PMT module feeds back the number of luminous photons, and the client outputs the detection result.

[0080] In this embodiment, at the magnetic separation station 310, the magnetic separation module 300 needs to clean the reaction cup 3000 four times, each cleaning includes injecting cleaning liquid, mixing and extracting waste liquid to clean the waste liquid in the reaction cup 3000, so that the target object remains in the reaction cup 3000. Then, the magnetic separation module 300 adds substrate 1 into the reaction cup 3000, and then the gripper of the magnetic separation module 300 mixes the substrate in the reaction cup 3000. The cup holder 530 of the reading station module 500 moves from the second reading station 502 (PMT module) to the first reading station 501. (at the cup inlet and outlet 511), the cup holder 530 contacts the first shock-absorbing pad 543 to push the first baffle plate 541 to slide along the second guide rail 512, so that the cup inlet and outlet 511 is opened, and the gripper of the magnetic separation module 300 places the reaction cup 3000 in the cup holder 530, and the cup holder 530 moves from the first reading station 501 (at the cup inlet and outlet 511) to the second reading station 502 (at the PMT module), and the substrate 2 (excitation liquid) is injected into the reaction cup 3000 through the excitation liquid filling assembly, and the PMT module performs optical detection on the reactants in the reaction cup 3000.

[0081] Preferably, the reading station module 500 also includes a calibration component 570, which is installed on the base 510 and arranged adjacent to the PMT module. When the number of photons recognized by the photosensitive component in the PMT module attenuates, the calibration component 570 calibrates the PMT module through the calibration light source hole 571 to avoid light attenuation.

[0082] Optionally, the reading station module 500 also includes a cup inlet and outlet position sensor 581, an origin sensor 582, and a light measuring position position sensor 583, which are all arranged on the base 510 and electrically connected to the control component. The origin sensor 582 corresponds to the initial position of the cup carrier 530, the cup inlet and outlet position sensor 581 corresponds to the position of the cup inlet and outlet 511, and the light measuring position position sensor 583 corresponds to the position of the PMT module. When the origin sensor 582 identifies the cup holder 530, the control component controls the driving assembly to start, and the cup holder 530 is driven by the synchronous belt 522 to move in the positive direction to the position of the cup inlet and outlet 511. The cup inlet and outlet position sensor 581 identifies the cup holder 530, and the cup holder 530 contacts the first shock-absorbing pad 543 to push the first shielding plate 541 to slide along the second guide rail 512, so that the cup inlet and outlet 511 is opened, and the reaction cup 3000 to be tested is placed in the cup holder 530 through the cup inlet and outlet 511. Then, the cup holder 530 The synchronous belt 522 drives the reaction cup 3000 to move in the reverse direction to the position of the PMT module. The photometric position sensor 583 identifies the cup holder 530. The third shock-absorbing pad 532 contacts the second baffle plate 551 to push the second baffle plate 551 to slide along the third guide rail 513, so that the lens hole of the PMT module is opened. The excitation liquid is injected into the excitation liquid filling fixing seat 561 and injected into the reaction cup 3000 after being heated by the excitation liquid heating seat 562. The PMT module feeds back the number of luminous photons, and the client outputs the detection result. After the photometric measurement is completed, the cup holder 530 is driven by the synchronous belt 522 to move with the reaction cup 3000 to the position of the inlet and outlet cup 511 again. The cup holder 530 contacts the first shock-absorbing pad 543 again to push the first baffle plate 541 to slide along the second guide rail 512, so that the inlet and outlet cup 511 is opened, and the reaction cup 3000 is taken out. The cup holder 530 is driven by the synchronous belt 522 to move in the reverse direction to the initial position.

[0083] Optionally, a baffle 590 is provided at the bottom of the cup holder 530 to trigger the cup inlet and outlet position sensor 581 , the origin sensor 582 and the light measuring position position sensor 583 .

[0084] Obviously, the above embodiments of the present invention are merely examples for the purpose of clearly illustrating the present invention, and are not intended to limit the implementation methods of the present invention. For those skilled in the art, various obvious changes, readjustments and substitutions can be made without departing from the scope of protection of the present invention. It is not necessary and impossible to list all implementation methods here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the scope of protection of the claims of the present invention.

Claims

1. An automatic analysis device, characterized in that include: An incubation tray module (100), used for incubating the reaction solution in the reaction cup (3000) and transporting the reaction cup (3000) to a designated location; A dispatching tray module (200) is used for transporting and dispatching the reaction cups (3000), and the dispatching tray module (200) is independently arranged around the incubation tray module (100); A magnetic separation module (300) is used to clean impurities from the magnetic beads after the reaction, and the magnetic separation module (300) is arranged at a distance on one side of the scheduling disk module (200); A reagent tray module (400) for refrigerating and transporting reagents of different components, wherein the reagent tray module (400) is arranged at intervals on the same side of the scheduling tray module (200) and the magnetic separation module (300); The reading station module (500) is used to analyze and test the reaction liquid in the reaction cup (3000). The reading station module (500) includes a first reading station (501) and a second reading station (502). The first reading station (501) is located between the scheduling disk module (200), the magnetic separation module (300) and the reagent disk module (400). The second reading station (502) is located on the side of the magnetic separation module (300) and the reagent disk module (400) away from the scheduling disk module (200). The reading station module (500) can transfer the reaction cup (3000) from the first reading station (501) to the second reading station (502).

2. The automatic analysis device according to claim 1, characterized in that A first gripper (600) is provided between the incubation tray module (100) and the magnetic separation module (300), and the first gripper (600) is used to transfer the reaction cup (3000) between the incubation tray module (100) and the magnetic separation module (300).

3. The automatic analysis device according to claim 1, characterized in that The automatic analysis device further comprises an automatic cup adding module (700), which is used to screen, correct the posture of and sort the reaction cups (3000) in the hopper, and place the reaction cups (3000) onto a cup distribution plate (710) of the automatic cup adding module (700).

4. The automatic analysis device according to claim 3, characterized in that: The automatic analysis device also includes a second gripper (800) and a sample mixing module (900), wherein the sample mixing module (900) is disposed on one side of the scheduling tray module (200), and the sample mixing module (900) is used to mix the sample and reagent in the reaction cup (3000), and the second gripper (800) is disposed between the automatic cup adding module (700), the sample mixing module (900) and the scheduling tray module (200), and the second gripper (800) is used to transport the reaction cup (3000) between the automatic cup adding module (700), the scheduling tray module (200), the sample mixing module (900) and the incubation tray module (100).

5. The automatic analysis device according to claim 1, characterized in that The automatic analysis device also includes a photometric module (1000) and a counting module (1100). The photometric module (1000) is disposed at the second reading station (502) and is used to collect optical signal data of the reaction liquid in the reaction cup (3000) moved to the second reading station (502). The counting module (1100) is disposed at the bottom of the reading station module (500) and is used to process the optical signal data.

6. The automatic analysis device according to claim 5, characterized in that: The reading station module (500) comprises a base (510), a driving assembly and a cup carrier (530), wherein the driving assembly comprises a first guide rail (521) arranged on the base (510), a synchronous belt (522) and a driving motor (523), wherein the cup carrier (530) is fixedly arranged on the synchronous belt (522), and the cup carrier (530) is used to carry the reaction cup (3000), and the driving motor (523) can drive the synchronous belt (522) to move, so that the synchronous belt (522) drives the cup carrier (530) to move along the first guide rail (521); The base (510) is provided with a cup inlet and outlet opening (511) and a first shielding component for closing or opening the cup inlet and outlet opening (511); the first shielding component is arranged close to the first end of the first guide rail (521); when the cup carrier (530) moves along the first guide rail (521), it can push the first shielding component to move, so that the cup inlet and outlet opening (511) is opened.

7. The automatic analysis device according to claim 6, characterized in that: The first shielding assembly comprises a first shielding plate (541), a first return spring (542), a first shock absorbing pad (543) and a second shock absorbing pad (544); the first shielding plate (541) is slidably arranged on a second guide rail (512) of the base (510); the first shock absorbing pad (543) is arranged on the first shielding plate (541); the second shock absorbing pad (544) is arranged on the base (510); one end of the first return spring (542) is connected to the base (510); the first return spring (542) is connected to the base (510); and the first return spring (543) is connected to the base (510). The other end of the spring (542) is connected to the first baffle plate (541), and the cup holder (530) contacts the first shock-absorbing pad (543) to push the first baffle plate (541) to slide along the second guide rail (512), so that the cup inlet and outlet opening (511) is opened. After the cup holder (530) is separated from the first shock-absorbing pad (543), the first return spring (542) drives the first baffle plate (541) to rest against the second shock-absorbing pad (544), so that the cup inlet and outlet opening (511) is closed.

8. The automatic analysis device according to claim 6, characterized in that: The photometric module (1000) is configured as a PMT module, and the reading station module (500) further comprises a second shielding component, wherein the PMT module is disposed on the base (510) and is disposed close to the second end of the first guide rail (521), and the second shielding component is used to close or open a lens hole corresponding to the lens (1010) of the PMT module, and a third shock absorbing pad (532) is disposed on the cup holder (530), and when the cup holder (530) moves along the first guide rail (521), the third shock absorbing pad (532) contacts the second shielding component to push the second shielding component to move, so that the lens hole of the PMT module is opened.

9. The automatic analysis device according to claim 8, characterized in that: The second shielding assembly comprises a second shielding plate (551), a second return spring (552) and a fourth shock absorbing pad (553); the second shielding plate (551) is slidably arranged on the third guide rail (513) of the base (510); the fourth shock absorbing pad (553) is arranged on the base (510); one end of the second return spring (552) is connected to the base (510); the other end of the second return spring (552) is connected to the second shielding plate (551); the cup holder (530) is arranged along the first guide rail When (521) moves, the third shock absorbing pad (532) contacts with the second baffle plate (551) to push the second baffle plate (551) to slide along the third guide rail (513), so that the lens hole of the PMT module is opened. After the third shock absorbing pad (532) is separated from the second baffle plate (551), the second return spring (552) drives the second baffle plate (551) to slide along the third guide rail (513) to reach the fourth shock absorbing pad (553), so that the cup inlet and outlet (511) is closed.

10. The automatic analysis device according to claim 9, characterized in that: The cup carrier (530) is provided with a fifth shock-absorbing pad (533). After the lens hole of the PMT module is opened, the cup carrier (530) abuts against the PMT module via the fifth shock-absorbing pad (533).

Images