Medicine raw material purification device

Abstract

The utility model discloses a medicine raw material purification device which comprises a base assembly, an upper cover assembly, a centrifugal assembly and a condensation assembly, the upper end of the base assembly is fixedly connected with the upper cover assembly, the centrifugal assembly and the condensation assembly, and the lower end of the upper cover assembly is fixedly connected with the condensation assembly. The base assembly comprises a base, a controller, a fixing groove and a purification barrel, the rear end of the base is fixedly connected with the centrifugal barrel, the controller is fixedly connected to the right side of the base, the fixing groove is formed in the upper end of the base, and the purification barrel is fixedly connected to the front end of the base through the fixing groove; and by arranging the centrifugal assembly capable of centrifuging the stirred and distilled raw materials, the device does not need to be moved to a specified device for centrifuging when the stirred and distilled raw materials need to be centrifuged, so that the device is relatively convenient.

Description

Technical Field

[0001] The utility model relates to the field of drug processing, in particular to a device for purifying drug raw materials. Background Art

[0002] The purification device for drug raw materials is a device used to separate drug raw materials from a mixture. This device usually involves chemical, physical or biological methods. Different purification devices can be selected according to different raw material characteristics and purification requirements. The selection of a suitable purification device needs to take into account factors such as the properties of the drug raw materials, the required purity, production scale, cost and safety. In actual operation, it may be necessary to combine multiple purification methods to achieve the best purification effect.

[0003] For example, a purification device for drug processing described in (authorization announcement number CN215995654U) includes an outer protective shell composed of a bottom plate, a protective container and an outer cover, and a limiting structure and a purification device are arranged on the outer protective shell. The purification device includes an electric heater and a mounting column arranged on the inner bottom wall of the protective container, a processing container movably mounted on the upper surface of the electric heater, a mounting cover plate mounted on the upper surface of the mounting column, and a control motor and a pressure plate fixed to the upper and lower surfaces of the mounting cover plate.

[0004] The device can ensure the structural stability of the purification device by rotating the threaded adjustment rod to make the pressure plate press the installation cover plate. However, the above device does not have a device for centrifuging the raw material body obtained by stirring and distilling, which makes it inconvenient to move the above device to a designated device for centrifugation when the raw material obtained by stirring and distilling needs to be centrifuged. Utility Model Content

[0005] Therefore, in order to solve the above-mentioned shortcomings, the utility model provides a purification device for drug raw materials.

[0006] The utility model is implemented in this way, constructing a purification device for drug raw materials, the device includes a base component, an upper cover component, a centrifugal component, and a condensation component, the upper end of the base component is fixedly connected to the upper cover component, the centrifugal component and the condensation component, and the lower end of the upper cover component is fixedly connected to the condensation component, and is characterized in that it also includes a base component, the base component includes a base, the rear end of the base is fixedly connected to the centrifugal bucket, a controller, the controller is fixedly connected to the right side of the base, a fixed groove, the fixed groove is arranged at the upper end of the base, a purification barrel, the purification barrel is fixedly connected to the front end of the base through the fixed groove, an electric heating element, the electric heating element is fixedly connected to the outside of the purification barrel, a discharge pipe, the discharge pipe is fixedly connected to the lower end of the purification barrel, and an opening and closing valve, the opening and closing valve is fixedly connected to the lower end of the discharge pipe.

[0007] Preferably, the upper cover assembly includes an upper cover, which is rotatably connected to the upper end of the purification barrel, a feed pipe, which is fixedly connected to the upper end of the upper cover, a motor, which is fixedly connected to the upper end of the upper cover, a stirring rod, which is rotatably connected to the upper cover, which is fixedly connected to the lower end of the motor drive shaft, which is rotatably connected to the purification barrel, a material guide rod, which is fixedly connected to the lower end of the stirring rod, a steam outlet pipe, which is fixedly connected to the upper end of the upper cover, a condenser, which is fixedly connected to the middle of the steam outlet pipe, and a material storage tank, which is placed at the lower end of the condenser.

[0008] Preferably, the centrifugal assembly includes a first turntable, a middle portion of the first turntable is fixedly connected to the stirring rod, a transmission belt, a front end of the transmission belt is transmission-connected to the first turntable, a second turntable, the second turntable is transmission-connected to the rear end of the transmission belt, the second turntable is fixedly connected to the lower end of the rotating block, a rotating block, the rotating block is rotationally connected to the centrifugal bucket, a slide groove, the slide groove is arranged at the upper end of the rotating block, a centrifugal bucket, the lower end of the centrifugal bucket is also rotationally connected to the rotating block, and a protective cover, the protective cover is rotationally connected to the upper end of the centrifugal bucket.

[0009] Preferably, the condensation component includes a condensation box, which is fixedly connected to the upper end of the base, a cooling trough, which is arranged at the front end of the condensation box, a fixed frame, which is fixedly connected to the front and rear ends of the condensation box, and the upper end of the fixed frame is fixedly connected to the steam outlet pipe, an infusion pump, which is fixedly connected to the upper end of the condensation box, an infusion pipe, the lower end of the infusion pipe is fixedly connected to the infusion pump, and the upper end of the infusion pipe is fixedly connected to the condensation pipe, and a return pipe, the upper end of the return pipe is also fixedly connected to the condensation pipe, and the lower end of the return pipe is also fixedly connected to the condensation box.

[0010] Preferably, the controller is fixedly connected to the electric heating element, the motor, the condensation tank and the infusion pump through wires.

[0011] Preferably, the material storage tank is slidably connected to the rotating block via a slide groove.

[0012] Preferably, there are two sets of the fixing frames and both are arranged at the upper end of the condensation box.

[0013] The utility model has the following advantages: The utility model provides a purification device for drug raw materials through improvement, which has the following improvements compared with the same type of equipment:

[0014] The utility model discloses a drug raw material purification device, which is provided with a centrifugal assembly capable of centrifuging the raw material obtained by stirring and distilling, so that the device does not need to be moved to a designated device for centrifugation when the raw material obtained by stirring and distilling needs to be centrifuged, which is more convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the structure of the utility model;

[0016] Figure 2 It is a schematic diagram of the base assembly structure of the utility model;

[0017] Figure 3 It is a schematic diagram of the structure of the upper cover assembly of the utility model;

[0018] Figure 4 It is a schematic diagram of the structure of the centrifugal assembly of the utility model;

[0019] Figure 5 It is a schematic diagram of the structure of the condensation component of the utility model.

[0020] Among them: base assembly-1, base-11, controller-12, fixed trough-13, purification barrel-14, electric heating element-15, discharge pipe-16, opening and closing valve-17, upper cover assembly-2, upper cover-21, feed pipe-22, motor-23, stirring rod-24, guide rod-25, steam outlet pipe-26, condenser-27, material tank-28, centrifugal assembly-3, first turntable-31, transmission belt-32, second turntable-33, rotating block-34, slide trough-35, centrifugal barrel-36, protective cover-37, condensation assembly-4, condensation box-41, cooling trough-42, fixed frame-43, infusion pump-44, infusion pipe-45, return pipe-46. DETAILED DESCRIPTION

[0021] The following is combined with Figures 1 to 5 The principles and features of the present invention are described, and the examples given are only used to explain the present invention, and are not used to limit the scope of the present invention. The present invention is described in more detail in the following paragraphs by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer according to the following description and claims. It should be noted that the drawings are all in a very simplified form and are not in precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention.

[0022] It should be noted that when a component is referred to as being "fixed to" another component, it may be directly on the other component or there may also be a component centered. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may also be a component centered. When a component is considered to be "set on" another component, it may be directly set on the other component or there may also be a component centered. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art in the technical field of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0024] Embodiment 1:

[0025] See also Figure 1 to Figure 5 The utility model is a purification device for drug raw materials, comprising a base assembly 1, an upper cover assembly 2, a centrifugal assembly 3, and a condensation assembly 4. The upper end of the base assembly 1 is fixedly connected to the upper cover assembly 2, the centrifugal assembly 3 and the condensation assembly 4, and the lower end of the upper cover assembly 2 is fixedly connected to the condensation assembly 4. It is characterized in that: it also includes a base assembly 1, a rear end of the base 11 is fixedly connected to the centrifugal bucket 36, a controller 12 is fixedly connected to the right side of the base 11, a fixed groove 13 is arranged at the upper end of the base 11, a purification bucket 14 is fixedly connected to the front end of the base 11 through the fixed groove 13, an electric heating element 15 is fixedly connected to the outside of the purification bucket 14, a discharge pipe 16 is fixedly connected to the lower end of the purification bucket 14, an opening and closing valve 17 is fixedly connected to the lower end of the discharge pipe 16, and the opening and closing valve 17 can be opened after being started so that the raw materials in the purification bucket 14 can be discharged through the discharge pipe 16, and the controller 12 is fixedly connected to the electric heating element 15, the motor 23, the condensation box 41 and the infusion pump 44 through electric wires;

[0026] The upper cover assembly 2, the upper cover 21 is rotatably connected to the upper end of the purification barrel 14, the feed pipe 22 is fixedly connected to the upper end of the upper cover 21, the motor 23 is fixedly connected to the upper end of the upper cover 21, the upper end of the stirring rod 24 is rotatably connected to the upper cover 21, the upper end of the stirring rod 24 is fixedly connected to the driving shaft at the lower end of the motor 23, and the motor 23 can drive the stirring rod 24 to rotate after starting, and the lower end of the stirring rod 24 is rotatably connected to the purification barrel 14, the guide rod 25 is fixedly connected to the lower end of the stirring rod 24, the steam outlet pipe 26 is fixedly connected to the upper end of the upper cover 21, the condenser 27 is fixedly connected to the middle of the steam outlet pipe 26, the material tank 28 is placed at the lower end of the condenser 27, and the material tank 28 is slidably connected to the rotating block 34 through the slide groove 35.

[0027] The utility model provides a purification device for drug raw materials through improvement, and its working principle is as follows;

[0028] First, when using this device, first place the device in the working area, and then connect the device to an external power source to provide the required power for the operation of the device;

[0029] Second, when the present device is needed, a specified weight of 2-fluoro-5-(3-oxo-3H-isobenzofuran-1-ylmethylene)benzonitrile (compound of formula II) can be first fed into the purification barrel 14 through the feed pipe 22, and then a certain amount of water is added to the reactor, and then the motor 23 is started to drive the stirring rod 24 to rotate to stir the raw materials in the purification barrel 14. At the same time, 80% of hydrazine hydrate is added, and the electric heating element 15 is started to heat and raise the temperature to 80°C. After reacting for 24 hours, the opening and closing valve 17 is started to allow the raw materials to be discharged through the discharge pipe 16, and then cooled to 20 degrees, filtered, and washed with an appropriate amount of water to obtain a wet product of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzonitrile (compound of formula III).

[0030] Embodiment 2:

[0031] See also Figure 1 to Figure 5 The utility model is a purification device for drug raw materials. Compared with the first embodiment, the present embodiment further includes: a centrifugal assembly 3, a first turntable 31 is fixedly connected to the stirring rod 24 in the middle, a front end of a transmission belt 32 is transmission-connected to the first turntable 31, a second turntable 33 is transmission-connected to the rear end of the transmission belt 32, the second turntable 33 is fixedly connected to the lower end of a rotating block 34, and can drive the first turntable 31 to rotate when the stirring rod 24 rotates, the rotating block 34 is rotationally connected to the centrifugal bucket 36, a chute 35 is provided at the upper end of the rotating block 34, the lower end of the centrifugal bucket 36 is also rotationally connected to the rotating block 34, a protective cover 37 is rotationally connected to the upper end of the centrifugal bucket 36, and a total of two sets of fixed frames 43 are provided and are both provided at the upper end of the condensation box 41;

[0032] The condensation assembly 4, the condensation box 41 is fixedly connected to the upper end of the base 11, the cooling tank 42 is arranged at the front end of the condensation box 41, the fixing frame 43 is fixedly connected to the front and rear ends of the condensation box 41, the upper end of the fixing frame 43 is fixedly connected to the steam outlet pipe 26, the infusion pump 44 is fixedly connected to the upper end of the condensation box 41, after the infusion pump 44 is started, the liquid in the condensation box 41 can be extracted and transported to the condensation pipe 27 through the infusion pipe 45, the lower end of the infusion pipe 45 is fixedly connected to the infusion pump 44, the upper end of the infusion pipe 45 is fixedly connected to the condensation pipe 27, the upper end of the return pipe 46 is also fixedly connected to the condensation pipe 27, and the lower end of the return pipe 46 is also fixedly connected to the condensation box 41.

[0033] In this embodiment:

[0034] First, when the raw material obtained by stirring and distillation needs to be centrifuged, steam is generated when the purification barrel 14 heats the internal drug raw material and is transported to the material storage tank 28 through the steam outlet pipe 26. At the same time, the controller 12 controls the condensation tank 41 and the infusion pump 44 to start. After the condensation tank 41 is started, the liquid in the condensation tank 41 can be extracted and transported to the condensation pipe 27 through the infusion pipe 45 to condense the steam in the steam outlet pipe 26. After the condensation pipe 27 condenses the steam in the steam outlet pipe 26, the steam can be returned to the condensation tank 41 through the return pipe 45. 6 is refluxed into the condensation box 41 for circulation, and the material tank 28 can be cooled and kept warm while being placed in the cooling tank 42. When the material tank 28 is placed in the chute 35, the protective cover 37 is closed. When the stirring rod 24 rotates, the first turntable 31 can be driven to rotate, and when the first turntable 31 rotates, the transmission belt 32 can be driven to rotate, and the second turntable 33 can be driven to rotate. When the second turntable 33 rotates, the rotating block 34 can be driven to rotate, and the material tank 28 in the chute 35 can be centrifuged.

[0035] The utility model provides a purification device for drug raw materials through improvement. By setting a centrifugal component 3 that can centrifuge the raw materials obtained by stirring and distilling, the device does not need to be moved to a designated device for centrifugation when the raw materials obtained by stirring and distilling need to be centrifuged, which is more convenient.

[0036] The above shows and describes the basic principle, main features and advantages of the utility model, and the standard parts used in the utility model can be purchased from the market, and special-shaped parts can be customized according to the description and the drawings. The specific connection methods of each part adopt mature conventional means such as bolts, rivets, welding, etc. in the prior art. Machinery, parts and equipment all adopt conventional models in the prior art, and the circuit connection adopts the conventional connection method in the prior art, which will not be described in detail here.

[0037] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A purification device for pharmaceutical raw materials, comprising a base assembly (1), an upper cover assembly (2), a centrifugal assembly (3), and a condensation assembly (4), wherein the upper end of the base assembly (1) is fixedly connected to the upper cover assembly (2), the centrifugal assembly (3), and the condensation assembly (4), and the lower end of the upper cover assembly (2) is fixedly connected to the condensation assembly (4), characterized in that: It also includes a base assembly (1), the base assembly (1) comprising: A base (11), wherein the rear end of the base (11) is fixedly connected to the centrifugal bucket (36); A controller (12), wherein the controller (12) is fixedly connected to the right side of the base (11); A fixing groove (13), wherein the fixing groove (13) is arranged at the upper end of the base (11); A purification barrel (14), wherein the purification barrel (14) is fixedly connected to the front end of the base (11) through a fixing groove (13); An electric heating element (15), wherein the electric heating element (15) is fixedly connected to the outside of the purification barrel (14); A discharge pipe (16), wherein the discharge pipe (16) is fixedly connected to the lower end of the purification barrel (14); An opening and closing valve (17), wherein the opening and closing valve (17) is fixedly connected to the lower end of the discharge pipe (16).

2. A purification device for pharmaceutical raw materials according to claim 1, characterized in that: The upper cover assembly (2) comprises: An upper cover (21), the upper cover (21) being rotatably connected to the upper end of the purification barrel (14); A feed pipe (22), wherein the feed pipe (22) is fixedly connected to the upper end of the upper cover (21); A motor (23), wherein the motor (23) is fixedly connected to the upper end of the upper cover (21); A stirring rod (24), wherein the upper end of the stirring rod (24) is rotatably connected to the upper cover (21), the upper end of the stirring rod (24) is fixedly connected to the driving shaft at the lower end of the motor (23), and the lower end of the stirring rod (24) is rotatably connected to the purification barrel (14); A material guide rod (25), wherein the material guide rod (25) is fixedly connected to the lower end of the stirring rod (24); A steam outlet pipe (26), wherein the steam outlet pipe (26) is fixedly connected to the upper end of the upper cover (21); A condenser (27), wherein the condenser (27) is fixedly connected to the middle portion of the steam outlet pipe (26); A material storage tank (28) is disposed at the lower end of the condenser tube (27).

3. A purification device for pharmaceutical raw materials according to claim 1, characterized in that: The centrifugal assembly (3) comprises: A first rotating disk (31), wherein the middle portion of the first rotating disk (31) is fixedly connected to the stirring rod (24); A transmission belt (32), the front end of which is in transmission connection with the first rotating disk (31); A second rotating disk (33), the second rotating disk (33) is drivingly connected to the rear end of the transmission belt (32), and the second rotating disk (33) is fixedly connected to the lower end of the rotating block (34); A rotating block (34), wherein the rotating block (34) is rotatably connected to the centrifugal bucket (36); A slide groove (35), wherein the slide groove (35) is arranged at the upper end of the rotating block (34); A centrifugal bucket (36), wherein the lower end of the centrifugal bucket (36) is also rotatably connected to the rotating block (34); A protective cover (37) is rotatably connected to the upper end of the centrifugal bucket (36).

4. The purification device for pharmaceutical raw materials according to claim 1, characterized in that: The condensation component (4) comprises: A condensation box (41), wherein the condensation box (41) is fixedly connected to the upper end of the base (11); A cooling trough (42), wherein the cooling trough (42) is arranged at the front end of the condensation box (41); A fixing frame (43), wherein the fixing frame (43) is fixedly connected to the front and rear ends of the condensation box (41), and the upper end of the fixing frame (43) is fixedly connected to the steam outlet pipe (26); an infusion pump (44), wherein the infusion pump (44) is fixedly connected to the upper end of the condensation tank (41); An infusion tube (45), wherein the lower end of the infusion tube (45) is fixedly connected to the infusion pump (44), and the upper end of the infusion tube (45) is fixedly connected to the condenser tube (27); A liquid return pipe (46), the upper end of which is also fixedly connected to the condenser pipe (27), and the lower end of which is also fixedly connected to the condenser tank (41).

5. The purification device for pharmaceutical raw materials according to claim 1, characterized in that: The controller (12) is fixedly connected to the electric heating element (15), the motor (23), the condensation tank (41) and the infusion pump (44) via electric wires.

6. A purification device for pharmaceutical raw materials according to claim 2, characterized in that: The material storage tank (28) is slidably connected to the rotating block (34) via a sliding groove (35).

7. A purification device for pharmaceutical raw materials according to claim 4, characterized in that: The fixing frames (43) are provided in two groups and are both arranged at the upper end of the condensation box (41).

Images