Multi-claw puncture needle suitable for multi-point injection of nuclide medicine
By designing a multi-claw puncture needle, the multi-point injection of nanogun drugs is achieved using the radial structure of the branch tube, solving the problem of large volume of hypoxic tumors and short β-ray radiation distance, and improving the tumor killing coverage and radiotin radiation area volume.
Patent Information
- Application Number
- CN202420607050.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-27
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2034-03-27
AI Technical Summary
In the prior art, hypoxic tumors are large in size and the nanogun β-ray radiation distance is short, resulting in limited killing of tumor tissue, making it difficult to achieve comprehensive tumor killing.
A multi-claw puncture needle suitable for multi-point injection of nuclide drugs was designed. The structure of the outer sheath tube and several branch tubes is extended through the guide groove to form a radial structure to realize multi-point injection of nanogun drugs.
Through multi-point injection, the tumor killing coverage rate is improved, the defects of single-point administration are changed, the number of punctures is reduced, and the volume of radiotin radiation area is expanded through the reasonable setting of branch waterways.
Smart Images
Figure CN222657138U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field related to puncture needles, in particular to a multi-claw puncture needle suitable for multi-point injection of radionuclide drugs. Background Art
[0002] Hypoxia is one of the important characteristics of solid tumors such as pancreatic cancer and liver cancer. Hypoxic tumors are generally large in size and are easily resistant to traditional anti-tumor treatments such as radiotherapy or chemotherapy, and the efficacy is often poor. At present, there is a lack of effective treatments for advanced liver cancer and liver metastases. TACE and radiofrequency ablation are limited in their use due to efficacy and adverse reactions related to anti-tumor treatment. The innovative nano-sustained-release 188RE targeted delivery technology (nanogun, 188Re-ImDendrim) is one of the optional treatments. At present, most puncture needles are developed for taking living tissues, so the main focus is on how to improve the accuracy of puncture.
[0003] At present, thoracic puncture, lumbar puncture or abdominal puncture are all performed with coaxial cannula needles. The needle is quickly punctured to the edge of the lesion according to the predetermined needle insertion path, and then the needle core is removed. The automatic biopsy gun is inserted through the channel of the coaxial cannula needle. The direction of the coaxial cannula needle is adjusted as needed, and the lesion is cut and sampled from different angles and depths. After fixation, a pathological examination is performed. The purpose is to obtain cytological or histological materials of the lesion to clarify the nature of the lesion. When the puncture node and nanogun are used to administer the drug, only a single point of administration can be performed.
[0004] Hypoxic tumors are generally large in size, and the maximum range of the radionuclide 188Re high-energy beta rays used by the nanogun to kill tumor cells is 2 cm in soft tissue. Therefore, when the tumor lesion is large, it is difficult to kill the entire tumor through percutaneous puncture injection of the target lesion, resulting in incomplete tumor killing. Utility Model Content
[0005] The utility model aims to overcome the shortcomings of the prior art in that the tumor lesions are large and the β-ray radiation distance of the nanogun is short, which limits the killing of tumor tissues, and provides a multi-claw puncture needle suitable for multi-point injection of radionuclide drugs, which is beneficial to improving the tumor killing coverage.
[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:
[0007] A multi-claw puncture needle suitable for multi-point injection of radionuclide drugs, comprising an outer sheath tube and a plurality of branch tubes, a push tube being arranged in one end of the outer sheath tube, the push tube being slidably connected to the outer sheath tube, a puncture body being arranged in the other end of the outer sheath tube, one end of the puncture body being located in the outer sheath tube and being fixedly connected to the outer sheath tube, a plurality of guide grooves matching the plurality of branch tubes one by one being arranged on the outer side wall of the end of the puncture body being located in the outer sheath tube, the plurality of guide grooves being distributed along the circumference of the puncture body, the other end of the puncture body being located outside the outer sheath tube, a part of the guide groove being located in the outer sheath tube and being connected to the interior of the outer sheath tube, the other part of the guide groove being located outside the outer sheath tube, one end of the branch tube being located in the outer sheath tube and being fixedly connected to the end of the push tube, the other ends of the plurality of branch tubes being distributed in a suspended state on the side of the puncture body and being located outside the outer sheath tube after passing through the guide groove.
[0008] A push tube is provided in one end of the outer sheath tube, and the push tube is slidably connected to the outer sheath tube. A puncture body is provided in the other end of the outer sheath tube. One end of the puncture body is located in the outer sheath tube and fixedly connected to the outer sheath tube. A plurality of guide grooves matching a plurality of branch tubes are provided on the outer side wall of one end of the puncture body located in the outer sheath tube. The plurality of guide grooves are distributed along the circumference of the puncture body. The other end of the puncture body is located outside the outer sheath tube. A part of the guide groove is located in the outer sheath tube and communicated with the interior of the outer sheath tube, and the other part of the guide groove is located outside the outer sheath tube. One end of the branch tube is located in the outer sheath tube and fixedly connected to the end of the push tube. The other ends of the plurality of branch tubes are distributed in a suspended state on the side of the puncture body and are located outside the outer sheath tube after passing through the guide groove. The material of the puncture needle can be radiation-proof material, which is beneficial to improving the safety of use; the puncture body of the puncture needle is the main waterway, and the multiple branch tubes are the branch waterways. In the initial state, the multiple branch tubes are all located in the outer sheath tube to facilitate percutaneous puncture of the puncture needle; when the puncture needle reaches the target position of the human body, the operator pushes the push tube by operating the distal handle to extend the multiple branch tubes outward through the corresponding guide grooves, and the nanogun is injected through this structure, which can make the radioactive element evenly distributed, so that the therapeutic agent can be three-dimensionally distributed under the action of the puncture body and the multiple branch tubes, changing the defects of single-point drug administration, and achieving the purpose of improving the tumor killing coverage through multi-point injection, while helping to reduce the number of punctures.
[0009] Preferably, a plurality of guide grooves are evenly distributed along the circumference of the puncture body, one end of the guide groove located inside the outer sheath is located at the end of the puncture body, and the other end of the guide groove located outside the outer sheath is located on the outer side wall of the puncture body. This design facilitates the uniform distribution of a plurality of branch tubes around the puncture body after extending out of the outer sheath through the corresponding guide grooves, thereby ensuring the uniform distribution of the radioactive element and increasing the tumor killing range.
[0010] Preferably, the portion of the guide groove located inside the outer sheath is parallel to the pushing direction of the pushing tube, the portion of the guide groove located outside the outer sheath is in an arc shape, the portion of the guide groove located inside the outer sheath and the portion of the guide groove located outside the outer sheath are in a continuous and uniform transition, and the ends of the several branches located on the side of the puncture body are arc-shaped and open outward to form a radial structure. The design of the guide groove facilitates the branch tube to smoothly extend out of the outer sheath under the pushing action of the pushing tube, which is convenient for operation; the ends of the several branches located on the side of the puncture body are arc-shaped and open outward to form a radial structure, which can make the radioactive element evenly distributed, make the therapeutic agent three-dimensionally distributed, and increase the killing range of the tumor.
[0011] Preferably, a plurality of groups of water outlet holes 1 are evenly distributed along the circumference of the suspended end of the branch pipe, each group of water outlet holes 1 includes a plurality of water outlet holes 1, the plurality of water outlet holes 1 are evenly distributed along the shape of the branch pipe, and the apertures of the plurality of water outlet holes 1 gradually increase in the direction from one end of the branch pipe fixedly connected to the push pipe to the other end of the branch pipe. The design of the branch pipe and the water outlet hole makes the radioactive element evenly distributed, while the radiation area overlaps, so that the therapeutic agent is distributed three-dimensionally; in order to further expand the volume of the radioactive element radiation area, according to the Bernoulli equation p+1 / 2 𝜌𝜈^2+ρgh=C, it can be known that in the water flow, if the speed is small, the pressure is large, and vice versa. The water flow in the pipe needs to overcome the friction of the inner wall of the pipe to do work, and there will be water flowing out of the opening to lose part of the mechanical energy, so the water flow speed near the needle tip will be lower. According to the viscosity and injection pressure of the nano sustained-release preparation, the size of the water outlet hole is pre-designed, and the extension state of the branch water channel is adjusted according to the measured area of the tumor. In order to obtain a radioactive range that can cover the tumor area, different branch extension states can be set (including changing the curvature of the branch, hole spacing and other parameters), and the size of the injection area can be measured to obtain the appropriate size parameters and branch structure shape.
[0012] Preferably, the puncture body includes a connection seat, an end tube and a puncture head, one end of the connection seat is located in the outer sheath tube and fixedly connected to the outer sheath tube, the guide groove is located on the outer side wall of the connection seat, and a plurality of guide grooves are evenly distributed along the circumference of the connection seat, the other end of the connection seat is fixedly connected to the puncture head through the end tube, and a nickel-titanium tube is provided through the connection seat, and the nickel-titanium tube is connected to the puncture head after passing through the end tube. The nickel-titanium tube is connected to the puncture head to form a main waterway, and is combined with a plurality of branch waterways, so that the radioactive element is evenly distributed, the radiation area overlaps, and the therapeutic agent is distributed three-dimensionally, and the number of punctures is reduced at the same time. By reasonably setting the spacing between the branch waterways, the radioactive range that can cover the tumor area is obtained with the least number of puncture injections.
[0013] Preferably, one end of the puncture head is fixedly connected to the end tube and a flow groove is provided in the center thereof, one end of the flow groove is located in the end tube and is fixedly connected and communicated with the nickel-titanium tube, one or more flow holes are provided on the side wall of the other end of the flow groove, a uniform cover is sleeved on the outer wall of one end of the puncture head, the uniform cover is fixedly connected to the puncture head and a gap is formed between the outer wall of the puncture head, the uniform cover is provided with a plurality of groups of water outlet holes 2 evenly distributed along its circumference, the flow hole is communicated with a plurality of groups of water outlet holes 2 through the gap, and a needle is provided at the other end of the puncture head. Under the premise of ensuring the stress of the puncture head, the number of flow holes is optimally two, and the two flow holes are distributed on the left and right sides of the flow groove; the radioactive element partially enters the flow groove after passing through the nickel-titanium tube, then enters the gap through the flow hole, and finally flows out through a plurality of groups of water outlet holes 2 respectively, so as to achieve a uniform distribution effect; similarly, in order to further expand the radiation area of the radioactive element, the size of the water outlet hole can be pre-designed according to the viscosity and injection pressure of the nano sustained-release preparation.
[0014] Preferably, each group of water outlet holes 2 includes a plurality of water outlet holes 2, the plurality of water outlet holes 2 are evenly distributed along the axial direction of the puncture head, the apertures of the plurality of water outlet holes 2 gradually increase from one end of the puncture head fixedly connected to the end tube to the other end of the puncture head, and the aperture of the flow hole is larger than the maximum aperture of the water outlet hole 2. The liquid medicine flowing out through the flow hole can be distributed in the gap and then flow out through the water outlet hole 2, which is conducive to the uniform distribution of the radioactive element.
[0015] Preferably, an annular mounting groove is provided on the outer side wall of one end of the puncture head, the uniform cover is fixed to the puncture head through the mounting groove, a U-shaped groove is provided in the mounting groove, the gap is formed by the U-shaped groove and the uniform cover, and the flow hole is located in the U-shaped groove. The liquid medicine flowing out through the flow hole enters the gap and then flows out through the second water outlet hole, so that the radioactive element is evenly distributed.
[0016] The beneficial effects of the utility model are as follows: by injecting the nanogun through the structure, the radioactive element can be evenly distributed, the radiation area can be overlapped, the therapeutic agent can be distributed three-dimensionally, the defects of single-point administration can be changed, and the purpose of improving the tumor killing coverage rate can be achieved through multi-point injection, while reducing the number of punctures; by reasonably setting the spacing between branch water channels, the radioactive range that can cover the tumor area can be obtained with the least number of puncture injections. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 It is a structural schematic diagram of the utility model;
[0018] Figure 2 It is the front view of the utility model;
[0019] Figure 3 yes Figure 2 Sectional view of AA in the middle;
[0020] Figure 4 yes Figure 3 A magnified view of the structure at B in the middle;
[0021] Figure 5 yes Figure 3 Enlarged view of the structure at C in the middle.
[0022] In the figure: 1. outer sheath, 2. branch tube, 3. push tube, 4. puncture body, 5. guide groove, 6. water outlet hole 1, 7. connecting seat, 8. end tube, 9. puncture head, 10. nickel titanium tube, 11. flow groove, 12. flow hole, 13. uniform cover, 14. gap, 15. water outlet hole 2, 16. needle, 17. installation groove, 18. U-shaped groove. DETAILED DESCRIPTION
[0023] The utility model is further described below in conjunction with the accompanying drawings and specific implementation methods.
[0024] like Figure 1 , Figure 2 , Figure 3 and Figure 4 In the described embodiment, a multi-claw puncture needle suitable for multi-point injection of radionuclide drugs comprises an outer sheath tube 1 and a plurality of branch tubes 2, a push tube 3 is arranged in one end of the outer sheath tube 1, and the push tube 3 is slidably connected to the outer sheath tube 1, a puncture body 4 is arranged in the other end of the outer sheath tube 1, one end of the puncture body 4 is located in the outer sheath tube 1 and is fixedly connected to the outer sheath tube 1, a plurality of guide grooves 5 matching one by one with the plurality of branch tubes 2 are arranged on the outer side wall of one end of the puncture body 4 located in the outer sheath tube 1, and the plurality of guide grooves 5 are distributed along the circumference of the puncture body 4, the other end of the puncture body 4 is located outside the outer sheath tube 1, a part of the guide groove 5 is located in the outer sheath tube 1 and is connected to the interior of the outer sheath tube 1, and the other part of the guide groove 5 is located outside the outer sheath tube 1, one end of the branch tube 2 is located in the outer sheath tube 1 and is fixedly connected to the end of the push tube 3, and the other ends of the plurality of branch tubes 2 are suspended and distributed on the side of the puncture body 4 and are located outside the outer sheath tube 1 after passing through the guide groove 5.
[0025] like Figure 1 , Figure 3 and Figure 4As shown, a plurality of guide grooves 5 are evenly distributed along the circumference of the puncture body 4, one end of the guide groove 5 located inside the outer sheath 1 is located at the end of the puncture body 4, and the other end of the guide groove 5 located outside the outer sheath 1 is located on the outer side wall of the puncture body 4. The portion of the guide groove 5 located inside the outer sheath 1 is parallel to the pushing direction of the pushing tube 3, and the portion of the guide groove 5 located outside the outer sheath 1 is in an arc shape, and the portion of the guide groove 5 located inside the outer sheath 1 and the portion of the guide groove 5 located outside the outer sheath 1 are continuously and evenly transitioned, and one end of the plurality of branch tubes 2 located on the side of the puncture body 4 is arc-shaped and opens outward to form a radial structure.
[0026] like Figure 1 , Figure 2 and Figure 3 As shown, a plurality of groups of water outlet holes 6 are evenly distributed along the circumference of the branch pipe 2 on the side wall at one end in a suspended state, each group of water outlet holes 6 includes a plurality of water outlet holes 6, and the plurality of water outlet holes 6 are evenly distributed along the shape of the branch pipe 2, and the apertures of the plurality of water outlet holes 6 gradually increase in the direction from one end of the branch pipe 2 fixedly connected to the push pipe 3 to the other end of the branch pipe 2.
[0027] like Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 As shown, the puncture body 4 includes a connecting seat 7, an end tube 8 and a puncture head 9. One end of the connecting seat 7 is located in the outer sheath 1 and is fixedly connected to the outer sheath 1. The guide groove 5 is located on the outer wall of the connecting seat 7. A plurality of guide grooves 5 are evenly distributed along the circumference of the connecting seat 7. The other end of the connecting seat 7 is fixedly connected to the puncture head 9 through the end tube 8. A nickel-titanium tube 10 is penetrated in the connecting seat 7. The nickel-titanium tube 10 is connected to the puncture head 9 after penetrating the end tube 8.
[0028] like Figure 3 and Figure 5 As shown, one end of the puncture head 9 is fixedly connected to the end tube 8 and a flow groove 11 is provided at the center thereof, one end of the flow groove 11 is located in the end tube 8 and is fixedly connected and communicated with the nickel-titanium tube 10, one end of the flow groove 11 is provided with one or more flow holes 12 on the side wall, one end of the puncture head 9 is provided with a uniform cover 13 on the outer wall, the uniform cover 13 is fixedly connected to the puncture head 9 and a gap 14 is formed between the outer wall of the puncture head 9, a plurality of groups of water outlet holes 15 uniformly distributed along the circumference thereof are provided on the uniform cover 13, the flow hole 12 is communicated with a plurality of groups of water outlet holes 15 through the gap 14, and a needle 16 is provided at the other end of the puncture head 9.
[0029] like Figure 1 and Figure 5As shown, each group of water outlet holes 15 includes a plurality of water outlet holes 15, and the plurality of water outlet holes 15 are evenly distributed along the axial direction of the puncture head 9, and the apertures of the plurality of water outlet holes 15 gradually increase from one end where the puncture head 9 is fixedly connected to the end tube 8 to the other end of the puncture head 9, and the aperture of the flow hole 12 is larger than the maximum aperture of the water outlet holes 15.
[0030] like Figure 5 As shown, an annular mounting groove 17 is provided on the outer side wall of one end of the puncture head 9, and the uniform cover 13 is fixed to the puncture head 9 through the mounting groove 17. A U-shaped groove 18 is provided in the mounting groove 17. The gap 14 is formed by the U-shaped groove 18 and the uniform cover 13, and the flow hole 12 is located in the U-shaped groove 18.
[0031] The material of the puncture needle can be radiation-proof material, which is beneficial to improving the safety of use; the nickel-titanium tube 10 is connected with the puncture head 9 to form a main waterway, and the multiple branch tubes 2 are branch waterways; in the initial state, the multiple branch tubes 2 are all located in the outer sheath tube 1 to facilitate percutaneous puncture of the puncture needle; when the puncture needle reaches the target position of the human body, the operator pushes the push tube 3 by operating the distal handle to extend the multiple branch tubes 2 outward through the corresponding guide grooves 5, so that the extended parts of the multiple branch tubes 2 are arc-shaped and open outward to form a radial structure, and the nano gun is injected through the structure, so that the radioactive element can be injected through the water outlet hole 2 15 on the main waterway and the water outlet hole 1 6 on the branch waterway respectively, which is beneficial to the uniform distribution of the radioactive element and the overlapping of the radiation area, so that the therapeutic agent is three-dimensionally distributed under the action of the puncture head 9 and the multiple branch tubes 2, changing the defects of single-point administration, and achieving the purpose of improving the tumor killing coverage through multi-point injection, while helping to reduce the number of punctures.
[0032] In order to further expand the volume of the radioactive element radiation area, according to the Bernoulli equation p+1 / 2 𝜌𝜈^2+ρgh=C, it can be known that in water flow, if the speed is small, the pressure is large, and vice versa. The water flow in the pipe needs to overcome the friction of the inner wall of the pipe to do work, and the water will flow out of the opening and lose part of the mechanical energy, so the water flow speed near the needle tip will be lower. According to the viscosity and injection pressure of the nano sustained-release preparation, the size of the water outlet hole 16 and the water outlet hole 2 15 is pre-designed, and the extension state of the branch 2 water channel is adjusted according to the measured area of the tumor. In order to obtain a radioactive range that can cover the tumor area, different extension states of the branch 2 can be set (including changing the curvature of the branch, hole spacing and other parameters), and the size of the injection area can be measured to obtain the appropriate size parameters and branch structure shape.
Claims
1. A multi-claw puncture needle suitable for multi-point injection of radionuclide drugs, characterized in that: It comprises an outer sheath tube and a plurality of branch tubes, a push tube is arranged in one end of the outer sheath tube, the push tube is slidably connected to the outer sheath tube, a puncture body is arranged in the other end of the outer sheath tube, one end of the puncture body is located in the outer sheath tube and is fixedly connected to the outer sheath tube, a plurality of guide grooves matching the plurality of branch tubes are arranged on the outer side wall of the end of the puncture body located in the outer sheath tube, the plurality of guide grooves are distributed along the circumference of the puncture body, the other end of the puncture body is located outside the outer sheath tube, a part of the guide groove is located in the outer sheath tube and is connected to the inside of the outer sheath tube, the other part of the guide groove is located outside the outer sheath tube, one end of the branch tube is located in the outer sheath tube and is fixedly connected to the end of the push tube, the other ends of the plurality of branch tubes are distributed in a suspended state on the side of the puncture body and are located outside the outer sheath tube after passing through the guide groove.
2. A multi-claw puncture needle suitable for multi-point injection of radionuclide drugs according to claim 1, characterized in that: A plurality of guide grooves are evenly distributed along the circumference of the puncture body, one end of the guide groove located inside the outer sheath is located at the end of the puncture body, and the other end of the guide groove located outside the outer sheath is located on the outer side wall of the puncture body.
3. A multi-claw puncture needle suitable for multi-point injection of radionuclide drugs according to claim 1, characterized in that: The part of the guide groove located inside the outer sheath is parallel to the pushing direction of the pushing tube, the part of the guide groove located outside the outer sheath is arc-shaped, the part of the guide groove located inside the outer sheath and the part of the guide groove located outside the outer sheath are continuously and evenly transitioned, and one end of a plurality of branch tubes located on the side of the puncture body is arc-shaped and opens outward to form a radial structure.
4. A multi-claw puncture needle suitable for multi-point injection of radionuclide drugs according to claim 1, 2 or 3, characterized in that: A plurality of groups of water outlet holes 1 are evenly distributed along the circumference of the branch pipe on the side wall of one end in a suspended state, each group of water outlet holes 1 includes a plurality of water outlet holes 1, and the plurality of water outlet holes 1 are evenly distributed along the shape of the branch pipe, and the apertures of the plurality of water outlet holes 1 gradually increase in the direction from one end of the branch pipe fixedly connected to the push pipe to the other end of the branch pipe.
5. A multi-claw puncture needle suitable for multi-point injection of radionuclide drugs according to claim 1, 2 or 3, characterized in that: The puncture body includes a connecting seat, an end tube and a puncture head. One end of the connecting seat is located in the outer sheath tube and is fixedly connected to the outer sheath tube. The guide groove is located on the outer side wall of the connecting seat. Several guide grooves are evenly distributed along the circumference of the connecting seat. The other end of the connecting seat is fixedly connected to the puncture head through the end tube. A nickel-titanium tube is arranged through the connecting seat. The nickel-titanium tube is connected to the puncture head after passing through the end tube.
6. The multi-claw puncture needle suitable for multi-point injection of radionuclide drugs according to claim 5, characterized in that: One end of the puncture head is fixedly connected to the end tube and a flow groove is provided at the center thereof, one end of the flow groove is located in the end tube and is fixedly connected and communicated with the nickel-titanium tube, one end of the flow groove is provided with one or more flow holes on the side wall, one end of the puncture head is sleeved with a uniform cover on the outer wall, the uniform cover is fixedly connected to the puncture head and a gap is formed between the uniform cover and the outer wall of the puncture head, a plurality of groups of water outlet holes 2 uniformly distributed along the circumference thereof are provided on the uniform cover, the flow hole is communicated with a plurality of groups of water outlet holes 2 through the gap, and a needle is provided at the other end of the puncture head.
7. A multi-claw puncture needle suitable for multi-point injection of radionuclide drugs according to claim 6, characterized in that: Each group of water outlet holes 2 includes a plurality of water outlet holes 2, and the plurality of water outlet holes 2 are evenly distributed along the axial direction of the puncture head. The apertures of the plurality of water outlet holes 2 gradually increase from one end of the puncture head fixedly connected to the end tube to the other end of the puncture head, and the aperture of the flow hole is larger than the maximum aperture of the water outlet holes 2.
8. The multi-claw puncture needle suitable for multi-point injection of radionuclide drugs according to claim 6, characterized in that: An annular mounting groove is provided on the outer side wall of one end of the puncture head, the uniform cover is fixed to the puncture head through the mounting groove, a U-shaped groove is provided in the mounting groove, the gap is formed by the U-shaped groove and the uniform cover, and the flow hole is located in the U-shaped groove.