DNA methylation detection kit

Abstract

The utility model relates to the technical field of detection kits, in particular to a DNA (deoxyribonucleic acid) methylation detection kit which comprises a storage box, a box cover is arranged at the top end of the storage box, the box cover is connected with the storage box through a hinge, a connecting block is arranged at the bottom of one side of the box cover, a mounting block is arranged above one side of the storage box, and the mounting block is connected with the box cover through a hinge. The mounting block is fixedly connected with the storage box, the mounting block is located in the middle of the connecting block, clamping grooves are formed in the two sides of the interior of the connecting block, a placement plate is arranged at the bottom end of the interior of the storage box, the bottoms of sample test tubes can be clamped and fixed through the clamping assembly, and the stability of the sample test tubes in the storage box is guaranteed; the sample test tube storage box has the advantages that the sample test tube storage box is simple in structure and convenient to use, shaking during transfer is avoided, sample test tubes can be firmly fixed in the sample test tube storage box, the height of a movable plate can be conveniently adjusted through a threaded rod, the sample test tubes of different heights can be placed in the sample test tube storage box, and the use convenience of the sample test tube storage box is further improved.

Description

Technical Field

[0001] The utility model relates to the technical field of detection kits, in particular to a DNA methylation detection kit. Background Art

[0002] DNA methylation is one of the earliest discovered gene epigenetic modifications. Methylation in eukaryotes only occurs on cytosine, that is, the cytosine at the 5'-end of the CpG dinucleotide is converted to 5'-methylcytosine under the action of DNA methyltransferases (DNMTs). DNA methylation usually inhibits gene expression, while demethylation induces gene reactivation and expression.

[0003] Existing DNA methylation detection kits cannot effectively store reagents during use, and the methylation DNA extraction room and the detection room of some detection institutions are not in the same location. The kit needs to be transported to the detection room. The collection box will inevitably be shaken during transportation, thereby once again increasing the risk of leakage. In summary, it will directly affect the sales volume of the product. Utility Model Content

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies in the prior art, the utility model provides a DNA methylation detection kit.

[0006] (II) Technical solution

[0007] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a DNA methylation detection kit, comprising a storage box, a box cover is arranged at the top of the storage box, the box cover and the storage box are hinged, a connecting block is arranged at the bottom of one side of the box cover, a mounting block is arranged above one side of the storage box, the mounting block and the storage box are fixedly connected, the mounting block is located in the middle of the connecting block, slots are arranged on both sides of the connecting block, a placement plate is arranged at the bottom end of the storage box, a placement groove is arranged inside the top of the placement plate, a clamping assembly is arranged at the top of the placement plate, a movable plate is arranged in the storage box, and the movable plate A threaded rod is provided in the middle, the bottom end of the threaded rod is rotatably connected to the placement plate, the threaded rod is threadedly connected to the movable plate, a handle is provided on the top of the threaded rod, through grooves are provided on both sides of the top of the movable plate, a mounting groove is provided inside the mounting block, a connecting rod is provided in the mounting groove, a second spring is provided on the connecting rod, a movable block is provided on the connecting rod, one end of the second spring rests on the movable block, the movable block and the connecting rod are slidably connected, a clamping block is provided on one side of the movable block, one end of the clamping block passes through the mounting block and rests on the inside of the clamping slot, a pull plate is provided at the bottom of the movable block, and the pull plate is located at the bottom of the mounting block.

[0008] In order to improve the use effect of the clamping assembly, the utility model is improved, the clamping assembly includes three groups of fixed blocks, the three groups of fixed blocks are evenly arranged on the top of the placement groove, grooves are provided inside the two ends of one side of the fixed block, a fixing rod is provided in the groove, a first spring is provided on the fixed rod, a sliding sleeve is provided on the fixed rod, the sliding sleeve is slidably provided on the fixed rod, an elastic plate is provided between the sliding sleeves, the two ends of the elastic plate are rotatably connected to the sliding sleeve, and the three groups of fixed blocks have the same structure.

[0009] In order to improve the use effect of the elastic plate, the utility model is improved in that the elastic plate is made of an elastic plastic plate.

[0010] In order to improve the practicability of the elastic plate, the utility model is improved in that a gasket is arranged on the outer wall of the elastic plate, and the gasket is made of rubber material.

[0011] In order to improve the stability of the movable plate when it is lifted or lowered, the utility model is improved in that slide grooves are arranged on both sides of the movable plate, and slide rails are arranged on both sides of the inner wall of the storage box, and the slide rails are slidably arranged inside the slide grooves.

[0012] In order to improve the use effect of the pull plate, the utility model is improved in that the pull plate is fixedly connected to the movable block, and anti-slip patterns are arranged on the pull plate.

[0013] In order to improve the use effect of the storage box, the utility model is improved in that an anti-corrosion layer is used on the surface of the storage box and the box cover, and the anti-corrosion layer is made of epoxy resin.

[0014] In order to improve the protective effect of the movable plate, the utility model is improved in that a rubber sleeve is arranged in the through slot, and the rubber sleeve is fitted with the through slot.

[0015] (III) Beneficial effects

[0016] Compared with the prior art, the utility model provides a DNA methylation detection kit, which has the following beneficial effects:

[0017] The DNA methylation detection kit can clamp and fix the bottom of the sample test tube through the clamping component, thereby ensuring the stability of the sample test tube in the storage box and avoiding shaking during transportation, so that the sample test tube can be firmly fixed in the storage box, and the movable plate can be conveniently adjusted in height through the setting of the threaded rod, so that the storage box can hold sample test tubes of different heights, further improving the convenience of use of the storage box. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the structure of the utility model;

[0019] Figure 2For this utility model Figure 1 Schematic diagram of the internal structure;

[0020] Figure 3 For this utility model Figure 2 A schematic diagram of the enlarged structure at the middle fixed block;

[0021] Figure 4 For this utility model Figure 1 A schematic diagram of the local enlarged structure at point A in the middle;

[0022] In the figure: 1. storage box; 2. box cover; 3. connecting block; 4. placement plate; 5. clamping assembly; 6. movable plate; 7. threaded rod; 8. through slot; 9. handle; 10. slide rail; 11. groove; 12. fixing rod; 13. first spring; 14. sliding sleeve; 15. elastic plate; 16. mounting block; 17. connecting rod; 18. second spring; 19. movable block; 20. clamping block; 21. pull plate. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] See also Figure 1-4A DNA methylation detection kit comprises a storage box 1, a box cover 2 is arranged at the top of the storage box 1, the box cover 2 is hingedly connected to the storage box 1, a connecting block 3 is arranged at the bottom of one side of the box cover 2, a mounting block 16 is arranged above one side of the storage box 1, the mounting block 16 is fixedly connected to the storage box 1, the mounting block 16 is located in the middle of the connecting block 3, and slots are arranged on both sides of the connecting block 3, a placement plate 4 is arranged at the bottom end of the storage box 1, a placement groove is arranged inside the top of the placement plate 4, a clamping assembly 5 is arranged at the top of the placement plate 4, a movable plate 6 is arranged in the storage box 1, a threaded rod 7 is arranged in the middle of the movable plate 6, and the bottom end of the threaded rod 7 is connected to the placement The set plate 4 is rotatably connected, the threaded rod 7 is threadedly connected to the movable plate 6, a handle 9 is provided at the top of the threaded rod 7, through grooves 8 are provided on both sides of the top of the movable plate 6, a mounting groove is provided inside the mounting block 16, a connecting rod 17 is provided in the mounting groove, a second spring 18 is provided on the connecting rod 17, a movable block 19 is provided on the connecting rod 17, one end of the second spring 18 is against the movable block 19, the movable block 19 and the connecting rod 17 are slidably connected, a clamping block 20 is provided on one side of the movable block 19, one end of the clamping block 20 passes through the mounting block 16 and is against the inside of the clamping slot, a pull plate 21 is provided at the bottom of the movable block 19, and the pull plate 21 is located at the bottom of the mounting block 16.

[0025] In actual use of the above structure, first, the connecting block 3 on the box cover 2 is engaged with the card block 20 on the mounting block 16, which is convenient for fixing the box cover 2 and ensuring the stability of the box cover 2. At the same time, it is also more convenient to open the box cover 2. When opening, the pull plate 21 is manually pushed, and the pull plate 21 drives the movable block 19 to slide on the connecting rod 17 and squeeze the second spring 18. At this time, the moving block drives the card block 20 to exit the card slot, and the connecting block 3 loses its limit, so that the box cover 2 can be opened, which is convenient for the storage box 1 to be used. When in use, The test tube containing the DNA sample is placed between the clamping components 5 through the through groove 8, and the sample test tube is clamped and fixed by the clamping component 5 to ensure the stability of the sample test tube in the storage box 1 and avoid shaking during transportation, so that the sample test tube can be firmly fixed in the storage box 1, and when the height of the movable plate 6 needs to be adjusted, the handle 9 is manually rotated to make the handle 9 drive the threaded rod 7 to rotate, and the threaded rod 7 drives the movable plate 6 to rise or fall, so that the storage box 1 can place sample test tubes of different heights, which is more convenient to use.

[0026] In this embodiment, the clamping assembly 5 includes three groups of fixed blocks, and the three groups of fixed blocks are evenly arranged on the top of the placement groove. Grooves 11 are provided inside the two ends of one side of the fixed block, and a fixing rod 12 is provided in the groove 11. A first spring 13 is provided on the fixing rod 12, and a sliding sleeve 14 is provided on the fixing rod 12. The sliding sleeve 14 is slidably provided on the fixing rod 12, and an elastic plate 15 is provided between the sliding sleeves 14. The two ends of the elastic plate 15 are rotatably connected to the sliding sleeves 14. The three groups of fixed blocks have the same structure. Through the setting of the elastic plate 15, the sample test tube can be squeezed and clamped, so that the sample test tube can be firmly clamped between the three groups of fixed blocks, and the elastic plate 15 can also squeeze the first spring 13 on the fixing rod 12 through the sliding sleeve 14, further improving the elasticity of the elastic plate 15, so that the elastic plate 15 can also clamp and fix sample test tubes of different sizes, which is more practical.

[0027] In this embodiment, a gasket is disposed on the outer wall of the elastic plate 15 . The gasket is made of rubber material, and the surface of the sample tube can be prevented from being scratched.

[0028] In this embodiment, slide grooves are provided on both sides of the movable plate 6, and slide rails 10 are provided on both sides of the inner wall of the storage box 1. The slide rails 10 are slidably provided inside the slide grooves. Through the provision of the slide grooves and the slide rails 10, the stability of the movable plate 6 during lifting and lowering adjustment can be improved.

[0029] In this embodiment, an anti-corrosion layer is applied on the surface of the storage box 1 and the box cover 2 , and the anti-corrosion layer is made of epoxy resin, thereby improving the durability of the storage box 1 and the box cover 2 .

[0030] In this embodiment, a rubber sleeve is provided in the through slot 8 , and the rubber sleeve fits the through slot 8 , thereby improving the protective effect of the sample test tube in the through slot 8 .

[0031] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A DNA methylation detection kit, characterized in that: The storage box (1) comprises a storage box (1), wherein a box cover (2) is arranged at the top of the storage box (1), wherein the box cover (2) and the storage box (1) are hingedly connected, a connecting block (3) is arranged at the bottom of one side of the box cover (2), a mounting block (16) is arranged above one side of the storage box (1), wherein the mounting block (16) and the storage box (1) are fixedly connected, wherein the mounting block (16) is located in the middle of the connecting block (3), wherein slots are arranged on both sides of the connecting block (3), a placement plate (4) is arranged at the bottom end of the storage box (1), a placement groove is arranged inside the top end of the placement plate (4), a clamping assembly (5) is arranged at the top end of the placement plate (4), a movable plate (6) is arranged in the middle of the movable plate (6), and a threaded rod (7) is arranged, wherein the bottom end of the threaded rod (7) and the placement plate (4) are rotatable. The threaded rod (7) and the movable plate (6) are connected in a threaded manner. A handle (9) is provided at the top of the threaded rod (7). Through grooves (8) are provided on both sides of the top of the movable plate (6). A mounting groove is provided inside the mounting block (16). A connecting rod (17) is provided in the mounting groove. A second spring (18) is provided on the connecting rod (17). A movable block (19) is provided on the connecting rod (17). One end of the second spring (18) abuts against the movable block (19). The movable block (19) and the connecting rod (17) are slidably connected. A clamping block (20) is provided on one side of the movable block (19). One end of the clamping block (20) passes through the mounting block (16) and abuts against the inside of the clamping groove. A pull plate (21) is provided at the bottom of the movable block (19). The pull plate (21) is located at the bottom of the mounting block (16).

2. A DNA methylation detection kit according to claim 1, characterized in that: The clamping assembly (5) comprises three groups of fixed blocks, the three groups of fixed blocks are evenly arranged at the top of the placement groove, grooves (11) are arranged inside the two ends of one side of the fixed block, a fixed rod (12) is arranged in the groove (11), a first spring (13) is arranged on the fixed rod (12), a sliding sleeve (14) is arranged on the fixed rod (12), the sliding sleeve (14) is slidably arranged on the fixed rod (12), an elastic plate (15) is arranged between the sliding sleeves (14), the two ends of the elastic plate (15) are rotatably connected to the sliding sleeve (14), and the three groups of fixed blocks have the same structure.

3. A DNA methylation detection kit according to claim 2, characterized in that: The elastic plate (15) is made of an elastic plastic plate.

4. A DNA methylation detection kit according to claim 3, characterized in that: A gasket is also arranged on the outer wall of the elastic plate (15), and the gasket is made of rubber material.

5. A DNA methylation detection kit according to claim 4, characterized in that: Slide grooves are arranged on both sides of the movable plate (6), and slide rails (10) are arranged on both sides of the inner wall of the storage box (1), and the slide rails (10) are slidably arranged inside the slide grooves.

6. A DNA methylation detection kit according to claim 5, characterized in that: The pull plate (21) is fixedly connected to the movable block (19), and anti-slip patterns are provided on the pull plate (21).

7. A DNA methylation detection kit according to claim 6, characterized in that: An anti-corrosion layer is applied on the surface of the storage box (1) and the box cover (2), and the anti-corrosion layer is made of epoxy resin.

8. A DNA methylation detection kit according to claim 7, characterized in that: A rubber sleeve is arranged in the through slot (8), and the rubber sleeve is fitted with the through slot (8).

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