Diagnosis and treatment assembly used after brain glioma operation

Abstract

The utility model discloses a brain glioma postoperative diagnosis and treatment assembly which comprises an implantation catheter body and an irradiation catheter body, the top end of the irradiation catheter body is connected with a handle, a photodynamic irradiation optical fiber is arranged in the irradiation catheter body, the lower portion of the irradiation catheter body is of a spine structure, and the spine structure comprises a plurality of vertebrae. A vertebral hole of each vertebra is filled with resin, and vertebral bodies of any two adjacent vertebrae are connected together through an elastic body; an angle knob is arranged on the handle, two traction wires are wound on the angle knob in the forward and reverse directions, and the end, away from the angle knob, of each traction wire is connected with the lower end of the spine structure so as to drive the spine structure to be bent in the first direction and the second direction. The lower portion of the irradiation catheter body is of the spine structure made of the biocompatible materials, the spine structure is bent gently, the bending degree is not large, damage to the photodynamic irradiation optical fiber can be reduced, and the service life of the photodynamic irradiation optical fiber can be prolonged.

Description

Technical Field

[0001] The utility model belongs to the field of medical equipment, and more specifically, relates to a diagnosis and treatment component for post-operative brain glioma. Background Art

[0002] Gliomas are the most common primary malignant tumors in the brain, characterized by invasive growth and in situ recurrence.

[0003] Even with comprehensive treatments such as surgery, radiotherapy and chemotherapy, the median survival of patients with the most malignant glioblastoma (GBM) is only 15 months, and the prognosis is extremely poor. Photodynamic therapy (PDT) is another new therapy that is extremely active in the field of tumor treatment after surgery, radiotherapy and chemotherapy. It has been used to treat a variety of malignant tumors including skin, bladder and esophageal tumors. PDT can not only achieve a killing effect on tumor cells through photosensitivity reactions, but also induce local immune responses to play a tumor treatment role. Due to the selectivity of photosensitizers and complications such as brain edema after PDT, the further application of PDT in the clinical treatment of brain gliomas is hindered. If the key technologies of PDT can be optimized and innovative devices can be developed based on existing photosensitizers, and the feasibility of photosensitizer-guided surgery and intraoperative and postoperative PDT treatment can be enhanced, PDT is expected to become one of the effective treatments for brain gliomas.

[0004] Patent 201910063694.6 discloses a device for diagnosing and treating gliomas, in which the movable bending part of the lower part of the irradiation catheter tube body is a fin tube structure, which can adjust the posture of the lower end of the photodynamic irradiation optical fiber after bending, so that the photodynamic irradiation optical fiber can perform photodynamic irradiation treatment on recurrent tumor tissue. However, this fin tube structure can make the fin tube structure bend greatly even if the rotation stroke of the angle knob is very small, that is, a slight rotation of the angle knob (see Figure 1 , Figure 1 The arc in the figure represents the fin tube structure), and the photodynamic irradiation optical fiber is fixed in the irradiation catheter tube body, and has poor bending performance. Long-term large curvature bending will cause the photodynamic irradiation optical fiber to be easily damaged. Utility Model Content

[0005] In response to the above defects or improvement needs of the prior art, the utility model provides a diagnostic and treatment component for postoperative brain glioma, in which the lower part of the irradiation catheter tube body is a spinal structure made of biocompatible material. The curvature of the spinal structure is relatively gentle and the degree of curvature is not large, which is beneficial to reduce the damage to the photodynamic irradiation optical fiber and extend the service life of the photodynamic irradiation optical fiber.

[0006] To achieve the above-mentioned purpose, according to the utility model, a diagnosis and treatment assembly for postoperative brain glioma is provided, comprising a vertically arranged implantation catheter body and an irradiation catheter body for inserting into the inner hole of the implantation catheter body, the top end of the irradiation catheter body is connected to a handle, the irradiation catheter body is built with a photodynamic irradiation optical fiber, the upper end of the photodynamic irradiation optical fiber is connected to a photodynamic interface, and is characterized in that:

[0007] The lower part of the irradiation catheter tube body is a hollow spinal column structure, which includes a plurality of hollow vertebrae movably connected together, and the vertebral foramen of each vertebra is respectively filled with resin to fix the photodynamic irradiation optical fiber in the spinal column structure, and the vertebral bodies of any two adjacent vertebrae are connected together by an elastic body;

[0008] The handle is provided with an angle knob, and two traction wires are wound around the angle knob in both directions. One end of each traction wire away from the angle knob is respectively connected to the lower end of the spinal structure to drive the spinal structure to bend in a first direction and in a second direction opposite to the first direction.

[0009] Preferably, the elastomer is rubber.

[0010] Preferably, the minimum bending radius of the photodynamic irradiation optical fiber is 15 mm±5 mm, and the minimum bending radius of the spinal column structure is greater than or equal to 20 mm.

[0011] Preferably, the resin is epoxy resin with a bending strength of 100 MPa-120 MPa.

[0012] Preferably, the number of the vertebrae is 8 to 15.

[0013] Preferably, the traction wire is connected to the lower end of the spinal column structure via a boss at the lower end of the spinal column structure, and the boss has a through hole for facilitating connection of the traction wire.

[0014] Preferably, the inner cavity of the upper part of the irradiation catheter body is filled with a filler to fix the photodynamic irradiation optical fiber.

[0015] Preferably, an imaging fiber bundle is also installed in the tube body of the irradiation catheter, and the resin in the spinal structure fixes the imaging fiber bundle in the spinal structure, and the imaging fiber bundle is connected to the video interface on the handle.

[0016] Preferably, an illumination optical fiber is also installed in the irradiation catheter tube body, and the resin in the spinal column structure fixes the illumination optical fiber in the spinal column structure, and the illumination optical fiber is connected to the illumination interface on the handle.

[0017] Preferably, the implantation catheter body, the irradiation catheter body and each of the traction wires are made of biocompatible materials respectively.

[0018] In general, the above technical solutions conceived by the utility model can achieve the following beneficial effects compared with the prior art:

[0019] The utility model is a diagnostic and treatment component for postoperative brain glioma. The lower part of the irradiation catheter body is a spinal structure made of biocompatible materials. The spinal structure is a vertebrae flexibly connected together, so that when the rotation of the angle knob drives the spinal structure to bend, the spinal structure bends relatively gently, and the degree of bending (curvature) is not large, which is conducive to reducing the damage to the photodynamic irradiation optical fiber and extending the service life of the photodynamic irradiation optical fiber. In addition, an elastic body is set between adjacent vertebrae for buffering, which can effectively reduce the wear between the vertebrae, thereby increasing the service life of the irradiation catheter body. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the existing structure when the irradiation catheter tube body is bent;

[0021] Figure 2 It is an overall schematic diagram of the utility model;

[0022] Figure 3 It is a schematic diagram of the vertebral foramen of the vertebra of the present invention containing resin, photodynamic irradiation optical fiber, imaging optical fiber bundle and illumination optical fiber;

[0023] Figure 4 It is a schematic diagram of the irradiation catheter body of the utility model when it is bent. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the utility model and are not used to limit the utility model. In addition, the technical features involved in each embodiment of the utility model described below can be combined with each other as long as they do not conflict with each other.

[0025] Reference Figure 2 to Figure 4 A diagnostic and treatment component for postoperative brain glioma includes a vertically arranged implantation catheter body 1 and an irradiation catheter body 2 for inserting into the inner hole of the implantation catheter body 1, the top of the irradiation catheter body 2 is connected with a handle 3, and the irradiation catheter body 2 is equipped with a photodynamic irradiation optical fiber 4, the lower end of the photodynamic irradiation optical fiber 4 can be exposed at the lower end of the irradiation catheter body 2, or it can not exceed the lower end of the irradiation catheter body 2, as long as the emitted laser can irradiate on human tissue, and a photodynamic interface 41 is connected to the upper end of the photodynamic irradiation optical fiber 4.

[0026] The lower part of the irradiation catheter body 2 is a hollow spinal column structure 5, and the upper part of the irradiation catheter body 2 is a hollow connecting tube 21. The spinal column structure 5 includes a plurality of hollow vertebrae 51 that are movably connected together. The vertebral holes of each vertebra 51 are filled with resin 52 to fix the photodynamic irradiation optical fiber 4 in the spinal column structure 5. The vertebral bodies of any two adjacent vertebrae 51 are connected together by an elastic body 53. The elastic body 53 is preferably rubber, which can play a good buffering role and help protect the vertebrae 51. The spinal column structure 5 of the utility model is modeled after the spinal column and is a bionic structure. The connection between the vertebrae 51 also models the vertebrae of the human spine. The number of the vertebrae 51 is preferably 8 to 15. After the vertebrae 51 are manufactured one by one, they can be assembled to form the spinal column structure 5. After the spinal column structure 5 is assembled, the photodynamic irradiation optical fiber 4 is inserted, and then the resin 52 is added into the vertebral hole to fix the photodynamic irradiation optical fiber 4. The upper end of the spinal column structure 5 is fixedly connected to the upper part (connecting tube 21) of the irradiation catheter body 2. The spine structure 5 and the connecting pipe 21 can be fixedly connected together by existing methods such as welding (if both are made of metal materials), or interference fit, gluing, side-driven pinning, etc.

[0027] The handle 3 is provided with an angle knob 6, on which two traction wires 61 are wound in the forward and reverse directions (i.e., one traction wire 61 is wound forward, and one traction wire 61 is wound reversely, and the two traction wires 61 are wound in opposite directions on the angle knob 6), and one end of each traction wire 61 away from the angle knob 6 is respectively connected to the lower end of the spinal structure 5, so as to drive the spinal structure 5 to bend in a first direction and in a second direction opposite to the first direction (the bending in the first direction and the bending in the second direction are equivalent to the bending of a person in the forward and backward directions). Since the spinal structure 5 is relatively gentle when bending, the spinal structure 5 will not bend greatly when the angle knob 6 is slightly turned, which helps to protect the photodynamic irradiation optical fiber 4.

[0028] The photodynamic irradiation optical fiber 4 is connected to a clinical photodynamic therapy light source to perform photodynamic irradiation therapy on recurrent tumor tissue. The spinal structure 5 drives the photodynamic irradiation optical fiber 4 to bend in coordination with the angle knob 6, and the posture of the lower end of the photodynamic irradiation optical fiber 4 can be adjusted. If the irradiation direction of the photodynamic irradiation optical fiber 4 needs to be adjusted, the handle 3 can be manually driven to rotate around the vertical line, and the entire postoperative diagnosis and treatment assembly for brain gliomas also rotates around the vertical line.

[0029] Furthermore, the minimum bending radius of the photodynamic irradiation optical fiber 4 is 15mm±5mm, and the maximum bending curvature of the spine structure 5 is greater than or equal to the minimum bending radius of 20mm. The curvatures of the two bends are adapted to each other, so that the photodynamic irradiation optical fiber 4 is not easily damaged when the spine is bent.

[0030] Further, the resin 52 is an epoxy resin, and the bending strength is preferably 100MPa-120MPa. The bending strength is large and it is not easy to break. The epoxy resin shows excellent performance when subjected to bending load and has a long service life. In order to improve the bending performance of the epoxy resin, reinforcing materials such as glass fiber can be added to the epoxy resin, which can increase the bending strength and impact resistance of the epoxy resin at the same time. High-performance epoxy resin itself has high tensile strength and bending strength.

[0031] Furthermore, the inner cavity of the upper portion of the irradiation catheter body 2 (connecting tube 21 ) is filled with a filler to fix the photodynamic irradiation optical fiber 4 and prevent the photodynamic irradiation optical fiber 4 from shaking in the irradiation catheter body 2 .

[0032] Furthermore, an imaging fiber bundle 7 is installed in the irradiation catheter body 2, and the resin 52 in the spinal structure 5 fixes the imaging fiber bundle 7 in the spinal structure 5. The imaging fiber bundle 7 is connected to the video interface 71 on the handle 3 to obtain images of human tissue in the tumor cavity.

[0033] Furthermore, an illumination fiber 8 is installed in the irradiation catheter body 2, and the illumination fiber 8 is connected to the illumination interface 9 on the handle 3. The resin 52 in the spinal structure 5 fixes the illumination fiber 8 in the spinal structure 5 to illuminate the position of the tumor cavity. The illumination fiber 8 emits light to diagnose the tumor cavity, and the recurrence of the glioma is judged by exciting the clinical glioma marker fluorescent agent to emit fluorescence and using the imaging fiber bundle 7 for real-time imaging.

[0034] Furthermore, the implantation catheter body 1, the irradiation catheter body 2 and each of the traction wires 61 are made of biocompatible materials, respectively, and are safe to use.

[0035] Furthermore, the traction wire 61 is connected to the lower end of the spine structure 5 via the boss 54 at the lower end of the spine structure 5 , and the boss 54 has a through hole for connecting the traction wire 61 , so that the traction wire 61 can be connected and fixed conveniently.

[0036] A catheter plug 10 is also provided at the upper end of the implantable catheter body 1. The photodynamic irradiation optical fiber 4 and the illumination optical fiber 8 are plastic optical fibers, glass optical fibers or quartz optical fibers. The implantable catheter body 1, the catheter plug 10 and the irradiation catheter body 2 are made of silicone, polyurethane or other flexible polymer materials with good biocompatibility.

[0037] It will be easily understood by those skilled in the art that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A diagnostic and treatment assembly for postoperative glioma, comprising a vertically arranged implantation catheter body and an irradiation catheter body for inserting into the inner hole of the implantation catheter body, the top end of the irradiation catheter body is connected to a handle, the irradiation catheter body is built with a photodynamic irradiation optical fiber, the upper end of the photodynamic irradiation optical fiber is connected to a photodynamic interface, characterized in that: The lower part of the irradiation catheter tube body is a hollow spinal column structure, which includes a plurality of hollow vertebrae movably connected together, and the vertebral foramen of each vertebra is respectively filled with resin to fix the photodynamic irradiation optical fiber in the spinal column structure, and the vertebral bodies of any two adjacent vertebrae are connected together by an elastic body; The handle is provided with an angle knob, and two traction wires are wound around the angle knob in both directions. One end of each traction wire away from the angle knob is respectively connected to the lower end of the spinal structure to drive the spinal structure to bend in a first direction and in a second direction opposite to the first direction.

2. A postoperative diagnosis and treatment assembly for glioma according to claim 1, characterized in that: The elastomer is rubber.

3. A postoperative diagnosis and treatment assembly for glioma according to claim 1, characterized in that: The minimum bending radius of the photodynamic irradiation optical fiber is 15 mm±5 mm, and the minimum bending radius of the spine structure is greater than or equal to 20 mm.

4. The diagnostic and therapeutic component for postoperative glioma according to claim 1, characterized in that: The resin is epoxy resin, and the bending strength is 100MPa-120MPa.

5. The postoperative diagnosis and treatment assembly for glioma according to claim 1, characterized in that: The inner cavity at the upper part of the irradiation catheter body is filled with a filler to fix the photodynamic irradiation optical fiber.

6. A postoperative diagnosis and treatment assembly for glioma according to claim 1, characterized in that: The number of the vertebrae is 8 to 15.

7. The postoperative diagnosis and treatment assembly for glioma according to claim 1, characterized in that: The traction wire is connected to the lower end of the spine structure through a boss at the lower end of the spine structure, and the boss has a through hole for connecting the traction wire.

8. The postoperative diagnosis and treatment assembly for brain glioma according to claim 1, characterized in that: An imaging fiber bundle is also installed in the irradiation catheter tube body. The resin in the spinal structure fixes the imaging fiber bundle in the spinal structure. The imaging fiber bundle is connected to the video interface on the handle.

9. The postoperative diagnosis and treatment assembly for glioma according to claim 1, characterized in that: An illumination optical fiber is also installed in the irradiation catheter tube body. The resin in the spinal column structure fixes the illumination optical fiber in the spinal column structure. The illumination optical fiber is connected to the illumination interface on the handle.

10. The postoperative diagnosis and treatment component for brain glioma according to claim 1, characterized in that: The implantation catheter body, the irradiation catheter body and each traction wire are respectively made of biocompatible materials.

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