A reagent mixing device and chemiluminescence immunoassay analyzer

Abstract

The present application relates to a reagent mixing device, comprising a reagent compartment turntable and a bottle holder arranged on the reagent compartment turntable, a reagent bottle is detachably mounted on the bottle holder, the bottle holder comprises a fixing rod and a base arranged on the top of the fixing rod, a first bracket and a second bracket extending upwards along both sides of the upper surface of the base, respectively, a rotating shaft is rotatably provided between the first bracket and the second bracket; a plurality of claws are convexly provided at the bottom of the reagent bottle, and a positioning groove is formed between two adjacent claws; when the reagent bottle is inserted into the bottle holder, the claws contact the rotating shaft and rotate it, and the rotating shaft is rotated into the positioning groove and interlaced with it for positioning. The reagent mixing device provided by the present application can ensure that the reagent bottle and the bottle holder can form a good match when the reagent bottle is vertically inserted into the bottle holder.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a reagent mixing device and a chemiluminescent immunoassay analyzer. Background Art

[0002] The chemiluminescent immunoassay analyzer is a tool for diagnosing some diseases using immunodiagnostic technology, which includes a reagent mixing device. The existing reagent mixing device generally includes a reagent test kit and a reagent compartment turntable. The reagent test kit contains a reagent bottle and a bottle holder is provided on the reagent compartment turntable. In order to mix the reagent inside the reagent bottle, the reagent bottle needs to be rotated. For this purpose, a first connecting part is provided at the bottom of the reagent bottle, and a second connecting part is provided in the bottle holder. The two are connected together by the cooperation of the first connecting part and the second connecting part. For example, the first connecting part is a claw, and the second connecting part is a groove, and the groove and the claw are engaged. Since the automatic replacement of the reagent test kit usually requires the electric clamp to clamp the reagent test kit and then insert it into the bottle holder under the drive of the Z-axis motion mechanism, when the first connecting part is in a random position, it is difficult to insert vertically or the rebound force is large when the first connecting part and the second connecting part may be misaligned, or the reagent bottle may cause the reagent compartment turntable to rotate when inserted into the bottle holder, causing the reagent compartment turntable to rotate and the claws at the bottom of the reagent bottle to fail to form a good staggered meshing problem with the bottle holder.

[0003] Therefore, how to ensure that the reagent bottle and the bottle holder can form a good match when the reagent bottle is vertically inserted into the bottle holder is a problem that needs to be solved urgently. Utility Model Content

[0004] In response to the technical problems existing in the prior art, the present application proposes, on the one hand, a reagent mixing device, comprising a reagent compartment turntable and a bottle holder arranged on the reagent compartment turntable, on which a reagent bottle is detachably mounted, the bottle holder comprising a fixing rod and a base arranged on the top of the fixing rod, a first bracket and a second bracket extending upward along both sides of the upper surface of the base, respectively, a rotating shaft rotatably passing through the first bracket and the second bracket; a plurality of claws are protruding from the bottom of the reagent bottle, and a positioning groove is formed between two adjacent claws; when the reagent bottle is inserted into the bottle holder, the claws contact the rotating shaft and rotate it, so that the rotating shaft is rotated and introduced into the positioning groove and interlaced with it for positioning.

[0005] Optionally, a rounded chamfer is provided at the end of the claw to facilitate contact with the outer surface of the rotating shaft and to be guided into the positioning groove.

[0006] Optionally, a first through hole is respectively formed on the first bracket and the second bracket, and the rotating shaft passes through the first through hole and extends outwardly with a first connecting end for staggered engagement with the positioning groove.

[0007] Optionally, the first bracket, the second bracket and the base form a U-shaped structure.

[0008] Optionally, a limiting mechanism is also included, which includes an annular groove correspondingly arranged on the rotating shaft and a limiting plate sleeved on the rotating shaft, one side of the limiting plate abuts against the side of the first bracket and / or the second bracket to prevent axial movement of the rotating shaft.

[0009] Optionally, the annular groove is located on the inner side of the first bracket and / or the second bracket respectively.

[0010] Optionally, the limiting plate is circular with a fan-shaped opening at the circumferential edge, a second through hole is opened in the middle of the limiting plate, the second through hole is connected to the fan-shaped opening for the rotating shaft to pass through, and the limiting plate is embedded in the annular groove through the fan-shaped opening.

[0011] Optionally, a sector-shaped hole is further formed on the limiting plate, and a long arc side of the sector-shaped hole is away from the second through hole.

[0012] Optionally, the number of the claws is an even number.

[0013] On the other hand, the present application proposes a chemiluminescent immunoassay analyzer, including a liquid adding needle and a reagent mixing device as described above, wherein the reagent mixing device is used to mix the reagent in the reagent bottle so that the liquid adding needle absorbs the mixed reagent to a predetermined position.

[0014] According to the reagent mixing device provided by the present application, a rotating shaft is arranged on the bottle seat and the rotatable characteristic of the rotating shaft is utilized. When the reagent bottle is vertically inserted, the claw will contact the rotating shaft and cause the rotating shaft to rotate. The rotation of the rotating shaft can reduce the force required for vertical insertion. The rotation of the rotating shaft can transmit the force to the bottle seat, causing the bottle seat to rotate. In this way, the reagent bottle can be easily inserted into the bottle seat and interlocked with the bottle seat. At the same time, the vertical insertion will not cause the position of the reagent compartment turntable to rotate. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Below, the preferred embodiments of the present application will be further described in detail with reference to the accompanying drawings, wherein:

[0016] Figure 1 is a three-dimensional diagram of a reagent mixing device according to an embodiment of the present application;

[0017] Figure 2 yes Figure 1 Sectional view in the AA direction;

[0018] Figure 3 This is a schematic diagram of the structure of the connection between the bottle holder and the reagent compartment turntable according to an embodiment of the present application;

[0019] Figure 4is a schematic structural diagram of a bottle holder according to an embodiment of the present application;

[0020] Figure 5 is a schematic structural diagram of a reagent bottle according to an embodiment of the present application;

[0021] Fig. 6A and Figure 6B They are schematic diagrams of the clamping claws of the embodiment of the present application when they are about to be introduced into the rotating shaft and when they have been introduced into the rotating shaft;

[0022] Figure 7 It is a schematic diagram of the structure of the limiting piece of an embodiment of the present application. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0024] In the following detailed description, reference may be made to the various specification drawings that are part of the present application and are used to illustrate specific embodiments of the present application. In the accompanying drawings, similar reference numerals describe substantially similar components in different figures. The various specific embodiments of the present application are described below in sufficient detail so that a person of ordinary skill in the art with relevant knowledge and skills in the art can implement the technical solutions of the present application. It should be understood that other embodiments may also be used or structural, logical or electrical changes may be made to the embodiments of the present application.

[0025] The present application provides a reagent mixing device, which is mainly used in medical analyzers such as chemiluminescence immunoassay analyzers.

[0026] Figure 1 is a stereoscopic diagram of a reagent mixing device according to an embodiment of the present application, Figure 2 yes Figure 1 The cross-sectional view along the AA direction. Figure 1 , Figure 2 As shown, the reagent mixing device includes a reagent compartment turntable 10 and a bottle holder 11 disposed on the reagent compartment turntable 10, and a reagent bottle 20 is detachably mounted on the bottle holder 11. The reagent compartment turntable 10 can be sleeved on a central shaft 30, and the motor drives the central shaft 30 to rotate and drives the reagent compartment turntable 10 to rotate.

[0027] Figure 3 is a schematic diagram of the structure of the connection between the bottle holder and the reagent compartment turntable according to an embodiment of the present application, Figure 4 Schematic diagram of the structure of the bottle holder according to the embodiment of the present application. Figure 3 , Figure 4 As shown, the bottle holder 11 includes a fixing rod 110, and the bottle holder 11 can be installed on the reagent compartment turntable 10 through the fixing rod 110. The bottle holder 11 is rotatably connected to the reagent compartment turntable 10, and can rotate itself under the action of external force, and can rotate along with the reagent compartment turntable 10, so that the reagent in the reagent bottle 20 is fully mixed. Figure 2 As shown, in some embodiments, a first gear 31 is provided at the bottom of the reagent compartment turntable 10, and the first gear 31 is fixedly mounted on the central shaft 30. A second gear 1100 is mounted at the bottom of the fixed rod 110, and the first gear 31 and the second gear 1100 are meshed with each other. The first gear 31 rotates with the central shaft 30, and drives the second gear 1100 to rotate the bottle holder 11.

[0028] like Figure 4 As shown, the bottle holder 11 also includes a base 111 disposed on the top of the fixing rod 110, and a first bracket 1110 and a second bracket 1111 are extended upwardly along both sides of the upper surface of the base 111, and a rotating shaft 112 is rotatably provided between the first bracket 1110 and the second bracket 1111. In some embodiments, the first bracket 1110 and the second bracket 1111 are arranged opposite to each other, forming a U-shaped structure with the base 111, and the two have the same shape and size, for example, both are square protrusions. In some embodiments, a first through hole 1112 is respectively provided on the first bracket 1110 and the second bracket 1111, and the rotating shaft 112 is provided in the first through hole 1112 and extends outward to form a first connecting end 1120, and the first connecting end 1120 is used to install the reagent bottle 20.

[0029] Figure 5 Schematic diagram of the structure of the reagent bottle according to the embodiment of the present application. Figure 5 As shown, a plurality of claws 21 are convexly provided at the bottom of the reagent bottle 20, and a positioning groove 22 is formed between two adjacent claws 21. When the reagent bottle 20 is inserted into the bottle holder 11, the claws 21 contact and rotate the shaft 112, and rotate the shaft 112 into the positioning groove 22 and interlock and engage with it for positioning. In some embodiments, the claws 21 interlock and engage with the first connecting end 1120.

[0030] In some embodiments, the bottom of the reagent bottle 20 is circular, and the number of the claws 21 can be set to an even number, and the number of the positioning grooves 22 is also an even number, for example, the number of the claws 21 and the positioning grooves 22 are both 6. By providing a plurality of positioning grooves 22, the claws 21 can be contacted with the rotating shaft 112 so that no matter which side it rotates to, there is a positioning groove 22 for it to be introduced, ensuring that the claws 21 can be staggered and meshed with the rotating shaft 112.

[0031] In some embodiments, the end of the claw 21 that contacts the rotating shaft 112 is a circular chamfer, which can be set to a semicircular or fan-shaped arc, etc., so that the claw 21 is smoother when contacting the rotating shaft 112, thereby increasing the efficiency of guiding the rotating shaft 112 into the positioning groove 22.

[0032] In some embodiments, the reagent bottle 20 is also rotatable. When the reagent bottle 20 is in the preparation state before being fully inserted into the bottle seat 11, the bottle seat 11 cannot rotate, and the claw 21 is in contact with the rotating shaft 112. Since the rotating shaft 112 can rotate, the friction between the claw and the rotating shaft is reduced. In addition, the reagent bottle 20 can also rotate, so that the reagent bottle can be quickly and accurately inserted into the bottle seat. Fig. 6A and Figure 6B Schematic diagrams of the clamping claws of the embodiment of the present application when they are about to be introduced into the rotating shaft and when they have been introduced into the rotating shaft, as shown in FIG. Fig. 6A As shown, at this time, the right side of the end of the claw 21 contacts the left side of the rotating shaft 112. When the reagent bottle 20 continues to move downward along the Z axis, the claw 21 will drive the rotating shaft 112 to rotate toward A, and at the same time drive the reagent bottle 20 to rotate toward B, thereby adjusting the position of the positioning groove 22 and the rotating shaft 112, as shown in FIG. Figure 6B As shown, the rotating shaft 112 is smoothly introduced into the positioning groove 22.

[0033] In some embodiments, when the reagent bottle 20 is in the working state after being fully inserted into the bottle holder 11, the bottle holder 11 can rotate, and the rotation of the bottle holder drives the reagent bottle to rotate, starting the mixing operation process to mix the reagent in the reagent bottle.

[0034] Figure 7 Schematic diagram of the structure of the limiter in the embodiment of the present application. Figure 3 , Figure 4 , Figure 7 As shown, the bottle holder 11 is also provided with a limiting mechanism 120, and the limiting mechanism 120 includes an annular groove (not shown) correspondingly arranged on the rotating shaft 112 and a limiting piece 122 sleeved on the rotating shaft 112, and one side of the limiting piece 122 abuts against the side of the first bracket 1110 and / or the second bracket 1111 to prevent the axial movement of the rotating shaft 112. The number of the annular groove and the limiting piece 122 can be an even number, for example, 2, and the two limiting pieces 122 can both abut against the two sides of the first bracket 1110 or the second bracket 1111, or the two limiting pieces 122 respectively abut against one side of the opposite surface of the first bracket 1110 and the second bracket 1111, and the corresponding annular groove is provided at the corresponding position of the limiting piece 122 on the rotating shaft 112. The number of the annular groove and the limiting plate 122 may also be one. In this case, the limiting plate 122 is fixedly connected to one side of the first bracket 1110 or the second bracket 1111 by welding or forging, for example.

[0035] In some embodiments, the annular groove is located on the inner side of the first bracket 1110 and / or the second bracket 1111 respectively.

[0036] In some embodiments, the middle of the limiting piece 122 is provided with a second through hole 1220 for passing the rotating shaft 112, and the limiting piece 122 can be in any shape, such as square, elongated or circular. Figure 7 As shown, in one embodiment, the limiting piece 122 is circular, and a fan-shaped opening 1221 is provided on the circumferential edge, which is connected to the second through hole 1220 provided in the middle thereof for passing the rotating shaft 112, and the limiting piece 122 is embedded in the annular groove through the fan-shaped opening 1221. The limiting piece 122 may also be provided with a fan-shaped hole 1222, the long arc side of the fan-shaped hole 1222 is away from the second through hole 1220, and the number of the fan-shaped holes 1222 may be one or more.

[0037] The present application also proposes a chemiluminescent immunoassay analyzer, including a liquid adding needle and a reagent mixing device as described above, wherein the reagent mixing device is used to mix the reagent in the reagent bottle so that the liquid adding needle draws the mixed reagent to a predetermined position. The chemiluminescent immunoassay analyzer proposed in the embodiment of the present application includes the aforementioned reagent mixing device, which can mix the reagents used in the analyzer, and can use the reagent needle to draw the mixed reagent into the reaction tube.

[0038] To summarize, the reagent mixing device provided in the embodiment of the present application, by setting a rotating shaft on the bottle seat and utilizing the rotatable characteristic of the rotating shaft, when the reagent bottle is vertically inserted, the claw will contact the rotating shaft and cause the rotating shaft to rotate. The rotation of the rotating shaft can reduce the force required for vertical insertion. The rotation of the rotating shaft can transmit the force to the bottle seat, causing the bottle seat to rotate, so that the reagent bottle can be easily inserted into the bottle seat and interlocked with the bottle seat. At the same time, the vertical insertion will not cause the position of the reagent compartment turntable to rotate.

[0039] The above embodiments are only used to illustrate the present invention, but not to limit the present invention. Ordinary technicians in the relevant technical field can make various changes and modifications without departing from the scope of the present invention. Therefore, all equivalent technical solutions should also fall within the scope of the present invention.

Claims

1. A reagent mixing device, comprising a reagent compartment turntable and a bottle holder arranged on the reagent compartment turntable, wherein a reagent bottle is detachably mounted on the bottle holder, characterized in that: The bottle holder comprises a fixing rod and a base arranged on the top of the fixing rod, a first bracket and a second bracket extending upwards along both sides of the upper surface of the base, respectively, and a rotating shaft is rotatably arranged between the first bracket and the second bracket; a plurality of claws are convexly arranged at the bottom of the reagent bottle, and a positioning groove is formed between two adjacent claws; When the reagent bottle is inserted into the bottle holder, the clamping claw contacts the rotating shaft and rotates it, so that the rotating shaft is rotated and guided into the positioning groove and interlacedly engaged with the positioning groove for positioning.

2. The reagent mixing device according to claim 1, characterized in that: The end of the claw is provided with a rounded chamfer to facilitate contact with the outer surface of the rotating shaft and to be guided into the positioning groove.

3. The reagent mixing device according to claim 1, characterized in that: The first bracket and the second bracket are respectively provided with a first through hole, the rotating shaft is passed through the first through hole and a first connecting end extends outwardly for staggered engagement with the positioning groove.

4. The reagent mixing device according to claim 1, characterized in that: The first bracket, the second bracket and the base form a U-shaped structure.

5. The reagent mixing device according to claim 1, characterized in that: It also includes a limiting mechanism, which includes an annular groove correspondingly arranged on the rotating shaft and a limiting plate sleeved on the rotating shaft, one side of the limiting plate abuts against the side of the first bracket and / or the second bracket to prevent axial movement of the rotating shaft.

6. The reagent mixing device according to claim 5, characterized in that: The annular groove is located on the inner side of the first bracket and / or the second bracket respectively.

7. The reagent mixing device according to claim 5, characterized in that: The limiting plate is circular, with a fan-shaped opening at the circumferential edge, a second through hole is opened in the middle of the limiting plate, the second through hole is connected to the fan-shaped opening, and is used for the shaft to pass through, and the limiting plate is embedded in the annular groove through the fan-shaped opening.

8. The reagent mixing device according to claim 7, characterized in that: The limiting plate is also provided with a sector-shaped hole, and the long arc side of the sector-shaped hole is away from the second through hole.

9. The reagent mixing device according to claim 1, characterized in that: The number of the claws is an even number.

10. A chemiluminescent immunoassay analyzer, comprising a liquid addition needle, characterized in that: It also includes a reagent mixing device as described in any one of claims 1 to 9, wherein the reagent mixing device is used to mix the reagent in the reagent bottle so that the liquid adding needle draws the mixed reagent to a predetermined position.

Images