Platelet-rich plasma preparation device

Abstract

The utility model relates to the technical field of medical instruments, in particular to a platelet-rich plasma preparation device which comprises a first injector and a second injector which are detachably connected. The first injector comprises a first nipple, a first centrifugal hollow cylinder, a limiting plate fixedly arranged at the bottom of the first centrifugal hollow cylinder, a single piston embedded in the first centrifugal hollow cylinder in a sliding manner, a single push rod used for controlling the single piston, and a first branch pipe mainly used for conveying PRP; the second injector comprises a second nipple, a secondary centrifugal hollow cylinder, an upper piston and a lower piston which are embedded in the secondary centrifugal hollow cylinder in a sliding manner, a lower push rod and an upper push rod which are respectively used for controlling the upper piston and the lower piston, and a second branch pipe for conveying serum; an upper glue film for extracting red blood cells and a lower glue film for extracting serum are fixedly arranged on the secondary centrifugal empty cylinder; according to the scheme, serum, PRP and red blood cells in centrifuged blood can be independently stored and are convenient to take and use, and positive influences on improvement of the recovery rate of the PRP and simplification of a preparation method are achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to a platelet-rich plasma preparation device. Background Art

[0002] Platelet-rich plasma therapy is a treatment method that involves drawing a certain amount of whole blood from the patient, then centrifuging the blood into three layers from top to bottom, including serum, platelet-rich plasma (PRP), and red blood cells. The middle layer of PRP is then extracted and re-injected into a specific part of the patient's body. It is commonly used in the treatment of osteoarthritis.

[0003] Up to now, there are two commonly used methods for preparing PRP. One method is to separate the blood after one centrifugation into the above-mentioned three-layer structure with clear layers through a special separation gel. Referring to a controllable component platelet-rich plasma preparation tube and its preparation method disclosed in the prior art (application number: 202010512899.0), the separation gel is made of an organic gelling agent, which can separate serum (transparent light yellow), PRP (bright red), and red blood cells (close to black) with different densities into a three-layer structure with clear layers, and then use a syringe to extract the PRP in the middle for use; the other method is to prepare PRP by manual centrifugation. Referring to an integrated PRP collection and preparation device disclosed in the prior art (application number: 201921627906.0), the syringe for extracting blood is directly centrifuged twice. After the first centrifugation, the syringe is placed with the push rod facing up and the nipple facing down, and the push rod and the piston are used to push the excess red blood cells in the tube body into the pipette. After the second centrifugation, the PRP in the tube body is pushed into another pipette.

[0004] However, the above preparation methods all have obvious disadvantages. The preparation process of the separation gel used in the first method is very strict and the purchase cost is very high, which some patients cannot afford. The second method is not applicable in actual application because if the blood is centrifuged without separation gel, the above three-layer structure with clear layers cannot appear. Specifically, the boundaries between serum and PRP and between PRP and red blood cells are not clear, and they appear to be gradient in color. Therefore, in the process of pushing the piston after the first centrifugation, the three layers of serum, PRP, and red blood cells will penetrate each other. The original intention is to push out the red blood cells in the bottom layer, but in the process of pushing, part of the PRP will penetrate into the red blood cells again, causing PRP waste, which in turn affects the effect of treating patients. If a larger number of centrifugations are used and only a small amount of material close to the nipple is pushed each time, it will take up too much working time of medical staff and affect work efficiency. Therefore, there is a technical problem of low PRP recovery rate when preparing PRP by manual centrifugation. Utility Model Content

[0005] The utility model provides a platelet-rich plasma preparation device, which can solve the technical problem of low PRP recovery rate when the existing device adopts a manual centrifugation method to prepare PRP.

[0006] This application provides the following technical solutions:

[0007] A platelet-rich plasma preparation device comprises a first syringe and a second syringe that are detachably connected; the first syringe comprises a first nipple, a first centrifugal empty cylinder, a limit plate fixedly arranged at the bottom of the first centrifugal empty cylinder, a single piston slidably embedded in the first centrifugal empty cylinder, and a single push rod for controlling the single piston, a first branch pipe with a one-way valve is fixedly arranged on the side wall of the first centrifugal empty cylinder, an internal threaded hole is provided on the limit plate, and the interior of the single push rod is hollowed out; the second syringe comprises a second nipple, a second centrifugal empty cylinder, an upper piston and a lower piston slidably embedded in the second centrifugal empty cylinder, a lower push rod and an upper push rod respectively used to control the upper piston and the lower piston, a second branch pipe with a one-way valve is fixedly arranged on the side wall of the second centrifugal empty cylinder, an external thread threadedly connected to the internal threaded hole on the limit plate is fixedly arranged on the second nipple, and an upper film for extracting red blood cells and a lower film for extracting serum are fixedly arranged on the secondary centrifugal empty cylinder.

[0008] Beneficial effects:

[0009] 1. Improve the recovery rate of PRP when preparing PRP by manual centrifugation: After the first centrifugation of whole blood in the first syringe to preliminarily separate the three layers of substances, namely serum, PRP and red blood cells, the middle part rich in PRP (hereinafter referred to as the substance requiring secondary centrifugation) is extracted into the cavity under the single piston through the first branch tube on the side wall of the empty cylinder for the first centrifugation, and the second syringe threaded on the limit plate is used to extract the substance requiring secondary centrifugation for secondary centrifugation to obtain high-purity PRP. Specifically, the proportion of PRP in the empty cylinder for secondary centrifugation has been greatly increased, and the boundary between PRP and the small amount of red blood cells and serum separated has become clearer. This strategy of selectively extracting the middle layer rich in PRP for secondary centrifugation using the first branch tube on the first syringe improves the accuracy and efficiency of secondary centrifugation and ensures the high recovery rate and purity of PRP.

[0010] 2. PRP is finally placed on the top layer of the second syringe to meet the needs of immediate treatment: This design mainly achieves accurate stratification and isolation of serum, PRP and red blood cells through the coordinated work of the double-piston structure and the three-way assembly without the use of traditional separation gel. This mechanism not only simplifies the operating process, but also reduces the use of additional chemicals, reduces costs and alleviates the financial burden on patients. At the same time, after some operations, the top layer in the secondary centrifugal empty cylinder is a high-purity PRP substance, which can directly push the upper piston for direct injection into the human body, meeting the needs of immediate treatment.

[0011] 3. Flexible serum reuse mechanism: The serum after the second centrifugation is originally located at the top layer of the second syringe. At this time, the second branch tube on the side wall of the empty cylinder of the second centrifugation is used to extract all the serum into the cavity between the upper piston and the lower piston for separate storage. The red blood cell layer is directly discarded after being extracted from the upper film position with a new syringe because the trace amount of PRP contained therein is negligible. However, if additional PRP is needed after using the above-mentioned high-purity PRP, this solution allows the serum containing a small amount of PRP extracted from the lower film position by a new syringe to be reused through simple operation. This design not only makes full use of the precious PRP resources, but also ensures the convenience of operation.

[0012] Furthermore, as an improvement, it also includes a first barrel cap and a second barrel cap for respectively closing the top of the first syringe and the top of the second syringe, and the first barrel cap and the second barrel cap are respectively threadedly connected to the first nipple and the second nipple.

[0013] Beneficial effects: The first barrel cap and the second barrel cap are mainly used to respectively seal the first syringe and the second syringe, which is beneficial to the safety of the centrifugal process and creates a negative pressure environment to facilitate the extraction of required substances. The threaded connection method has a simple structure and is easy to disassemble.

[0014] Further, as an improvement, the upper rubber film and the lower rubber film are made of rubber material.

[0015] Beneficial effects: The upper and lower rubber films made of rubber material not only have good sealing performance but are also easy to puncture, which makes it convenient for medical personnel to use a new syringe to puncture the upper rubber film to extract red blood cells and discard them, and puncture the lower rubber film to extract serum for recycling. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a front view of the first syringe in the first embodiment of the utility model;

[0017] Figure 2 It is a front view of the second syringe in the first embodiment of the utility model;

[0018] Figure 3 For the corresponding Figure 2 Schematic diagram of positional changes after serum separation. DETAILED DESCRIPTION

[0019] The following is further described in detail through specific implementation methods:

[0020] The symbols in the drawings of the specification include: first syringe 1, first barrel cap 11, first nipple 12, first centrifugal empty cylinder 13, single piston 14, single push rod 15, limit plate 16, internal threaded hole 161, first branch tube 17, second syringe 2, second barrel cap 21, second nipple 22, second centrifugal empty cylinder 23, upper piston 24, lower piston 25, lower push rod 26, upper push rod 27, second branch tube 28, upper film 29a, lower film 29b, serum 3, PRP (4), red blood cells 5.

[0021] Embodiment 1

[0022] Combination Figure 1-Figure 3 As shown, a platelet-rich plasma preparation device comprises a first syringe 1 and a second syringe 2 with a smaller specification than the first syringe 1, wherein the first syringe 1 is used to draw a certain amount of whole blood from a patient and to undergo a first centrifugation, and the second syringe 2 is used to draw a middle layer of PRP (4)-rich material (hereinafter collectively referred to as "material requiring secondary centrifugation") from the first syringe 1 after the first centrifugation and to undergo a second centrifugation to obtain high-purity PRP (4).

[0023] The first syringe 1 comprises Figure 1 As shown, from top to bottom, a first barrel cap 11, a first nipple 12, a first centrifugal empty cylinder 13, a single piston 14 slidably embedded in the first centrifugal empty cylinder 13, a single push rod 15 for controlling the single piston 14, and a limit plate 16 fixedly arranged at the bottom of the first centrifugal empty cylinder 13 are arranged in sequence. The first nipple 12 is provided with an external thread threadedly connected to the first barrel cap 11, a first branch pipe 17 with a one-way valve is fixedly arranged on the side wall of the first centrifugal empty cylinder 13, the single push rod 15 is fixedly connected to the single piston 14, and the interior of the single push rod 15 is hollowed out for the second syringe 2 to pass through, and an internal threaded hole 161 is opened at the center of the limit plate 16.

[0024] The second syringe 2 includes Figure 2The second cylinder cap 21, the second nipple 22, the secondary centrifugal empty cylinder 23, the upper piston 24 and the lower piston 25 slidably embedded in the secondary centrifugal empty cylinder 23, the lower push rod 26 and the upper push rod 27 respectively used to control the upper piston 24 and the lower piston 25, and the second branch pipe 28 with a one-way valve fixedly arranged on the side wall of the secondary centrifugal empty cylinder 23 are arranged in sequence from top to bottom; the second nipple 22 is fixedly provided with an external thread so that the second nipple 22 can be threaded with the internal thread hole 161 on the limit plate 16 The connection is used to realize fixed assembly between the first syringe 1 and the second syringe 2, and the second nipple 22 can also be threadedly connected to the second barrel cap 21; a mounting channel is set on the central axis of the lower piston 25 and the upper push rod 27, and the lower push rod 26 is inserted into the mounting channel and fixedly connected to the upper piston 24; an upper rubber film 29a for extracting red blood cells 5 and a lower rubber film 29b for extracting serum 3 are fixedly set on the side wall of the secondary centrifugal empty cylinder 23, wherein the lower rubber film 29b is located below the second branch tube 28.

[0025] The specific application process includes the following steps:

[0026] Step 1: First, use the first syringe 1 to connect the needle to collect a certain amount of whole blood from the patient. Note that the single piston 14 cannot exceed the outlet position of the first branch tube 17. Then remove the needle connected to the first nipple 12 and thread the first barrel cap 11 to connect the first nipple 12. Then send the first syringe 1 to the centrifuge for the first centrifugation. After the first centrifugation, the whole blood is divided into the following: Figure 1 The three-layer structure shown includes serum 3 (transparent light yellow), PRP (4) (bright red), and red blood cells 5 (close to black) from top to bottom, but in the Figure 1 The bottom of the serum layer 3 and the top of the red blood cell layer 5 shown in the figure also contain a small amount of PRP (4) substance, among which the amount of PRP (4) permeated in the serum 3 is the largest. Figure 1 The portion above the dotted line is considered to be only serum 3, and the portion below the dotted line is considered to be serum 3 infiltrated with PRP (4). This portion has a gradient color appearance. In most cases, the contents of the three layers of material are similar after a certain amount of whole blood is extracted and centrifuged. Therefore, at this time, the inlet of the first branch tube 17 just corresponds to the bottom of the PRP (4) layer, so that the first branch tube 17 can move PRP (4) and serum 3 infiltrated with PRP (4), that is, the material to be centrifuged for the second time, to the cavity below the single piston 14 in the empty cylinder 13 of the first centrifugation. Even if there is a difference in the proportion of red blood cells 5 due to individual differences among patients, a small portion of the red blood cells 5 placed on the top layer can be placed in the material to be centrifuged for the second time using the second syringe 2 and extracted for the second centrifugation to improve the recovery rate of PRP (4).

[0027] Step 2: Assemble the second syringe 2 onto the first syringe 1 through the threaded connection between the second nipple 22 and the internal threaded hole 161. At this time, open the one-way valve on the first branch pipe 17 and pull the upper piston 24 downward to extract the material to be centrifuged again in step 1 from the first branch pipe 17 into the secondary centrifugal empty cylinder 23.

[0028] Step 3: Secondary centrifugation The material to be centrifuged again in the empty cylinder 23 is also divided into the following after the second centrifugation: Figure 2 The three-layer structure shown from top to bottom is serum 3, PRP (4), and red blood cells 5. However, the proportion of the PRP (4) layer is much higher than that in step 1. The reason for this is that in addition to the targeted extraction of PRP (4)-rich material that requires secondary centrifugation, the more slender secondary centrifugation empty cylinder 23 also plays an important role, and the boundaries between the three layers of material are clearer.

[0029] At this time, the one-way valve on the second branch pipe 28 is opened, the upper piston 24 is kept stationary, and the upper push rod 27 is pulled downward to pull the lower piston 25 downward to move the uppermost layer of serum 3 as shown in FIG. Figure 3 As shown, the serum 3 in the second branch tube 28 is extracted into the cavity between the upper piston 24 and the lower piston 25 in the secondary centrifugal empty cylinder 23 and stored separately. Note that when pulling the lower piston 25, it is necessary to ensure that the serum 3 in the second branch tube 28 is completely extracted and then close the one-way valve on the second branch tube 28, and at the same time, the lower piston 25 is moved to the bottom of the lower rubber film 29b. Then the medical staff takes a new syringe and inserts it into the upper rubber film 29a to extract the red blood cells 5 and discard them. After the operation of extracting the red blood cells 5 is completed, pay attention to push the upper piston 24 upward so that the upper piston 24 pushes the PRP (4) to be located above the upper rubber film 29a. At this time, only the high-purity PRP (4) is left on the top layer, which can be pushed out by the second nipple 22 and directly injected into the patient's body to meet the requirements of immediate treatment.

[0030] Step 4: After the above steps, a portion of the serum 3 infiltrated with a small amount of PRP (4) is temporarily stored in the cavity between the upper piston 24 and the lower piston 25 in the secondary centrifugal empty cylinder 23. If the high-purity PRP (4) is insufficient, the medical staff will take a new syringe and insert it into the lower rubber film 29b to extract the portion of serum 3 and continue to extract the PRP (4) therein, thereby avoiding the need to draw blood from the patient again.

[0031] Embodiment 2

[0032] The difference between this embodiment and the first embodiment is that a third rubber film with the same structure and material as the upper rubber film 29a and the lower rubber film 29b is fixedly set on the side wall of the first centrifugal empty cylinder 13. After the medical staff uses the first syringe 1 for the first centrifugation, they can use the second syringe 2 to connect a needle and insert it into the third rubber film to extract the material that needs a second centrifugation in the first centrifugal empty cylinder. In this embodiment, the middle of the single push rod 15 is solid and the internal threaded hole 161 is not provided on the limit plate 16.

[0033] The above is only an embodiment of the utility model, and the utility model is not limited to the field involved in this embodiment. The common knowledge such as the known specific structure and characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the structure of the utility model, several deformations and improvements can be made, which should also be regarded as the protection scope of the utility model, and these will not affect the effect of the implementation of the utility model and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A platelet-rich plasma preparation device, characterized in that: comprising a first syringe and a second syringe that are detachably connected; The first syringe comprises a first nipple, a first centrifugal empty cylinder, a limit plate fixedly arranged at the bottom of the first centrifugal empty cylinder, a single piston slidably embedded in the first centrifugal empty cylinder, and a single push rod for controlling the single piston. A first branch pipe with a one-way valve is fixedly arranged on the side wall of the first centrifugal empty cylinder, an internal threaded hole is provided on the limit plate, and the interior of the single push rod is hollowed out; The second syringe includes a second nipple, a secondary centrifugal empty cylinder, an upper piston and a lower piston slidably embedded in the secondary centrifugal empty cylinder, a lower push rod and an upper push rod respectively used to control the upper piston and the lower piston, a second branch pipe with a one-way valve fixedly arranged on the side wall of the secondary centrifugal empty cylinder, an external thread threadedly connected to the internal threaded hole on the limit plate fixedly arranged on the second nipple, and an upper rubber membrane for extracting red blood cells and a lower rubber membrane for extracting serum fixedly arranged on the secondary centrifugal empty cylinder.

2. A platelet-rich plasma preparation device according to claim 1, characterized in that: It also includes a first barrel cap and a second barrel cap for respectively closing the top of the first syringe and the top of the second syringe, wherein the first barrel cap and the second barrel cap are respectively threadedly connected to the first nipple and the second nipple.

3. A platelet-rich plasma preparation device according to claim 2, characterized in that: The upper rubber film and the lower rubber film are made of rubber material.

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