Detection card with positive and negative pressure switching device

Abstract

The utility model relates to a detection card with a positive and negative pressure switching device, which is characterized by comprising a positive and negative pressure switching device and a detection card, the detection card comprises an anticoagulation tube, a cabin, a microfluidic duckbill valve and an output end, the anti-coagulation pipe, the cabin and the duckbill valve are sequentially communicated through a pipeline, and the cabin is communicated with the output end through an environment pipeline; the positive and negative pressure switching device comprises a positive and negative pressure switching valve, a switch switching valve and an air locking valve. The positive and negative pressure switching valve is communicated with the switch switching valve through a pipeline, the switch switching valve is further communicated with the output end and the air blocking valve through pipelines, one end of the air blocking valve is communicated with the switch switching valve through a pipeline, and the other end of the air blocking valve is communicated with the atmospheric environment. By switching the states of a positive-negative pressure switching valve, a switch switching valve and an air blocking valve in the positive-negative pressure switching device, positive-pressure and negative-pressure airflow can be fed into the detection card, the detection card can be identical to the atmospheric environment, the opening of the duckbill valve can be opened or closed through the change of the pressure, and the detection card can be controlled to be in a closed state. Fluid within the compartment is injected into a storage container that interfaces with the microfluidic duckbill valve.

Description

Technical Field

[0001] The present application relates to the field of microfluidics technology, and in particular to a detection card with a positive and negative pressure switching device. Background Art

[0002] Thrombelastogram (TEG) is a graph drawn by a thromboelastometry instrument, which is an indicator that reflects the dynamic changes of blood coagulation (including the formation rate of fibrin, the dissolution state and the firmness and elasticity of the coagulation). Although the thromboelastometry instrument has a series of advanced, convenient and innovative features in detection methods, detection processes and detection accuracy, it is based on its inherent characteristics under the premise of its own detection principle. The current thromboelastometry instrument still has a series of shortcomings and deficiencies in terms of patient experience, detection efficiency, degree of automation, etc., which greatly limits its application prospects in hospitals, professional clinical testing institutions, and especially in the field of patient home health monitoring.

[0003] There is a need in the art for a pre-processing device for a thrombelastometer and components for the device. Utility Model Content

[0004] In view of this, the present application provides a pre-treatment device with a simple structure, convenient control, and can be easily introduced into a thrombelastograph. The device can freely switch between positive and negative pressure environments, control the opening and closing of the duckbill valve in the device, and the circulation of fluid.

[0005] To achieve the above-mentioned purpose, a detection card with a positive and negative pressure switching device is characterized in that it comprises: a positive and negative pressure switching device, and a detection card;

[0006] The test card comprises: an anticoagulation tube, a chamber, a microfluidic duckbill valve and an output end; the anticoagulation tube, the chamber and the duckbill valve are connected in sequence through a pipeline, and the chamber is connected to the output end through an environmental pipeline;

[0007] The positive and negative pressure switching device includes: a positive and negative pressure switching valve, a switch switching valve, and an air lock valve; the positive and negative pressure switching valve is connected to the switch switching valve through a pipeline, and the switch switching valve is also connected to the output end and the air lock valve through pipelines respectively, one end of the air lock valve is connected to the switch switching valve through a pipeline, and the other end of the air lock valve is connected to the atmospheric environment.

[0008] According to one embodiment of the present application, the microfluidic duckbill valve includes: a duckbill valve cavity, the duckbill valve cavity having a first cavity, an inlet pipeline being arranged in the first cavity, a duckbill valve body being arranged at one end of the inlet pipeline; a second cavity is also arranged in the duckbill valve cavity, the first cavity and the second cavity are connected through an outlet pipeline between three second cavity connecting holes arranged at the top of the first cavity and three first cavity connecting holes arranged at the bottom of the second cavity, and a storage container is arranged in the second cavity.

[0009] According to one embodiment of the present application, the duckbill valve body can be switched between an open state and a closed state based on changes in pressure conditions in the duckbill valve cavity.

[0010] According to one embodiment of the present application, when the pressure supplied by the output end is greater than the pressure in the duckbill valve cavity, the duckbill valve body is in an open state.

[0011] According to one embodiment of the present application, when the pressure supplied by the output end is less than the pressure in the duckbill valve cavity, the duckbill valve body is in a closed state.

[0012] According to one embodiment of the present application, one end of the positive-negative pressure switching valve is connected to a positive pressure device and a negative pressure device, and by operating the positive-negative pressure switching valve, the positive pressure environment or the negative pressure environment is connected to the detection card.

[0013] According to one embodiment of the present application, the positive pressure environment is provided by a positive pressure device, and the positive pressure environment provides positive pressure airflow into the detection card, and the positive pressure airflow adopts a positive pressure turbo fan or a positive air compressor.

[0014] According to one embodiment of the present application, the negative pressure environment is provided by a negative pressure device, and the negative pressure environment provides negative pressure airflow into the detection card, and the negative pressure airflow adopts a negative pressure turbo fan or a negative air compressor.

[0015] According to one embodiment of the present application, the positive and negative pressure switching valve, the on / off switching valve and the air lock valve are solenoid valves.

[0016] According to one embodiment of the present application, the environmental pipeline is connected to the output end and the top of the chamber, the anticoagulation pipeline is connected to the anticoagulation tube and the side wall of the chamber near the bottom, and the output pipeline is connected to the inlet pipeline and the bottom of the chamber.

[0017] The beneficial effects of this application are:

[0018] The detection card with a positive and negative pressure switching device provided in the present application has a microfluidic duckbill valve and a positive and negative pressure switching device. The microfluidic duckbill valve has a simple structure and is easy to operate and control. It also has reliable sealing properties to avoid leakage of fluid during use and operation. The positive and negative pressure switching device can provide a positive or negative pressure environment for the detection card as needed, and is used to control the opening and closing of the microfluidic duckbill valve. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The accompanying drawings are used to better understand the present application and do not constitute an improper limitation on the present application.

[0020] Figure 1 A test card with a positive and negative pressure switching device provided in this application;

[0021] Figure 2 A schematic diagram of a microfluidic duckbill valve provided for this application, wherein the storage container is omitted;

[0022] Figure 3 A stereoscopic view of the duckbill valve body provided for this application;

[0023] Figure 4 A cross-sectional view of the duckbill valve body provided for this application;

[0024] Figure 5 A cross-sectional view of the duckbill valve body provided for this application;

[0025] Figure 6 A schematic diagram of a positive and negative pressure switching device provided for this application;

[0026] Figure 7 A schematic diagram of a state in which the positive and negative pressure switching device outputs positive pressure;

[0027] Figure 8 A schematic diagram of the state of the positive and negative pressure switching device outputting negative pressure;

[0028] Fig. 9 Schematic diagram of the positive and negative pressure switching device maintaining the same state as the atmospheric environment.

[0029] Description of Reference Numerals

[0030] 1-anticoagulation tube, 2-microfluidic duckbill valve, 3-positive and negative pressure switching device, 4-output end, 5-environmental pipeline, 6-anticoagulation pipeline, 7-cabin, 8-output pipeline, 21-duckbill valve cavity, 22-second cavity, 23-outlet pipeline, 24-first cavity, 25-inlet pipeline, 26-duckbill valve body, 27-outer wall of duckbill valve cavity, 31-positive pressure device, 32-negative pressure device, 33-positive and negative pressure switching valve, 34-switch switching valve, 35-air lock valve, 261-base part, 262-duckbill part, 2621-duckbill valve pore. DETAILED DESCRIPTION

[0031] The specific embodiments of the present application will be described in more detail below with reference to the accompanying drawings. Although the specific embodiments of the present application are shown in the accompanying drawings, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present application and to fully convey the scope of the present application to those skilled in the art.

[0032] It should be noted that certain words are used in the specification and claims to refer to specific components. Those skilled in the art should understand that technicians may use different nouns to refer to the same component. This specification and claims do not use the difference in nouns as a way to distinguish components, but use the difference in the functions of the components as the criterion for distinction. As mentioned throughout the specification and claims, "including" or "comprising" is an open term, so it should be interpreted as "including but not limited to". The subsequent description of the specification is a preferred embodiment of the implementation of the present application, but the description is based on the general principles of the specification and is not used to limit the scope of the present application. The scope of protection of the present application shall be determined by the attached claims.

[0033] In the description of the present application, it should be noted that the terms "upper", "lower", "inside", "outside", "front", "back", "left", "right", etc. indicate directions or positional relationships based on the directions or positional relationships in the working state of the present application. They are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction. Therefore, they should not be understood as limitations on the present application.

[0034] like Figure 1 As shown, the present application provides a detection card with a positive and negative pressure switching device, including: an anticoagulation tube 1, a chamber 7, a microfluidic duckbill valve 2, and an output end 4. The anticoagulation tube 1 is connected to the chamber 7 through the anticoagulation pipeline 6, the microfluidic duckbill valve 2 is connected to the chamber 7 through the output pipeline 8 in the chamber 7, close to the side wall at the bottom of the chamber 7, and the output end 4 is connected to the chamber 7 through the environmental pipeline 5 at the top of the chamber 7.

[0035] like Figure 6 The positive and negative pressure switching device 3 shown in the figure includes a positive and negative pressure switching valve 33, a switch switching valve 34 and an air lock valve 35. The positive and negative pressure switching valve 33 is connected to the switch switching valve 34 through a pipeline. The switch switching valve 34 is also connected to the output end 4 and the air lock valve 35 through a pipeline. One end of the air lock valve 35 is connected to the switch switching valve 34 through a pipeline, and the other end of the air lock valve 35 is connected to the atmospheric environment. One end of the positive and negative pressure switching valve 33 is connected to the positive pressure device 31 and the negative pressure device 32.

[0036] like Figure 2-Figure 5 As shown, the present application provides a microfluidic duckbill valve 2, including a duckbill valve cavity 21, wherein the duckbill valve cavity 21 has a first cavity 24, wherein an inlet pipeline 25 is arranged in the first cavity 24, wherein a duckbill valve body 26 is arranged at one end of the inlet pipeline 25, wherein the top of the first cavity 24 is connected to three outlet pipelines 23; the duckbill valve body 26 can be switched between an open state and a closed state based on the change of the pressure condition in the duckbill valve cavity 21. The three outlet pipelines 23 are connected to the second cavity 22, wherein a storage container can be arranged in the second cavity 22, wherein the storage container is connected to the outlet pipeline 23, and the inlet pipeline 25 can be connected to an external pipeline.

[0037] like Figure 3-Figure 5 As shown in the figure, the duckbill valve body 26 is composed of a base part 261 and a duckbill part 262, the base part 261 is made of acrylic plate, the duckbill part 262 is made of silicone, a duckbill valve pore 2621 is opened at the top center of the duckbill part, the duckbill valve pore 2621 is a rectangular slit, the base part 261 and the duckbill part 262 are combined and fixed by means of sleeve connection, when the duckbill valve cavity 21 is subjected to positive pressure, the duckbill valve pore 621 remains open.

[0038] like Figure 1 As shown, when the positive and negative pressure switching device 3 maintains a negative pressure state (the air lock valve remains closed), affected by the air pressure, the fluid in the anticoagulation tube 1 flows into the cabin 7 through the anticoagulation pipeline 6, and the fluid continues to accumulate in the cabin 7. Before the cabin 7 is filled with fluid, the positive and negative pressure switching device 3 is switched to a positive pressure state (the air lock valve is opened until the switching valve pipeline is connected to the atmosphere). Under the influence of air pressure, the duckbill valve pore 2621 remains open, and the fluid flows out of the test card from the cabin 7 through the output pipeline 8, and flows into the first cavity 24 through the inlet pipeline 25. After the first cavity 24 is full, the fluid flows out from the outlet pipeline 23 and finally enters the storage container. When there is no fluid in the cabin or the storage container is full, the switch switching valve 34 is switched to a closed state, and the air lock valve is switched to closed at the same time, so as to keep the fluid in the storage container unchanged for a long time.

[0039] In a specific embodiment of the present application, the positive and negative pressure switching device 3 is in the following state: Figure 7 In the positive pressure state shown in the figure, the positive and negative pressure switching valve 33 switches and maintains the positive pressure state (keeps the left module connected), the switch switching valve 34 remains in the open state (keeps the left module connected), and the air locking valve 35 remains in the closed air locking state (keeps the left module connected). The positive pressure device 31 outputs positive pressure airflow, and the positive pressure airflow flows through the pipeline and is output through the output terminal 4.

[0040] In a specific embodiment of the present application, the positive and negative pressure switching device 3 is in the following state: Figure 8 In the negative pressure state shown in the figure, the positive and negative pressure switching valve 33 switches and maintains a closed state (keeps the right module connected), the switch switching valve 34 remains in an open state (keeps the left module connected), and the air locking valve 35 remains in a closed air locking state (keeps the left module connected). The positive pressure device 31 outputs a negative pressure airflow, and the negative pressure airflow flows through the pipeline and is output through the output terminal 4.

[0041] In a specific embodiment of the present application, the positive and negative pressure switching device 3 is in the following state: Fig. 9 In this state, since no positive pressure airflow or negative pressure airflow is required, the switch valve 34 is kept closed (the right module is connected), and the air lock valve 35 is kept open (the right module is connected), so that the output terminal 4 is connected to the atmosphere.

[0042] In a specific embodiment of the present application, the positive and negative pressure switching valve 33 is a solenoid valve or other valve or switch that can connect the positive pressure device 31 or the negative pressure device 32 to the positive and negative pressure switching device 3 .

[0043] In a specific embodiment of the present application, the switch switching valve 34 is a solenoid valve or other valve or switch that can keep the positive and negative pressure switching device open or closed.

[0044] In a specific embodiment of the present application, the air lock valve 35 is a solenoid valve or other valve or switch that can achieve connection or isolation between the atmosphere and the output end.

[0045] In a specific embodiment of the present application, one end of the environmental pipeline 5 is connected to the positive and negative pressure switching device 3 through the output end 4, and the other end is connected to the cabin 7. The environmental pipeline 5 is connected to the cabin 7 at the top of the cabin 7.

[0046] In a specific embodiment of the present application, one end of the output pipeline 8 is connected to the microfluidic duckbill valve 2 through the inlet pipeline 25, and the other end is connected to the chamber 7, and the output pipeline 8 is connected to the bottom of the chamber 7.

[0047] In a specific embodiment of the present application, one end of the anticoagulation line 6 is connected to the anticoagulation tube 1 , and the other end is connected to the side wall near the bottom end of the chamber 7 .

[0048] In a specific embodiment of the present application, the test card is made of acrylic plate, and the test card is a rectangular parallelepiped, a cube, a sphere, a frustum, or any other shape and size that can accommodate the anticoagulation tube 1, the microfluidic duckbill valve 2, the positive and negative pressure switching device 3, the output end 4, the environmental pipeline 5, the anticoagulation pipeline 6, the cabin 7, and the output pipeline 8, while not affecting the connection between the output end 4 and the positive and negative pressure switching device 3.

[0049] In a specific embodiment of the present application, the positive and negative pressure switching device 3 is composed of three two-position three-way solenoid valves, namely a positive and negative pressure switching valve 33 , a switch switching valve 34 and an air lock valve 35 , and a plurality of pipelines.

[0050] In a specific embodiment of the present application, the anticoagulant tube 1 is a test tube treated with an anticoagulant to prevent blood clotting, and is commonly used in medical treatment, biological experiments, etc.

[0051] In a specific embodiment of the present application, the chamber 7 is a storage space formed by hollowing out a portion of an acrylic plate in the detection card, and the size of the storage space varies according to the needs of the usage scenario.

[0052] In a specific embodiment of the present application, the output end 4 is a port exposed on the detection card, and the size, shape and material of the port can be changed according to the needs of the usage scenario.

[0053] In a specific embodiment of the present application, when the duckbill valve is not affected by external force, the duckbill valve body is in a closed state.

[0054] In a specific embodiment of the present application, the duckbill valve body 26 is composed of a base portion 261 and a duckbill portion 262 .

[0055] In a specific embodiment of the present application, the duckbill portion 262 is made of rubber material, and the rubber material is selected from one or more of chloroprene rubber, nitrile rubber and ethylene propylene rubber.

[0056] In a specific embodiment of the present application, the external pipeline is usually carried by a microfluidic chip or a detection card, and the microfluidic chip or the detection card is made of an acrylic plate.

[0057] In a specific embodiment of the present application, the outer wall 27 of the duckbill valve cavity is made of acrylic plate, which is in direct contact with the microfluidic chip or the detection card, and the outer wall 27 of the duckbill valve cavity is combined and fixed with the microfluidic chip or the detection card by means of UV shadowless glue and irradiation with ultraviolet light. When the outer wall 27 of the duckbill valve cavity is combined and fixed with the microfluidic chip or the detection card, the duckbill valve cavity 21 and the base part 261 of the duckbill valve body 26 are pressed and fixed, and the duckbill part 262 of the duckbill valve body 6 is just embedded in the first cavity 24, and is attached and fastened to the duckbill valve cavity 21.

[0058] In a specific embodiment of the present application, the duckbill valve cavity 21 further comprises a second cavity 22 , and the first cavity 24 is connected to the second cavity 22 .

[0059] In a specific embodiment of the present application, the first cavity 24 is connected to the second cavity 22 via an outlet pipe 23 .

[0060] In a specific embodiment of the present application, the number of the outlet pipeline 3 is one, for example, one, two, or three.

[0061] In a specific embodiment of the present application, one inlet pipeline is provided.

[0062] In a specific embodiment of the present application, three second cavity connecting holes are arranged at the top of the first cavity 24, and three first cavity connecting holes are arranged at the bottom center of the second cavity 22; one end of the outlet pipe 23 is connected with the three first cavity connecting holes, and the other end of the outlet pipe 23 is connected with the three second cavity connecting holes, that is, one end of the outlet pipe 23 is located at the top of the first cavity 24 and is connected with the first cavity 24, and the other end of the outlet pipe 23 is located at the bottom of the second cavity 22 and is connected with the second cavity 22.

[0063] In a specific embodiment of the present application, a storage container is disposed in the second cavity 22 , and the bottom of the storage container has an opening. When the fluid enters the second cavity 22 through the outlet pipe 23 , the fluid enters the storage container through the opening.

[0064] In a specific embodiment of the present application, the storage container is detachably connected to the second cavity 22 to facilitate replacement and cleaning of the storage container.

[0065] The present application provides a test card with a positive and negative pressure switching device, and the duckbill valve has a simple structure, is easy to operate and control, and has reliable sealing to avoid fluid leakage during use and operation. The positive and negative pressure switching device can provide a positive or negative pressure environment for the test card as needed, and is used to control the opening and closing of the microfluidic duckbill valve, and can be easily introduced into the pre-treatment equipment of the thromboelastography instrument.

[0066] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.

Claims

1. A detection card with a positive and negative pressure switching device, characterized in that: include: Positive and negative pressure switching device, and detection card; The test card comprises: an anticoagulation tube, a chamber, a microfluidic duckbill valve and an output end; the anticoagulation tube, the chamber and the duckbill valve are connected in sequence through a pipeline, and the chamber is connected to the output end through an environmental pipeline; The positive and negative pressure switching device includes: a positive and negative pressure switching valve, a switch switching valve, and an air lock valve; the positive and negative pressure switching valve is connected to the switch switching valve through a pipeline, and the switch switching valve is also connected to the output end and the air lock valve through pipelines respectively, one end of the air lock valve is connected to the switch switching valve through a pipeline, and the other end of the air lock valve is connected to the atmospheric environment.

2. The detection card according to claim 1, characterized in that: The microfluidic duckbill valve comprises: A duckbill valve cavity, wherein the duckbill valve cavity has a first cavity, an inlet pipeline is arranged in the first cavity, and a duckbill valve body is arranged at one end of the inlet pipeline; A second cavity is also provided in the duckbill valve cavity. The first cavity and the second cavity are connected through an outlet pipeline between three second cavity connecting holes provided at the top of the first cavity and three first cavity connecting holes provided at the bottom of the second cavity. A storage container is provided in the second cavity.

3. The detection card according to claim 2, characterized in that: The duckbill valve body can be switched between an open state and a closed state based on changes in pressure conditions within the duckbill valve cavity.

4. The detection card according to claim 3, characterized in that: When the pressure supplied by the output end is greater than the pressure in the duckbill valve cavity, the duckbill valve body is in an open state.

5. The detection card according to claim 3, characterized in that: When the pressure supplied by the output end is less than the pressure in the duckbill valve cavity, the duckbill valve body is in a closed state.

6. The detection card according to claim 1, characterized in that: One end of the positive-negative pressure switching valve is connected to a positive pressure device and a negative pressure device. By operating the positive-negative pressure switching valve, a positive pressure environment or a negative pressure environment is connected to the detection card.

7. The detection card according to claim 6, characterized in that: The positive pressure environment is provided by a positive pressure device, and the positive pressure environment provides positive pressure airflow into the detection card. The positive pressure airflow adopts a positive pressure turbo fan or a positive air compressor.

8. The detection card according to claim 6, characterized in that: The negative pressure environment is provided by a negative pressure device, and the negative pressure environment provides negative pressure airflow into the detection card. The negative pressure airflow adopts a negative pressure turbo fan or a negative air compressor.

9. The detection card according to claim 1, characterized in that: The positive and negative pressure switching valve, the on / off switching valve and the air lock valve are solenoid valves.

10. The detection card according to claim 1, characterized in that: The environmental pipeline is connected to the output end and the top of the chamber, the anticoagulation pipeline is connected to the anticoagulation tube and the side wall of the chamber near the bottom, and the output pipeline is connected to the inlet pipeline and the bottom of the chamber.

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