Purification device for antibiotic production
By designing a purification device for antibiotic production, the problems of complicated operation and high production costs of traditional chromatography equipment are solved, and rapid filtration and efficient purification of antibiotic fermentation broth are achieved.
Patent Information
- Application Number
- CN202421530009.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-01
- Publication Date
- 2025-05-02
- Estimated Expiration
- 2034-07-01
AI Technical Summary
Traditional chromatography equipment has complicated steps to separate impurities in antibiotic fermentation broth, resulting in high cost of large-scale industrial production.
A purification device for the production of antibiotics is designed, including the lower box and the upper box. By setting a filter mesh and a cotton layer in the upper box, and using a motor-driven hitting disc and linkage gear system, the preliminary filtration of the antibiotic fermentation broth and filtration purification of different degrees is achieved.
The device can quickly perform preliminary filtration of antibiotic fermentation broth, separate impurities with large structural properties and homologs with similar structural properties, improve product purity and reduce production costs.
Smart Images
Figure CN222816458U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of antibiotic production, in particular to a purification device for antibiotic production. Background Art
[0002] Traditional chromatography equipment uses tubular equipment with uniform diameter, with baffles and discharge pipes at the bottom of the column and a feed pipe at the top. Short columns are used for some compounds with large structural differences, while for homologous compounds with similar structures, a longer height-to-diameter ratio is often required to achieve separation and purification. Fermentation antibiotic products are often accompanied by different types of impurities, including impurities with large structural properties and homologous compounds with similar structural properties. In order to effectively separate these impurities, different chromatography methods need to be changed, resulting in complicated operating steps and other factors, which will cause high production costs for industrial large-scale production.
[0003] Based on this, this scheme proposes a purification device for antibiotic production. Utility Model Content
[0004] The purpose of the utility model is to provide a purification device for antibiotic production to solve the problems raised in the above background technology.
[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solution: a purification device for antibiotic production, comprising a lower box and an upper box,
[0006] A connecting box is fixedly installed between the lower box and the upper box, and a discharge pipe and a feed pipe are fixedly installed on the side of the lower box and the upper box away from each other, a fixing box is fixedly installed on one side of the upper box, and two filter screens are clamped and installed in the upper box;
[0007] Two movable holes are provided on one side of the connecting box, and sealing plates are movably installed in the two movable holes, mounting frames are fixedly installed on the inner sides of the two sealing plates, and the same movable frame is fixedly installed on the outer sides of the two sealing plates, and cotton layers are fixedly installed on the two mounting frames, and a screw rod is rotatably installed on one side of the connecting box close to the movable frame, the movable frame is threadedly sleeved on the screw rod, a limit gear is fixedly sleeved on the screw rod, and a crank is fixedly sleeved on one end of the screw rod.
[0008] Preferably, a motor is fixedly mounted on the fixed box and mounting holes are provided on both sides of the fixed box, sliding rods are fixedly mounted in the two mounting holes, the same sliding sleeve is slidably sleeved on the two sliding rods, linkage racks are fixedly mounted on both sides of the sliding sleeve, a striking plate matched with the sliding sleeve is fixedly sleeved on the output shaft of the motor, a rotating shaft is rotatably mounted on one side of the upper box body close to the fixed box and two metal rods are fixedly mounted in the upper box body, elliptical wheels and linkage gears are fixedly sleeved at both ends of the two rotating shafts, the two linkage gears are respectively meshed with corresponding linkage racks, two through holes are provided on the two metal rods, a striking rod is movably mounted in any one of the through holes, and a connecting rod is fixedly mounted on one end of any one of the striking rods.
[0009] By adopting the above technical scheme, the striking plate is driven to rotate by starting the motor, and the striking plate hits the sliding sleeve back and forth, which can drive the sliding sleeve and the two linked racks to move back and forth up and down, and the two linked racks drive the two linked gears to rotate back and forth, which can drive the two elliptical wheels to rotate back and forth, and the two elliptical wheels hit the corresponding connecting rods on both sides back and forth, which can drive the two striking rods to move back and forth up and down, and the striking rods hit the corresponding filter nets respectively, which can prevent the two filter nets from being blocked.
[0010] Preferably, a return spring is sleeved on any one of the striking rods, one end of any one of the return springs is fixed on the striking rod, and one end of any one of the return springs is fixed on the inner wall of the corresponding through hole.
[0011] By adopting the above technical solution, the striking rod can be easily reset through the reset spring.
[0012] Preferably, the output shaft of the motor is located eccentrically of the striking disc.
[0013] Preferably, compression springs are sleeved on the two slide bars, one end of the two compression springs is fixed on the corresponding slide bar, and the other ends of the two compression springs are fixed on the sliding sleeve.
[0014] By adopting the above technical solution, the sliding sleeve can be easily reset by compressing the spring.
[0015] Preferably, a metal block is fixedly mounted on one side of the connection box close to the movable frame, a locking bolt is threadedly mounted on the metal block, and a limiting rack is rotatably mounted on one end of the locking bolt.
[0016] By adopting the above technical solution, the locking bolt is rotated inwardly to drive the limit rack to move inward, so that the limit rack is engaged with the limit gear, the limit gear and the screw rod can be locked, and the positions of the two mounting frames can be locked and fixed.
[0017] Preferably, both the discharge pipe and the feed pipe are provided with valves.
[0018] Compared with the prior art, the utility model has the following beneficial effects: first, the antibiotic fermentation liquid is added into the upper box through the feed pipe, and the large granular impurities in the antibiotic fermentation liquid can be preliminarily filtered through the two filter screens, and different types of chromatographic filler layers can be added on the top of the two cotton layers in advance, and different degrees of filtration and purification are performed by adding different fillers, and the structure in the lower box is mainly used to separate homologous components, separate structural analogs, and improve product purity, and the process of adding fillers: the rotation of the screw rod is driven by turning the crank handle, and the screw rod drives the outward movement of the movable frame, which can drive the outward movement of the two sealing plates, which can drive the outward movement of the two mounting frames, and the fillers can be filled on the top of the two cotton layers, and then the crank handle is rotated in the opposite direction to make the movable frame move inward, which can drive the two sealing plates to move outward. The plate moves inward to seal the two movable holes, and then the locking bolt is driven to move inward by locking and rotating the locking bolt inward, so that the limit rack is meshed with the limit gear, and the limit gear and the screw rod can be locked, and the positions of the two mounting frames can be locked and fixed; in order to increase the filtering effect of the two filter screens, the striking plate is driven to rotate by starting the motor, and the striking plate hits the sliding sleeve back and forth, which can drive the sliding sleeve and the two linked racks to move back and forth up and down, and the two linked racks drive the two linked gears to rotate back and forth, which can drive the two elliptical wheels to rotate back and forth, and the two elliptical wheels hit the corresponding connecting rods on both sides back and forth, which can drive the two striking rods to move back and forth up and down, and the striking rods hit the corresponding filter screens respectively, which can prevent the two filter screens from being blocked and increase the filtering effect of the two filter screens. The utility model has a simple structure and is easy to use. The purification device for antibiotic production is convenient for rapid preliminary filtration of antibiotic fermentation broth and can simultaneously separate impurities with greatly different structural properties and homologues with similar structural properties, thereby increasing the purification efficiency of the antibiotic fermentation broth. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 It is a three-dimensional diagram of the utility model;
[0020] Figure 2 It is a three-dimensional diagram of the internal structure of the installation box of the utility model;
[0021] Figure 3 It is a three-dimensional diagram of the internal structure of the upper box body of the utility model;
[0022] Figure 4 This is a schematic diagram of the structure of part A of the utility model;
[0023] Figure 5 It is a three-dimensional diagram of the internal structure of the connection box of the utility model;
[0024] Figure 6 This is a schematic structural diagram of part B of the utility model.
[0025] In the figure: 1. lower box; 2. discharge pipe; 3. crank; 4. upper box; 5. feed pipe; 6. fixed box; 7. linkage gear; 8. motor; 9. connecting box; 10. slide rod; 11. linkage rack; 12. striking plate; 13. sliding sleeve; 14. filter screen; 15. striking rod; 16. rotating shaft; 17. elliptical wheel; 18. connecting rod; 19. reset spring; 20. metal rod; 21. mounting frame; 22. cotton layer; 23. sealing plate; 24. screw rod; 25. moving frame; 26. metal block; 27. locking bolt; 28. limit rack; 29. limit gear; 30. compression spring. DETAILED DESCRIPTION
[0026] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0027] See also Figure 1-6The utility model provides a technical solution: a purification device for antibiotic production, comprising a lower box body 1 and an upper box body 4, a same connecting box 9 is fixedly installed between the lower box body 1 and the upper box body 4, and a discharge pipe 2 and a feed pipe 5 are fixedly installed on the side of the lower box body 1 and the upper box body 4 away from each other, respectively, and valves are provided on the discharge pipe 2 and the feed pipe 5, a fixed box 6 is fixedly installed on one side of the upper box body 4, and two filter screens 14 are clamped and installed in the upper box body 4, one side of the connecting box 9 is provided with two movable holes, sealing plates 23 are movably installed in the two movable holes, mounting frames 21 are fixedly installed on the inner sides of the two sealing plates 23, and the same moving frame 25 is fixedly installed on the outer sides of the two sealing plates 23, and cotton layers 22 are fixedly installed on the two mounting frames 21, and a screw rod 24 is rotatably installed on the side of the connecting box 9 close to the moving frame 25, and the moving frame 25 is threadedly sleeved on the screw rod 24, and a limit gear 29 is fixedly sleeved on the screw rod 24 and the screw rod 24 is fixedly sleeved with a limit gear 29 ... A crank 3 is fixedly sleeved at one end. Through the above-mentioned structural arrangement, the antibiotic fermentation liquid is first added into the upper box body 4 through the feed pipe 5, and the large granular impurities in the antibiotic fermentation liquid can be preliminarily filtered through the two filter screens 14. Different types of chromatographic filler layers can be added on the top of the two cotton layers 22 in advance, and different degrees of filtration and purification are performed by adding different fillers. The structure in the lower box body 1 is mainly used to separate homologous components, separate structural analogs, and improve product purity. The process of adding fillers: the rotation of the crank 3 drives the rotation of the screw rod 24, and the screw rod 24 drives the outward movement of the movable frame 25, which can drive the outward movement of the two sealing plates 23, which can drive the outward movement of the two mounting frames 21, and the filler can be filled on the top of the two cotton layers 22, and then the crank 3 is rotated in the opposite direction to make the movable frame 25 move inward, which can drive the inward movement of the two sealing plates 23 to seal the two movable holes.
[0028] Combination Figure 1-6As shown, a motor 8 is fixedly installed on the fixed box 6, and mounting holes are provided on both sides of the fixed box 6, and slide bars 10 are fixedly installed in the two mounting holes. The two slide bars 10 are slidably sleeved with the same slide sleeve 13, and linkage racks 11 are fixedly installed on both sides of the slide sleeve 13. Compression springs 30 are sleeved on the two slide bars 10, and one end of the two compression springs 30 is fixed on the corresponding slide bar 10, and the other ends of the two compression springs 30 are fixed on the slide sleeve 13. A striking disk 12 adapted to the slide sleeve 13 is fixedly sleeved on the output shaft of the motor 8, and the output shaft of the motor 8 is located at the eccentric part of the striking disk 12. A rotating shaft 16 is rotatably installed on one side of the upper box body 4 close to the fixed box 6, and two metal rods 20 are fixedly installed in the upper box body 4, and elliptical wheels 17 and linkage gears 7 are fixedly sleeved on both ends of the two rotating shafts 16, respectively, and the two linkage gears 7 are respectively meshed with the corresponding linkage racks 11. Two through holes are provided on the two metal rods 20, and any through hole is movable A striking rod 15 is installed, and a connecting rod 18 is fixedly installed at one end of any striking rod 15. A return spring 19 is sleeved on any striking rod 15, and one end of any return spring 19 is fixed on the striking rod 15, and one end of any return spring 19 is fixed on the inner wall of the corresponding through hole. Through the above-mentioned structural arrangement, in order to increase the filtering effect of the two filter screens 14, the striking disk 12 is driven to rotate by starting the motor 8, and the striking disk 12 hits the sliding sleeve 13 back and forth, which can drive the sliding sleeve 13 and the two linked racks 11 to reciprocate up and down. The two linked racks 11 drive the two linked gears 7 to rotate back and forth, which can drive the two elliptical wheels 17 to rotate back and forth. The two elliptical wheels 17 hit the corresponding connecting rods 18 on both sides back and forth, which can drive the two striking rods 15 to reciprocate up and down. The striking rods 15 hit the corresponding filter screens 14 respectively, which can prevent the two filter screens 14 from being blocked and increase the filtering effect of the two filter screens 14.
[0029] Combination Figure 1-6 As shown, a metal block 26 is fixedly installed on one side of the connecting box 9 close to the movable frame 25, and a locking bolt 27 is threadedly installed on the metal block 26. One end of the locking bolt 27 is rotatably installed with a limit rack 28. Through the above-mentioned structural setting, the locking bolt 27 is rotated inwardly to drive the limit rack 28 to move inward, so that the limit rack 28 is engaged with the limit gear 29, and the limit gear 29 can be locked with the screw rod 24, so that the position of the two mounting frames 21 can be locked and fixed.
[0030] The working principle of the utility model is as follows: first, the antibiotic fermentation liquid is added into the upper box body 4 through the feed pipe 5, and the large granular impurities in the antibiotic fermentation liquid can be preliminarily filtered through the two filter screens 14. Different types of chromatographic filler layers can be added on the top of the two cotton layers 22 in advance, and different degrees of filtration and purification are performed by adding different fillers. The structure in the lower box body 1 is mainly used to separate homologous components, separate structural analogs, and improve product purity. The process of adding fillers: the rotation of the crank 3 drives the rotation of the screw rod 24, and the screw rod 24 drives the outward movement of the movable frame 25, which can drive the outward movement of the two sealing plates 23, which can drive the outward movement of the two mounting frames 21, and the fillers can be filled on the top of the two cotton layers 22, and then the crank 3 is rotated in the opposite direction to make the movable frame 25 move inward, which can drive the inward movement of the two sealing plates 23, and the two movable holes are sealed. The locking bolt 27 is then rotated inwardly to tighten and rotate the limit rack 28, so that the limit rack 28 is meshed with the limit gear 29, and the limit gear 29 and the screw rod 24 are locked, so that the positions of the two mounting frames 21 are locked and fixed; in order to increase the filtering effect of the two filter screens 14, the striking disk 12 is driven to rotate by starting the motor 8, and the striking disk 12 hits the sliding sleeve 13 back and forth, which can drive the sliding sleeve 13 and the two linkage racks 11 to reciprocate up and down, and the two linkage racks 11 drive the two linkage gears 7 to rotate back and forth, which can drive the two elliptical wheels 17 to rotate back and forth, and the two elliptical wheels 17 hit the corresponding connecting rods 18 on both sides back and forth, which can drive the two striking rods 15 to reciprocate up and down, and the striking rods 15 hit the corresponding filter screens 14 respectively, which can prevent the two filter screens 14 from being blocked and increase the filtering effect of the two filter screens 14. The utility model has a simple structure and is easy to use. The purification device for antibiotic production is convenient for rapid preliminary filtration of antibiotic fermentation broth and can simultaneously separate impurities with greatly different structural properties and homologues with similar structural properties, thereby increasing the purification efficiency of the antibiotic fermentation broth.
[0031] The contents not described in detail in this specification belong to the prior art known to professional and technical personnel in the field. Although the embodiments of the utility model have been shown and described, it is understandable to those of ordinary skill in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principle and spirit of the utility model. The scope of the utility model is defined by the attached claims and their equivalents.
Claims
1. A purification device for antibiotic production, comprising a lower housing (1) and an upper housing (4), characterized in that: A connecting box (9) is fixedly installed between the lower box body (1) and the upper box body (4), and a discharge pipe (2) and a feed pipe (5) are fixedly installed on the sides of the lower box body (1) and the upper box body (4) away from each other, respectively, a fixing box (6) is fixedly installed on one side of the upper box body (4), and two filter screens (14) are snap-fitted and installed in the upper box body (4); Two movable holes are provided on one side of the connection box (9), and sealing plates (23) are movably installed in the two movable holes. Mounting frames (21) are fixedly installed on the inner sides of the two sealing plates (23), and the same movable frame (25) is fixedly installed on the outer sides of the two sealing plates (23). Cotton layers (22) are fixedly installed on the two mounting frames (21). A screw rod (24) is rotatably installed on one side of the connection box (9) close to the movable frame (25), and the movable frame (25) is threadedly sleeved on the screw rod (24). A limit gear (29) is fixedly sleeved on the screw rod (24), and a crank (3) is fixedly sleeved on one end of the screw rod (24).
2. The purification device for antibiotic production according to claim 1, characterized in that: The fixed box (6) is fixedly mounted with a motor (8), and mounting holes are provided on both sides of the fixed box (6), and sliding rods (10) are fixedly mounted in the two mounting holes, and the two sliding rods (10) are slidably sleeved with a same sliding sleeve (13), and linkage racks (11) are fixedly mounted on both sides of the sliding sleeve (13), and a striking plate (12) adapted to the sliding sleeve (13) is fixedly sleeved on the output shaft of the motor (8), and a side of the upper box body (4) close to the fixed box (6) is rotatably mounted. A rotating shaft (16) is provided and two metal rods (20) are fixedly installed in the upper box body (4). The two ends of the two rotating shafts (16) are respectively fixedly sleeved with elliptical wheels (17) and linkage gears (7). The two linkage gears (7) are respectively meshed with corresponding linkage racks (11). Two through holes are provided on the two metal rods (20). A striking rod (15) is movably installed in any one of the through holes. A connecting rod (18) is fixedly installed at one end of any one of the striking rods (15).
3. A purification device for antibiotic production according to claim 2, characterized in that: A return spring (19) is sleeved on any striking rod (15), one end of any return spring (19) is fixed on the striking rod (15), and one end of any return spring (19) is fixed on the inner wall of the corresponding through hole.
4. The purification device for antibiotic production according to claim 2, characterized in that: The output shaft of the motor (8) is located at the eccentric position of the striking disc (12).
5. The purification device for antibiotic production according to claim 2, characterized in that: The two slide bars (10) are sleeved with compression springs (30), one end of the two compression springs (30) is fixed on the corresponding slide bars (10), and the other ends of the two compression springs (30) are fixed on the sliding sleeves (13).
6. The purification device for antibiotic production according to claim 1, characterized in that: A metal block (26) is fixedly mounted on one side of the connection box (9) close to the movable frame (25), a locking bolt (27) is threadedly mounted on the metal block (26), and a limiting rack (28) is rotatably mounted on one end of the locking bolt (27).
7. The purification device for antibiotic production according to claim 1, characterized in that: The discharge pipe (2) and the feed pipe (5) are both provided with valves.