Biological sample box
By designing a biological sample box with convex strips and through-hole structures, the problem of time-consuming and poor embedding effects in the prior art during dehydration and embedding is solved, and the effect of simplifying operation steps, improving work efficiency and reducing waste of medical resources is achieved.
Patent Information
- Application Number
- CN202421672144.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-16
- Publication Date
- 2025-05-09
- Estimated Expiration
- 2034-07-16
AI Technical Summary
Existing biological sample boxes take a long time during tissue dehydration and embedding, and have poor embedding effects, especially when processing large numbers of specimens, resulting in low work efficiency and waste of medical resources.
A biological sample box is designed, with a plurality of convex strips protruding outwardly on the inner surface of the box cover, a plurality of through holes are provided in the peripheral part, a groove for placing biological samples is provided inside the box body, and a plurality of through holes are provided on the side wall. This design does not require opening the box cover during dehydration and embedding, and improves the embedding effect and efficiency through the convex strips and through-hole structures.
The biological sample box simplifies work steps, improves work efficiency, shortens patient hospitalization time, reduces unnecessary waste of medical resources, and increases the timely rate of pathological reporting.
Smart Images
Figure CN222845722U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of medical equipment, in particular to a biological sample box. Background Art
[0002] Pathology plays an irreplaceable role in the medical field and is of great significance for clinical diagnosis, treatment and disease research. The basic workflow of the pathology department includes important steps such as receiving specimens, tissue sampling, dehydration, embedding, sectioning, and issuing reports. Tissue dehydration and embedding are very important steps and have a key impact on subsequent pathological examinations and diagnostic results.
[0003] Tissue dehydration refers to the dehydration process usually using ethanol or isopropanol solutions with increasing concentrations, gradually replacing the water in the tissue with organic solvents, and finally completely removing the water in the tissue. Tissue embedding refers to the method usually using molten paraffin immersion, immersing the dehydrated tissue specimen in molten paraffin, so that the tissue is completely wrapped in paraffin, and then cooled and solidified to form a paraffin block.
[0004] In the sampling, dehydration and embedding operations, a dehydration embedding box is required. In the prior art, the following are commonly used: Figure 1 The dehydration embedding box shown includes a box cover 1 and a box body 2. The box body and the box cover are buckled on one side by a buckle structure 3, and the other side is detachably connected by a connecting structure 4. A plurality of grid holes 1a are arranged on the surface of the box cover, and a plurality of grid holes are also arranged on the surface of the box body. During the operation, the specific steps include: connecting the box body and the box cover, taking materials (i.e., putting tissues into the box body), buckling the box cover and the box body, dehydrating the buckled box, removing the box cover from the box body and discarding it, and manually embedding the dehydrated tissue. If the biopsy small specimen is required, the tissue needs to be wrapped with embedding paper. The process of processing each tissue block takes about 1-2 minutes. With the increasing number of specimens in the pathology department, the average number of tissue blocks per day is as high as 1,000, so it is very time-consuming. In the case of insufficient staff, the above problems are becoming increasingly prominent. In addition, there are several grid holes on the box body and the box cover. During the tissue embedding process, if the wax is automatically immersed, the wax will flow in faster due to the large grid holes. When encountering smaller tissues, the smaller tissues will float in the cavity surrounded by the box body and the box cover, affecting the embedding effect.
[0005] Therefore, there is an urgent need for a biological sample box that can reduce processing time. Summary of the invention
[0006] In order to solve the above problems existing in the prior art, the utility model provides a biological sample box with simple structure, easy use, simplified working steps, improved working efficiency, good embedding effect, and efficient pathology department workflow, which can shorten the patient's hospital stay and reduce unnecessary waste of medical resources.
[0007] To achieve the above-mentioned purpose of the utility model, the utility model provides a biological sample box, comprising a box body and a box cover that can be buckled on the box body, wherein: the inner surface of the box cover facing the box body is a plane; the inner surface of the box cover is provided with a plurality of convex strips protruding outward; a plurality of box cover through holes are provided on the peripheral portion of the box cover located outside the plurality of convex strips; a groove for accommodating biological samples is provided inside the box body; and a plurality of box body through holes are provided on the side wall of the box body located outside the groove.
[0008] Preferably, the plurality of box cover through holes include two or more rows of through holes arranged side by side along the peripheral portion of the box cover.
[0009] Preferably, the box cover through hole penetrates the box cover along the thickness direction of the box cover.
[0010] Preferably, the plurality of convex strips are arranged in parallel on the box cover.
[0011] Preferably, the plurality of box body through holes include one or more rows of through holes arranged along the side wall of the box body.
[0012] Preferably, the box body through hole extends along the width direction of the box body and is connected with the groove.
[0013] Preferably, it also includes a side wall groove arranged on a side wall of the box body.
[0014] Preferably, it also includes a pressing rod for being placed in the groove of the side wall of the box body.
[0015] Preferably, it also includes a code placement area arranged on the outer surface of the box cover, and the code placement area is used to place the box cover code.
[0016] Preferably, the box cover through hole and the box body through hole are straight holes or curved holes.
[0017] Compared with the prior art, the biological sample box of the utility model has the following advantages:
[0018] 1. The biological sample box of the utility model has a simple structure and is easy to use. It can simplify working steps, improve working efficiency, and has a good embedding effect. The efficient workflow of the pathology department can shorten the patient's hospital stay and reduce unnecessary waste of medical resources.
[0019] 2. The biological sample box of the utility model does not need to open the box cover during the dehydration and embedding process after the biological sample is placed in the box body and the box cover is closed. Compared with the embedding process after dehydration in the prior art, it reduces the process of opening the box cover, clamping the tissue in the box body with tweezers, and placing the tissue in a stainless steel container to accumulate the tissue before the wax liquid is injected. It greatly simplifies the operating steps, saves embedding time, saves manpower in the pathology department, improves the timeliness of pathology reports, greatly shortens the patient's discharge time, and reduces the waste of medical resources.
[0020] The embodiments of the utility model are described in detail below with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] Figure 1 It is a structural schematic diagram of a biological sample box in the prior art (the box body and the box cover are in a separated state and have not yet been connected);
[0022] Figure 2 It is a structural schematic diagram of the biological sample box of the utility model (the box body and the box cover are in a separated state and have not yet been connected);
[0023] Figure 3 This is another structural schematic diagram of the box body of the utility model;
[0024] Figure 4 It is a cross-sectional view of the utility model in which a through hole of the first shape is provided on the box cover;
[0025] Figure 5 It is a cross-sectional view showing that the box cover of the utility model is provided with a through hole of a second shape. DETAILED DESCRIPTION
[0026] like Figure 2 As shown in the figure, it is a simplified structural diagram of the biological sample box of the utility model. As can be seen from the figure, the biological sample box of the utility model comprises a box body 2 and a box cover 1 that can be buckled on the box body, wherein: the inner surface of the box cover facing the box body is a plane; the inner surface of the box cover is provided with a plurality of convex strips 6 protruding outward; a plurality of box cover through holes 5 are provided on the peripheral portion of the box cover located outside the plurality of convex strips; a groove 8 for accommodating biological samples is provided inside the box body; and a plurality of box body through holes 7 are provided on the side wall of the box body located outside the groove.
[0027] Specifically, the structure of the box cover and the box body of the utility model is basically the same as the existing technical structure (such as Figure 1 The two are connected together in a detachable manner and can be buckled with each other. One side of the two is detachably connected by a buckle structure 3, and the other side is detachably connected by a connecting structure 4. After the two are buckled, a box capable of containing tissues is formed. Since the appearance of the box cover and the box body, the buckle structure and the connecting structure are all existing technical structures, these two structures will not be described in detail here.
[0028] Different from the prior art, the utility model no longer has a plurality of grid holes on the box cover and the box body, and the inner surface of the box cover facing the box body has a plane (i.e., the original Figure 1 The part of the middle box cover where the grid is set is no longer provided with a recessed part that is sunken relative to the inner surface, and no grid is set at the recessed part). A plurality of convex strips protruding outward are provided on the plane, and the plurality of convex strips are arranged in parallel on the box cover, and a groove for placing biological samples is provided inside the box body. When designed, the flat part of the box cover can be buckled into the groove of the box body. In the process of embedding the tissue in the box after the box cover and the box body are buckled, the adhesion between the box cover and the tissue wrapped by the wax liquid can be increased by the plurality of convex strips, so that the tissue is not easy to float, and the embedding effect is improved.
[0029] Among them, the convex strip and the box cover can be made of the same material, such as, both are made of polyethylene material; in addition, the convex strip can also be made of a material different from the box cover, such as the box cover is made of polyethylene material, and the convex strip is made of an elastic material, such as rubber, after being made separately, they are fixed together by gluing.
[0030] In order to allow the organic solvent to enter the box and replace the tissue block placed in the box during the tissue dehydration process so that the water in the tissue can be analyzed out to dehydrate it; and in the process of embedding the tissue in the box, the dissolved wax liquid can enter the box to wrap the tissue, and when encountering smaller tissues, the accumulation of broken tissues is ensured not to be destroyed. The utility model arranges a plurality of box cover through holes around the box cover. The plurality of box cover through holes can be two rows of through holes arranged side by side along the peripheral portion of the box cover, or more than two rows of through holes, and each box cover through hole penetrates the box cover along the thickness direction of the box cover.
[0031] In addition, a plurality of box body through holes are also arranged at the four side walls of the outer periphery of the groove of the box body. The plurality of box body through holes can be one row or two rows of through holes arranged along the side walls of the box body, or more than two rows of through holes. Each box body through hole extends along the width direction of the box body and is connected to the groove in the box body, so that channels for the liquid to flow inside and outside are formed inside and outside the box body.
[0032] During design, both the box cover through hole and the box body through hole can be straight holes (such as Figure 5 As shown), it can also be a curved hole, such as Figure 4 The quasi-S-shaped hole shown may also be a through hole (not shown) extending in a spiral shape along the thickness direction of the box cover or the width direction of the box body. The number of the through holes in the box cover and the through holes in the box body can be determined according to actual conditions.
[0033] Compared with the prior art method of setting grids on both the box body and the box cover, the utility model sets through holes around the box cover and the box body respectively, so that when the tissue is embedded, the dissolved wax liquid can flow into the box evenly and slowly, and cooperate with the convex strips on the box cover, so that the accumulation of smaller tissues such as broken tissues will not be destroyed, the tissues are wrapped evenly, and the embedding effect is improved.
[0034] Furthermore, the utility model can also set a side wall groove on one side wall of the box body, and the side wall groove can be a sink groove (not shown in the figure) with an opening located on the inner surface of the box body, or a connecting groove (such as Figure 3 As shown in the figure). Accordingly, a pressing rod (not shown in the figure) with a suitable size can be placed in the groove of the side wall of the box body. The pressing rod can press the tissue, so that after the tissue is dehydrated and when necessary, the pressing rod can be placed in the box body to reduce the gap between the dehydrated tissue and the inner cavity of the box, and further prevent the tissue from floating in the box during embedding.
[0035] In addition, the utility model also provides a code placement area on the outer surface of the box cover, and the code placement area is used to place the box cover code. The box cover code can be a code printed on the box cover, or a code sticker pasted on the outer surface of the box cover.
[0036] The general process of using the biological sample box of the utility model to process pathological tissue is as follows:
[0037] Sampling → Place the tissue in a box with a lid connected to the box body (depending on the size of the tissue specimen, the size of the specimen box can be designed into different specifications, such as 2 specifications, and different specifications of sample boxes can be used according to the size of the specimen) → Place the box in a dehydrator for automatic dehydration → Place the dehydrated box in wax liquid for automatic embedding → After the wax liquid solidifies, open the lid and discard the box body. At this time, the wax-soaked tissue will be attached to the lid → Slice the tissue on the lid.
[0038] The actual use process of the biological sample box of the utility model is described as follows:
[0039] The technician sets the box cover code by printing or sticking on the box cover, and then hands the box to the doctor who collects the specimens. The cut tissue block is placed in the groove of the box body, and the box cover and the box body are buckled to form a sample box; the box is placed in the specimen frame and placed in formalin fixative, and the liquid will enter the tissue block through the through holes on the box cover and the box body to fix the tissue; after a batch of specimens are collected, the technician can dehydrate the specimens on the machine. During dehydration, the organic solvent will enter the box through the through holes and replace the water in the tissue block for dehydration; the dehydrated tissue box is placed in the dissolved wax liquid, and the wax liquid slowly flows into the sample box through the through holes on the box body and the box cover to wrap the tissue. Since the liquid flows in evenly and slowly, the accumulation of the broken tissue can be guaranteed not to be destroyed. The wax liquid is solidified at room temperature, and the tissue embedding is completed. Open the lid. Since the inner surface of the lid has convex strips that can increase adhesion, the wax liquid wrapped in the tissue will adhere to the convex strips when solidified. The inner surface of the box body lacks such convex strips, so the surface in contact with the wax liquid wrapped in the tissue is smooth. Therefore, when the lid is opened, the wax block wrapped in the tissue can adhere firmly to the lid. Since the surface of the lid has a case number (i.e., the lid code), the lid and the tissue wrapped in the wax block can be directly used for subsequent slicing and archiving.
[0040] It can be seen that the use of the utility model biological sample box has overturned the traditional technician embedding process after dehydration: manually opening the lid, losing the lid, using tweezers to clamp the tissue in the box body, re-placing it in a stainless steel container, accumulating tissue, infusing wax liquid, placing the box body on the tissue surface, and after the wax liquid condenses, manually separating the box body connected to the wax block from the container before subsequent sectioning. The use of the utility model biological sample box reduces the process of the doctor who collects the sample connecting the box lid and the box body, and the subsequent whole process from fixation to embedding is easy to realize automation. Compared with the prior art, the use of the utility model biological sample box to process tissues can save about 30 seconds for each wax block. For the pathology department of a large general hospital where the average daily amount of wax blocks is often greater than 1,000, it can save 8.5 hours a day, thus greatly saving manpower in the pathology department, improving the timeliness of pathology reports, greatly shortening the patient's discharge time, and reducing the waste of medical resources.
[0041] Although the embodiments of the present invention are described in detail above, the embodiments of the present invention are not limited thereto. Technicians in this technical field can make modifications based on the principles of the embodiments of the present invention. Therefore, all kinds of modifications made according to the principles of the embodiments of the present invention should be understood to fall within the protection scope of the embodiments of the present invention.
Claims
1. A biological sample box, comprising a box body and a box cover that can be snapped onto the box body, characterized in that: The inner surface of the box cover facing the box body is a plane; The inner surface of the box cover is provided with a plurality of convex strips protruding outwards; A plurality of cover through holes are arranged on the peripheral portion of the cover located outside the plurality of convex strips; The box body is provided with a groove inside for accommodating the biological sample; A plurality of box body through holes are arranged on the side wall of the box body located at the periphery of the groove.
2. The biological sample box according to claim 1, characterized in that: The plurality of box cover through holes include two or more rows of through holes arranged side by side along the peripheral portion of the box cover.
3. The biological sample box according to claim 1 or 2, characterized in that: The box cover through hole penetrates the box cover along the thickness direction of the box cover.
4. The biological sample box according to any one of claims 1 to 3, characterized in that: The plurality of convex strips are arranged in parallel on the box cover.
5. The biological sample box according to claim 1, characterized in that: The plurality of box body through holes include one or more rows of through holes arranged along the side wall of the box body.
6. The biological sample box according to claim 5, characterized in that: The box body through hole extends along the width direction of the box body and is communicated with the groove.
7. The biological sample box according to any one of claims 1 to 6, characterized in that: It also includes a side wall groove arranged on a side wall of the box body.
8. The biological sample box according to claim 7, characterized in that: It also includes a pressing rod for being placed in the groove of the side wall of the box body.
9. The biological sample box according to claim 1, characterized in that: It also includes a code placement area arranged on the outer surface of the box cover, and the code placement area is used to place the box cover code.
10. The biological sample box according to claim 1, characterized in that: The box cover through hole and the box body through hole are straight holes or curved holes.