Electric positioning instrument for small animal brain operation

Abstract

The utility model discloses an electric positioning instrument for small animal brain operation, which belongs to the technical field of biological experiments and comprises a U-shaped platform, a three-coordinate moving mechanism and a centering clamping mechanism which are arranged on a base. An operation fixing rod is arranged at the output end of the three-coordinate moving mechanism; the operation fixing rod is positioned above the U-shaped platform; the centering clamping mechanism is located at a U-shaped notch of the U-shaped platform. The centering clamping mechanism comprises two clamping seats arranged on the base, and clamping heads are arranged at the ends of the clamping seats; first dial gauges are arranged at the two ends of the U-shaped groove, and second dial gauges matched with the first dial gauges and used for displaying the moving distance of the clamping base are arranged on the clamping base. A two-way lead screw mechanism used for controlling the two clamping seats to move relatively is installed on the bottom face of the base, and a driving hand wheel is arranged on the two-way lead screw mechanism. And a camera is arranged on the U-shaped platform. The small animal brain operation device is simple in structure, convenient to operate, accurate in positioning and capable of improving the efficiency and accuracy of small animal brain operation.

Description

Technical Field

[0001] The utility model belongs to the technical field of biological experiments, and particularly relates to an electric positioning instrument for small animal brain operations. Background Art

[0002] In the field of neuroscience, a stereotaxic instrument is a key device for precise operations in the brain. These operations require extremely high precision. Traditional positioning instruments mainly rely on manual adjustment and lack automated and high-precision feedback mechanisms.

[0003] Defects and deficiencies of the prior art:

[0004] Lack of high-precision feedback: Traditional positioning instruments are not equipped with sensors for precise feedback, which limits the positioning accuracy and makes it difficult to achieve high precision at the nanometer level.

[0005] Poor repeat positioning accuracy: Due to the lack of an accurate position feedback mechanism, the repeat positioning accuracy of manual operations is poor, resulting in inconsistent experimental results.

[0006] Complex operation and high technical dependence: Traditional manual operations rely on the experience and technical level of the operator, making the operation complex and error-prone. Content of the Utility Model

[0007] In view of the above problems, the utility model provides an electric positioning instrument for small animal brain operations, which has a simple structure, convenient operation, accurate positioning, and can improve the efficiency and accuracy of small animal brain operations.

[0008] To achieve the above object, the technical solution adopted by the utility model is:

[0009] An electric positioning instrument for small animal brain operations, comprising a U-shaped platform arranged on a base, a three-coordinate moving mechanism, and a centering clamping mechanism for fixing the brain; the output end of the three-coordinate moving mechanism is provided with an operation fixing rod; the operation fixing rod is located above the U-shaped platform; the centering clamping mechanism is located at the U-shaped notch of the U-shaped platform; the centering clamping mechanism includes two clamping seats arranged on the base and capable of relative movement, and a clamping head for clamping the brain is arranged at the end of the clamping seat; first scale tables are arranged on the upper surfaces of both ends of the U-shaped notch, and a second scale table for displaying the moving distance of the clamping seat in cooperation with the first scale table is arranged on the upper surface of the clamping seat; a bidirectional lead screw mechanism for controlling the relative movement of the two clamping seats is installed on the bottom surface of the base, and a driving handwheel is arranged on the bidirectional lead screw mechanism; a camera is arranged on the U-shaped platform.

[0010] Compared with the prior art, the beneficial effects of the utility model are:

[0011] The electric positioning instrument is designed with a U-shaped platform and a centering clamping mechanism, which can achieve precise positioning and fixation of the small animal's brain. At the same time, it is equipped with an operating fixing rod and a scale table, which is convenient for the operator to make precise adjustments and record the fixing position, improving the accuracy and repeatability of brain operations. The experimental process of brain operations can be photographed through a camera. The principle adopted is: through the design of the U-shaped platform and the centering clamping mechanism, the stable fixation of the brain is realized; the movement of the clamping seat is controlled by a bidirectional lead screw mechanism and a driving handwheel, and in cooperation with the first scale table and the second scale table, the precise adjustment of the brain position is realized, and the operation is recorded through the camera.

[0012] As a further improvement of the above solution, the three-coordinate moving mechanism includes an X-axis mover, a Y-axis mover, a Z-axis mover, a linear guide mechanism, and a hinge mechanism; an installation seat is arranged on the base; the linear guide mechanism is installed on the installation seat, and the slider of the linear guide mechanism is connected to the output end of the Y-axis mover; the lower end of the Z-axis mover is installed on the slider through the hinge mechanism; the X-axis mover is installed on the output end of the Z-axis mover; the fixing rod is installed on the output end of the X-axis mover.

[0013] The technical effect of the above improvement is:

[0014] The design of the three-coordinate moving mechanism makes the electric positioning instrument highly flexible and precise in the X, Y, and Z directions. The addition of the linear guide mechanism and the hinge mechanism further improves the stability of positioning and the convenience of operation. The X-axis, Y-axis, and Z-axis movers are connected to each other through the linear guide mechanism and the hinge mechanism to achieve precise movement on the three coordinate axes; the hinge mechanism allows the Z-axis mover to make angular adjustments on the slider of the Y-axis mover, increasing the flexibility of operation.

[0015] As a further improvement of the above solution, the X-axis mover, the Y-axis mover, and the Z-axis mover are composed of a moving motor, a guide rod, a lead screw, a moving part, and a magnetic grating sensor; the lead screw is connected to the moving motor; the guide rods are arranged on both sides of the lead screw and are parallel to it; the moving part is connected to the magnetic grating sensor; the moving part is slidably arranged on the guide rod and is driven by the lead screw to move; an adjusting handwheel is arranged at the tail end of the moving motor.

[0016] The technical effect of the above improvement is: the combination of the moving motor and the lead screw, through the feedback of the magnetic grating sensor, realizes the precise control of the position of the moving part, improving the positioning accuracy and operation reliability of the electric positioning instrument. The moving motor drives the lead screw to rotate, and the lead screw drives the moving part to move along the guiding direction through the guide rod; the magnetic grating sensor monitors the position of the moving part in real time to ensure the accuracy of movement.

[0017] As a further improvement of the above solution, the linear guide mechanism is composed of a wedge-shaped seat and a slider; the slider is slidably arranged in the wedge-shaped seat.

[0018] The technical effects of the above improvements are as follows: The design of the linear guide mechanism ensures the smooth sliding of the slider within the wedge-shaped seat, reduces friction and wear, and improves the service life and stability of the locator. The slider slides within the wedge-shaped seat through the linear guide. This design makes the movement of the slider smoother and reduces the errors caused by friction.

[0019] As a further improvement to the above solution, the lead screw of the bidirectional lead screw mechanism is connected to a driving motor, and a driving handwheel is connected to the tail end of the driving motor.

[0020] The technical effects of the above improvements are as follows: The combination of the lead screw mechanism with the driving motor and the driving handwheel provides the operator with two operation modes, electric and manual, increasing the flexibility and convenience of operation. The driving motor drives the clamping seat to move through the lead screw. At the same time, the driving handwheel is connected to the lead screw, allowing the operator to manually adjust the position of the clamping seat to achieve dual control of electric and manual.

[0021] As a further improvement to the above solution, the hinge mechanism includes a hinge seat connected to the slider, and a pin shaft is provided on the hinge seat; a hinge head that can rotate around the pin shaft to adjust the angle is sleeved on the pin shaft.

[0022] The technical effects of the above improvements are as follows: The design of the hinge mechanism allows for angle adjustment of the Z-axis mover in the vertical plane, increasing the applicability and flexibility of the locator under different operating conditions. Through the design of the pin shaft and the hinge head, the hinge head can rotate around the pin shaft, thereby adjusting the angle of the Z-axis mover to meet different operating requirements.

[0023] As a further improvement to the above solution, a control box is provided on the base.

[0024] The technical effects of the above improvements are as follows: The setting of the control box enables the operator to centrally control the various functions of the electric locator, simplifies the operation process, and improves the convenience and efficiency of operation. The control box integrates all the control functions of the electric locator. The operator can centrally control the three-coordinate moving mechanism, the centering clamping mechanism, etc. through the control box to achieve precise positioning of brain operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 is a schematic structural diagram of the present utility model.

[0026] Figure 2 is a schematic structural diagram of the centering clamping mechanism.

[0027] Figure 3 is a schematic side structural diagram of the present utility model.

[0028] Figure 4It is a schematic structural diagram of the installation position of the control box.

[0029] Figure 5 It is a schematic top view structural diagram of the present utility model.

[0030] In the figure: 1. Z-axis mover; 2. X-axis mover; 3. Y-axis mover; 4. Magnetic grating sensor; 5. Hinge mechanism; 6. Linear guide rail mechanism; 7. Operation fixing rod; 8. Camera; 9. U-shaped platform; 10. First scale; 11. Centering clamping mechanism; 12. Control box; 14. Base; 15. Support feet; 16. Bidirectional lead screw mechanism; 17. Driving handwheel; 18. Linear slide rail; 19. Mounting seat; 61. Wedge-shaped seat; 62. Slide block; 101. Adjusting handwheel; 102. Moving motor; 103. Lead screw; 104. Guide rod; 105. Moving part; 111. Clamping seat; 112. Clamping head; 113. Second scale. Specific embodiments

[0031] In order to enable those skilled in the art to better understand the technical solution, the present utility model will be described in detail below in conjunction with embodiments. The description of this part is only exemplary and explanatory, and should not have any restrictive effect on the protection scope of the present utility model.

[0032] Embodiment 1

[0033] In the first embodiment, an electric positioner is used for precise positioning of a mouse brain. The U-shaped platform 9 is fixed on the base 14, and feet 15 are installed at the four corners of the bottom of the base 14; the three-coordinate moving mechanism includes an X-axis mover 2, a Z-axis mover 1, and a Y-axis mover 3, all driven by a moving motor 102, and the guide rod 104 and the lead screw 103 are used in cooperation to achieve precise movement. The centering clamping mechanism 11 is controlled by a bidirectional lead screw mechanism 16. The clamping seat 111 of the centering clamping mechanism 11 passes through the movable hole on the base 14 and is connected to the linear slide rail 18 at the bottom of the base 14. The two clamping seats 111 are connected to the bidirectional lead screw 103 and move relative to each other by controlling the rotation of the bidirectional lead screw 103. The clamping heads 112 fix both sides of the mouse brain, and the operation fixing rod 7 is used to assist in fixing the top of the mouse brain; the clamping heads 112 are generally conical, and the ends are spherical. The first scale 10 and the second scale 113 are used to display the moving position of the clamping seat 111. The control box 12 is connected to the three-coordinate moving mechanism and the camera 8 to control the entire positioning process. The linear guide rail mechanism 6 is used to improve the running stability of the three-seat moving mechanism; the hinge mechanism 5 can also enable the Z-axis mover 1 together with the X-axis mover 2 to flip in the vertical plane, so as to facilitate quickly controlling the position of the operation fixing rod 7 and avoid frequently operating the positions of the X-axis mover 2 or the Z-axis mover 1. The three-coordinate moving mechanism includes an X-axis mover 2, a Z-axis mover 1, a Y-axis mover 3, a linear guide rail mechanism 6, and a hinge mechanism 5; an installation seat 19 is provided on the base 14; the linear guide rail mechanism 6 is installed on the installation seat 19, and the slider 62 of the linear guide rail mechanism 6 is connected to the output end of the Y-axis mover 3, and the slider 62 of the linear guide rail mechanism 6 is driven to move by the Y-axis mover 3; the lower end of the Z-axis mover 1 is installed on the slider 62 through the hinge mechanism 5; the X-axis mover 2 is installed at the output end of the Z-axis mover 1; the fixing rod is installed at the output end of the X-axis mover 2.

[0034] Embodiment 2

[0035] In the second embodiment, an electric positioner is used for fixing and operating a rat brain. The size of the U-shaped platform 9 is correspondingly increased to adapt to the body size of the rat. The moving range and load-bearing capacity of the X-axis mover 2, the Z-axis mover 1, and the Y-axis mover 3 are correspondingly enhanced. The clamping force of the centering clamping mechanism 11 is also correspondingly increased to ensure that the rat brain can be stably clamped. The camera 8 is used to record the experimental process or to magnify and observe the details of the brain to improve the accuracy of the operation.

[0036] Embodiment 3

[0037] In the third embodiment, the electric positioner is used for brain monitoring in long-term experiments. The moving motor 102 is equipped with a low-noise design to reduce interference during the experiment. The magnetic grating sensor 4 has a high resolution and can monitor minute brain movements in real time. The time control function is integrated in the control box 12, which can record the changes in brain position at regular intervals for studying the stability of the brain during long-term experiments.

[0038] Embodiment 4

[0039] In the fourth embodiment, the electric positioner is used for brain operations on different types of small animals. The centering clamping mechanism 11 is designed with clamping heads 112 of various shapes to adapt to the brains of animals of different sizes and shapes. The control box 12 provides multiple preset modes to facilitate the operator to select the most suitable operation parameters according to different animals.

[0040] Operation process

[0041] 1. Preparation stage: Place the electric positioner on a stable experimental table, connect the power supply, and turn on the control box 12.

[0042] 2. Fixation on both sides of the brain: Place the small animal on the U-shaped platform 9, adjust the centering clamping mechanism 11 so that the clamping head 112 can stably clamp the animal's brain, automatically adjust the position of the centering clamping mechanism 11 through the driving motor, or precisely adjust the position of the centering clamping mechanism 11 by adjusting the driving handwheel 17. According to the indications of the first scale 10 and the second scale 113, precisely adjust the position of the brain.

[0043] 3. Brain operation or positioning: Operate the moving motor 102 of the X-axis mover 2, Z-axis mover 1, and Y-axis mover 3 to rotate through the control box 12, adjust the position of the three-coordinate moving mechanism, or precisely adjust the position of the three-coordinate moving mechanism by adjusting the handwheel, so that the operation fixing rod 7 is located above the animal's brain, perform operations on the brain or cooperate with the centering clamping mechanism to fix the animal's brain. The magnetic grating sensor 4 can improve the positioning accuracy of the X-axis mover 2, Z-axis mover 1, and Y-axis mover 3, record the operation process of the three-coordinate moving mechanism, and transmit it to the control box 12 for data storage or analysis.

[0044] 4. Angle adjustment: If necessary, adjust the angle of the Z-axis mover 1 through the hinge mechanism 5 to adapt to different operation angles.

[0045] 5. Real-time monitoring: Turn on the camera 8 to observe the brain state in real time to ensure the accuracy of the operation.

[0046] 7. Completion of operation: After completing the brain operation, turn off the power supply, restore the electric positioner to its initial state, and prepare for the next use.

[0047] Through the description of the above four specific embodiments and operation processes, the electric positioning instrument of the present utility model can meet the needs of different small animal brain operations, has high adaptability and precision, and can be widely applied to the field of biomedical research.

[0048] It should be noted that in this text, the terms: including, containing and any other variants are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed, or also includes elements inherent to such a process, method, article or device. Specific examples are used in this article to elaborate on the principle and implementation mode of the technical solution of the present utility model. The description of the above examples is only used to help understand the method and its core idea of the present utility model. The above is only the preferred implementation mode of the present utility model. It should be pointed out that due to the limitation of literal expression and the objectively infinite specific structures, for those of ordinary skill in the art, without departing from the principle of the present utility model, several improvements, retouches or changes can be made, and the above technical features can also be combined in an appropriate way; these improvements, retouches, changes or combinations, or directly applying the concept and technical solution of the present utility model to other occasions without improvement, shall all be regarded as the protection scope of the present utility model.

Claims

1. An electric positioning device for small animal brain operation, characterized in that: The invention comprises a U-shaped platform (9) arranged on a base (14), a three-coordinate moving mechanism, and a centering clamping mechanism (11) for fixing the brain; an operating fixing rod (7) is arranged at the output end of the three-coordinate moving mechanism; the operating fixing rod (7) is located above the U-shaped platform (9); the centering clamping mechanism (11) is located at the U-shaped notch of the U-shaped platform (9); the centering clamping mechanism (11) comprises two clamping seats (111) arranged on the base (14) and capable of relative movement, and a useful A clamping head (112) for clamping the brain; first scales (10) are arranged on both ends of the U-shaped groove, and a second scale (113) is arranged on the clamping seat (111) for cooperating with the first scale (10) to display the moving distance of the clamping seat (111); a bidirectional screw mechanism (16) for controlling the relative movement of the two clamping seats (111) is installed on the bottom surface of the base (14), and a driving hand wheel (17) is arranged on the bidirectional screw mechanism (16); a camera (8) is arranged on the U-shaped platform (9).

2. The electric positioning device for small animal brain operation according to claim 1, characterized in that: The three-coordinate moving mechanism comprises an X-axis mover (2), a Z-axis mover (1), a Y-axis mover (3), a linear guide mechanism (6), and a hinge mechanism (5); a mounting seat (19) is provided on the base (14); the linear guide mechanism (6) is mounted on the mounting seat (19), and a slider (62) of the linear guide mechanism (6) is connected to the output end of the Y-axis mover (3); the lower end of the Z-axis mover (1) is mounted on the slider (62) through the hinge mechanism (5); the X-axis mover (2) is mounted on the output end of the Z-axis mover (1); and a fixing rod is mounted on the output end of the X-axis mover (2).

3. The electric positioning device for small animal brain operation according to claim 2, characterized in that: The X-axis mover (2), Z-axis mover (1), and Y-axis mover (3) are composed of a moving motor (102), a guide rod (104), a screw rod (103), a moving part (105), and a magnetic grating sensor (4); the screw rod (103) is connected to the moving motor (102); the guide rod (104) is located on both sides of the screw rod (103) and is arranged parallel to the screw rod (103); the moving part is connected to the magnetic grating sensor (4); the moving part (105) is slidably arranged on the guide rod (104) and is driven to move by the screw rod (103); and an adjusting hand wheel (101) is arranged at the tail end of the moving motor (102).

4. The electric positioning device for small animal brain operation according to claim 2, characterized in that: The linear guide mechanism (6) is composed of a wedge-shaped seat (61) and a slider (62); the slider (62) is slidably arranged in the wedge-shaped seat (61).

5. The electric positioning device for small animal brain operation according to claim 1, characterized in that: The screw rod (103) of the bidirectional screw rod mechanism is connected to a drive motor, and a drive hand wheel (17) is connected to the rear end of the drive motor.

6. The electric positioning device for small animal brain operation according to claim 2, characterized in that: The hinge mechanism (5) comprises a hinge seat connected to a slider (62), a pin being arranged on the hinge seat; a hinge head which can rotate around the pin to adjust the angle is sleeved on the pin.

7. The electric positioning device for small animal brain operation according to claim 1, characterized in that: A control box (12) is arranged on the base (14).

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