Extracorporeal circulation pipeline for hemofiltration

Abstract

The utility model discloses an extracorporeal circulation pipeline for hemofiltration, which comprises a blood supply pipeline, an artery pot, a hemofiltration device, a vein pot with a filter screen and a blood return pipeline which are sequentially connected, a blood pump pipe is arranged on the blood supply pipeline, and a replacement liquid pipeline is further arranged on the circulation pipeline. The replacement liquid pipeline comprises a rear dilution bypass connected with the inlet end of the vein kettle and a front dilution bypass with one end connected with the rear dilution bypass and the other end connected with the inlet end of the artery kettle, and the rear dilution bypass and the front dilution bypass can be controlled through a liquid stopping clamp to input replacement liquid into the extracorporeal circulation pipeline. The pre-dilution bypass and the post-dilution bypass are simultaneously arranged on the extracorporeal circulation pipeline for hemofiltration, a pure post-dilution method can be replaced by a pure pre-dilution method, and blood clots are prevented, so that the hemofiltration time is prolonged, unplanned tube blockage is reduced, the use amount of anticoagulant is reduced, and bleeding of a patient is avoided; the treatment effect of the artificial liver is ensured.

Description

Technical Field

[0001] The utility model relates to a blood filtration circulation pipeline, in particular to an extracorporeal blood filtration circulation pipeline in artificial liver treatment. Background Art

[0002] Hemofiltration is a treatment method in non-bioartificial liver. It refers to passing the patient's blood through a machine (pump) to make the blood flow through a filter in the extracorporeal circulation pipeline. Under the action of transmembrane pressure, a large amount of liquid and solutes are filtered out, namely ultrafiltrate (waste liquid). The retained part is supplemented with electrolyte solution similar to human plasma composition, namely replacement fluid, which returns to the human body to regulate human electrolyte disorder and acid-base balance to achieve the purpose of treatment. Non-bioartificial liver technology has been widely recognized and used in clinical practice. Among them, hemofiltration is particularly important for patients with liver failure and internal environment disorder. The length of hemofiltration time affects the final effect of non-bioartificial liver treatment. However, due to the abnormal coagulation function of patients with liver failure and the difficulty in using anticoagulants, unplanned blockage of the extracorporeal circulation pipeline and hemofilter often occurs during clinical treatment. At present, according to the different positions of the replacement fluid entering the extracorporeal circulation pipeline, it is divided into simple pre-dilution method (the replacement fluid enters from the front of the hemofilter) and simple post-dilution method (the replacement fluid enters from the back of the hemofilter). The simple pre-dilution method requires a large amount of replacement fluid, but it is not easy to cause blood clotting, so the amount of anticoagulant can be reduced; the clearance rate of the simple post-dilution method is higher than that of the simple pre-dilution method, but as the treatment progresses, blood clots appear in the extracorporeal circulation circuit, leading to blockage of the extracorporeal circulation circuit and (or) the blood filter, causing increased pressure. At this time, clinical medical staff are likely to increase the amount of anticoagulants, but it is easy to induce bleeding risks in patients, so they can only shorten the treatment time and end the treatment early. Utility Model Content

[0003] The technical problem to be solved by the utility model is to provide an extracorporeal circulation pipeline for blood filtration, which simultaneously comprises a post-dilution bypass and a pre-dilution bypass, so that when the pressure in the extracorporeal circulation pipeline and (or) the blood filter increases when the blood filtration by the simple post-dilution method is used for artificial liver treatment, the blood filtration by the pre-dilution method can be replaced, thereby prolonging the treatment time, further reducing the amount of anticoagulant, achieving the treatment purpose, and ensuring the safety of the patient.

[0004] In order to solve the above technical problems, the utility model discloses an extracorporeal circulation pipeline for blood filtration, comprising a blood supply blood circuit, an arterial pot, a blood filter, a venous pot with a filter and a blood return blood circuit connected in sequence, a blood supply blood circuit is provided with a blood pump tube, and a replacement fluid circuit is also provided on the circulation pipeline, the replacement fluid circuit comprises a post-dilution bypass connected to the inlet end of the venous pot, and a front dilution bypass connected to the post-dilution bypass at one end and to the inlet end of the arterial pot at the other end, the post-dilution bypass and the front dilution bypass can be controlled by a liquid stop clamp to respectively input replacement fluid into the extracorporeal circulation pipeline.

[0005] Furthermore, a main branch is arranged at the entrance end of the arterial pot, a first side branch with a liquid-stopping clamp is arranged on the rear dilution bypass, and both ends of the front dilution bypass are respectively connected to the main branch and the first side branch through a locking joint.

[0006] Furthermore, a liquid storage pot with a filter is provided on the pre-dilution bypass.

[0007] Furthermore, an infusion branch is provided on the blood supply line, and the infusion branch is connected to an external infusion set via a locking joint.

[0008] Furthermore, an arterial pressure monitoring branch is provided on the blood supply line, and a hydrophobic pressure sensor is provided on the arterial pressure monitoring branch.

[0009] Furthermore, an arterial pot pressure monitoring branch is provided at the inlet end of the arterial pot, and a hydrophobic pressure sensor is provided on the arterial pot pressure monitoring branch.

[0010] Furthermore, a side branch is provided on the main branch, and the side branch can be connected to a front dilution bypass or an air extraction device through a locking joint.

[0011] Furthermore, a venous pot pressure monitoring branch is provided at the inlet end of the venous pot, and a hydrophobic pressure sensor is provided on the venous pot pressure monitoring branch.

[0012] Furthermore, a second side branch is provided on the post-dilution bypass, and the second side branch can be connected to the pre-dilution bypass or the air extraction device via a locking joint.

[0013] Furthermore, a blood collection device is provided on each of the blood supply line and the blood return line.

[0014] The utility model simultaneously sets a pre-dilution bypass and a post-dilution bypass on the extracorporeal circulation pipeline for blood filtration. When the pressure is increased by adopting the simple post-dilution method for blood filtration, the passage of the post-dilution bypass can be closed and the passage of the pre-dilution bypass can be opened to realize the pre-dilution method for blood filtration, prevent the appearance of blood clots, thereby prolonging the blood filtration time, reducing unplanned tube blockage, reducing the amount of anticoagulants, avoiding bleeding of patients, and ensuring the treatment effect of artificial liver. The utility model has a simple structure and obvious effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a connection diagram of the utility model.

[0016] Numbers in the figure: 1-blood supply line; 1.1-infusion branch; 1.1.1-hemostatic clamp; 1.1.2-screw cap; 1.2-arterial pressure monitoring branch; 1.2.1-hemostatic clamp; 1.2.2-pressure sensor; 1.3-blood pump tube; 1.4-hemostatic clamp; 1.5-blood collection piece; 2-blood return line; 2.1-hemostatic clamp; 2.2-blood collection piece; 3-arterial pot; 3.1-arterial pot pressure monitoring branch; 3.1.1-hemostatic clamp; 3.1.2-pressure sensor; 3.2-main branch; 3.2.1-hemostatic clamp; 3.2.2- Locking connector; 3.3-side branch; 3.3.1-hemostatic clamp; 3.3.2-screw cap; 4-blood filter; 5-venous pot; 5.1-venous pot pressure monitoring branch; 5.1.1-hemostatic clamp; 5.1.2-pressure sensor; 6-post-dilution bypass; 6.1-Luer connector; 6.2-hemostatic clamp; 6.3-second side branch; 6.3.1-hemostatic clamp; 6.3.2-screw cap; 6.4-first side branch; 6.4.1-hemostatic clamp; 6.4.2-locking connector; 7-front-dilution bypass; 7.1-fluid reservoir; 8-hemostatic clamp. DETAILED DESCRIPTION

[0017] The present invention is further explained below in conjunction with the examples. The following examples are only used to illustrate the present utility model, but are not intended to limit the scope of implementation of the present utility model.

[0018] Example 1

[0019] Extracorporeal blood circulation circuits, such as Figure 1 As shown, it includes a blood supply line 1, an arterial pot 3, a blood filter 4, a venous pot with a filter 5 and a blood return line 2 which are connected in sequence.

[0020] The blood supply line 1 is provided with a hemostatic clamp 1.4, a blood sampling piece 1.4, an infusion branch 1.1, an arterial pressure monitoring branch 1.2 and a blood pump tube 1.3 in sequence from the blood supply end. The blood sampling piece 1.5 is used to draw blood from the blood supply line 1 for analysis and to confirm the electrolyte and acid-base levels in the blood so as to timely configure the corresponding replacement fluid; the infusion branch 1.1 is provided with a stop clamp 1.1.1, and is connected to an external infusion set through a locking connector, which is used to supplement physiological saline and also for blood return after blood filtration. When the external infusion set is not connected, the locking connector is covered with a screw cap 1.1.2; the arterial pressure monitoring branch 1.2 is provided with a hemostatic clamp 1.2.1, and is connected to a hydrophobic pressure sensor 1.2.2, which is used to monitor the blood pressure on the blood supply line 1 and is displayed on an externally connected display screen. When the negative pressure on the blood supply line 1 is large, it indicates that the blood in the patient's body cannot be drawn out, and the pressure sensor 1.2.2 will sound an alarm; the blood pump tube 1.3 draws blood from the patient under the action of the blood pump, prompting the blood to circulate in the replacement circulation pipeline.

[0021] A replacement fluid pipeline is also provided on the circulation pipeline, and the replacement fluid pipeline includes a post-dilution bypass 6 connected to the inlet end of the venous pot 5, and a pre-dilution bypass 7 connected to the post-dilution bypass 6 at one end and to the inlet end of the arterial pot 3 at the other end.

[0022] The inner end of the post-dilution bypass 6 is connected to the inlet end of the intravenous pot 5, and the outer end is connected to the external replacement fluid bypass through the Luer connector 6.1, and the external replacement fluid bypass can be an existing one. The post-dilution bypass 6 is provided with a liquid stop clamp 6.2, a second side branch 6.3 and a first side branch 6.4 with a liquid stop clamp 6.4.1 in sequence from the inner end to the outer end; the end of the first side branch 6.4 is provided with a locking connector 6.4.2 for connecting with the front dilution bypass 7.

[0023] The second side branch 6.3 is provided with a hemostatic clip 6.3.1, and can be connected to the pre-dilution bypass 7 or an external suction device through a locking joint. When there is a problem with the first side branch 6.4 pipeline (such as the port is contaminated, or cracks appear in the pipeline, etc.), the second side branch 6.3 can be used to replace the connection; when the liquid level in the venous pot 5 is too low, the second side branch 6.3 can also be connected to an external suction device to pump air from the venous pot 5 and raise the liquid level in the venous pot 5 to avoid the formation of blood clots in the venous pot 5 or directly draw out blood clots. When the locking joint is not externally connected to the pre-dilution bypass 7 or the suction device, it is covered with a screw cap 6.3.2. The external suction device can be a syringe without a needle.

[0024] A venous pot pressure monitoring branch 5.1 is also provided at the entrance end of the venous pot 5. A hemostatic clamp 5.1.1 is provided on the venous pot pressure monitoring branch 5.1 and a hydrophobic pressure sensor 5.1.2 is connected to monitor the pressure in the venous pot 5 and display it on an externally connected display screen.

[0025] A main branch 3.2 with a liquid-stopping clamp 3.2.1 is provided at the inlet end of the arterial pot 3, and a locking joint 3.2.2 is provided at the end of the main branch 3.2 for connection with the pre-dilution bypass 7.

[0026] An arterial pot pressure monitoring branch 3.1 is also provided at the entrance end of the arterial pot 3. A hemostatic clamp 3.1.1 is provided on the arterial pot pressure monitoring branch 3.1 and a hydrophobic pressure sensor 3.1.2 is connected to monitor the pressure in the arterial pot 3.

[0027] The main branch 3.2 is provided with a side branch 3.3, and a liquid stop clamp 3.3.1 is provided on the side branch 3.3, and can be connected to the front dilution bypass 7 or the suction device through a locking joint. When the main branch 3.2 has a problem (port contamination or pipeline crack, etc., the pipeline crack does not include the section shared with the side branch 3.3), the side branch 3.3 is used to replace the main branch 3.2 and connect to the front dilution bypass 7; when the liquid level of the arterial pot 3 is too low, the side branch 3.3 can be connected to an external suction device to increase the liquid level in the arterial pot 3 to avoid the formation of blood clots or directly draw out blood clots, and is covered with a screw cap when not connected.

[0028] The post-dilution bypass 6 and the pre-dilution bypass 7 can be controlled by a liquid stop clamp to input replacement fluid into the extracorporeal circulation pipeline respectively. The pre-dilution bypass 7 is provided with a liquid storage pot 7.1 with a filter screen.

[0029] A hemostatic clamp 8 is also provided between the blood filter 4 and the intravenous pot 5.

[0030] The return blood line 2 is provided with a hemostatic clamp 2.1 and a blood sampling piece 2.2. The blood sampling piece 2.2 is used to draw blood from the return blood line 1 for analysis to confirm the electrolyte and acid-base levels in the blood so as to timely prepare the corresponding replacement fluid. In particular, when the blood sampling piece 1.5 of the supply blood line 1 cannot function, the blood sampling piece 2.2 can be used as a substitute.

[0031] Regardless of the blood supply line 1 or the blood return line 2, the blood collection piece and the hemostatic clamp are arranged in such a way that the hemostatic clamp is on the side close to the human body and the blood collection piece is on the side away from the human body, so as to avoid accidental injury to the patient by the needle during the blood collection operation.

[0032] When the front dilution bypass 7 is not in use, it can be removed from the entire circulation pipeline and both ends can be sealed with protective covers.

[0033] When the utility model is used, first close the liquid-stopping clamp 6.4.1 and the liquid-stopping clamp 3.2.1, open the hemostatic clamp 1.4, the hemostatic clamp 8, the hemostatic clamp 2.1 and the liquid-stopping clamp 6.2, and start the blood pump. The liquid-stopping clamps and the hemostatic clamps on the remaining branches are opened or closed as needed (such as the hemostatic clamp 6.3.1 on the second side branch 6.3 and the liquid-stopping clamp 3.3.1 on the side branch 3.3 are only opened when they need to replace the pre-dilution bypass 7 or connect the suction device, and are closed at other times). Blood enters the blood supply blood path 1 from the human body through the blood supply end, and then passes through the arterial pot 3, the blood filter 4, the hemostatic clamp 8, the venous pot 5 in sequence, reaches the blood return blood path 2, and then enters the human body from the blood return end. At this time, the post-dilution bypass 6 inputs the replacement fluid into the venous pot 5, which is a simple post-dilution blood filtration. After a certain period of circulation, when the pressure in the arterial pot 3 and the pressure in the venous pot 5 are monitored to increase and approach the upper limit, the stop clamp 6.2 is closed, and the stop clamps 6.4.1 and 3.2.1 are opened to allow the replacement fluid to enter the arterial pot 3 from the pre-dilution bypass 7, and the blood is replaced with a simple pre-dilution method. 3 Solution to prepare, while NaHCO 3 Crystallization will occur during the circulation process, so the liquid storage pot 7.1 with a filter will filter out the crystals to ensure the filtering effect of the replacement fluid after mixing with the blood.

Claims

1. An extracorporeal circulation pipeline for blood filtration, comprising a blood supply line (1), an arterial pot (3), a blood filter (4), a venous pot with a filter (5) and a blood return line (2) connected in sequence, a blood supply line (1) being provided with a blood pump tube (1.3), and a replacement fluid line being further provided on the circulation pipeline, characterized in that: The replacement fluid pipeline comprises a post-dilution bypass (6) connected to an inlet end of a venous pot (5), and a pre-dilution bypass (7) having one end connected to the post-dilution bypass (6) and the other end connected to an inlet end of an arterial pot (3). The post-dilution bypass (6) and the pre-dilution bypass (7) can be controlled by a liquid stop clamp to respectively input replacement fluid into the extracorporeal circulation pipeline; a liquid storage pot (7.1) with a filter is provided on the pre-dilution bypass (7); and a blood sampling component is provided on each of the blood supply line (1) and the blood return line (2).

2. The extracorporeal blood circulation circuit for blood filtration according to claim 1, characterized in that: The entrance end of the arterial pot (3) is provided with a main branch (3.2), the rear dilution bypass (6) is provided with a first side branch (6.4), and both ends of the front dilution bypass (7) are respectively connected to the main branch (3.2) and the first side branch (6.4) via a locking joint.

3. The extracorporeal blood circulation circuit for blood filtration according to claim 1, characterized in that: An infusion branch (1.1) is provided on the blood supply line (1), and the infusion branch (1.1) is connected to an external infusion set via a locking joint.

4. The extracorporeal blood circulation circuit for hemofiltration according to claim 1, characterized in that: An arterial pressure monitoring branch (1.2) is provided on the blood supply line (1), and a hydrophobic pressure sensor (1.2.2) is provided on the arterial pressure monitoring branch (1.2).

5. The extracorporeal blood circulation circuit for hemofiltration according to claim 1, characterized in that: An arterial pot pressure monitoring branch (3.1) is arranged at the inlet end of the arterial pot (3), and a hydrophobic pressure sensor (3.1.2) is arranged on the arterial pot pressure monitoring branch (3.1).

6. The extracorporeal blood circulation circuit for blood filtration according to claim 2, characterized in that: A side branch (3.3) with a screw cap (3.2.2) is provided on the main branch (3.2), and the side branch (3.3) can be connected to a pre-dilution bypass (7) or a suction device via a locking joint.

7. The extracorporeal blood circulation circuit for hemofiltration according to claim 1, characterized in that: A venous pot pressure monitoring branch (5.1) is provided at the inlet end of the venous pot (5), and a hydrophobic pressure sensor (5.1.2) is provided on the venous pot pressure monitoring branch (5.1).

8. The extracorporeal blood circulation circuit for blood filtration according to claim 1 or 2, characterized in that: The post-dilution bypass (6) is also provided with a second side branch (6.3) with a screw cap (6.3.2), and the second side branch (6.3) can be connected to the pre-dilution bypass (7) or the exhaust device via a locking joint.

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