Chemical drug synthesis membrane concentration equipment

Abstract

The utility model discloses chemical drug synthesis membrane concentration equipment in the technical field of concentration equipment, which comprises a raw material tank and a plurality of concentration tanks, and the bottoms of the raw material tank and the concentration tanks are connected with supporting seats. The bottom of the raw material tank is connected with a plurality of distribution plates through a plurality of flow guide pipes, the distribution plates are used for dividing fluid, the divided fluid is guided into a plurality of vertical concentration filter membranes, the concentration filter membranes are used for concentrating and filtering through the osmotic pressure of the fluid, and the filtered fluid is guided out through a plurality of liquid permeation holes and stored in the concentration tank. The liquid is timely guided out through the liquid permeable pipe, the vertical concentration filter membrane always keeps high osmotic pressure, after the fluid in the concentration filter membrane is filtered and concentrated for the first time, the piston is pushed through the hydraulic rod, the fluid is continuously guided into the concentration filter membrane through the one-way valve, the operation is repeated, multiple times of concentration and filtration are carried out, and multiple times of membrane filtration and concentration can be continuously carried out.

Description

Technical Field

[0001] The utility model relates to the technical field of concentration equipment, in particular to a chemical drug synthesis membrane concentration equipment. Background Technique

[0002] Synthetic drugs are drugs made by chemical synthesis or biologic synthesis methods. Chemical synthesis includes organic synthesis and inorganic synthesis. Biologic synthesis includes total biologic synthesis and partial biologic and partial chemical synthesis. Drug synthesis plays an extremely important role in the pharmaceutical industry. Nitrofurantoin is an organic compound drug. In the production process of nitrofurantoin, chemical drug concentration is a necessary step to increase the concentration of active substances. Using membrane concentration in chemical drug synthesis is a modern new process. Membrane concentration is a technology that reforms traditional processes to achieve high-efficiency purification and concentration. It uses the difference in the molecular weights of active ingredients and liquids to achieve directional separation and achieve the effect of concentration.

[0003] However, most of the existing chemical drug synthesis membrane concentration equipment adopts the intermittent feeding method, adding the liquid to be concentrated into the equipment containing the nanofiltration membrane and filtering and concentrating through osmotic pressure. It is inconvenient for continuous operation, inconvenient for concentration under high concentration gradients, the concentration effect is not good, and the intermittent operation is cumbersome, requiring frequent operations and is not convenient to use. Based on this, the utility model designs a chemical drug synthesis membrane concentration equipment to solve the above problems. Content of the Utility Model

[0004] The purpose of the utility model is to provide a chemical drug synthesis membrane concentration equipment to solve the problems of the above-mentioned intermittent feeding method, adding the liquid to be concentrated into the equipment containing the nanofiltration membrane and filtering and concentrating through osmotic pressure, which is inconvenient for continuous operation, inconvenient for concentration under high concentration gradients, and the concentration effect is not good.

[0005] To achieve the above purpose, the utility model provides the following technical solutions:

[0006] A chemical drug synthesis film concentration device, comprising a raw material tank and a concentration tank. A plurality of the concentration tanks are provided. Support seats are connected to the bottoms of both the raw material tank and the concentration tanks. A hydraulic rod is welded to the upper end of the raw material tank. A piston is welded to the free end of the hydraulic rod. The piston is arranged inside the raw material tank. A liquid inlet pipe is welded to the bottom end of the raw material tank. A main valve is installed on the liquid inlet pipe. A plurality of diversion pipes are welded to the bottom of the raw material tank. A sealing valve and a one-way valve are installed on the diversion pipe. A lead-out pipe is welded to one side of the upper end of the diversion pipe. A sealing valve is installed on the lead-out pipe. A distribution plate is welded to the lower end of the concentration tank and is connected to the liquid outlet end of the diversion pipe. A distribution plate is hermetically clamped and installed on the upper end of the concentration tank. A plurality of sleeves are hermetically clamped between the two distribution plates. A plurality of liquid permeation holes are formed in the sleeve. A cylindrical concentration filter membrane is installed inside the sleeve. The two open ends of the concentration filter membrane communicate with the two distribution plates. An end cover is buckled on the distribution plate at the upper end of the concentration tank. Vent holes are provided on the end cover. A liquid permeation pipe is welded to one side of the concentration tank.

[0007] As a further scheme of the utility model: A plurality of embedding grooves are formed on the edge of the piston. A rubber ring is installed in the embedding groove of the piston.

[0008] As a further scheme of the utility model: The plurality of sleeves inside the concentration tank are annularly and equidistantly distributed, and the plurality of sleeves are perpendicularly and parallelly distributed.

[0009] As a further scheme of the utility model: The plurality of liquid permeation holes on the sleeve are vertically and equidistantly distributed, and the liquid permeation holes are U-shaped.

[0010] As a further scheme of the utility model: The vertical height of the liquid permeation pipe is less than the bottom height of the sleeve.

[0011] As a further scheme of the utility model: A bent pipe is connected to the air outlet at the upper end of the end cover, and the bent pipe is L-shaped.

[0012] As a further scheme of the utility model: A vertical perspective window is installed on one side of the concentration tank, and the height of the perspective window matches the height of the sleeve.

[0013] Compared with the prior art, the beneficial effects of the utility model are:

[0014] 1. In the utility model, multiple distribution plates are connected through multiple guide tubes through the bottom of the raw material tank, and the distribution plates perform fluid diversion. The diverted fluid is introduced into multiple vertical concentration filter membranes, and the concentration filter membranes perform concentration and filtration by the osmotic pressure of the fluid. The filtered fluid is discharged through multiple liquid-permeable holes, stored in the concentration tank, and timely discharged through the liquid-permeable tubes, so that the vertical concentration filter membranes always maintain a high osmotic pressure. After the fluid in the concentration filter membrane completes the first filtration and concentration, the piston is pushed by the hydraulic rod to allow the fluid to continue to be introduced into the concentration filter membrane through the one-way valve. The operation is repeated to perform multiple concentration and filtration. Multiple membrane filtration and concentration can be performed continuously to perform concentration operations under high concentration and different gradients.

[0015] 2. In the utility model, a bending tube is connected to the air outlet at the upper end of the end cover. The L-shaped bending tube connected to the upper end of the end cover can prevent dust from falling vertically into the air outlet, thereby ensuring the cleanliness of the interior of the device. A vertical perspective window is installed on one side of the concentration tank. The perspective window installed on one side of the concentration tank is used for internal observation. The perspective window matches the height of the sleeve, and a comprehensive observation at a vertical height can be performed. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0017] Figure 2 It is a schematic diagram of the overall explosion structure of the utility model;

[0018] Figure 3 For the utility model Figure 2 The enlarged structural diagram at A in the middle;

[0019] Figure 4 It is a schematic diagram of the overall cross-sectional structure of the utility model.

[0020] In the figure: 1. raw material tank; 2. support seat; 3. hydraulic rod; 4. piston; 5. liquid inlet pipe; 6. main valve; 7. guide pipe; 8. sealing valve; 9. one-way valve; 10. outlet pipe; 11. concentration tank; 12. distribution plate; 13. sleeve; 14. liquid permeable hole; 15. concentration filter membrane; 16. end cover; 17. bending pipe; 18. liquid permeable pipe; 19. perspective window. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] Example:

[0023] See also Figures 1-4 In the embodiment of the utility model, a chemical drug synthesis membrane concentration device includes a raw material tank 1 and a concentration tank 11, a plurality of concentration tanks 11 are provided, the bottoms of the raw material tank 1 and the concentration tank 11 are connected with a support seat 2, a hydraulic rod 3 is welded to the upper end of the raw material tank 1, a piston 4 is welded to the free end of the hydraulic rod 3, the piston 4 is arranged inside the raw material tank 1, a liquid inlet pipe 5 is welded to the bottom end of the raw material tank 1, a main valve 6 is installed on the liquid inlet pipe 5, a plurality of guide pipes 7 are welded to the bottom of the raw material tank 1, a sealing valve 8 and a one-way valve 9 are installed on the guide pipe 7, a guide pipe 10 is welded to one side of the upper end of the guide pipe 7, a sealing valve 8 is installed on the guide pipe 10, a distribution plate 12 is welded to the lower end of the concentration tank 11, and The outlet end of the flow guide pipe 7 is connected, and a distribution plate 12 is sealed and clamped at the upper end of the concentration tank 11. A plurality of sleeves 13 are sealed and clamped between the two distribution plates 12. The sleeve 13 is provided with a plurality of liquid permeable holes 14. A cylindrical concentration filter membrane 15 is installed in the sleeve 13. The openings at both ends of the concentration filter membrane 15 are connected to the two distribution plates 12. The distribution plate 12 at the upper end of the concentration tank 11 is buckled with an end cover 16. The end cover 16 is provided with air holes. The upper distribution plate 12 is sealed by the end cover 16 to prevent foreign matter from entering. A liquid permeable pipe 18 is welded on one side of the concentration tank 11. The raw material tank 1 introduces the chemical drug synthesis concentrated fluid that needs to be concentrated through the liquid inlet pipe 5 at the bottom. The sealing valve 8 on the flow guide pipe 7 is opened. After the raw material injection is completed, the main valve 6 is closed and the sealing valve 8 is opened. The bottom of the raw material tank 1 is connected to multiple distribution plates 12 through multiple guide pipes 7. The distribution plates 12 divide the fluid, and the divided fluid is introduced into multiple vertical concentration filter membranes 15. The concentration filter membranes 15 concentrate and filter by the osmotic pressure of the fluid to concentrate the fluid. The concentration filter membranes 15 are supported by the sleeves 13. The filtered fluid is led out through multiple liquid permeable holes 14 and stored in the concentration tank 11. The filtered liquid is concentrated at the bottom and led out in time through the liquid permeable pipes 18, so that the vertical concentration filter membranes 15 always maintain a high osmotic pressure. The fluid introduced by the bottom distribution plate 12 can avoid the vertical tubular concentration filter. There are many air bubbles remaining inside the membrane 15 to ensure the filtration efficiency of the concentration filter membrane 15. The distribution plate 12 at the upper end of the concentration tank 11 introduces and exhausts air to balance the air pressure. After the fluid in the concentration filter membrane 15 completes the first filtration and concentration, the piston 4 is pushed by the hydraulic rod 3 to allow the fluid to continue to be introduced into the concentration filter membrane 15 through the one-way valve 9. The operation is repeated to perform multiple concentration and filtration. Multiple membrane filtration and concentration can be performed continuously to perform concentration operations under high concentration and different gradients. After the concentration is completed, the concentrate in the concentration filter membrane 15 is taken out after opening the outlet pipe 10. The operation is simple, and multiple distributed concentration tanks 11 perform continuous and large-scale chemical drug synthesis membrane concentration operations, with high concentration efficiency and good use effect.

[0024] Preferably, Figure 2As shown, multiple embedding grooves are provided on the edge of the piston 4, and rubber rings are installed in the embedding grooves of the piston 4. The multiple embedding grooves provided on the edge of the piston 4 and the installation of rubber rings increase the connection sealing performance, perform multi-layer ring sealing, and have good sealing effect.

[0025] Preferably, as Figure 2 shown, multiple sleeves 13 in the concentration tank 11 are annularly and equidistantly distributed, and the multiple sleeves 13 are perpendicular and parallel to each other. The multiple sleeves 13 in the concentration tank 11 that are annularly equidistant and perpendicular and parallel to each other facilitate the derivation of the filtered fluid between the liquid permeating holes 14, ensuring the rapid derivation of the filtered fluid.

[0026] Preferably, as Figure 2 and Figure 3 shown, multiple liquid permeating holes 14 on the sleeve 13 are vertically and equidistantly distributed, and the liquid permeating holes 14 are U-shaped. The multiple U-shaped liquid permeating holes 14 on the sleeve 13 ensure the multi-point rapid derivation of the filtered fluid.

[0027] Preferably, as Figure 4 shown, the vertical height of the liquid permeating pipe 18 is less than the bottom height of the sleeve 13. The bottom of the concentration tank 11 stores the filtered fluid at the bottom, and the liquid permeating pipe 18 at the bottom position ensures the rapid derivation of the filtered fluid, enabling the concentrated filter membrane 15 in the sleeve 13 at a higher position to maintain a higher osmotic pressure for osmotic filtration.

[0028] Preferably, as Figure 1 and Figure 2 shown, the upper air outlet of the end cover 16 is connected with a bent pipe 17, and the bent pipe 17 is L-shaped. Connecting the L-shaped bent pipe 17 to the upper end of the end cover 16 can prevent dust from vertically falling into the air outlet, ensuring the cleanliness inside the device.

[0029] Preferably, as Figure 1 shown, a vertical perspective window 19 is installed on one side of the concentration tank 11, and the height of the perspective window 19 matches the height of the sleeve 13. The perspective window 19 installed on one side of the concentration tank 11 is used for internal observation, and the perspective window 19 matches the height of the sleeve 13, enabling comprehensive observation in the vertical height direction.

[0030] The working principle of the utility model is as follows: the raw material tank 1 introduces the chemical drug synthesis concentrated fluid that needs to be concentrated through the liquid inlet pipe 5 at the bottom, the sealing valve 8 on the guide pipe 7 is opened, and after the raw material injection is completed, the main valve 6 is closed and the sealing valve 8 is opened. The bottom of the raw material tank 1 is connected to multiple distribution plates 12 through multiple guide pipes 7, and the distribution plates 12 perform fluid diversion. The diverted fluid is introduced into multiple vertical concentration filter membranes 15, and the concentration filter membranes 15 perform concentration filtration by the osmotic pressure of the fluid to concentrate the fluid. The concentration filter membranes 15 are supported by the sleeve 13, and the filtered fluid is led out through multiple liquid permeable holes 14 and stored in the concentration tank 11. The filtered liquid is concentrated at the bottom and is promptly led out through the liquid permeable pipe 18, so that the vertical concentration filter membranes 15 always maintain a high The osmotic pressure is high, and the fluid introduced by the bottom distribution plate 12 can avoid the residual air bubbles in the vertical tubular concentration filter membrane 15, so as to ensure the filtration efficiency of the concentration filter membrane 15. The distribution plate 12 at the upper end of the concentration tank 11 introduces and discharges air to balance the air pressure. After the fluid in the concentration filter membrane 15 completes the first filtration and concentration, the piston 4 is pushed by the hydraulic rod 3 to allow the fluid to continue to be introduced into the concentration filter membrane 15 through the one-way valve 9. The operation is repeated for multiple concentration and filtration. Multiple membrane filtration and concentration can be performed continuously, and concentration operations under high concentration and different gradients can be performed. After the concentration is completed, the concentrated liquid in the concentration filter membrane 15 is taken out after opening the outlet pipe 10. The operation is simple, and multiple distributed concentration tanks 11 are used to perform continuous and large-scale chemical drug synthesis membrane concentration operations, and the concentration efficiency is high.

[0031] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A chemical drug synthesis membrane concentration device, comprising a raw material tank (1) and a concentration tank (11), wherein a plurality of the concentration tanks (11) are provided, and the bottoms of the raw material tank (1) and the concentration tank (11) are both connected to a support seat (2), characterized in that: A hydraulic rod (3) is welded to the upper end of the raw material tank (1), a piston (4) is welded to the free end of the hydraulic rod (3), and the piston (4) is arranged inside the raw material tank (1). A liquid inlet pipe (5) is welded to the bottom end of the raw material tank (1), and a main valve (6) is installed on the liquid inlet pipe (5). A plurality of guide pipes (7) are welded to the bottom of the raw material tank (1), and a sealing valve (8) and a one-way valve (9) are installed on the guide pipes (7). A guide pipe (10) is welded to one side of the upper end of the guide pipe (7), and a sealing valve (8) is installed on the guide pipe (10). A distribution plate is welded to the lower end of the concentration tank (11). (12) and connected to the liquid outlet end of the guide pipe (7), the upper end of the concentration tank (11) is sealed and clamped with a distribution plate (12), a plurality of sleeves (13) are sealed and clamped between the two distribution plates (12), a plurality of liquid permeable holes (14) are provided on the sleeve (13), a cylindrical concentration filter membrane (15) is installed in the sleeve (13), the two end openings of the concentration filter membrane (15) are connected to the two distribution plates (12), the distribution plate (12) at the upper end of the concentration tank (11) is buckled with an end cover (16), the end cover (16) is provided with a vent hole, and a liquid permeable tube (18) is welded to one side of the concentration tank (11).

2. A chemical drug synthesis membrane concentration device according to claim 1, characterized in that: A plurality of embedding grooves are provided on the edge of the piston (4), and rubber rings are installed in the embedding grooves of the piston (4).

3. The chemical drug synthesis membrane concentration device according to claim 1, characterized in that: The plurality of sleeves (13) in the concentration tank (11) are distributed in an annular manner with equal spacing, and the plurality of sleeves (13) are distributed perpendicularly and parallel to each other.

4. The chemical drug synthesis membrane concentration device according to claim 1, characterized in that: The plurality of liquid-permeable holes (14) on the sleeve (13) are vertically equidistantly distributed, and the liquid-permeable holes (14) are arranged in a U shape.

5. The chemical drug synthesis membrane concentration device according to claim 1, characterized in that: The vertical height of the liquid-permeable tube (18) is smaller than the bottom end height of the sleeve (13).

6. The chemical drug synthesis membrane concentration device according to claim 1, characterized in that: The upper air outlet of the end cover (16) is connected to a bent tube (17), and the bent tube (17) is L-shaped.

7. The chemical drug synthesis membrane concentration device according to claim 1, characterized in that: A vertical perspective window (19) is installed on one side of the concentration tank (11), and the height of the perspective window (19) matches the height of the sleeve (13).

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