Single-dose type dry powder administration device

Abstract

The utility model relates to a single-dose type dry powder administration device, and belongs to the field of dry powder inhalers. Comprising a device body and a medicine bin assembly. Wherein the medicine bin assembly comprises a medicine bin main body, a medicine bin cover, a sealing film and a gasket, the medicine bin main body is used for storing medicine powder, an empty groove is formed in the medicine bin cover, the sealing film is packaged and fixed on the medicine bin cover, and the medicine bin main body and the medicine bin cover are fixed through a buckle; the gasket is arranged between the medicine bin body and the medicine bin cover. By means of the structure, the packaging piece and the medicine powder are separated, the situation that in the packaging process, due to the temperature, the biomacromolecule medicine powder loses activity is avoided, and medicine with the strict requirement for the storage temperature can be treated through a dry powder inhalation means.

Description

Technical Field

[0001] The utility model relates to a dry powder inhaler for use with medicated powder that requires a specific storage temperature, particularly a biologic macromolecule inhaler. Background Art

[0002] The most common administration routes for biologic macromolecules are subcutaneous injection and intravenous injection. Intravenous injection is mostly used when patients are hospitalized in a hospital and cannot be conveniently used by patients at home or when going out in their daily lives. If subcutaneous injection is often performed at the same location, it will cause subcutaneous fat dystrophy and require frequent changes of the injection site, leaving multiple injection marks on the patient's body. The injection-based administration method will inevitably cause pain to the patient during the needle insertion process, and the patient's compliance during the administration process is poor. For oral administration and nasal administration, due to the limited absorption capacity of the human mucosa, the administration effect is not ideal.

[0003] Making biologic macromolecules into inhalable fine powder with a powder particle size less than 5 microns and directly entering the human respiratory and circulatory systems through oral inhalation can reduce the pain and inconvenience caused by injection administration while ensuring the administration effect. However, biologic macromolecules have strict temperature storage conditions, which limits the encapsulation method of biologic macromolecule dry powder drugs.

[0004] In existing biologic macromolecule inhalers on the market, the high temperature generated during the thermoplastic sealing process of the sealing film structure will cause the stored biologic macromolecule drugs to lose their activity. The medicine storage component that directly contacts the medicated powder uses the moving fit between two plastic parts to complete the storage of the medicated powder. To ensure that the medicated powder can be driven to move by the inhalation airflow during use, the medicine storage component is actually a non-sealed structure, and problems such as the medicated powder being scattered outside the medicine storage component may occur due to large movements such as shaking during daily carrying, and the accuracy of the dose in the medicine storage component cannot be guaranteed. Summary of the Utility Model

[0005] The main purpose of the utility model is: to provide a single-dose dry powder administration device that can be used for medicated powder with specific storage temperature requirements and has good sealing performance in view of the above problems.

[0006] A single-dose dry powder administration device includes: a device main body and a medicine storage component. Further, the medicine storage component includes a medicine storage main body, a medicine storage cover, a sealing film, and a gasket. The medicine storage main body is used for storing medicated powder. An empty slot is provided on the medicine storage cover. The sealing film is fixedly encapsulated on the medicine storage cover. The medicine storage main body and the medicine storage cover are fixed by a buckle. The gasket is arranged between the medicine storage main body and the medicine storage cover.

[0007] Furthermore, flexible arms are provided on both sides of the medicine cartridge cover. A snap structure is provided on the flexible arms to cooperate with and fix to the device main body. The flexible arms can provide a certain amount of elastic deformation to realize the assembly and disassembly of the medicine cartridge assembly and the device main body.

[0008] Furthermore, two openings are provided in the device main body along the horizontal direction, namely an air inlet and a suction nozzle. A vertical partition is provided inside the device main body, and a ventilation opening is provided on the vertical partition.

[0009] Preferably, the ventilation opening is located at a non-central position of the vertical partition, and a baffle is provided on the straight-line path from the ventilation opening to the suction nozzle.

[0010] Furthermore, two ventilation columns are provided on the device main body. The ventilation columns are located on both sides of the vertical partition, and the ventilation columns are of a hollow structure.

[0011] Preferably, the lower end of the ventilation column is of an inclined surface structure.

[0012] Preferably, the inclined surfaces at the lower ends of the ventilation columns are inclined towards each other.

[0013] Furthermore, two empty slots are arranged in parallel on the medicine cartridge cover. After the medicine cartridge is installed on the device main body, the positions of the empty slots correspond to the positions of the ventilation columns.

[0014] Furthermore, the area of the ventilation opening is smaller than the cross-sectional area of the hollow inside a single ventilation column.

[0015] Preferably, the ratio of the area of the ventilation opening to the cross-sectional area of the hollow position of a single ventilation column is less than or equal to one-third.

[0016] Compared with the prior art, the present utility model has the following beneficial effects:

[0017] 1. A film sealing structure is adopted to store the medicinal powder, improving the sealing performance during storage, ensuring the accurate dosage of the medicinal powder in the medicine cartridge assembly, and at the same time facilitating the rapid piercing of the sealing film by using the ventilation column structure during the use of the device main body, so that the medicinal powder is exposed inside the device to complete inhalation administration.

[0018] 2. The sealing film is arranged on the medicine cartridge cover, so that the sealing film encapsulation operation can be separated from the medicinal powder filling operation, avoiding the loss of activity of the medicinal powder due to excessive temperature during the heat sealing process. In particular, it enables drugs with certain requirements for storage temperature, such as biological macromolecules, to be used for dry powder inhalation administration treatment in a powder structure. The way of using the sealing film in cooperation with the rubber ring to complete the sealing ensures the complete storage of the medicinal powder during transportation and is not easy to leak.

[0019] 3. The use of a medicine cartridge assembly to store medicine solves the defects in the use of dry powder capsules. When using a capsule as a dry powder container, a relatively large inhalation force is required to drive the entire capsule to shake and rotate. When the inhalation force does not reach the preset value, the medicine powder in the capsule may not be completely shaken into the drug delivery structure in the device, resulting in incomplete drug delivery.

[0020] 4. There are two built-in air flow channels. During use, the air flows in the two channels form a counterflow, which is beneficial to dispersing the powder inside the device and facilitating human absorption. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The above and / or additional aspects and advantages of the present utility model will become apparent and be readily understood from the following description of the embodiments with reference to the accompanying drawings, in which:

[0022] Figure 1 is an exploded view of the structure of a single-dose dry powder delivery device according to a preferred embodiment of the present utility model

[0023] exploded view

[0024] Figure 2 is an exploded view of the structure of a medicine cartridge assembly according to a preferred embodiment of the present utility model;

[0025] Figure 3 is a schematic structural view of a medicine cartridge assembly with the film removed according to a preferred embodiment of the present utility model;

[0026] Figure 4 is a front side cross-sectional view of the device body according to a preferred embodiment of the present utility model;

[0027] Figure 5 is a bottom view of the device body according to a preferred embodiment of the present utility model;

[0028] Figure 6 is a schematic structural view of the air inlet end of a single-dose dry powder delivery device according to a preferred embodiment of the present utility model;

[0029] Figure 7 is a front side cross-sectional view of a single-dose dry powder delivery device according to a preferred embodiment of the present utility model;

[0030] Figure 8 is a cross-sectional structural view of a single-dose dry powder delivery device according to a preferred embodiment of the present utility model;

[0031] Wherein: 1-device body, 2-medicine cartridge assembly, 3-film, 4-medicine cartridge cover, 5-gasket, 6-medicine cartridge body, 7-nozzle opening, 8-air inlet, 9-stop block, 10-air vent, 11-air vent column, 12-empty slot, 13-flexible arm, 14-vertical partition. Detailed implementation mode

[0032] The following description is used to disclose the present utility model so that those skilled in the art can implement the present utility model. The preferred embodiments in the following description are only examples, and those skilled in the art can think of other obvious variations.

[0033] Figures 1 to 8 A preferred embodiment of the single-dose dry powder administration device of the present utility model is shown, which includes: a device main body 1 and a medicine storage component 2. The medicine storage component 2 includes a sealing film 3, a medicine storage cover 4, a gasket 5 and a medicine storage main body 6, wherein:

[0034] As Figure 1 shown, when storing the device daily, the device main body 1 and the medicine storage component 2 are in a separated state, and the two can be stored separately, which is convenient for special storage according to the environmental temperature requirements of the biological macromolecule drug in the medicine storage component 2.

[0035] As Figures 2-3 shown, two empty slots 12 are arranged side by side on the medicine storage cover 4, flexible arms 13 are arranged on both sides of the medicine storage cover 4, and a convex structure cooperating with the device main body 1 is arranged on the flexible arms 13. The medicine storage main body 6 is used to store drug powder. The sealing film 3 is fixed on the medicine storage cover 4 in a thermoplastic sealing manner. The medicine storage main body 6 and the medicine storage cover 4 are fixed by buckles, and a gasket 5 is arranged between the medicine storage main body 6 and the medicine storage cover 4 for sealing.

[0036] As Figures 4-6 shown, the device main body 1 is provided with two openings in the horizontal direction, namely a suction nozzle 7 and an air inlet 8. A vertical partition 14 is arranged between the suction nozzle 7 and the air inlet 8. An air vent 10 is arranged at a non-central position of the vertical partition 14, and a stop block 9 is arranged on the straight path between the air vent 10 and the suction nozzle 7.

[0037] Two ventilation columns 11 are arranged on the device main body 1, and the positions of the ventilation columns 11 are respectively located on both sides of the vertical partition 14. The ventilation columns 11 are of a hollow structure, and the ratio of the air vent 10 to the hollow cross-section of a single ventilation column 11 is 3:1. When the device main body 1 and the medicine storage component 2 are installed, the positions of the ventilation columns 11 correspond to the positions of the empty slots 12, so that the inside of the medicine storage component 2 is connected to the inside of the device main body 1. The lower inclined surface of the ventilation column 11 is inclined oppositely, which is convenient for piercing the sealing film 3 thermoplastically sealed on the medicine storage cover 4.

[0038] When the device main body 1 and the medicine storage component 2 are installed, the elasticity of the flexible arms 13 makes the convex structures of the device main body 1 and the medicine storage component 2 come into contact, so that the two are fixed. And when the device is used up, the lower ends of the flexible arms 13 are exposed at the positions accessible to the patient. By squeezing the two ends of the flexible arms 13, the convex structures of the device main body 1 and the medicine storage component 2 move away from each other, and the patient can easily disassemble the medicine storage component 2.

[0039] As Figures 7-8 shown, during the use of the device, the patient inhales through the mouthpiece 7, and air enters the interior of the device through the air inlet 8. Most of the air flow enters the interior of the medicine bin assembly 2 through the ventilation column 11. After initially dispersing the medicine powder, it re-enters the main body of the device carrying the medicine powder stored in the medicine bin assembly 2. A small part of the air flow collides with the baffle 9 after passing through the ventilation port 11, changing the air flow direction to form a counter-flow with most of the air flow carrying the medicine powder. The counter-flow of the air flow further disperses the medicine powder, and finally enters the patient's oral cavity through the mouthpiece 7 to complete oral inhalation drug delivery.

[0040] In the description of the present utility model, it should be understood that the orientation or positional relationship indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is only for the convenience of simplifying the description of the present utility model, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be understood as a limitation to the present utility model. In addition, in the description of the present utility model, the meaning of "a plurality of" is two or more, unless otherwise specifically defined.

[0041] The above shows and describes the basic principles, main features and advantages of the present utility model. Those skilled in the art of this industry should understand that the present utility model is not limited by the above embodiments. What is described in the above embodiments and the specification is only the principle of the present utility model. Without departing from the spirit and scope of the present utility model, the present utility model will have various changes and improvements, and these changes and improvements all fall within the scope of the present utility model claimed. The scope of protection claimed by the present utility model is defined by the appended claims and their equivalents.

Claims

1. A single-dose dry powder drug delivery device, comprising: The device body and the medicine bin assembly are characterized in that the medicine bin assembly includes a medicine bin body, a medicine bin cover, a sealing film and a gasket, the medicine bin body is used to store drug powder, the medicine bin cover is provided with an empty groove, the sealing film is packaged and fixed on the medicine bin cover, the medicine bin body and the medicine bin cover are fixed by snap fasteners, and the gasket is arranged between the medicine bin body and the medicine bin cover.

2. A single-dose dry powder drug delivery device according to claim 1, characterized in that: Flexible arms are provided on both sides of the medicine bin cover, and snap-fit ​​structures are provided on the flexible arms to cooperate and fix with the device body. The flexible arms can provide a certain elastic deformation to realize the assembly and disassembly of the medicine bin assembly and the device body.

3. A single-dose dry powder drug delivery device according to claim 1, characterized in that: The device body is provided with two openings in the horizontal direction, which are an air inlet and a suction nozzle. A vertical partition is provided inside the device body, and a vent is provided on the vertical partition.

4. A single-dose dry powder drug delivery device according to claim 3, characterized in that: The vent is located at a non-central position of the vertical partition, and a stopper is provided on a straight path from the vent to the suction nozzle.

5. A single-dose dry powder drug delivery device according to claim 3, characterized in that: Two ventilation columns are arranged on the device body, and the ventilation columns are located on both sides of the vertical partition, and the ventilation columns are hollow structures.

6. A single-dose dry powder drug delivery device according to claim 5, characterized in that: The lower end of the ventilation column is an inclined surface structure.

7. A single-dose dry powder drug delivery device according to claim 5, characterized in that: The medicine bin cover is provided with two empty slots in parallel. After the medicine bin and the device body are installed, the positions of the empty slots correspond to the positions of the ventilation columns.

8. A single-dose dry powder drug delivery device according to claim 5, characterized in that: The area of ​​the vent is smaller than the cross-sectional area of ​​the hollow interior of a single vent column.

9. A single-dose dry powder drug delivery device according to claim 8, characterized in that: The ratio of the vent area to the cross-sectional area of ​​the hollow position of a single vent column is less than or equal to one third.

Images