Water bath heating device for sialic acid preparation

Abstract

The utility model discloses a water bath heating device for preparing sialic acid, which is characterized in that the inside of a water bath heater main body consists of a reaction kettle, a water tank bin, an electric heating wire, a heat conducting plate, a stirring rod and a spiral stirring blade, and the side surface of the reaction kettle penetrates through one end of the water bath heater main body through a shaft rod and is fixedly connected with a gear I; a first servo motor is fixedly connected to the upper surface of the fixing frame, a second gear is fixedly connected to the output end of the first servo motor, the first gear is meshed with the second gear, a second servo motor is fixedly connected to the end, away from the first servo motor, of the fixing frame, and an electric telescopic rod is fixedly connected to the output end of the second servo motor. The output end of the electric telescopic rod is fixedly connected with the stirring rod, so that the reaction kettle rotates in a high-temperature steam environment, the overall sterilization effect is improved, more uniform stirring can be realized, flow field distribution can be optimized, the heat transfer effect is enhanced, sediment accumulation is prevented, and the operation flexibility is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of sialic acid preparation, in particular to a water bath heating device for sialic acid preparation. Background Art

[0002] Sialic acids are a class of amino sugar acids containing nine carbon atoms, and the most common one is N-acetylneuraminic acid (Neu5Ac). They are usually linked in the form of glycosidic bonds to the ends of cell surface glycoproteins or glycolipids and play important roles in physiological processes such as cell-cell recognition, immune regulation, and cell adhesion. They can also be used to treat nervous system diseases, immune system diseases, etc. They can also be used as vaccine adjuvants, drug carriers, etc. and have broad application prospects in the medical field. All in all, sialic acids are an important class of bioactive molecules and have broad application prospects in the biomedical field.

[0003] In the process of sialic acid preparation, the reaction solution in the reaction kettle is reacted through a water bath heating device to improve the quality of sialic acid preparation. However, when the reaction solution is placed in the water bath heating device in the reaction kettle and the temperature is controlled between 80-90°C, the reaction time is generally 2-4 hours, and the reaction solution needs to be continuously stirred during this period. Existing stirring devices are all set as fixed types and can only stir at fixed positions during the stirring process, which may affect the temperature transfer of the reaction solution and the uniformity of stirring. Therefore, in order to further improve the practicability of the water bath heating device, we propose a water bath heating device for sialic acid preparation to solve the above problems. Content of the Utility Model

[0004] The purpose of the utility model is to solve at least one of the technical problems existing in the prior art, and provide a water bath heating device for sialic acid preparation. By setting a servo motor one, a gear one and a gear two on the side of the water bath heater main body and connecting the reaction kettle through a shaft rod, the reaction kettle can rotate in a high-temperature steam environment, ensuring that all corners in the kettle can fully contact the high-temperature steam, which can more thoroughly kill various microorganisms that may exist in the kettle, improve the overall sterilization effect, and by adjusting the position of the adjustable spiral stirring blade, not only can more uniform stirring be achieved, but also the flow field distribution can be optimized, the heat transfer effect can be enhanced, sediment accumulation can be prevented, and the operation flexibility can be improved. These all contribute to improving the overall efficiency and product quality of sialic acid preparation.

[0005] The present utility model also provides a water bath heating device for preparing sialic acid as described above, comprising: a water bath heater main body, the interior of which is composed of a reaction kettle, a water tank chamber, an electric heating wire, a heat conducting plate, a stirring rod, and a spiral stirring blade. A fixing frame is fixedly connected to the bottom surface of the water bath heater main body. One end of the reaction kettle is fixedly connected with a first gear through a shaft rod penetrating through one end of the water bath heater main body. A first servo motor is fixedly connected to the upper surface of the fixing frame, and an output end of the first servo motor is fixedly connected with a second gear. The first gear meshes with the second gear. A second servo motor is fixedly connected to one end of the fixing frame away from the first servo motor, and an output end of the second servo motor is fixedly connected with an electric telescopic rod. The output end of the electric telescopic rod is fixedly connected with the stirring rod.

[0006] For the water bath heating device for preparing sialic acid according to the present utility model, the water tank chamber is located between the heat conducting plate and the inner wall of the water bath heater main body, and is used for containing a heating medium and transferring heat to the reaction kettle.

[0007] For the water bath heating device for preparing sialic acid according to the present utility model, the electric heating wire is located inside the water tank chamber, and the electric heating wire is arranged in a spiral shape and is attached to the heat conducting plate, and is used for quickly transferring heat energy to the heat conducting plate while heating.

[0008] For the water bath heating device for preparing sialic acid according to the present utility model, a high-temperature steam sterilization box is fixedly connected to the upper surface of the fixing frame, and a delivery pipe is fixedly connected to the side surface of the high-temperature steam sterilization box, and is used for performing high-temperature sterilization inside the reaction kettle to ensure that the final preparation of sialic acid can reach a sterile state.

[0009] For the water bath heating device for preparing sialic acid according to the present utility model, the other end of the delivery pipe penetrates through the water bath heater main body and is communicated with the reaction kettle, and the delivery pipe penetrates through the water bath heater main body and the reaction kettle and is rotatably connected, so that the reaction kettle can rotate while performing high-temperature sterilization, and finally the inside of the reaction kettle can be sterilized.

[0010] For the water bath heating device for preparing sialic acid according to the present utility model, a temperature sensor is fixedly connected to the side surface of the water bath heater main body, and a display board is fixedly connected to the upper surface of the fixing frame, and is used for controlling the temperature of the heated water to ensure that the yield and purity of sialic acid can be improved.

[0011] For the water bath heating device for preparing sialic acid according to the present utility model, the reaction kettle is attached to the heat conducting plate and is rotatably connected, and a spiral stirring blade is fixedly connected to one end of the stirring rod away from the electric telescopic rod, which is convenient for the operation of the reaction kettle, enables the generation of downward and upward flows, and effectively mixes the upper and lower layers of the reaction liquid.

[0012] Beneficial effects: By arranging a first servo motor, a first gear and a second gear on the side of the water bath heater main body and connecting the reaction kettle through a shaft rod, the reaction kettle can rotate in a high-temperature steam environment, ensuring that all corners inside the kettle can fully contact the high-temperature steam, so that various microorganisms that may exist inside the kettle can be more thoroughly killed, improving the overall sterilization effect;

[0013] By adjusting the position of the adjustable spiral stirring blade, not only can more uniform stirring be achieved, but also the flow field distribution can be optimized, the heat transfer effect can be enhanced, the accumulation of sediment can be prevented, and the operation flexibility can be improved, all of which contribute to improving the overall efficiency and product quality of sialic acid preparation. Description of the drawings

[0014] The following further describes the present utility model in conjunction with the drawings and embodiments;

[0015] Figure 1 It is the overall structure diagram of the water bath heating device for sialic acid preparation of the present utility model;

[0016] Figure 2 It is the top view structure diagram of the water bath heating device for sialic acid preparation of the present utility model;

[0017] Figure 3 It is the internal structure schematic diagram of the water bath heater main body of the water bath heating device for sialic acid preparation of the present utility model Figure 1 ;

[0018] Figure 4 It is the internal structure schematic diagram of the water bath heater main body of the water bath heating device for sialic acid preparation of the present utility model Figure 2 .

[0019] Legend description:

[0020] 1. Fixed frame; 2. Water bath heater main body; 201. Reaction kettle; 202. Water tank chamber; 203. Electric heating wire; 204. Heat conduction plate; 205. Stirring rod; 206. Spiral stirring blade; 3. First servo motor; 4. Second servo motor; 5. Display board; 6. First gear; 7. Second gear; 8. High-temperature steam sterilization box; 9. Delivery pipe; 10. Electric telescopic rod. Specific implementation manners

[0021] This part will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the drawings. The role of the drawings is to supplement the description of the text part of the specification, enabling people to intuitively and vividly understand each technical feature and the overall technical solution of the present utility model, but it cannot be understood as a limitation on the protection scope of the present utility model.

[0022] Refer to Figures 1-4, an embodiment of the utility model provides a water bath heating device for preparing sialic acid, which includes: a water bath heater main body 2 that converts energy into heat by an electric heating wire 203 and controls and adjusts the heating process through a temperature sensor to meet the requirement for the temperature of hot water. The inside of the water bath heater main body 2 consists of a reaction kettle 201, a water tank chamber 202, an electric heating wire 203, a heat conduction plate 204, a stirring rod 205, and a spiral stirring blade 206, which are used to ensure that the reaction kettle 201 operates under the optimal temperature conditions, thereby improving the yield and purity of sialic acid. A fixing frame 1 is fixedly connected to the bottom surface of the water bath heater main body 2, which is used to fix and support the water bath heater main body 2 and a high-temperature steam sterilization box 8, as well as other equipment. A gear one 6 is fixedly connected to the side of the reaction kettle 201 through a shaft rod penetrating one end of the water bath heater main body 2, which is used to mesh with a gear two 7. A servo motor one 3 is fixedly connected to the upper surface of the fixing frame 1, which is used to provide driving power for the gear one 6 and the gear two 7. The output end of the servo motor one 3 is fixedly connected to the gear two 7, which is used to drive the gear one 6. The gear one 6 meshes with the gear two 7, and its function is to enable the reaction kettle 201 to rotate and ensure that its interior can be fully sterilized. A servo motor two 4 is fixedly connected to one end of the fixing frame 1 away from the servo motor one 3, which is used to provide operating power for the electric telescopic rod 10, the stirring rod 205, and the spiral stirring blade 206 to stir the reaction solution. The output end of the servo motor two 4 is fixedly connected to the electric telescopic rod 10, which is used to drive the stirring rod 205 and the spiral stirring blade 206 to extend and retract to different stirring positions, so that the interior of the reaction kettle 201 can be fully stirred. The output end of the electric telescopic rod 10 is fixedly connected to the stirring rod 205.

[0023] The water tank chamber 202 is located between the heat conduction plate 204 and the inner wall of the water bath heater main body 2, and is used to hold the heated medium and transfer heat to the reaction kettle 201. The electric heating wire 203 is located inside the water tank chamber 202. The electric heating wire 203 is arranged in a spiral shape and is attached to the heat conduction plate 204, so as to quickly transfer heat energy to the heat conduction plate 204 while heating. The upper surface of the fixing frame 1 is fixedly connected with a high-temperature steam sterilization box 8. The side surface of the high-temperature steam sterilization box 8 is fixedly connected with a delivery pipe 9, which is used to perform high-temperature sterilization in the reaction kettle 201 to ensure that the preparation of sialic acid can finally reach a sterile state. The other end of the delivery pipe 9 penetrates through the water bath heater main body 2 and is connected to the reaction kettle 201. The delivery pipe 9 is rotatably connected to both the water bath heater main body 2 and the reaction kettle 201, so that the reaction kettle 201 can rotate as a whole while being sterilized at high temperature, and finally the inside of the reaction kettle 201 can be sterilized. The side surface of the water bath heater main body 2 is fixedly connected with a temperature sensor, and the upper surface of the fixing frame 1 is fixedly connected with a display board 5, which plays a role in precise temperature control to ensure the improvement of the yield and purity of sialic acid. The reaction kettle 201 is attached to the heat conduction plate 204 and is rotatably connected. One end of the stirring rod 205 away from the electric telescopic rod 10 is fixedly connected with a spiral stirring blade 206, which facilitates the operation of the reaction kettle, enables the generation of downward and upward flows, effectively mixes the upper and lower layers of the reaction solution, and the spiral stirring blade 206 can generate eddy currents, enhancing the convective heat transfer between the reaction solution and the heating surface, improving the temperature uniformity of the reaction solution, ensuring that the temperature distribution is consistent throughout the reaction volume, and being beneficial to the progress of the reaction.

[0024] Working principle: When using the water bath heating device for the preparation of sialic acid, first, under the action of the high-temperature steam sterilization box 8, high-temperature steam is transported into the reaction kettle 201 through the delivery pipe 9. At the same time, the servo motor 1 3 drives the gear 2 7, causing the meshing gear 1 6 to rotate, and then driving the rotation of the reaction kettle 201 through the connected shaft rod, so that the inside of the reaction kettle 201 is fully sterilized. Then, after turning off the high-temperature steam sterilization box 8, the water medium in the water tank chamber 202 can be heated by the electric heating wire 203 connected inside the water bath heater main body 2. The temperature sensor controls the stability of the temperature inside the water tank chamber 202. The heated heat energy is transferred to the reaction kettle 201 through the heat conduction plate 204, and the suitability of the temperature is confirmed through the display board 5 to ensure that the reaction solution maintains an accurate and appropriate temperature in the reaction kettle 201. At the same time, under the action of the servo motor 2 4, the stirring rod 205 connected to the electric telescopic rod 10 rotates, driving the rotation of the spiral stirring blade 206. According to needs, the stirring plate 202 and the spiral stirring blade 206 are pushed and pulled to different positions inside the reaction kettle 201 through the electric telescopic rod 10 to facilitate more uniform stirring.

[0025] The embodiments of the present utility model have been described in detail above in conjunction with the accompanying drawings. However, the present utility model is not limited to the above embodiments, and various changes can be made without departing from the gist of the present utility model within the scope of knowledge possessed by those of ordinary skill in the relevant art.

Claims

1. A water bath heating device for preparing sialic acid, characterized in that, Including: A water bath heater main body (2), the interior of the water bath heater main body (2) is composed of a reaction kettle (201), a water tank chamber (202), an electric heating wire (203), a heat conducting plate (204), a stirring rod (205), and a spiral stirring blade (206). The bottom surface of the water bath heater main body (2) is fixedly connected to a fixing frame (1). The side surface of the reaction kettle (201) is fixedly connected to a first gear (6) through a shaft rod penetrating one end of the water bath heater main body (2). The upper surface of the fixing frame (1) is fixedly connected to a first servo motor (3). The output end of the first servo motor (3) is fixedly connected to a second gear (7). The first gear (6) meshes with the second gear (7). One end of the fixing frame (1) away from the first servo motor (3) is fixedly connected to a second servo motor (4). The output end of the second servo motor (4) is fixedly connected to an electric telescopic rod (10). The output end of the electric telescopic rod (10) is fixedly connected to the stirring rod (205).

2. The water bath heating device for preparing sialic acid according to claim 1, wherein, The water tank chamber (202) is located between the heat conducting plate (204) and the inner wall of the water bath heater main body (2).

3. A water bath heating device for preparing sialic acid according to claim 1, characterized in that, The electric heating wire (203) is located inside the water tank chamber (202). The electric heating wire (203) is arranged in a spiral shape and is attached to the heat conducting plate (204).

4. A water bath heating device for preparing sialic acid according to claim 1, characterized in that, The upper surface of the fixing frame (1) is fixedly connected to a high-temperature steam sterilization box (8). The side surface of the high-temperature steam sterilization box (8) is fixedly connected to a delivery pipe (9).

5. A water bath heating device for preparing sialic acid according to claim 4, characterized in that, The other end of the delivery pipe (9) penetrates the water bath heater main body (2) and is communicated with the reaction kettle (201). The delivery pipe (9) is rotatably connected to both the water bath heater main body (2) and the reaction kettle (201).

6. A water bath heating device for preparing sialic acid according to claim 1, characterized in that, The side surface of the water bath heater main body (2) is fixedly connected to a temperature sensor. The upper surface of the fixing frame (1) is fixedly connected to a display board (5).

7. A water bath heating device for preparing sialic acid according to claim 1, characterized in that, The reaction kettle (201) is attached to and rotatably connected to the heat conducting plate (204). The end of the stirring rod (205) away from the electric telescopic rod (10) is fixedly connected to a spiral stirring blade (206).

Images