Disorder of consciousness detection awakening system fused with personalized multi-mode biological feedback stimulation

Abstract

The utility model discloses a disturbance of consciousness detecting and waking-up system fusing personalized multi-mode biological feedback stimulation, which comprises a detecting and evaluating module and a waking-up rehabilitation module, and an audio-visual body sensation stimulation generating unit is arranged in the detecting and evaluating module. One side of the audio-visual body sense stimulation generation unit is electrically connected with an audio-visual body sense stimulation unit; an evoked electroencephalogram acquisition unit is arranged in the detection and evaluation module, and the other end of the evoked electroencephalogram acquisition unit is electrically connected with an ERP-MMN extraction unit. By fusing multi-mode individuation and biofeedback thoughts to implement stimulation, the defects that existing disturbance of consciousness detection and evaluation are poor in accuracy and reliability, single in stimulation and awakening means and poor in dispersion effect can be overcome, intelligent integration of detection and evaluation and awakening rehabilitation is achieved, and development and application of a new generation of neural rehabilitation technology are powerfully promoted.

Description

Technical Field

[0001] The utility model relates to the field of biomedical engineering, and in particular to a consciousness disorder detection and awakening system integrating personalized multi-modal biofeedback stimulation. Background Art

[0002] In recent years, with the development of emergency and critical care medicine in my country, the mortality rate has dropped significantly, but the proportion of patients with impaired consciousness (such as coma, vegetative state, minimally conscious state, etc.) is getting higher and higher. Every year, there are 70,000 to 100,000 new patients with impaired consciousness, and each person costs 100,000 to 500,000 yuan for treatment and nursing. Such a large number of patients and huge expenses have brought a huge burden to families and society. In the face of the above situation, how to objectively and accurately evaluate the state and level of consciousness of patients with impaired consciousness and conduct effective awakening and rehabilitation is a major problem that needs to be solved urgently. In recent years, with the sharp increase in clinical treatment needs, the detection and evaluation of impaired consciousness and awakening and rehabilitation have developed rapidly. In addition to behavioral scales, neuroimaging technologies such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), neuroelectrophysiological technologies such as electroencephalogram (EEG), evoked potentials (EP), and event-related potentials (ERP), as well as neuromodulation technologies such as median nerve stimulation (MNS), (trigeminal nerve stimulation) TNS, transcutaneous direct current stimulation (tDCS), transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS), spinal cord stimulation (SCS), and deep brain stimulation (DBS) have also begun to be used in clinical practice, improving the objectivity, quantification, and evaluation of clinical diagnosis of consciousness disorders, and enhancing the ability to promote awakening and rehabilitation of consciousness disorders. Among the existing detection and awakening technologies, the stimulation represented by visual, auditory, and somatosensory perception can match the corresponding neural conduction pathways with the neural functions of the brain, and then the method of targeted induction and enhancement of the hidden consciousness expression function has shown good application potential. However, because consciousness is a high-level and complex psychological function, the consciousness-related neural function response is often difficult to capture or even ignored, and the recovery of consciousness is also very difficult. Existing stimulation methods use traditional repetitive stimulation standard patterns, which are difficult to induce good conscious responses and cannot achieve excellent rehabilitation effects. Utility Model Content

[0003] The utility model aims to provide a consciousness disorder detection and awakening system integrating personalized multimodal biofeedback stimulation, which solves the problems of low accuracy and reliability of existing consciousness disorder detection and evaluation, single and scattered awakening methods, and poor rehabilitation effect.

[0004] To achieve the above object, the present utility model adopts the following technical solutions. An awareness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation includes a detection and evaluation module and an arousal and rehabilitation module. An audio-visual somatosensory stimulation generation unit is provided inside the detection and evaluation module, and an audio-visual somatosensory stimulation unit is electrically connected to one side of the audio-visual somatosensory stimulation generation unit;

[0005] An evoked electroencephalogram acquisition unit is provided inside the detection and evaluation module, and an ERP-MMN extraction unit is electrically connected to one end of the evoked electroencephalogram acquisition unit.

[0006] As a further description of the above technical solution: A visual stimulation module is provided inside the audio-visual somatosensory stimulation unit, and an auditory stimulation module is provided on one side of the visual stimulation module.

[0007] As a further description of the above technical solution: A somatosensory stimulation module is provided at the other end of the auditory stimulation module, and an ERP-MMN wave amplitude weighted average module is electrically connected to one end of the ERP-MMN extraction unit.

[0008] As a further description of the above technical solution: A personalized multi-modal stimulation generation unit is provided inside the arousal and rehabilitation module, and the personalized multi-modal stimulation generation unit is electrically connected to the ERP-MMN extraction unit.

[0009] As a further description of the above technical solution: A personalized audio-visual stimulation unit is electrically connected to one side of the personalized multi-modal stimulation generation unit, and a multi-channel electrical stimulation unit is provided at one end of the personalized audio-visual stimulation unit.

[0010] As a further description of the above technical solution: A temperature stimulation unit is provided on one side of the multi-channel electrical stimulation unit, and a mechanical stimulation unit is provided at the other end of the temperature stimulation unit.

[0011] As a further description of the above technical solution: A physiological behavior signal monitoring unit is provided at the other end of the mechanical stimulation unit, a monitoring data analysis and processing unit is provided at the other end of the physiological behavior signal monitoring unit, and the monitoring data analysis and processing unit is electrically connected to the personalized multi-modal stimulation generation unit at the other end.

[0012] The present utility model has the following beneficial effects:

[0013] 1. Compared with the prior art, the awareness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation can overcome the defects of poor accuracy and reliability in the existing awareness disorder detection and evaluation, and single and scattered stimulation and arousal means with poor effects by integrating multi-modal personalization and biofeedback ideas, realize the integration of detection evaluation and arousal rehabilitation wisdom, and strongly promote the development and application of a new generation of neurorehabilitation technologies;

[0014] 2. Compared with the prior art, the consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation selects the most valuable ERP-MMN mismatch negativity for consciousness disorder assessment, proposes a multi-modal audiovisual somatosensory combined stimulation to enhance the evoked EPR-MMN wave, and provides a new method for comprehensively evaluating consciousness from multiple angles. It can more accurately reflect the degree of consciousness of the brain and provide a more accurate and reliable basis for the subsequent treatment of consciousness disorders.

[0015] 3. Compared with the prior art, the consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation combines personalized audiovisual stimulation, peripheral-central multi-channel electrical stimulation, and temperature and mechanical stimulation of somatosensory stimulation, and uses the method of multi-physiological and behavioral parameter monitoring and feedback for arousal. It is more conducive to causing strong consciousness and behavioral responses in patients with consciousness disorders, and is expected to become a reasonable and effective new arousal rehabilitation program, promoting the development of neurorehabilitation towards the intelligent direction.

[0016] The additional aspects and advantages of the present utility model will be partially given in the following description, partially become obvious from the following description, or be understood through the practice of the present utility model. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present utility model will be further described below in conjunction with the drawings and embodiments;

[0018] Figure 1 is a schematic diagram of the overall structure of the consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation of the present utility model;

[0019] Figure 2 is a schematic diagram of the detection and evaluation module of the consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation of the present utility model.

[0020] LEGEND DESCRIPTION:

[0021] 1. Detection and evaluation module; 2. Audiovisual somatosensory stimulation unit; 3. Human body; 4. Evoked electroencephalogram acquisition unit; 5. Personalized audiovisual stimulation unit; 6. Multi-channel electrical stimulation unit; 7. Temperature stimulation unit; 8. Mechanical stimulation unit; 9. Physiological and behavioral signal monitoring unit; 10. Monitoring data analysis and processing unit; 11. Personalized multi-modal stimulation generation unit; 12. Arousal rehabilitation module; 13. ERP-MMN extraction unit; 14. Audiovisual somatosensory stimulation production unit; 15. Visual stimulation module; 16. Auditory stimulation module; 17. Somatosensory stimulation module; 18. ERP-MMN wave amplitude weighted average module. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0022] This section will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the accompanying drawings. The function of the accompanying drawings is to supplement the description of the text part of the specification, enabling people to intuitively and vividly understand each technical feature and the overall technical solution of the present utility model. However, it should not be construed as a limitation on the protection scope of the present utility model.

[0023] Referring to Figure 1-2 , an embodiment provided by the present utility model, a consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation, includes a human detection and evaluation module 1 and an arousal rehabilitation module 12, and is used for the detection of the human body 3. An audio-visual somatosensory stimulation generation unit 14 is arranged inside the detection and evaluation module 1. One side of the audio-visual somatosensory stimulation generation unit 14 is electrically connected to an audio-visual somatosensory stimulation unit 2. In order to detect visual, auditory, and somatosensory ERP-MMN waves, an audio-visual somatosensory Oddball novel stimulation mode is designed respectively. Among them, the visual stimulus target stimulus adopts a star and moon pattern, and the non-target stimulus adopts a gossip pattern; the auditory stimulus target stimulus adopts a 1KHz short pure tone, and the non-target stimulus adopts a 2KHz short pure tone; the somatosensory stimulus adopts ipsilateral electrical pulse stimulation, the target stimulus frequency is 100Hz, and the non-target stimulus frequency is 250Hz. Each kind of stimulus constitutes a stimulus sequence with a random order according to a ratio of 5:1;

[0024] An evoked electroencephalogram acquisition unit 4 is arranged inside the detection and evaluation module 1. One end of the evoked electroencephalogram acquisition unit 4 is electrically connected to an ERP-MMN extraction unit 13. A visual stimulus module 15 is arranged inside the audio-visual somatosensory stimulation unit 2. An auditory stimulus module 16 is arranged on one side of the visual stimulus module 15. The other end of the auditory stimulus module 16 is provided with a somatosensory stimulus module 17. And one end of the ERP-MMN extraction unit 13 is electrically connected to an ERP-MMN wave amplitude weighted average module 18. For stimulus and data acquisition, the audio-visual somatosensory stimulation generator controls the audio-visual somatosensory stimulator to emit stimuli according to the set stimulus mode, sequence, and presentation method. The evoked electroencephalogram acquisition unit amplifies and filters the evoked electroencephalogram signals after the audio-visual somatosensory stimulation, and samples through an AD converter. In order to extract the ERP-MMN signal, the phase-locked superposition averaging method is used to extract the audio-visual somatosensory ERP signals respectively, and then the amplitudes of the audio-visual somatosensory ERP-MMN waves and the weighted average of the three amplitudes are calculated respectively;

[0025] The internal part of the arousal and rehabilitation module 12 is provided with a personalized multimodal stimulus generation unit 11, and the personalized multimodal stimulus generation unit 11 is electrically connected to the ERP-MMN extraction unit 13. According to the detection and evaluation results, based on the idea of multimodal personalization and biofeedback, a personalized, multimodal, feedback arousal stimulus rehabilitation plan is designed to apply personalized visual and auditory stimuli, multi-channel electrical stimuli, temperature stimuli, and mechanical stimuli to the patient. Through multimodal and multisensory stimuli, the rehabilitation effect is enhanced. At the same time, during the stimulation and arousal process, signals such as human electroencephalogram, electrocardiogram, skin electricity, respiration, eye movement, and body movement are monitored. According to the analysis of the monitored signals, the stimulation mode and stimulation parameters are feedback-regulated to further enhance the rehabilitation effect through feedback;

[0026] One side of the personalized multimodal stimulus generation unit 11 is electrically connected to a personalized visual and auditory stimulus unit 5. One end of the personalized visual and auditory stimulus unit 5 is provided with a multi-channel electrical stimulus unit 6. One side of the multi-channel electrical stimulus unit 6 is provided with a temperature stimulus unit 7. The other end of the temperature stimulus unit 7 is provided with a mechanical stimulus unit 8. The other end of the mechanical stimulus unit 8 is provided with a physiological behavior signal monitoring unit 9. Based on the comprehensive evaluation results of the patient's ERP-MMN for consciousness disorder, the consciousness scale score, and the most favorite and memorable people, things, and materials of the patient, a multimodal and personalized stimulus plan is formulated. The personalized visual and auditory stimulus unit 5, according to the principles of neurocognitive psychology, screens the people, things, and events that the consciousness disorder patients like the most and remember the most deeply to establish a multimedia database, and applies stimuli through a combination of sounds, pictures, videos, etc. The multi-channel electrical stimulus unit 6, according to the principles of neurology, applies stimuli to the median nerve, trigeminal nerve, vagus nerve, and cerebral cortex respectively through a multi-channel electrical stimulation circuit to achieve all-round neural regulation from the periphery to the center. Among them, the median nerve, trigeminal nerve, and vagus nerve adopt transcutaneous pulsed electrical stimulation, and the cerebral cortex adopts transcranial direct current stimulation. The temperature stimulus unit 7 generates a pulsed temperature source through a voltage temperature control circuit to stimulate the temperature-sensitive part of the patient's instep, and at the same time, the body movement sensor detects the response of the instep to the temperature stimulus. The mechanical stimulus unit 8 stimulates the itchy-sensitive part of the patient's sole through an electronically controlled roller, and at the same time, the body movement sensor detects the response of the sole to the mechanical stimulus. The above visual, auditory, electrical, temperature, and mechanical stimuli are jointly controlled by the personalized multimodal stimulus generation unit;

[0027] At the other end of the physiological behavior signal monitoring unit 9, a monitoring data analysis and processing unit 10 is provided, and the other end of the monitoring data analysis and processing unit 10 is electrically connected to the personalized multi-modal stimulus generation unit 11. During the stimulation and arousal process, the physiological behavior signal monitoring unit monitors physiological and behavioral signals related to stimulus consciousness responses such as electroencephalogram, electrocardiogram, galvanic skin response, respiration, eye movement, and body movement. The monitoring data analysis and processing unit performs fusion analysis on the monitored data and adjusts the stimulation mode and stimulation parameters, such as the mode, content, frequency, and time of audiovisual stimulus playback, and the mode, waveform, intensity, frequency, and time of electro-temperature-mechanical stimulation.

[0028] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the scope of knowledge possessed by those of ordinary skill in the art.

Claims

1. A consciousness disorder detection and arousal promotion system integrating personalized multimodal biofeedback stimulation, characterized in that It includes a detection and evaluation module (1) and a arousal and rehabilitation module (12). An audio-visual-somatosensory stimulation generation unit (14) is arranged inside the detection and evaluation module (1), and an audio-visual-somatosensory stimulation unit (2) is electrically connected to one side of the audio-visual-somatosensory stimulation generation unit (14). An evoked EEG acquisition unit (4) is arranged inside the detection and evaluation module (1), and an ERP-MMN extraction unit (13) is electrically connected to one end of the evoked EEG acquisition unit (4).

2. The consciousness disorder detection and arousal promotion system integrating personalized multimodal biofeedback stimulation according to claim 1, wherein A visual stimulation module (15) is arranged inside the audio-visual-somatosensory stimulation unit (2), and an auditory stimulation module (16) is arranged on one side of the visual stimulation module (15).

3. The consciousness disorder detection and arousal promotion system integrating personalized multimodal biofeedback stimulation according to claim 2, characterized in that Another somatosensory stimulation module (17) is arranged at the other end of the auditory stimulation module (16), and an ERP-MMN wave amplitude weighted average module (18) is electrically connected to one end of the ERP-MMN extraction unit (13).

4. The consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation according to claim 1, characterized in that, A personalized multi-modal stimulation generation unit (11) is arranged inside the arousal and rehabilitation module (12), and the personalized multi-modal stimulation generation unit (11) is electrically connected to the ERP-MMN extraction unit (13).

5. The awareness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation according to claim 4, characterized in that, A personalized audio-visual stimulation unit (5) is electrically connected to one side of the personalized multi-modal stimulation generation unit (11), and a multi-channel electrical stimulation unit (6) is arranged at one end of the personalized audio-visual stimulation unit (5).

6. The consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation according to claim 5, wherein, A temperature stimulation unit (7) is arranged on one side of the multi-channel electrical stimulation unit (6), and a mechanical stimulation unit (8) is arranged at the other end of the temperature stimulation unit (7).

7. The consciousness disorder detection and arousal promotion system integrating personalized multi-modal biofeedback stimulation according to claim 6, characterized in that, A physiological behavior signal monitoring unit (9) is arranged at the other end of the mechanical stimulation unit (8), a monitoring data analysis and processing unit (10) is arranged at the other end of the physiological behavior signal monitoring unit (9), and the monitoring data analysis and processing unit (10) is electrically connected to the personalized multi-modal stimulation generation unit (11) at the other end.

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