Biological sample cryopreservation device

Abstract

The application provides a biological sample cryopreservation device, comprising: a cavity defining an accommodating cavity; at least part of the first rotating shaft is arranged in the containing cavity, the first rotating shaft is a tubular rotating shaft with a tubular cavity, the first rotating shaft is connected with the at least one first cryopreservation frame so as to drive the at least one first cryopreservation frame to rotate, and the at least one first cryopreservation frame is arranged in the containing cavity; at least part of the second rotating shaft is arranged in the containing cavity, the second rotating shaft is provided with a first shaft section arranged in the pipe cavity and a second shaft section connected with the first shaft section and arranged outside the pipe cavity, the second shaft section is connected with the at least one second cryopreservation frame so as to drive the at least one second cryopreservation frame to rotate, and the at least one second cryopreservation frame is arranged in the containing cavity. When a biological sample is directly taken from the side part of the cryopreservation rack, the energy consumption is reduced, and when the cryopreservation rack is lifted for storing and taking the biological sample, a larger space does not need to be reserved above the cryopreservation rack.

Description

Technical Field

[0001] The present application relates to the technical field of biological sample cryopreservation, and particularly to a biological sample cryopreservation device. Background Art

[0002] With the rapid development of the biomedical industry, large-scale biological sample banks have emerged, and the storage volume of biological samples has become larger and larger. Generally, biological samples such as tissues and cells in clinics or laboratories are stored in a biological sample cryopreservation device. However, in related technologies, only one cryopreservation rack is arranged axially on the rotating shaft of the biological sample cryopreservation device, and the rotating shaft drives the cryopreservation rack to rotate for sampling biological samples. When directly taking biological samples from the side of the cryopreservation rack, the overall moving method has high energy consumption. When lifting the cryopreservation rack for accessing biological samples, sufficient space needs to be reserved above. Utility Model Content

[0003] In view of the above problems, the present application is proposed to provide a biological sample cryopreservation device that overcomes the above problems or at least partially solves the above problems.

[0004] The present application provides a biological sample cryopreservation device, including: a cavity that defines an accommodation cavity; a first rotating shaft, at least partially disposed in the accommodation cavity, the first rotating shaft being a tubular rotating shaft having a lumen, the first rotating shaft connecting at least one first cryopreservation rack to drive the at least one first cryopreservation rack to rotate, the at least one first cryopreservation rack being disposed in the accommodation cavity; a second rotating shaft, at least partially disposed in the accommodation cavity, the second rotating shaft having a first shaft segment disposed in the lumen and a second shaft segment connected to the first shaft segment and disposed outside the lumen, the second shaft segment connecting at least one second cryopreservation rack to drive the at least one second cryopreservation rack to rotate, the at least one second cryopreservation rack being disposed in the accommodation cavity.

[0005] Optionally, the biological sample cryopreservation device further includes: a driving assembly, disposed outside the accommodation cavity, for driving the first rotating shaft and / or the second rotating shaft to rotate.

[0006] Optionally, the upper end of the first rotating shaft and / or the second rotating shaft extends out of the accommodation cavity to be connected to the driving assembly, so that the driving assembly drives the first rotating shaft and / or the second rotating shaft to rotate, and the second shaft segment is located below the first shaft segment.

[0007] Optionally, the accommodation cavity has a top opening, and the biological sample cryopreservation device further includes a lifting mechanism for lifting the first cryopreservation rack and the second cryopreservation rack from the top opening.

[0008] Optionally, the at least one first cryopreservation rack is located above the at least one second cryopreservation rack, and there is a passage between at least two adjacent first cryopreservation racks for the second cryopreservation rack to transfer between below the at least one first cryopreservation rack and the top opening.

[0009] Optionally, the first rotating shaft is fixedly connected to a first frame that defines a plurality of first placement positions for placing the first cryopreservation rack. The first rotating shaft drives the first frame to rotate, thereby driving the rotation of the at least one first cryopreservation rack.

[0010] Optionally, the second rotating shaft is fixedly connected to a second frame that defines a plurality of second placement positions for placing the second cryopreservation rack. The second rotating shaft drives the second frame to rotate, thereby driving the rotation of the at least one second cryopreservation rack.

[0011] Optionally, the cavity includes an outer shell and an inner container disposed within the outer shell, and the inner container defines the accommodation cavity.

[0012] Optionally, a heat insulation device is filled or a vacuum is provided between the outer shell and the inner container.

[0013] Optionally, the height of the first cryopreservation rack is equal to the height of the second cryopreservation rack.

[0014] By improving the rotating shaft assembly, the biological sample cryopreservation device provided in this application enables different cryopreservation racks (the first cryopreservation rack and the second cryopreservation rack, which is equivalent to dividing a cryopreservation rack arranged along the axis in the related art into the first cryopreservation rack and the second cryopreservation rack) arranged along the axis to rotate separately. When directly taking biological samples from the side of the cryopreservation rack, it is not necessary for all the cryopreservation racks arranged along the axis to rotate. Only the first cryopreservation rack or the second cryopreservation rack needs to rotate, thereby reducing energy consumption. When lifting the cryopreservation rack for access to biological samples, there is no need to reserve a large space above (the related art needs to reserve the height of a cryopreservation rack arranged along the axis, while the solution of this application only needs to reserve the height of the higher one of the first cryopreservation rack and the second cryopreservation rack). BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Other objects and advantages of the present application will become apparent and help to provide a comprehensive understanding of the present application through the description of the present application with reference to the accompanying drawings below.

[0016] Figure 1 is a schematic structural diagram of a biological sample cryopreservation device according to some embodiments of the present application;

[0017] Figure 2 is a cross-sectional view of a biological sample cryopreservation device according to some embodiments of the present application;

[0018] Figure 3 It is a schematic structural diagram of a first rotating shaft and a second rotating shaft of a biological sample freezing device according to some embodiments of the present application;

[0019] Figure 4 It is a cross-sectional view of a first rotating shaft and a second rotating shaft of a biological sample freezing device according to some embodiments of the present application.

[0020] In the figure, 10 is a biological sample freezing device, 100 is a cavity, 110 is a receiving cavity, 111 is a top opening, 200 is a first rotating shaft, 300 is a first freezing rack, 400 is a second rotating shaft, 500 is a second freezing rack, 600 is a first frame, and 700 is a second frame. Detailed implementation manners

[0021] To make the objectives, technical solutions, and advantages of the present application clearer, the technical solutions of the present application will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only one embodiment of the present application, rather than all embodiments. Based on the described embodiments of the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0022] Unless otherwise defined, the technical terms or scientific terms used in the present application shall have the ordinary meanings understood by those of ordinary skill in the art to which the present application belongs.

[0023] This embodiment provides a biological sample freezing device 10, and the biological sample freezing device 10 includes a cavity 100, a first rotating shaft 200, and a second rotating shaft 400. Figure 1 It is a schematic structural diagram of the biological sample freezing device 10 according to some embodiments of the present application; Figure 2 It is a cross-sectional view of the biological sample freezing device 10 according to some embodiments of the present application; Figure 3 It is a schematic structural diagram of the first rotating shaft 200 and the second rotating shaft 400 of the biological sample freezing device 10 according to some embodiments of the present application; Figure 4 It is a cross-sectional view of the first rotating shaft 200 and the second rotating shaft 400 of the biological sample freezing device 10 according to some embodiments of the present application.

[0024] The cavity 100 defines a receiving cavity 110. The first rotating shaft 200 is at least partially disposed in the receiving cavity 110. The first rotating shaft 200 is a tubular rotating shaft having a lumen. The first rotating shaft 200 is connected to at least one first cryopreservation rack 300 to drive the at least one first cryopreservation rack 300 to rotate. The at least one first cryopreservation rack 300 is disposed in the receiving cavity 110. The second rotating shaft 400 is at least partially disposed in the receiving cavity 110. The second rotating shaft 400 has a first shaft section disposed in the lumen and a second shaft section connected to the first shaft section and disposed outside the lumen. The second shaft section is connected to at least one second cryopreservation rack 500 to drive the at least one second cryopreservation rack 500 to rotate. The at least one second cryopreservation rack 500 is disposed in the receiving cavity 110.

[0025] Wherein, the biological sample cryopreservation device 10 can be a refrigerator, a cold storage, a freezer, a storage device including a liquid nitrogen tank, etc. Correspondingly, the cavity 100 can be a box body, a library body, a cabinet body, a tank body, etc.

[0026] In some embodiments, the receiving cavity 110 has a side opening. The first cryopreservation rack 300 and the second cryopreservation rack 500 are rotated to the position of the side opening to perform sampling of biological samples. The first cryopreservation rack 300 and the second cryopreservation rack 500 can hold a plurality of cryopreservation boxes. The cryopreservation boxes are used to hold biological samples. Specifically, the biological samples can be placed in the cryopreservation boxes in the form of cryopreservation tubes or cryopreservation bags, that is, the biological samples are placed in the cryopreservation tubes or cryopreservation bags, and the cryopreservation tubes or cryopreservation bags are placed in the cryopreservation boxes. When taking and placing the biological samples on the first cryopreservation rack 300, only the first rotating shaft 200 needs to drive all the first cryopreservation racks 300 to rotate, and the second rotating shaft 400 does not need to rotate. When taking and placing the biological samples on the second cryopreservation rack 500, only the second rotating shaft 400 needs to drive all the second cryopreservation racks 500 to rotate, and the first rotating shaft 200 does not need to rotate. Thereby, the energy consumption can be reduced.

[0027] When the cryopreservation rack is lifted for access to biological samples, since the cryopreservation racks in the axial direction are changed to include the first cryopreservation rack 300 and the second cryopreservation rack 500, only the height of the higher one of the first cryopreservation rack 300 and the second cryopreservation rack 500 needs to be reserved above, saving space and improving the space utilization rate. Moreover, the first cryopreservation rack 300 and the second cryopreservation rack 500 rotate separately, which is convenient for access to biological samples (for example, when the receiving cavity 110 has a top opening 111 and the first cryopreservation rack 300 is located above the second cryopreservation rack 500, the rotation of the first cryopreservation rack 300 can provide a moving path for the second cryopreservation rack 500, avoiding interference caused by the first cryopreservation rack 300 to the movement of the second cryopreservation rack 500).

[0028] The biological sample freezing device 10 provided in this embodiment improves the rotating shaft assembly, so that different freezing racks arranged along the axial direction (the first freezing rack 300 and the second freezing rack 500, which is equivalent to dividing a freezing rack arranged along the axial direction in the related art into the first freezing rack 300 and the second freezing rack 500) can rotate separately. When directly taking biological samples from the side of the freezing rack, it is not necessary for all the freezing racks arranged along the axial direction to rotate. Only the first freezing rack 300 or the second freezing rack 500 needs to rotate, thereby reducing energy consumption. When lifting the freezing rack for access to biological samples, there is no need to reserve a large space above (the related art needs to reserve the height of a freezing rack arranged along the axial direction, while the solution of this application only needs to reserve the height of the higher one of the first freezing rack 300 and the second freezing rack 500).

[0029] In some embodiments, the biological sample freezing device 10 may further include a driving assembly, which is arranged outside the accommodation cavity 110 and is used to drive the first rotating shaft 200 and / or the second rotating shaft 400 to rotate.

[0030] For example, the driving assembly may include a first gear and / or a second gear, and a first motor and a second motor. The first gear is connected to the first rotating shaft 200 and the first motor, so that the first motor drives the first rotating shaft 200 to rotate through the first gear. The second gear is connected to the second rotating shaft 400 and the second motor, so that the second motor drives the second rotating shaft 400 to rotate through the second gear. Since the method of driving the rotating shaft to rotate is easy for those skilled in the art to implement, it will not be elaborated here.

[0031] By arranging the driving assembly outside the accommodation cavity 110, it is possible to avoid the influence of low temperature on the driving assembly and avoid the influence of the temperature generated by the driving assembly on biological samples.

[0032] In some embodiments, the upper ends of the first rotating shaft 200 and / or the second rotating shaft 400 extend out of the accommodation cavity 110 to be connected to the driving assembly, so that the driving assembly drives the first rotating shaft 200 and / or the second rotating shaft 400 to rotate. The second shaft segment is located below the first shaft segment. The upper ends of the first rotating shaft 200 and / or the second rotating shaft 400 extending out of the accommodation cavity 110 facilitate installation and maintenance.

[0033] In some embodiments, the accommodation cavity 110 has a top opening 111, and the biological sample freezing device 10 further includes a lifting mechanism for lifting the first freezing rack 300 and the second freezing rack 500 from the top opening 111. The provision of the lifting mechanism improves the automation level of the biological sample freezing device 10. Specifically, the lifting mechanism can lift the first freezing rack 300 and the second freezing rack 500 in various ways such as by clamping jaws, hooks, etc.

[0034] In some embodiments, at least one first freezing rack 300 is located above at least one second freezing rack 500, and there is a passage between at least two adjacent first freezing racks 300 for the second freezing rack 500 to transfer between below the at least one first freezing rack 300 and the top opening 111.

[0035] It can be understood that there can be multiple first freezing racks 300 and / or second freezing racks 500, thereby increasing the storage capacity.

[0036] In some embodiments, the first rotating shaft 200 is fixedly connected to the first frame 600 which defines a plurality of first placement positions for placing the first freezing rack 300. The first rotating shaft 200 drives the first frame 600 to rotate, thereby driving the at least one first freezing rack 300 to rotate. The first frame 600 can play roles such as limiting and guiding the first freezing rack 300.

[0037] In some embodiments, the second rotating shaft 400 is fixedly connected to the second frame 700 which defines a plurality of second placement positions for placing the second freezing rack 500. The second rotating shaft 400 drives the second frame 700 to rotate, thereby driving the at least one second freezing rack 500 to rotate. The second frame 700 can play roles such as limiting and guiding the second freezing rack 500.

[0038] In some embodiments, the cavity 100 includes an outer shell and an inner container disposed within the outer shell, and the inner container defines the accommodation cavity 110. Wherein, a heat insulation device is filled or a vacuum is provided between the outer shell and the inner container, thereby improving the heat insulation effect of the biological sample freezing device 10.

[0039] In some embodiments, the height of the first freezing rack 300 is equal to the height of the second freezing rack 500, thereby reducing the reserved space above and further improving the space utilization rate.

[0040] For the embodiments of the present application, it should also be noted that, without conflict, the embodiments of the present application and the features in the embodiments can be combined with each other to obtain new embodiments.

[0041] The above is only the specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. The protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A biological sample cryopreservation device, characterized in that, Comprising: A cavity that defines a receiving cavity; A first rotating shaft, at least partially disposed in the receiving cavity. The first rotating shaft is a tubular rotating shaft having a lumen. The first rotating shaft is connected to at least one first cryopreservation rack to drive the at least one first cryopreservation rack to rotate, and the at least one first cryopreservation rack is disposed in the receiving cavity; A second rotating shaft, at least partially disposed in the receiving cavity. The second rotating shaft has a first shaft section disposed in the lumen and a second shaft section connected to the first shaft section and disposed outside the lumen. The second shaft section is connected to at least one second cryopreservation rack to drive the at least one second cryopreservation rack to rotate, and the at least one second cryopreservation rack is disposed in the receiving cavity.

2. The biological sample freezing device according to claim 1, wherein Further comprising: A driving assembly, disposed outside the receiving cavity, for driving the first rotating shaft and / or the second rotating shaft to rotate.

3. The biological sample cryopreservation device according to claim 2, wherein The upper end of the first rotating shaft and / or the second rotating shaft extends out of the receiving cavity to be connected to the driving assembly, so that the driving assembly drives the first rotating shaft and / or the second rotating shaft to rotate, and the second shaft section is located below the first shaft section.

4. The biological sample cryopreservation device according to claim 1, wherein The receiving cavity has a top opening, and the biological sample cryopreservation device further comprises a lifting mechanism for lifting the first cryopreservation rack and the second cryopreservation rack from the top opening.

5. The biological sample cryopreservation device according to claim 4, wherein The at least one first cryopreservation rack is located above the at least one second cryopreservation rack, and there is a passage between at least two adjacent first cryopreservation racks for the second cryopreservation rack to transfer between below the at least one first cryopreservation rack and the top opening.

6. The biological sample cryopreservation device according to claim 1, wherein The first rotating shaft is fixedly connected to a first frame that defines a plurality of first placement positions for placing the first cryopreservation rack. The first rotating shaft drives the first frame to rotate, thereby driving the at least one first cryopreservation rack to rotate.

7. The biological sample cryopreservation device according to claim 1, wherein The second rotating shaft is fixedly connected to a second frame that defines a plurality of second placement positions for placing the second cryopreservation rack. The second rotating shaft drives the second frame to rotate, thereby driving the at least one second cryopreservation rack to rotate.

8. The biological sample cryopreservation device according to claim 1, wherein The cavity includes an outer shell and an inner liner disposed inside the outer shell, and the inner liner defines the receiving cavity.

9. The biological sample cryopreservation device according to claim 8, wherein A heat preservation device or a vacuum setting is filled between the outer shell and the inner liner.

10. The biological sample cryopreservation device according to claim 1, wherein The height of the first cryopreservation rack is equal to the height of the second cryopreservation rack.

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