Electrophysiological detection experiment device
By designing an electrophysiological detection device with fixed plates and limit spaces, the problem of EMG wire moving during animal physiological activities is solved, and the smooth progress of the experiment and animal protection is achieved.
Patent Information
- Application Number
- CN202421897715.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-07
- Publication Date
- 2025-07-29
- Estimated Expiration
- 2034-08-07
AI Technical Summary
EMG wires are easily moved during the physiological activities of animals, which leads to the inability to conduct experiments normally and damages the animals.
An electrophysiological detection experimental device including a fixing plate, a first fixing block and a second fixing block is designed to fix the wire through a limiting space to prevent it from moving during the physiological activities of the animal.
Effectively fix the wires, ensure that the experiment is carried out normally, and protect the animals from internal organ damage.
Smart Images
Figure CN223158378U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of experimental equipment, and in particular relates to an electrophysiological detection experimental device. Background Art
[0002] The measurement of visceral sensitivity in animals is primarily based on brainstem reflexes, which are described as pseudo-emotional responses. Visceromotor responses are recorded by quantifying the reflex contractions of the abdominal musculature induced by colorectal distension (CRD). The visceromotor response (VMR) is an important parameter in experimental animal models of visceral pain. Experimental procedures typically require the use of a BIOPAC / MP160 16-channel physiology instrument, an animal respiratory anesthesia machine, and electromyography (EMG) leads. These leads are typically inserted through the animal's neck and exit through the abdomen. During the experiment, the animal's physiological activity can easily cause the EMG leads to dislodge, potentially injuring the animal and affecting the experimental data, making the experiment inconvenient. Utility Model Content
[0003] The purpose of the embodiments of the present application is to provide an electrophysiological detection experimental device to solve the technical problem in the prior art that the EMG wires easily move with the animals, resulting in the inability to conduct the experiment normally.
[0004] To achieve the above objectives, the technical solution adopted in this application is to provide an electrophysiological detection experimental device, comprising:
[0005] a first fixing assembly, the first fixing assembly comprising a fixing plate, the fixing plate being worn on the neck of the animal;
[0006] a second fixing assembly, the second fixing assembly comprising a first fixing block, a second fixing block and a limiting space, the first fixing block being mounted on the fixing plate, the second fixing block being detachably mounted on an end of the first fixing block away from the animal's neck, and enclosing the second fixing block and the first fixing block to form the limiting space;
[0007] The guide wire includes a puncture section and a fixed head, the puncture section is inserted into the first fixed block, the fixed head is connected to one end of the puncture section and is limited in the limited space.
[0008] Optionally, a first limiting groove is formed at one end of the first fixing block close to the second fixing block; a second limiting groove is formed at one end of the second fixing block close to the first fixing block, and the second limiting groove and the first limiting groove together form the limiting space.
[0009] Optionally, the first fixing block is further provided with a first avoidance hole, and the first avoidance hole communicates with the limiting space; the second fixing block is further provided with a second avoidance hole, and the second avoidance hole communicates with the limiting space.
[0010] Optionally, the fixing plate includes a first plate body, two second plate bodies and two third plate bodies. The two second plate bodies are respectively connected to two ends of the first plate body, and the two third plate bodies are respectively connected to one ends of the two second plate bodies far away from the first plate body.
[0011] Optionally, the second plate body is provided with a hinge hole and a plurality of threaded holes. The plurality of threaded holes are distributed at intervals along the circumferential direction around the axis of the hinge hole; the first fixing block is further provided with a counterbore; the second fixing assembly further includes two hinge shafts and fastening screws. The two hinge shafts are both connected to the first fixing block and are respectively arranged in one-to-one correspondence with the two hinge holes, and the fastening screw is screwed into any one of the threaded holes.
[0012] Optionally, the first fixing block includes a block body and an internal thread sleeve. The internal thread sleeve is connected to one end of the block body close to the second fixing block and can be screwed with the second fixing block.
[0013] Optionally, the third plate body is arranged as an arc-shaped plate.
[0014] Optionally, the first fixing assembly further includes two fixing belts, and the two fixing belts are respectively passed through two ends of the fixing plate.
[0015] Optionally, the fixing belt includes a belt body, a plurality of fixing holes and a fixing buckle. The plurality of fixing holes are all opened on the belt body and are arranged at intervals. The fixing buckle is installed at one end of the belt body and is detachably installed in any one of the fixing holes.
[0016] Optionally, the fixing belt further includes a through hole, and the through hole is opened at one end of the belt body far away from the fixing buckle.
[0017] The beneficial effects of the electrophysiological detection experimental device provided by the present application are as follows:
[0018] For the electrophysiological detection experimental device provided by the embodiment of the present application, through the limiting space formed by the enclosure of the first fixing block and the second fixing block, after the puncture section is implanted into the animal body, the fixing head can be limited. With the cooperation of the fixing plate, it can prevent the wire from moving along with the physiological activities of the animal, facilitating the wire to collect data and facilitating the normal progress of the experiment. Moreover, it can also prevent the wire from moving along with the physiological activities of the animal from causing damage to the internal organs of the animal, and can effectively protect the animal. Description of the Drawings
[0019] To more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.
[0020] Figure 1 A perspective view of the electrophysiological detection experimental device provided by the embodiment of the present application;
[0021] Figure 2 An internal structure perspective view of the electrophysiological detection experimental device provided by the embodiment of the present application;
[0022] Figure 3 is Figure 2 A partial enlarged view of part A in
[0023] Among them, the reference numerals in the figure are as follows:
[0024] 1. First fixing component; 11. Fixing plate; 111. First plate body; 112. Second plate body; 113. Third plate body; 114. Hinge hole; 115. Threaded hole; 12. Fixing belt; 121. Belt body; 122. Fixing hole; 123. Fixing buckle; 124. Through hole;
[0025] 2. Second fixing component; 21. First fixing block; 211. First limiting groove; 212. First avoiding hole; 213. Counterbore; 214. Block body; 215. Internal thread sleeve; 216. Hinge shaft; 22. Second fixing block; 23. Limiting space; 24. Second limiting groove; 25. Fastening screw; 26. Second avoiding hole;
[0026] 3. Wire; 31. Puncture section; 32. Fixing head. Detailed implementation manners
[0027] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present application clearer, the present application will be further described in detail below with reference to the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.
[0028] It should be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.
[0029] It should be understood that the orientation or positional relationship indicated by terms such as "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the present application.
[0030] In addition, the terms "first" and "second" are only used for descriptive purposes and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present application, the meaning of "a plurality" is two or more, unless otherwise specifically defined.
[0031] Based on this, the present utility model provides an electrophysiological detection experimental device. After the wire 3 is implanted into an animal body, this experimental device can prevent the wire 3 from moving, facilitating the experiment, and can effectively protect the animal.
[0032] As Figures 1 to 3 shown, an embodiment of the present application provides an electrophysiological detection experimental device, including a first fixing component 1, a second fixing component 2, and a wire 3. The first fixing component 1 includes a fixing plate 11, and the fixing plate 11 is worn around the neck of the animal. The second fixing component 2 includes a first fixing block 21, a second fixing block 22, and a limiting space 23. The first fixing block 21 is installed on the fixing plate 11, and the second fixing block 22 is detachably installed at one end of the first fixing block 21 away from the neck of the animal and encloses the limiting space 23 with the first fixing block 21. The wire 3 includes a puncture segment 31 and a fixing head 32. The puncture segment 31 penetrates through the first fixing block 21, and the fixing head 32 is connected to one end of the puncture segment 31 and is limited within the limiting space 23.
[0033] It should be noted here that in this embodiment, the wire 3 is taken as an example of silver wire for illustration. Of course, in other embodiments, according to actual application requirements, the wire 3 can also be set as copper wire... other materials, and no unique limitation is made here.
[0034] It should also be noted here that in this embodiment, the animal is taken as an example of a mouse for illustration. Of course, in other embodiments, according to actual application requirements, the animal can also be set as other species, and no unique limitation is made here.
[0035] Specifically, when using this device, first wear the fixing plate 11 around the neck of the mouse, and align the first fixing block 21 with the neck of the mouse to implant the wire 3 into the mouse's body from the neck of the mouse. During this process, the puncture section 31 passes through the first fixing block 21, penetrates from the neck of the mouse, and exits from the abdomen of the mouse until the fixing head 32 is limited in the first fixing block 21. Install the second fixing block 22 on the first fixing block 21, and limit the fixing head 32 through the limiting space 23 formed by enclosing with the first fixing block 21.
[0036] More specifically, in the related art, experimenters usually set fixing heads 32 at both ends of the puncture section 31 to prevent the wire 3 from moving. In the actual application process, when disassembling the wire 3, it is necessary to first disassemble one end of the puncture section 31, and this action easily causes the puncture section 31 to deform. When removing the puncture section 31 from the mouse's body, the deformed part of the puncture section 31 is likely to scratch the internal organs of the mouse, and thus it is easy to cause the death of the mouse. Therefore, in this embodiment, only one end of the puncture section 31 is provided with a fixing head 32.
[0037] The electrophysiological detection experimental device provided by the present application can limit the fixing head 32 through the limiting space 23 formed by enclosing the first fixing block 21 and the second fixing block 22 after the puncture section 31 is implanted into the animal's body. With the cooperation of the fixing plate 11, it can prevent the wire 3 from moving along with the physiological activities of the animal, facilitating the wire 3 to collect data and facilitating the normal progress of the experiment. Moreover, it can also prevent the wire 3 from moving along with the physiological activities of the animal from causing damage to the internal organs of the animal, and can effectively protect the animal.
[0038] In an embodiment of the present application, please refer to Figures 1 to 3 , a first limiting groove 211 is opened at one end of the first fixing block 21 close to the second fixing block 22. A second limiting groove 24 is opened at one end of the second fixing block 22 close to the first fixing block 21, and the second limiting groove 24 and the first limiting groove 211 enclose to form the limiting space 23.
[0039] With such a setting, by using the first limiting groove 211, with the cooperation of the first fixing block 21, it can prevent the wire 3 from moving towards the neck of the animal. By using the second limiting groove 24, with the cooperation of the second fixing block 22, it can prevent the wire 3 from moving away from the neck of the animal. Through the limiting space 23 formed by enclosing the first limiting groove 211 and the second limiting groove 24, it can prevent the wire 3 from slipping out between the first fixing block 21 and the second fixing block 22. With the cooperation of the fixing plate 11 and the fixing belt 12, the wire 3 can be completely fixed, and the fixing effect is good.
[0040] In an embodiment of the present application, please refer to together Figures 1 to 3, the first fixing block 21 is further provided with a first avoiding hole 212, and the first avoiding hole 212 communicates with the limiting space 23. The second fixing block 22 is further provided with a second avoiding hole 26, and the second avoiding hole 26 communicates with the limiting space 23.
[0041] With such a setting, by using the first avoiding hole 212, when implanting the wire 3, the puncturing section 31 of the wire 3 can be avoided, which is convenient for implanting the wire 3 into the animal body. By using the second avoiding hole 26, after the second fixing block 22 is installed on the first fixing block 21, it is convenient for external experimental equipment to pass through the second fixing block 22 and connect with the wire 3, which is convenient for collecting data.
[0042] In an embodiment of the present application, refer to Figures 1 to 3 , the fixing plate 11 includes a first plate body 111, two second plate bodies 112 and two third plate bodies 113. The two second plate bodies 112 are respectively connected to both ends of the first plate body 111, and the two third plate bodies 113 are respectively connected to one ends of the two second plate bodies 112 far away from the first plate body 111.
[0043] With such a setting, through the first plate body 111, the two second plate bodies 112 can be connected, which helps to improve the structural stability between the two second plate bodies 112. Through the two second plate bodies 112, it is convenient to install the second fixing assembly 2. Through the two third plate bodies 113, it is convenient to fix the first plate body 111, the second plate body 112 and the second fixing assembly 2 on the animal neck, which helps to improve the convenience of use.
[0044] In an embodiment of the present application, please refer to Figures 1 to 3 , the second plate body 112 is provided with a hinge hole 114 and a plurality of threaded holes 115. The plurality of threaded holes 115 are distributed at intervals along the circumferential direction around the axis of the hinge hole 114. The first fixing block 21 is further provided with a counterbore 213. The second fixing assembly 2 further includes two rotating hinge shafts 216 and a fastening screw 25. The two hinge shafts 216 are both connected to the first fixing block 21 and are respectively arranged in one-to-one correspondence with the two hinge holes 114, and the fastening screw 25 is screwed into any one of the threaded holes 115.
[0045] Specifically, in the actual application process, the sizes of mice are not the same in each part. Therefore, after the fixing plate 11 is worn on the mouse neck, there is a situation that the first avoiding hole 212 cannot be directly opposite to the puncturing position on the mouse neck, and thus it is easy to cause the puncturing section 31 to be unable to be implanted into the target position.
[0046] More specifically, when the piercing position is above the first avoidance hole 212, that is, when the included angle between the first avoidance hole 212 and the mouse's neck is relatively large, the experimenter first rotates the fastening screw 25 to move the fastening screw 25 out of the counterbore 213 and the threaded hole 115. The experimenter can then press down on the end of the first fixing block 21 away from the animal's neck, causing the end of the first fixing block 21 close to the mouse's neck to rotate approximately away from the mouse's neck until the first avoidance hole 212 is directly opposite the piercing position. When the piercing position is below the first avoidance hole 212, that is, when the included angle between the first avoidance hole 212 and the mouse's neck is relatively small, the experimenter first rotates the fastening screw 25 to move the fastening screw 25 out of the counterbore 213. The experimenter can then lift up the end of the first fixing block 21 away from the animal's neck, causing the end of the first fixing block 21 close to the mouse's neck to rotate approximately towards the mouse's neck until the first avoidance hole 212 is directly opposite the piercing position. After the first avoidance hole 212 is approximately directly opposite the piercing position, the experimenter rotates the fastening screw 25 to cause the fastening screw 25 to enter the threaded hole 115 and the counterbore 213.
[0047] With this arrangement, through the rotating shaft and the hinge hole 114, the first fixing block 21 and the second plate body 112 can be hingedly connected, so that the first fixing block 21 can rotate relative to the second plate body 112. By rotating the first fixing block 21, the first avoidance hole 212 can always be directly opposite the piercing position, and thus the wire 3 can always be directly opposite the piercing position, which helps to increase the applicable range of the device and also helps to improve the convenience of using the device. Moreover, after rotating the first fixing block 21, the fastening screw 25 can fix the first fixing block 21 through any one of the threaded holes 115 and the counterbore 213, which can prevent the first fixing block 21 from rotating relative to the second plate body 112, helping to improve the structural stability between the first fixing block 21 and the second plate body 112 and making it difficult for the wire 3 to move. The use of the threaded hole 115 can prevent the fastening screw 25 from coming out of the counterbore 213, which helps to further improve the structural stability between the first fixing block 21 and the second plate body 112.
[0048] In an embodiment of the present application, please also refer to Figures 1 to 3 , the first fixing block 21 includes a block body 214 and an internal thread sleeve 215. The internal thread sleeve 215 is connected to the end of the block body 214 close to the second fixing block 22 and can be screwed to the second fixing block 22.
[0049] With this arrangement, through the block body 214 and the internal thread sleeve 215, the block body 214 can be detachably connected to the second fixing block 22, which is convenient for disassembly and installation and helps to improve the convenience of use.
[0050] In an embodiment of the present application, refer to Figures 1 to 3 , the third plate body 113 is provided as an arc-shaped plate.
[0051] With such a setting, the third plate body 113 is set as an arc-shaped plate, which can make the third plate body 113 fit more closely to the neck of the mouse, and thus make it difficult for the third plate body 113 to move relative to the neck of the mouse.
[0052] In an embodiment of the present application, please refer to Figures 1 to 3 , the first fixing component 1 further includes two fixing straps 12, and the two fixing straps 12 are respectively passed through both ends of the fixing plate 11.
[0053] With such a setting, by using two fixing straps 12, the fixing plate 11 can be fixed to the neck of the animal, preventing the fixing plate 11 from moving relative to the neck of the animal, and thus preventing the wire 3 from moving relative to the neck of the animal.
[0054] In an embodiment of the present application, please refer to Figures 1 to 3 together, the fixing strap 12 includes a strap body 121, a plurality of fixing holes 122 and a fixing buckle 123. The plurality of fixing holes 122 are all opened on the strap body 121 and are arranged at intervals. The fixing buckle 123 is installed at one end of the strap body 121 and is detachably installed in any one of the fixing holes 122.
[0055] Specifically, in the actual application process, since the sizes of mice are different, the fixing strap 12 cannot be applied to mice of different sizes, which easily causes the fixing plate 11 to move relative to the neck of the mouse, and thus easily causes the wire 3 to move relative to the neck of the mouse.
[0056] More specifically, when the size of the mouse is larger, the experimenter pulls the end of the strap body 121 away from the fixing buckle 123 to reduce the folded area of the strap body 121 and increase the distance between the end of the strap body 121 away from the fixing buckle 123 and the strap body 121 until the end of the strap body 121 away from the fixing buckle 123 is pulled to the position of the front limb of the mouse, and finally the fixing buckle 123 is snapped into the corresponding fixing hole 122. When the size of the mouse is smaller, the experimenter pulls the end of the strap body 121 close to the fixing buckle 123 to increase the folded area of the strap body 121 and reduce the distance between the end of the strap body 121 away from the fixing buckle 123 and the strap body 121 until the end of the strap body 121 away from the fixing buckle 123 is pulled to the position of the front limb of the mouse, and finally the fixing buckle 123 is snapped into the corresponding fixing hole 122.
[0057] With such a setting, by pulling the belt body 121, the distance between the end of the belt body 121 away from the fixed buckle 123 and the belt body 121 can be changed, which can be applicable to animals of different sizes, helps to improve the applicable range of the device, and enables the fixing plate 11 to be stably worn on the animal's neck. Through a plurality of fixing holes 122 and the fixed buckle 123, after adjusting the distance between the end of the belt body 121 away from the fixed buckle 123 and the belt body 121, the fixed buckle 123 can be clamped into any opposite fixing hole 122 to fix the belt body 121 and prevent the belt body 121 from moving relative to the fixing plate 11.
[0058] In one embodiment of the present application, referring to Figures 1 to 3 , the fixing belt 12 further includes a through hole 124, and the through hole 124 is opened at the end of the belt body 121 away from the fixed buckle 123.
[0059] With such a setting, by using the through hole 124, the front limb of the animal can pass through the through hole 124, preventing the end of the belt body 121 away from the fixed buckle 123 from lacking positioning and causing the fixing plate 11 to move relative to the animal's neck. Moreover, it will not affect the normal physiological activities of the animal and helps to improve the convenience of use.
[0060] One or more embodiments of the present application are intended to cover all such substitutions, modifications, and variations that fall within the broad scope of the present application. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of one or more embodiments of the present application shall be included within the protection scope of the present application.
Claims
1. An electrophysiological detection experimental device, characterized in that, Comprising: A first fixing component (1), the first fixing component (1) includes a fixing plate (11), and the fixing plate (11) is worn on the neck of an animal; A second fixing component (2), the second fixing component (2) includes a first fixing block (21), a second fixing block (22) and a limiting space (23), the first fixing block (21) is installed on the fixing plate (11), the second fixing block (22) is detachably installed at one end of the first fixing block (21) away from the animal's neck, and encloses the limiting space (23) with the first fixing block (21); A wire (3), the wire (3) includes a puncturing section (31) and a fixing head (32), the puncturing section (31) penetrates through the first fixing block (21), the fixing head (32) is connected to one end of the puncturing section (31), and is limited within the limiting space (23).
2. The electrophysiological detection experimental device according to claim 1, characterized in that, One end of the first fixing block (21) close to the second fixing block (22) is provided with a first limiting groove (211); one end of the second fixing block (22) close to the first fixing block (21) is provided with a second limiting groove (24), and the second limiting groove (24) and the first limiting groove (211) enclose the limiting space (23).
3. The electrophysiological detection experimental device according to claim 1, wherein The first fixing block (21) is further provided with a first avoiding hole (212), and the first avoiding hole (212) communicates with the limiting space (23); the second fixing block (22) is further provided with a second avoiding hole (26), and the second avoiding hole (26) communicates with the limiting space (23).
4. The electrophysiological detection experimental device according to claim 1, wherein The fixing plate (11) includes a first plate body (111), two second plate bodies (112) and two third plate bodies (113), the two second plate bodies (112) are respectively connected to both ends of the first plate body (111), and the two third plate bodies (113) are respectively connected to one ends of the two second plate bodies (112) away from the first plate body (111).
5. The electrophysiological detection experimental device according to claim 4, characterized in that, The second plate body (112) is provided with a hinge hole (114) and a plurality of threaded holes (115), and the plurality of threaded holes (115) are spaced apart along the circumferential direction around the axis of the hinge hole (114); the first fixing block (21) is further provided with a counterbore (213); the second fixing component (2) further includes two hinge shafts (216) and a fastening screw (25), the two hinge shafts (216) are both connected to the first fixing block (21), and are respectively arranged in one-to-one correspondence with the two hinge holes (114), and the fastening screw (25) is screwed into any one of the threaded holes (115).
6. The electrophysiological detection experimental device according to any one of claims 1-5, characterized in that, The first fixing block (21) includes a block body (214) and an internal thread sleeve (215), the internal thread sleeve (215) is connected to one end of the block body (214) close to the second fixing block (22), and can be screwed with the second fixing block (22).
7. The electrophysiological detection experimental device according to claim 5, wherein The third plate body (113) is arranged as an arc-shaped plate.
8. The electrophysiological detection experimental device according to claim 1, characterized in that, The first fixing component (1) further includes two fixing straps (12), and the two fixing straps (12) are respectively passed through two ends of the fixing plate (11).
9. The electrophysiological detection experimental device according to claim 8, wherein, The fixing strap (12) includes a strap body (121), a plurality of fixing holes (122) and a fixing buckle (123). The plurality of fixing holes (122) are all formed in the strap body (121) and are arranged at intervals. The fixing buckle (123) is installed at one end of the strap body (121) and is detachably installed in any one of the fixing holes (122).
10. The electrophysiological detection experimental device according to claim 9, characterized in that, The fixing strap (12) further includes a through hole (124), and the through hole (124) is formed in the end of the strap body (121) away from the fixing buckle (123).