Automatic chromosome slide making machine

Abstract

The utility model discloses an automatic chromosome slide making machine which comprises a machine body, an operation table is arranged at the upper end of the machine body, and a suspension frame, a glass dividing disc, a pipetting lifting drive, a pipetting rotating drive, an automatic pipetting gun, a glass loading assembly, a drying area and a dyeing tube are installed at the upper end of the operation table. A glass slide is mounted in the glass slide frame, a cell suspension test tube is mounted in the suspension frame, the staining tube is connected with a liquid pump, the liquid pump is located in the staining solution, and a plurality of glass clamping grooves for mounting the glass slide are formed in the circumference of the upper end of the glass separation disc in an array manner. According to the chromosome slide manufacturing device, the process of manufacturing chromosome slides is automatic, the slides are orderly transferred at each working position according to experimental steps through the glass separation disc, and the manufactured slides are taken back into the glass slide frame again, so that the automation degree of the experimental process is improved, and the chromosome slides can be conveniently manufactured on a large scale.

Description

Technical Field

[0001] The utility model belongs to the technical field of slide making machines, and relates to an automatic chromosome slide making machine. Background Art

[0002] A chromosome slide is a carrier for chromosomes used in chromosome observation experiments. During slide preparation, cells to be observed in the experiment are first processed to make a cell suspension, and then the cell suspension is dropped onto the slide through a dropper. After drying the cell suspension by baking or other means, a staining solution is dropped, and then after standing for a period of time, observation is carried out through a microscope. However, manual operation is required during the process of making slides from the cell suspension, which is rather troublesome when making multiple slides. Content of the Utility Model

[0003] In view of the above problems, the utility model provides an automatic chromosome slide making machine, which well solves the problems in the prior art.

[0004] To achieve the above object, the technical solution adopted by the utility model is as follows:

[0005] An automatic chromosome slide making machine, comprising:

[0006] A machine body, the upper end of the machine body is an operation table, a protective shell is fixedly installed on the upper end of the operation table, and a glass cover is hinged to the front end of the protective shell;

[0007] A suspension rack, the suspension rack is installed on the operation table, and a cell suspension test tube is installed on the suspension rack;

[0008] A glass dividing disc, the glass dividing disc is rotatably installed on the operation table, a plurality of glass clamping grooves are arranged in a circumferential array on the upper end of the glass dividing disc, and the glass dividing disc is connected with a driving motor;

[0009] A pipetting lifting drive, the pipetting lifting drive is installed on the operation table;

[0010] A pipetting rotation drive, the pipetting rotation drive is fixedly installed on the operation table, and the pipetting lifting drive is connected to the output end of the pipetting rotation drive;

[0011] An automatic pipette, the automatic pipette is installed on the output end of the pipetting lifting drive;

[0012] A glass loading assembly, the glass loading assembly includes,

[0013] A glass carrier rack, a plurality of glass carrier U-shaped racks are arranged on the glass carrier rack, and a slide is inserted and installed in the glass carrier U-shaped rack;

[0014] A glass carrier lifting drive, the glass carrier rack is detachably installed on the output end of the glass carrier lifting drive;

[0015] Push - glass drive, the output end of the push - glass drive faces one of the glass - clamping grooves of the glass - dividing disc. After the glass - holding rack rises, the opening end of one of the glass - holding U - racks faces the glass - clamping groove. A push - glass opening is provided at the closed end of the glass - holding U - rack. The push - glass drive pushes the glass slide into the glass - clamping groove along the push - glass opening;

[0016] Drying area, the drying area is arranged on the operating table, and a plurality of electric heating tubes are installed in the drying area;

[0017] Staining tube, the staining tube is connected with a liquid pump. Staining liquid is placed in the operating table, the liquid pump is installed in the staining liquid, and the staining tube faces one of the glass - clamping grooves;

[0018] Wherein, a conversion part is rotatably installed at the output end of the push - glass drive. The first end of the conversion part is a flat end, a clamping groove is opened in the middle of the second end, and the conversion part is connected with a driving motor.

[0019] Optionally, an air - extraction pump is installed in the operating table, and the input end of the air - extraction pump is located in the drying area.

[0020] Optionally, a plurality of suction ports are arranged on one side of the glass - loading assembly. When the glass - holding rack descends to the lowest position, the suction ports correspond to the glass slides one by one, and the suction ports are connected to the air - extraction pump.

[0021] Optionally, the output end of the air - extraction pump is connected with a waste - liquid box, and a water - absorbing cotton is arranged in the waste - liquid box.

[0022] Optionally, a rubber pad is installed in the clamping groove.

[0023] Optionally, arc - shaped flared parts are arranged at both ends of the glass - clamping groove opposite to the glass - holding U - rack.

[0024] Compared with the prior art, the utility model has the following beneficial effects:

[0025] 1. By setting a suspension rack, a glass - holding rack, an automatic pipette, a drying area and a staining tube, the process of making chromosome glass slides is automated. The glass - dividing disc orderly transfers the glass slides at each working position according to the experimental steps, and retrieves the completed glass slides back into the glass - holding rack, improving the automation degree of the experimental process and facilitating the large - batch production of chromosome glass slides;

[0026] 2. During the drying process, a certain amount of water vapor will be generated. By setting the input end of the air - extraction pump in the drying area, the water vapor is timely extracted, reducing the influence of the water vapor dispersion on other components, and at the same time accelerating the drying of the suspension by the flow of hot air;

[0027] 3. By setting up a suction port, after the standing of the glass slide staining is completed, the staining solution on it is suctioned to reduce the possibility of the staining solution spilling onto the device when the glass slide is taken. Description of the Drawings

[0028] Figure 1 is the overall structural schematic diagram of the embodiment of the present utility model;

[0029] Figure 2 is the structural schematic diagram of the operation table part of the embodiment of the present utility model;

[0030] Figure 3 is the structural schematic diagram of the glass loading assembly of the embodiment of the present utility model;

[0031] Figure 4 is Figure 3 the enlarged schematic diagram of part A in

[0032] Reference numerals: 1, body; 11, operation table; 12, protective shell; 13, glass cover;

[0033] 2, suspension rack;

[0034] 3, glass dividing plate; 301, glass clamping groove;

[0035] 31, pipetting lifting drive; 32, automatic pipette;

[0036] 4, glass loading assembly; 41, glass carrier rack; 411, glass carrier U-rack; 42, glass carrier lifting drive; 43, glass pushing drive; 431, conversion part; 432, clamping groove; 44, suction port;

[0037] 5, drying area;

[0038] 6, staining tube. Detailed Embodiment

[0039] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0040] Please refer to Figure 1, an automated chromosome slide making machine disclosed in an embodiment of the present utility model, comprising a machine body 1. The upper end of the machine body 1 is an operating table 11. A protective shell 12 is fixedly installed on the upper end of the operating table 11. A glass cover 13 is hinged to the front end of the protective shell 12. A suspension rack 2 is fixedly installed on the upper end of the operating table 11. A cell suspension test tube is installed on the suspension rack 2. A glass distributing disk 3 is rotatably installed on the operating table 11. A plurality of glass card slots 301 are arranged in a circumferential array on the upper end of the glass distributing disk 3. The glass distributing disk 3 is connected to a driving motor. A pipetting lifting drive 31 is rotatably installed on the operating table 11. The bottom of the pipetting lifting drive 31 is connected to a pipetting rotation drive. The output end of the pipetting lifting drive 31 is fixedly installed with an automatic pipette 32. An assembly 4 for installing glass slides is installed on the upper end of the operating table 11. The assembly 4 for installing glass slides includes a glass slide rack 41, a glass slide lifting drive 42 and a glass slide pushing drive 43. A plurality of glass slide U-shaped frames 411 are arranged on the glass slide rack 41. A glass slide is inserted and installed in the glass slide U-shaped frame 411. The glass slide rack 41 is detachably installed at the output end of the glass slide lifting drive 42. The output end of the glass slide pushing drive 43 faces one of the glass card slots 301 of the glass distributing disk 3. After the glass slide rack 41 rises, the opening end of one of the glass slide U-shaped frames 411 faces the glass card slot 301. A glass slide pushing port is arranged at the closed end of the glass slide U-shaped frame 411. The glass slide pushing drive 43 pushes the glass slide into the glass card slot 301 along the glass slide pushing port. The output end of the glass slide pushing drive 43 is rotatably installed with a conversion member 431. The first end of the conversion member 431 is a flat end, and a clamping groove 432 is arranged in the middle of the second end. The conversion member 431 is connected to a driving motor. A drying area 5 is arranged on the upper end of the operating table 11. A plurality of electric heating tubes are installed in the drying area 5. A staining tube 6 is also arranged on the upper end of the operating table 11. The staining tube 6 is connected to a liquid pump. A staining solution is placed in the operating table 11. The liquid pump is installed in the staining solution. The staining tube 6 faces one of the glass card slots 301.

[0041] Specifically, a glass slide rack 41 for installing glass slides is arranged on the operating table 11. The glass slide rack 41 aligns the corresponding glass slide with the glass card slot 301 on the glass distributing disk 3 through the glass slide lifting drive 42. A glass slide pushing drive 43 is arranged on the side of the glass slide rack 41 away from the glass distributing disk 3. The glass slide pushing drive 43 pushes the glass slide into the glass card slot 301. After the glass distributing disk 3 rotates, the pipetting lifting drive 31 and the pipetting rotation drive control the automatic pipette 32 to suck the cell suspension in the test tube on the suspension rack 2 and drop it on the glass slide. The glass distributing disk 3 rotates again. The glass slide enters the drying area 5 to dry the cell suspension. Subsequently, the glass distributing disk 3 rotates again to the position of the staining tube 6. After the staining tube 6 drops the staining solution, the glass distributing disk 3 rotates again to the area of the glass slide rack 41. The conversion member 431 rotates through the driving motor from the flat end to the clamping groove 432, and retrieves the glass slide into the glass slide U-shaped frame 411 for standing still through the clamping groove 432.

[0042] In this way, by setting up the suspension rack 2, the glass slide rack 41, the automatic pipette 32, the drying area 5 and the staining tube 6, the process of making chromosome slides is automated. The glass slides are orderly transferred to each working position by the glass slide distributing tray 3 according to the experimental steps, and the completed glass slides are retrieved back into the glass slide rack 41, which improves the automation degree of the experimental process and facilitates the mass production of chromosome slides.

[0043] In some feasible ways, the body 1 is rectangular, the operating table 11 is an installation platform, the protective shell 12 and the glass cover 13 are both shell-shaped, the glass slide distributing tray 3 is disk-shaped, a driving motor is arranged below the glass slide distributing tray 3, the glass slide clamping groove 301 is U-shaped, and an installation groove is opened on one side of the glass slide clamping groove 301 in contact with the glass slide distributing tray 3. The glass slide is inserted into the installation groove.

[0044] The glass slide rack 41 is a rectangular multi-layer rack. The glass slide U-shaped rack 411 has the same structure as the glass slide clamping groove 301. A glass slide pushing port is opened at the closed end of the glass slide U-shaped rack 411 for the glass slide pushing drive 43 to pass through. The glass slide lifting drive 42 includes an L-shaped mounting rack. An insertion port is arranged at the bottom of the L-shaped mounting rack. The glass slide rack 41 is inserted and mounted in the insertion port. A motor-driven threaded lead screw mechanism is arranged on the side of the L-shaped mounting rack, and the threaded lead screw mechanism drives the L-shaped mounting rack to lift. The glass slide pushing drive 43 includes a ball screw mechanism. The output end of the ball screw mechanism is connected with a rectangular rod. A rectangular groove is arranged at one end of the rectangular rod close to the glass slide rack 41. The conversion part 431 is rotatably mounted in the rectangular groove. For easy clamping, a rubber pad is mounted on the side wall of the clamping groove 432. The rubber pad has elasticity. The glass slide is clamped by the rubber pad. After entering the glass slide U-shaped rack 411, the glass slide U-shaped racks 411 on both sides of the glass slide pushing port block the glass slide, causing the glass slide to break away from the clamping groove 432.

[0045] The pipetting lifting drive 31 can be selected as an electric push rod. The pipetting rotation drive rotates the pipetting lifting drive 31 through rotation to align the automatic pipette 32 with the suspension test tube or the glass slide. The automatic pipette 32 can be selected as a syringe controlled by an electric push rod.

[0046] The drying area 5 is used to dry the suspension. The drying area 5 includes a plurality of electric heating tubes. The electric heating tubes are located below the glass slide clamping grooves 301 of the glass slide distributing tray 3. Since the drying takes a long time, electric heating tubes can be arranged below multiple glass slide clamping grooves 301. Through holes are opened at the positions of the glass slide distributing tray 3 below the glass slide clamping grooves 301 to facilitate drying.

[0047] As a specific implementation manner of an automatic chromosome slide making machine provided by the application, an air extraction pump is installed in the operating table 11, and the input end of the air extraction pump is located in the drying area 5.

[0048] Generally speaking, a certain amount of water vapor will be generated during the drying process. By setting the input end of the air extraction pump in the drying area 5, the water vapor is extracted in time, reducing the influence of the water vapor dispersion on other components, and at the same time accelerating the drying of the suspension by the flow of hot air.

[0049] In some feasible ways, a sector box is arranged at the upper end of the drying area 5. A porous plate is located below the sector box. The input end of the air extraction pump is connected to the sector box.

[0050] Furthermore, a plurality of suction ports 44 are arranged on one side of the glass loading assembly 4. When the glass carrier 41 descends to the lowest position, the suction ports 44 correspond to the glass slides one by one, and the suction ports 44 are connected to the air extraction pump.

[0051] It should be understood that by arranging the suction ports 44, after the staining of the glass slides is completed and left standing, the staining solution on them is suctioned, reducing the possibility of the staining solution splashing onto the equipment when the glass slides are taken.

[0052] In some feasible ways, the suction ports 44 are set as round tubes. The input ends of the suction ports 44 are facing the positions where the staining solution is dropped onto the glass slides. It should be understood that when the air extraction pump sucks the staining solution, it is a mixed fluid of air flow and liquid. A waste liquid box is arranged outside the air extraction pump for containing waste liquid, and absorbent cotton is arranged in the waste liquid box so that the staining solution is adsorbed by the absorbent cotton. At the same time, when the moisture in the suction drying area 5 is sucked, moisture absorption and drying are carried out through the absorbent cotton.

[0053] As a specific implementation manner of an automatic chromosome glass slide making machine provided by the application, arc-shaped flared portions are arranged at both ends of the glass clamping groove 301 opposite to the U-shaped glass carrier 411.

[0054] It should be understood that by arranging the flared portions, it is convenient to insert the glass slides.

[0055] Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An automated chromosome slide making machine, characterized in that, Including: A machine body, with an operating platform at the upper end of the machine body. A protective shell is fixedly installed on the upper end of the operating platform, and a glass cover is hinged to the front end of the protective shell; A suspension rack, which is installed on the operating platform, and cell suspension test tubes are installed on the suspension rack; A glass dividing disk, which is rotatably installed on the operating platform. A plurality of glass clamping grooves are circumferentially arranged on the upper end of the glass dividing disk, and the glass dividing disk is connected to a driving motor; A pipetting lifting drive, which is installed on the operating platform; A pipetting rotation drive, which is fixedly installed on the operating platform, and the pipetting lifting drive is connected to the output end of the pipetting lifting drive; An automatic pipette, which is installed on the output end of the pipetting lifting drive; A glass loading assembly, which includes A glass slide rack, on which a plurality of glass slide U-shaped racks are arranged, and glass slides are inserted and installed in the glass slide U-shaped racks; A glass slide lifting drive, and the glass slide rack is detachably installed on the output end of the glass slide lifting drive; A glass slide pushing drive, the output end of the glass slide pushing drive faces one of the glass clamping grooves of the glass dividing disk. After the glass slide rack rises, the opening end of one of the glass slide U-shaped racks faces the glass clamping groove, and a glass slide pushing port is opened at the closed end of the glass slide U-shaped rack. The glass slide pushing drive pushes the glass slide into the glass clamping groove along the glass slide pushing port; A drying area, which is arranged on the operating platform, and a plurality of electric heating tubes are installed in the drying area; A staining tube, which is connected to a liquid pump. A staining solution is placed in the operating platform, the liquid pump is installed in the staining solution, and the staining tube faces one of the glass clamping grooves; Wherein, a conversion part is rotatably installed at the output end of the glass slide pushing drive. The first end of the conversion part is a flat end, and a clamping groove is opened in the middle of the second end. The conversion part is connected to a driving motor.

2. The automated chromosome slide making machine according to claim 1, characterized in that: An air extraction pump is installed in the operating platform, and the input end of the air extraction pump is located in the drying area.

3. The automated chromosome slide making machine according to claim 2, characterized in that: A plurality of suction ports are arranged on one side of the glass loading assembly. When the glass slide rack descends to the lowest position, the suction ports correspond to the glass slides one by one, and the suction ports are connected to the air extraction pump.

4. An automated chromosome slide making machine according to claim 3, wherein: The output end of the air extraction pump is connected to a waste liquid box, and a water absorbent cotton is arranged in the waste liquid box.

5. An automated chromosome slide making machine according to claim 1, characterized in that: A rubber pad is installed in the clamping groove.

6. An automated chromosome slide making machine according to claim 1, characterized in that: Arc-shaped flared parts are arranged at the opposite ends of the glass clamping groove and the glass slide U-shaped rack.

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