Transcranial electrical stimulation electrode assembly, transcranial electrical stimulation device and electroencephalogram detection device

Abstract

The utility model relates to a transcranial electrical stimulation electrode set, a transcranial electrical stimulation electrode device and an electroencephalogram detection device, the transcranial electrical stimulation electrode set comprises at least one transcranial electrical stimulation electrode set, one end of a first stimulation electrode AE1 is used for being electrically connected with an external electrical stimulation device, and the first stimulation electrode AE1 is used for being attached to an external to-be-detected brain; one end of the second stimulation electrode AE2 is used for being electrically connected with an external electrical stimulation device, and the second stimulation electrode AE2 is used for being attached to an external brain to be tested; one end of the reference electrode PE is used for being electrically connected with an external electrical stimulation device, and the reference electrode PE is used for being attached to an external brain to be tested; the reference electrode PE is arranged between the first stimulating electrode AE1 and the second stimulating electrode AE2; the first stimulating electrode AE1 and the second stimulating electrode AE2 are symmetrically arranged with the reference electrode PE as the center. Due to the special structural design, stimulation current adjustment is facilitated, electroencephalogram detection based on impedance measurement is also suitable, and stimulation and detection are neglected.

Description

Technical Field

[0001] The utility model relates to the technical field of brain electrical stimulation and brain electrical detection, in particular to a transcranial electrical stimulation device and a brain electrical detection device. Background Art

[0002] Contact impedance testing is required for both electrical stimulation and EEG detection. The topology of EEG electrodes is crucial, directly impacting the subsequent EEG stimulation and detection circuit design.

[0003] If EEG stimulation and EEG detection are set up independently, they cannot share the EEG electrode topology; in impedance detection, they are independent and do not affect each other, but the device cost increases and the system structure is complicated.

[0004] If EEG stimulation and EEG detection share the same EEG electrode topology, this can pose challenges to the subsequent stimulation and detection circuits. Impedance detection requires continuous stimulation, allowing simultaneous detection. EEG detection typically uses a complex electrode topology with multiple electrodes. This multi-electrode topology can generate crosstalk between electrodes during impedance detection, affecting its accuracy.

[0005] How to design a transcranial electrical stimulation electrode, device and EEG detection device that can take into account both the EEG stimulation process and the EEG detection process is a technical problem to be solved. Summary of the Invention

[0006] The technical solution of the present invention overcomes the shortcomings of the existing technology and proposes a transcranial electrical stimulation electrode, device and EEG detection device that can take into account both the EEG stimulation process and the EEG detection process. Through the special structural design, it is convenient to adjust the stimulation current and is suitable for EEG detection based on impedance measurement, so that stimulation and detection can be achieved at the same time, and EEG stimulation and EEG detection are safer and more effective.

[0007] The technical solution for solving the above-mentioned technical problems in the present application is a transcranial electrical stimulation electrode group, comprising at least two stimulation electrodes and one reference electrode; the stimulation electrodes include at least a first stimulation electrode AE1 and a second stimulation electrode AE2, and the reference electrode includes a reference electrode PE; one end of the first stimulation electrode AE1 is used to be electrically connected to an external electrical stimulation device, and the first stimulation electrode AE1 is used to be attached to the external brain to be tested; one end of the second stimulation electrode AE2 is used to be electrically connected to an external electrical stimulation device, and the second stimulation electrode AE2 is used to be attached to the external brain to be tested; one end of the reference electrode PE is used to be electrically connected to an external electrical stimulation device, and the reference electrode PE is used to be attached to the external brain to be tested; the reference electrode PE is arranged between the first stimulation electrode AE1 and the second stimulation electrode AE2; the first stimulation electrode AE1 and the second stimulation electrode AE2 are symmetrically arranged with the reference electrode PE as the center.

[0008] The technical solution to solve the above technical problems in the present application can also be a transcranial electrical stimulation device, including at least one group of the above-mentioned transcranial electrical stimulation electrode groups.

[0009] The above-mentioned transcranial electrical stimulation device also includes an electrical stimulation device; the electrical stimulation device is respectively connected to the first stimulation electrode AE1, the second stimulation electrode AE2, and the reference electrode PE; forming two electrical stimulation current loops sharing the reference electrode, the first electrical stimulation current loop and the second electrical stimulation current loop; the first electrical stimulation current loop includes the AE1 electrode contact impedance R AE1 , the first human tissue impedance R t1 , PE electrode contact impedance R PE , PE electrode tissue impedance R t3 The second electrical stimulation current loop includes the AE2 electrode contact impedance R AE2 , the second human tissue impedance R t2 , PE electrode contact impedance R PE , PE electrode tissue impedance R t3 .

[0010] The above-mentioned electrical stimulation device is a constant current source stimulation device, including a high-precision Holland constant current source with compensation.

[0011] The above-mentioned electrical stimulation device is a constant current source stimulation device, and the constant current source includes: resistors R1~R3, R4A, R4B, R5~R6, capacitor C200, operational amplifier U10A and operational amplifier U10B; one end of resistor R1 is electrically connected to one end of capacitor C200, one end of resistor R2 is electrically connected to the reverse input terminal of operational amplifier U10A, and the other end of resistor R2 and the other end of capacitor C200 are electrically connected to the output terminal of operational amplifier U10A; the other end of resistor R1 is grounded; the output terminal of operational amplifier U10A is electrically connected to one end of resistor R4B; the other end of resistor R4B and one end of resistor R5 are electrically connected to the positive input terminal of operational amplifier U10B; the reverse input terminal of operational amplifier U10B is electrically connected to one end of resistor R4A, the other end of resistor R4A and one end of resistor R3 are electrically connected to the positive input terminal of operational amplifier U10A; the other end of resistor R3 is electrically connected to one end of resistor R6, and the other end of resistor R6 is used as an external voltage output terminal.

[0012] The above-mentioned transcranial electrical stimulation device also includes a main control MCU module and a DAC output module; the main control MCU module and the DAC output module are electrically connected, the DAC output module is electrically connected to the electrical stimulation device, and the DAC output module outputs an electrical stimulation signal to the electrical stimulation device.

[0013] The above-mentioned transcranial electrical stimulation device also includes a DDS signal modulation module and a signal operation module; the DDS signal modulation module and the signal operation module are electrically connected; the DAC output module and the signal operation module are electrically connected; the signal operation module is used to perform operations on the input signal; the signal operation module and the signal operation module are electrically connected, and the operation module and the DAC output module are jointly used to provide electrical stimulation signals for the electrical stimulation device.

[0014] The above-mentioned transcranial electrical stimulation device also includes an analog switch switching circuit, which is arranged between the operation module and the DAC output module and the electrical stimulation device; one end of the analog switch switching circuit is electrically connected to the operation module and the DAC output module; the other end of the analog switch switching circuit is electrically connected to the electrical stimulation device; the analog switch switching circuit is electrically connected to the main control MCU module; the main control MCU module is used to control the analog switch switching circuit.

[0015] The above-mentioned transcranial electrical stimulation device includes multiple groups of transcranial electrical stimulation electrode groups, each group of electrodes includes two stimulation electrodes and one reference electrode; the DAC output module is electrically connected to the electrical stimulation device, and the DAC output module outputs an electrical stimulation signal to the electrical stimulation device; each group of electrodes is electrically connected to the electrical stimulation device to obtain the electrical stimulation signal corresponding to the group of electrodes.

[0016] The technical solution for solving the above technical problems in the present application may also be an electroencephalogram (EEG) detection device, including the above-mentioned transcranial electrical stimulation device.

[0017] Compared with the existing technology, one of the beneficial effects of the present invention is that the two stimulation electrodes and one reference electrode in the transcranial electrical stimulation electrode group have a breakthrough structure that is simple and easy to implement. The special structural design is convenient for adjusting the stimulation current and is suitable for EEG detection based on impedance measurement, allowing both stimulation and detection to be achieved.

[0018] Compared with the prior art, one of the beneficial effects of the present invention is that the first stimulation electrode AE1 and the second stimulation electrode AE2 are symmetrically arranged with the reference electrode PE as the center, providing a physical basis for EEG detection based on the transcranial electrical stimulation device.

[0019] Compared with the prior art, one of the beneficial effects of the present invention is that the connection between the electrical stimulation device and the transcranial electrical stimulation electrode group is simple and suitable for adapting different electrical stimulation devices to the transcranial electrical stimulation electrode group.

[0020] Compared with the prior art, one of the beneficial effects of the present invention is that the constant current source stimulation device provides reliable current drive for the circuit network, which is more stable, and the detection and calculation of resistance are more accurate.

[0021] Compared with the prior art, one of the beneficial effects of the present invention is that the transcranial electrical stimulation device has a simple structure, is easy to implement, and is convenient for clinical use.

[0022] Compared with the existing technology, one of the beneficial effects of the present invention is that a transcranial electrical stimulation device is provided on the EEG detection device, which can improve the safety of the EEG detection device, and based on impedance detection, can reduce the risk of inappropriate stimulation current setting caused by inaccurate impedance detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of the connection of the transcranial electrical stimulation electrode group;

[0024] Figure 2 This is a schematic diagram of a transcranial electrical stimulation device. Figure 1 ;

[0025] Figure 3 yes Figure 1 Equivalent circuit diagram of

[0026] Figure 4 This is a schematic diagram of a transcranial electrical stimulation device. Figure 2 ;

[0027] Figure 5 This is the circuit diagram of a high-precision Holland constant current source. DETAILED DESCRIPTION

[0028] The present invention will be further described below in conjunction with the accompanying drawings.

[0029] As used herein, the term "prepared from" is synonymous with "comprising." As used herein, the terms "comprising," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus. The conjunction "consisting of" excludes any unrecited element, step, or component.

[0030] If used in a claim, this phrase renders the claim closed, excluding materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim, rather than immediately following the subject matter, it limits only the elements described in that clause; other elements are not excluded from the claim as a whole. When an amount, concentration, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper and lower preferred values, this should be understood to specifically disclose all ranges formed by any pairing of any upper range limit or preferred value with any lower range limit or preferred value, regardless of whether the range is disclosed separately. For example, when a range "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4," "1 to 3," "1 to 2," "1 to 2 and 4 to 5," "1 to 3 and 5," etc. When numerical ranges are described herein, unless otherwise specified, the ranges are intended to include the endpoints and all integers and fractions within the range. The singular includes the plural unless the context clearly dictates otherwise. "Optional" or "any one" means that the matter or event described thereafter may or may not occur, and the description includes situations in which the event occurs and situations in which the event does not occur. Approximate terms in the specification and claims are used to modify quantities, indicating that the utility model is not limited to the specific quantity, but also include acceptable and modified parts close to the quantity that do not result in changes in the relevant basic functionality. Accordingly, using "about", "approximately" and the like to modify a numerical value means that the utility model is not limited to the exact numerical value. In some examples, approximate terms may correspond to the accuracy of the instrument for measuring the numerical value. In the specification and claims of this application, range limits can be combined and / or interchanged, and if not otherwise specified, these ranges include all subranges contained therein. In addition, the indefinite articles "a" and "an" before the elements or components of the utility model are not restrictive on the quantity requirements (i.e., the number of occurrences) of the elements or components. Therefore, "a" or "an" should be interpreted as including one or at least one, and elements or components in the singular form also include plural forms, unless the above number obviously refers to the singular form.

[0031] like Figure 1In an embodiment of a transcranial electrical stimulation electrode group, at least two stimulation electrodes and one reference electrode are included; the stimulation electrodes include at least a first stimulation electrode AE1 and a second stimulation electrode AE2, and the reference electrode includes a reference electrode PE; one end of the first stimulation electrode AE1 is used to electrically connect to an external electrical stimulation device, and the first stimulation electrode AE1 is used to be attached to the external brain to be tested; one end of the second stimulation electrode AE2 is used to electrically connect to the external electrical stimulation device, and the second stimulation electrode AE2 is used to be attached to the external brain to be tested; one end of the reference electrode PE is used to electrically connect to the external electrical stimulation device, and the reference electrode PE is used to be attached to the external brain to be tested; the reference electrode PE is arranged between the first stimulation electrode AE1 and the second stimulation electrode AE2. The two stimulation electrodes also include electrical connecting wires, which are used to electrically connect the stimulation electrodes and the electrical stimulation device, and the electrical connecting wires of the two stimulation electrodes are symmetrically arranged; the reference electrode is designed to be centered.

[0032] like Figure 2 In an embodiment of a transcranial electrical stimulation device, the device comprises at least one of the above-mentioned transcranial electrical stimulation electrode groups.

[0033] like Figure 2 and Figure 3 In an embodiment of a transcranial electrical stimulation device, the device further includes an electrical stimulation device; the electrical stimulation device is respectively connected to the first stimulation electrode AE1, the second stimulation electrode AE2, and the reference electrode PE; two electrical stimulation current loops sharing the reference electrode are formed, namely, the first electrical stimulation current loop and the second electrical stimulation current loop; the first electrical stimulation current loop includes the AE1 electrode contact impedance R AE1 , the first human tissue impedance R t1 , PE electrode contact impedance R PE , PE electrode tissue impedance R t3 The second electrical stimulation current loop includes the AE2 electrode contact impedance R AE2 , the second human tissue impedance R t2 , PE electrode contact impedance R PE , PE electrode tissue impedance R t3 .

[0034] like Figure 3 As shown, Figure 1 Equivalent circuit diagram. Figure 3 In, R AE1 、R PE 、R AE2 are the contact impedances of AE1 electrode, PE electrode, and AE2 electrode, respectively; R t1 、R t2 、R t3are the impedances of the human tissues contacted by the AE1, AE2, and PE electrodes, respectively; i1 and i2 are the currents flowing through the AE1 and PE electrodes, and the currents flowing through the AE2 and PE electrodes, respectively.

[0035] like Figure 4 In an embodiment of the transcranial electrical stimulation device, it also includes a main control MCU module and a DAC output module; the main control MCU module and the DAC output module are electrically connected, the DAC output module and the electrical stimulation device are electrically connected, and the DAC output module outputs an electrical stimulation signal to the electrical stimulation device.

[0036] like Figure 4 In an embodiment of the transcranial electrical stimulation device, it also includes a DDS signal modulation module and a signal operation module; the DDS signal modulation module and the signal operation module are electrically connected; the DAC output module and the signal operation module are electrically connected; the signal operation module is used to perform operations on the input signal; the signal operation module and the signal operation module are electrically connected, and the operation module and the DAC output module are jointly used to provide electrical stimulation signals for the electrical stimulation device.

[0037] like Figure 4 In an embodiment of the transcranial electrical stimulation device, an analog switch switching circuit is further included, which is arranged between the operation module and the DAC output module and the electrical stimulation device; one end of the analog switch switching circuit is electrically connected to the operation module and the DAC output module; the other end of the analog switch switching circuit is electrically connected to the electrical stimulation device; the analog switch switching circuit is electrically connected to the main control MCU module; and the main control MCU module is used to control the analog switch switching circuit.

[0038] like Figure 5 The above-mentioned electrical stimulation device is a constant current source stimulation device, including a high-precision Holland constant current source with compensation. The above-mentioned electrical stimulation device is a constant current source stimulation device, and the constant current source includes: resistors R1~R3, R4A, R4B, R5~R6, capacitor C200, operational amplifier U10A and operational amplifier U10B; one end of resistor R1 is electrically connected to one end of capacitor C200, one end of resistor R2 is electrically connected to the reverse input terminal of operational amplifier U10A, and the other end of resistor R2 and the other end of capacitor C200 are electrically connected to the output terminal of operational amplifier U10A; the other end of resistor R1 is grounded; the output terminal of operational amplifier U10A is electrically connected to one end of resistor R4B; the other end of resistor R4B and one end of resistor R5 are electrically connected to the positive input terminal of operational amplifier U10B; the reverse input terminal of operational amplifier U10B is electrically connected to one end of resistor R4A, the other end of resistor R4A and one end of resistor R3 are electrically connected to the positive input terminal of operational amplifier U10A; the other end of resistor R3 is electrically connected to one end of resistor R6, and the other end of resistor R6 is used as an external voltage output terminal.

[0039] In some embodiments of the transcranial electrical stimulation device not shown in the accompanying drawings, it includes multiple groups of transcranial electrical stimulation electrode groups, each group of electrodes includes two stimulation electrodes and one reference electrode; the DAC output module is electrically connected to the electrical stimulation device, and the DAC output module outputs an electrical stimulation signal to the electrical stimulation device; each group of electrodes is electrically connected to the electrical stimulation device to obtain the electrical stimulation signal corresponding to the group of electrodes.

[0040] An embodiment of an electroencephalogram (EEG) detection device includes the above-mentioned transcranial electrical stimulation device.

[0041] In the present application, a transcranial electrical stimulation electrode, device and electroencephalogram (EEG) detection device include at least one transcranial electrical stimulation electrode group, each transcranial electrical stimulation electrode group including two stimulation electrodes and one reference electrode; one end of the first stimulation electrode AE1 is used to be electrically connected to an external electrical stimulation device, and the first stimulation electrode AE1 is used to be attached to an external brain to be tested; one end of the second stimulation electrode AE2 is used to be electrically connected to an external electrical stimulation device, and the second stimulation electrode AE2 is used to be attached to an external brain to be tested; one end of the reference electrode PE is used to be electrically connected to an external electrical stimulation device, and the reference electrode PE is used to be attached to an external brain to be tested; the reference electrode PE is arranged between the first stimulation electrode AE1 and the second stimulation electrode AE2; the first stimulation electrode AE1 and the second stimulation electrode AE2 are symmetrically arranged with the reference electrode PE as the center. The breakthrough structure is simple and easy to implement, and the special structural design is convenient for adjusting the stimulation current and suitable for EEG detection based on impedance measurement, so that stimulation and detection can be achieved at the same time.

[0042] The above are merely embodiments of the present application and do not limit the scope of application of the present application. Any equivalent structure or equivalent process transformation made using the contents of the application specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the scope of protection of the present application.

Claims

1. A transcranial electrical stimulation electrode set, characterized in that: comprising at least two stimulation electrodes and one reference electrode; The stimulation electrodes include at least a first stimulation electrode AE1 and a second stimulation electrode AE2, and the reference electrodes include a reference electrode PE; One end of the first stimulation electrode AE1 is used to be electrically connected to an external electrical stimulation device, and the first stimulation electrode AE1 is used to be attached to the external brain to be tested; One end of the second stimulation electrode AE2 is used to be electrically connected to an external electrical stimulation device, and the second stimulation electrode AE2 is used to be attached to the external brain to be tested; One end of the reference electrode PE is used to be electrically connected to an external electrical stimulation device, and the reference electrode PE is used to be attached to the external brain to be tested; The reference electrode PE is arranged between the first stimulation electrode AE1 and the second stimulation electrode AE2; The first stimulation electrode AE1 and the second stimulation electrode AE2 are symmetrically arranged with the reference electrode PE as the center.

2. A transcranial electrical stimulation device, characterized in that: Comprising at least one transcranial electrical stimulation electrode group according to claim 1.

3. The transcranial electrical stimulation device according to claim 2, characterized in that Also included are electrical stimulation devices; The electrical stimulation device is electrically connected to the first stimulation electrode AE1, the second stimulation electrode AE2, and the reference electrode PE respectively; forming two electrical stimulation current loops sharing a reference electrode, a first electrical stimulation current loop and a second electrical stimulation current loop; The first electrical stimulation current loop includes the AE1 electrode contact impedance R AE1 , the first human tissue impedance R t1 PE electrode, Contact resistance R PE , PE electrode tissue impedance R t3 ; The second electrical stimulation current loop includes the AE2 electrode contact impedance R AE2 , the second human tissue impedance R t2 PE electrode, contact resistance R PE , PE electrode tissue impedance R t3 .

4. The transcranial electrical stimulation device according to claim 3, wherein: The electrical stimulation device is a constant current source stimulation device, including a high-precision Holland constant current source with compensation.

5. The transcranial electrical stimulation device according to claim 3, wherein: The electrical stimulation device is a constant current source stimulation device, and the constant current source comprises: Resistors R1-R3, R4A, R4B, R5-R6, capacitor C200, operational amplifier U10A, and operational amplifier U10B; One end of the resistor R1 is electrically connected to one end of the capacitor C200, and one end of the resistor R2 is electrically connected to the reverse input terminal of the operational amplifier U10A, while the other end of the resistor R2 and the other end of the capacitor C200 are electrically connected to the output terminal of the operational amplifier U10A; the other end of the resistor R1 is grounded; the output terminal of the operational amplifier U10A is electrically connected to one end of the resistor R4B; the other end of the resistor R4B and one end of the resistor R5 are electrically connected to the positive input terminal of the operational amplifier U10B; the reverse input terminal of the operational amplifier U10B is electrically connected to one end of the resistor R4A, and the other end of the resistor R4A and one end of the resistor R3 are electrically connected to the positive input terminal of the operational amplifier U10A; the other end of the resistor R3 is electrically connected to one end of the resistor R6, and the other end of the resistor R6 is used as an external voltage output terminal.

6. The transcranial electrical stimulation device according to claim 3, characterized in that It also includes a main control MCU module and a DAC output module; The main control MCU module and the DAC output module are electrically connected. The DAC output module is electrically connected to the electrical stimulation device, and the DAC output module outputs an electrical stimulation signal to the electrical stimulation device.

7. The transcranial electrical stimulation device according to claim 6, characterized in that It also includes DDS signal modulation module and signal operation module; The DDS signal modulation module is electrically connected to the signal operation module; The DAC output module is electrically connected to the signal operation module; The signal operation module is used to operate the input signal; The signal operation module is electrically connected to the signal operation module. The operation module and the DAC output module are used together to provide an electrical stimulation signal to the electrical stimulation device.

8. The transcranial electrical stimulation device according to claim 7, characterized in that It also includes an analog switch switching circuit, which is arranged between the operation module, the DAC output module and the electrical stimulation device; one end of the analog switch switching circuit is electrically connected to the operation module and the DAC output module; the other end of the analog switch switching circuit is electrically connected to the electrical stimulation device; the analog switch switching circuit is electrically connected to the main control MCU module; the main control MCU module is used to control the analog switch switching circuit.

9. The transcranial electrical stimulation device according to claim 3, characterized in that It includes multiple groups of transcranial electrical stimulation electrode groups, each group of electrodes includes two stimulation electrodes and one reference electrode; the DAC output module is electrically connected to the electrical stimulation device, and the DAC output module outputs electrical stimulation signals to the electrical stimulation device; each group of electrodes is electrically connected to the electrical stimulation device to obtain the electrical stimulation signal corresponding to the group of electrodes.

10. An electroencephalogram (EEG) detection device, characterized in that: A transcranial electrical stimulation device comprising any one of claims 2 to 9.

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