Kit for prognosis evaluation after liver cancer treatment

Abstract

The utility model discloses a prognosis evaluation kit after liver cancer treatment, and relates to the technical field of kits, the prognosis evaluation kit after liver cancer treatment comprises a kit body, two sides of the kit body are respectively provided with a first side shell and a second side shell, the top of the kit body is provided with a handle, and the inner side of the handle is clamped with a top cover; according to the reagent box, different reagents can be stored through the design of the reagent partition plates, classified placement of the reagents is achieved, and the reagents can be stored through the arrangement of the elastic pockets. When the reagent is taken, the rotary locking disc can be rotated, so that the locking state of the rotary locking disc and the lifting handle is released, then the lifting handle and the top cover are deflected towards one side by taking the hinge as a reference, and the top cover is separated from the kit body, so that the kit is opened, and the reagent in the kit is convenient to take. When different reagents are taken, the second side shell can be pulled outwards, so that the second side shell is opened, and the reagents in the second side shell can be taken conveniently.

Description

Technical Field

[0001] The utility model specifically relates to the technical field of kits, in particular to a kit for evaluating the prognosis after treatment of liver cancer. Background Art

[0002] Liver cancer (HCC) is a malignant tumor that poses a serious threat to human health. Treatment options include surgical resection, liver transplantation, radiofrequency ablation, interventional therapy, and chemotherapy. However, even with aggressive treatment, the prognosis for HCC patients remains highly variable. Therefore, accurately assessing the prognosis after HCC treatment is crucial for developing personalized treatment plans and follow-up schedules.

[0003] Currently, commonly used clinical prognostic indicators for liver cancer include tumor size, number, vascular invasion, liver function, and serum alpha-fetoprotein levels. While these indicators can reflect liver cancer prognosis to a certain extent, they have certain limitations. For example, tumor size and number only reflect tumor burden, not its biological behavior; vascular invasion and liver function only reflect tumor aggressiveness and liver reserve, not the patient's overall prognosis; and, although serum alpha-fetoprotein levels are closely associated with the development and progression of liver cancer, they may not be elevated or may be subtly elevated in some patients. To complete these commonly used clinical prognostic indicators for liver cancer, antibody, nucleic acid, and cytokine reagents are required.

[0004] Since some patients need to bring the above reagents with them when they return home after treatment to visit the hospital and collect samples for testing; the traditional test kit is a simple box; there is no function to classify the placement of multiple reagents, and it is inconvenient to take them. Utility Model Content

[0005] The purpose of the present utility model is to provide a prognosis assessment kit after liver cancer treatment, which can classify and arrange multiple reagents and has two opening methods, so that medical staff can quickly open the kit and take the corresponding reagents to solve the technical problems raised in the above background technology.

[0006] To achieve the above objectives, the present invention provides the following technical solutions:

[0007] A kit for evaluating the prognosis of liver cancer after treatment comprises a kit body, a first side shell and a second side shell being respectively provided on both sides of the kit body, a handle being provided on the top of the kit body, a top cover being clamped on the inner side of the handle; semicircular grooves are formed on the upper ends of both ends of the kit body, and a fixed shaft is provided in the semicircular grooves; a rotary lock disk is rotatably connected to the fixed shaft; a clamping member is fixed on the inner side of the rotary lock disk;

[0008] The handle has two side ears, and a cross bar is fixed between the two side ears; a groove is opened on the outer side of the side ear to facilitate the rotation of the rotary lock disk, and a locking groove is opened on the side of the side ear that fits the clamp.

[0009] The handle is provided with hinges at both ends of one side of the first side shell, and the handle is movably connected to the first side shell through the hinges.

[0010] As a further technical solution of the present invention, the clamping member is arranged in an L shape; the clamping member is slidably connected in the locking groove.

[0011] As a further technical solution of the present invention, the locking groove is rotated 90 degrees with the axis of the fixed shaft as the center of the circle and the bottom surface of the side ear as the reference.

[0012] As a further technical solution of the present invention, the clamping member and the locking groove are both arranged in an L shape.

[0013] As a further technical solution of the present invention, the interior of the test kit body has a cavity that is convenient for installing semiconductor refrigeration plates and batteries; a ventilation component is also installed inside the cavity; the ventilation component includes an outer shell, at least one DC fan is provided on the top of the outer shell, and an air inlet is provided on the side of the outer shell.

[0014] As a further technical solution of the present invention, a plurality of positioning cylinders are further provided in the cavity inside the reagent box body, and the plurality of positioning cylinders are plugged and fixed to the positioning posts at the bottom of the partition; a reagent partition is also provided on the partition.

[0015] As a further technical solution of the present invention, an elastic pocket for storing reagents is further provided on the inner wall of the second side shell.

[0016] As a further technical solution of the present invention, pads are bonded to the four corners of the bottom of the reagent box body, and a ventilation slot is opened at one end of the bottom of the reagent box body; the ventilation slot is located below the ventilation component.

[0017] Compared with the prior art, the beneficial effects of the present invention are:

[0018] 1. The design of the reagent partition of the present invention can store different reagents, realizing the classified placement of reagents, and the setting of the elastic pocket can also store reagents. When taking the reagents, the rotary lock disk can be rotated to release the locking state of the rotary lock disk and the handle, and then the handle and the top cover are deflected to one side based on the hinge, and the top cover is separated from the reagent box body, so that the reagent box is opened and the reagents inside are easy to take. When taking different reagents, the second side shell can also be pulled outward to open the second side shell for taking the reagents inside.

[0019] 2. According to the present invention, when the reagent box is closed after use, the handle and the top cover are buckled with the reagent box body. At this time, the locking groove is just connected to the clamping piece. The rotating lock disk is rotated 90 degrees counterclockwise to make the clamping piece located at the top of the locking groove, thereby achieving the locking and fixation of the reagent box body and the top cover. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a three-dimensional structural diagram of the utility model.

[0021] Figure 2 This utility model Figure 1 Schematic diagram of the expanded structure.

[0022] Figure 3 This utility model Figure 2 Schematic diagram of the bottom structure.

[0023] Figure 4 This utility model Figure 1 Schematic diagram of the split structure.

[0024] Figure 5 This utility model Figure 4 Schematic diagram from another perspective.

[0025] Figure 6 This utility model Figure 4 A magnified schematic diagram of .

[0026] Figure 7 This utility model Figure 4 Enlarged schematic diagram of point B.

[0027] Figure 8 This utility model Figure 5 Enlarged schematic diagram of point C.

[0028] In the figure: 1- reagent box body, 2- partition, 3- ventilation assembly, 4- reagent partition, 5- first side shell, 6- second side shell, 7- handle, 8- top cover, 9- rotating lock disk, 10- semicircular groove, 11- fixed shaft, 12- clamp, 13- pad, 14- ventilation slot;

[0029] 31-outer shell, 32-DC fan, 33-positioning cylinder, 34-air inlet;

[0030] 71-side ear, 72-cross bar, 73-groove, 74-locking groove. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0032] See also Figure 1-8 In an embodiment of the present invention, a kit for evaluating the prognosis after treatment of liver cancer includes a kit body 1, a first side shell 5 and a second side shell 6 are respectively provided on both sides of the kit body 1, a handle 7 is provided on the top of the kit body 1, and a top cover 8 is clamped on the inner side of the handle 7; a semicircular groove is opened at the upper end of both ends of the kit body 1, and a fixed shaft 11 is provided in the semicircular groove; a rotary lock disk 9 is rotatably connected to the fixed shaft 11; a clamping member 12 is fixed on the inner side of the rotary lock disk 9;

[0033] The handle 7 is provided on one side of the first side shell 5 and has hinges at both ends, movably connected to the first side shell 5 via the hinges. The two sides and bottom of the first side shell 5 are fixedly connected to the reagent box body 1; the two sides of the lower end of the second side shell 6 are movably connected to the reagent box body 1 via a rotating shaft, and a magnet is provided on the top of the second side shell 6 for attracting the top cover 8.

[0034] By adopting the above technical solution, when taking out the reagent, the rotary lock disk 9 can be rotated to release the locking state of the rotary lock disk 9 and the handle 7, and then the handle 7 and the top cover 8 are deflected to one side based on the hinge, and the top cover 8 is separated from the reagent box body 1, so that the reagent box is opened, making it easier to take out the reagent inside.

[0035] When taking different reagents, the second side shell 6 can also be pulled outward to open the second side shell 6 so that the reagents inside can be taken out.

[0036] In this embodiment, the clamping member 12 is L-shaped; the clamping member 12 is slidably connected in the locking groove 74 .

[0037] In this embodiment, the handle 7 has two side ears 71, and a cross bar 72 is fixed between the two side ears 71; a groove 73 is provided on the outer side of the side ear 71 to facilitate the rotation of the rotary lock disk 9, and a locking groove 74 is provided on the side of the side ear 71 that is in contact with the clamp 12.

[0038] The locking groove 74 is formed by rotating 90 degrees with the axis of the fixed shaft 11 as the center and the bottom surface of the side ear 71 as the reference.

[0039] By adopting the above technical solution, when the handle 7 and the top cover 8 are buckled with the reagent box body 1, the locking groove 74 is just locked on the clamping member 12. By rotating the rotating lock disk 9 counterclockwise 90 degrees, the clamping member 12 can be located at the top of the locking groove 74, thereby realizing the locking and fixation of the reagent box body 1 and the top cover 8. The structure is simple and the operation is convenient.

[0040] In this embodiment, the card 12 and the locking groove 74 are both L-shaped, wherein the space of the locking groove 74 gradually decreases from bottom to top. This enables the card 12 to be better engaged and fixed with the locking groove 74, making it easier to lift and carry the entire test kit, and also preventing the card 12 from automatically falling off from the locking groove 74.

[0041] In this embodiment, the reagent box body 1 has a cavity inside for facilitating the installation of semiconductor refrigeration plates and batteries; a ventilation assembly 3 is also installed inside the cavity; the ventilation assembly 3 includes an outer shell 31, at least one DC fan 32 is provided on the top of the outer shell 31, and an air inlet 34 is provided on the side of the outer shell 31.

[0042] Since some reagents need to be refrigerated, we use semiconductor refrigeration sheets to generate cold air, and then the DC fan 32 blows the cold air into the inside of the reagent box body 1 so that the reagents can be better stored.

[0043] In this embodiment, a plurality of positioning cylinders 33 are further provided in the cavity inside the reagent box body 1 , and the plurality of positioning cylinders 33 are plugged and fixed to the positioning posts at the bottom of the partition 2 ; a reagent partition 4 is also provided on the partition 2 .

[0044] By adopting the above technical solution, the design of the reagent partition 4 can store different reagents, and realizes the classified placement of reagents to facilitate quick retrieval by subsequent staff.

[0045] In this embodiment, an elastic pocket for storing reagents is further provided on the inner wall of the second side shell 6 .

[0046] The elastic pocket can also store reagents, which can be directly taken out after opening the second side shell 6.

[0047] The inner side of the side ear 71 is integrally provided with a semicircular protrusion; both ends of the top cover 8 are provided with a semicircular groove, which realizes the detachable connection between the top cover 8 and the side ear 71.

[0048] In this embodiment, pads 13 are bonded to the four corners of the bottom of the reagent box body 1 , and a ventilation slot 14 is opened at one end of the bottom of the reagent box body 1 ; the ventilation slot 14 is located below the ventilation component 3 .

[0049] As a further description of the present invention:

[0050] Antibody reagents: These include antibodies targeting liver cancer-related proteins, such as alpha-fetoprotein antibodies, glypican-3 antibodies, and heat shock protein 70 antibodies. These antibodies can specifically recognize related proteins in liver cancer cells and detect protein expression levels in liver cancer tissue or serum through immunohistochemistry or immunoblotting, thereby reflecting the biological behavior and prognosis of liver cancer.

[0051] Preparation of antibody reagents: Hybridoma technology or genetic engineering techniques are used to prepare antibodies against liver cancer-related proteins, such as antibodies against alpha-fetoprotein, glypican-3, and heat shock protein 70. The prepared antibodies are purified and labeled, such as with horseradish peroxidase or fluorescein, to facilitate detection.

[0052] Nucleic acid reagents: These include primers and probes targeting liver cancer-related genes, such as p53, β-catenin, and VEGF. These primers and probes can specifically amplify and detect gene expression levels in liver cancer tissue or serum, thereby reflecting liver cancer gene mutations and signaling pathway abnormalities, and thus assessing liver cancer prognosis.

[0053] Preparation of nucleic acid reagents: PCR or gene chip technology is used to prepare primers and probes targeting liver cancer-related genes, such as p53, β-catenin, and VEGF. The prepared primers and probes are purified and labeled, such as with fluorescein or biotin, to facilitate detection.

[0054] Cytokine reagents: These include antibodies or ELISA kits targeting liver cancer-related cytokines, such as TGF-β1, IL-6, and IL-10. These cytokines can reflect the immune microenvironment and inflammatory status of liver cancer, thereby assessing the prognosis of liver cancer.

[0055] Preparation of cytokine reagents: Use ELISA or antibody chip technology to prepare antibodies or ELISA kits targeting liver cancer-related cytokines, such as TGF-β1, IL-6, and IL-10. Package and store the prepared antibodies or ELISA kits for easy use.

[0056] The working principle of the present invention is as follows: the design of the reagent partition 4 can store different reagents, realizing the classified placement of reagents, and the setting of the elastic pocket can also store reagents. When taking a reagent, the rotary lock disk 9 can be rotated to release the locking state of the rotary lock disk 9 and the handle 7, and then the handle 7 and the top cover 8 are deflected to one side based on the hinge, and the top cover 8 is separated from the reagent box body 1, so that the reagent box is opened and it is convenient to take the reagents inside. When taking different reagents, the second side shell 6 can also be pulled outward to open the second side shell 6 to facilitate the taking of the reagents inside.

[0057] After use, when closing the reagent box, snap the handle 7 and the top cover 8 together with the reagent box body 1. At this time, the locking groove 74 is just connected to the card 12. Rotate the rotating lock disk 9 90 degrees counterclockwise to make the card 12 located at the top of the locking groove 74, thereby achieving the locking and fixation of the reagent box body 1 and the top cover 8; the space of the locking groove 74 gradually decreases from bottom to top, which can make the card 12 better engaged and fixed with the locking groove 74, making it easier to lift and carry the entire reagent box, and can also prevent the card 12 from automatically falling off from the locking groove 74; generate cold air through the semiconductor refrigeration plate, and then the DC fan 32 blows the cold air into the inside of the reagent box body 1 so that the reagent can be better stored.

[0058] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be encompassed within the present invention. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

[0059] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A kit for evaluating the prognosis of liver cancer after treatment, characterized in that: The invention comprises a reagent box body (1), wherein the two sides of the reagent box body (1) are respectively provided with a first side shell (5) and a second side shell (6); a handle (7) is provided on the top of the reagent box body (1), and a top cover (8) is clamped on the inner side of the handle (7); a semicircular groove is provided at the upper end of both ends of the reagent box body (1), and a fixed shaft (11) is provided in the semicircular groove; a rotary lock disk (9) is rotatably connected to the fixed shaft (11); a clamping member (12) is fixed on the inner side of the rotary lock disk (9); The handle (7) has two side ears (71), and a cross bar (72) is fixed between the two side ears (71); a groove (73) is provided on the outer side of the side ear (71) to facilitate the rotation of the rotary lock disk (9), and a locking groove (74) is provided on the side of the side ear (71) that is in contact with the clamp (12).

2. The kit for evaluating prognosis of liver cancer after treatment according to claim 1, wherein: The clamping member (12) is arranged in an L shape; the clamping member (12) is slidably connected in the locking groove (74).

3. The kit for evaluating prognosis of liver cancer after treatment according to claim 1, wherein: The locking groove (74) is rotated 90 degrees with the axis of the fixed shaft (11) as the center of the circle and the bottom surface of the side ear (71) as the reference.

4. The kit for evaluating prognosis of liver cancer after treatment according to claim 3, wherein: The clamping member (12) and the locking groove (74) are both arranged in an L shape.

5. The kit for evaluating prognosis of liver cancer after treatment according to claim 1, wherein: The reagent box body (1) has a cavity inside for facilitating the installation of a semiconductor cooling plate and a battery; a ventilation assembly (3) is also installed inside the cavity; the ventilation assembly (3) includes an outer shell (31), at least one DC fan (32) is provided on the top of the outer shell (31), and an air inlet (34) is provided on the side of the outer shell (31).

6. The kit for evaluating prognosis of liver cancer after treatment according to claim 5, characterized in that: A plurality of positioning cylinders (33) are further provided in the cavity inside the reagent box body (1), and the plurality of positioning cylinders (33) are plugged and fixed to the positioning columns at the bottom of the partition (2); a reagent partition (4) is also provided on the partition (2).

7. The kit for evaluating prognosis of liver cancer after treatment according to claim 1, wherein: An elastic pocket for storing reagents is also provided on the inner wall of the second side shell (6).

8. The kit for evaluating prognosis of liver cancer after treatment according to claim 1, wherein: Pads (13) are bonded at the four corners of the bottom of the reagent box body (1), and a ventilation slot (14) is opened at one end of the bottom of the reagent box body (1); the ventilation slot (14) is located below the ventilation component (3).

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