Experimental mouse device

Abstract

The utility model relates to the technical field of mouse experiments, in particular to an experimental mouse device. The experimental mouse device comprises an experiment table, a transparent cover, a collecting hopper, a solid-liquid separation device and a material receiving hopper, the collecting hopper is vertically installed on a table top of the experiment table, a grid plate is installed at a top opening of the collecting hopper, the transparent cover is installed at the top opening of the collecting hopper so as to cover the grid plate, and the solid-liquid separation device is installed on the material receiving hopper. An inlet pipe for a mouse to enter is mounted on the transparent cover; a first bearing plate which is horizontally arranged is mounted on the experiment table, the solid-liquid separation device is placed on the first bearing plate, and a discharge port of the collection hopper is located above the solid-liquid separation device. According to the experimental mouse device, mouse excrement and mouse urine can be collected respectively, and effective separation of the mouse excrement and the mouse urine is achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of mouse experiments, in particular to a mouse experiment device. Background Art

[0002] Animal experimentation is a primary means of conducting scientific research, and laboratory mice are a common experimental subject. They have been used in biomedical research for many years due to their advantages: small size, rapid growth, short lifespan, high reproductive capacity, ease of breeding and management, fully sequenced genomes, and high genetic variability. Therefore, laboratory mice are widely used to study genetics, physiology, and behavior, as well as the pathogenesis and treatment of diseases.

[0003] Metabolic studies in experimental mice require the collection of urine and feces to monitor their growth and drug metabolism. Existing mouse metabolic cages typically collect urine and feces simultaneously, making subsequent separation difficult. Even with a separation net, removing and cleaning the net requires disassembling the cage from the metabolite collection rack, a cumbersome process that disrupts the normal life of the experimental mice. Utility Model Content

[0004] (1) The problem to be solved by the present invention is that the existing mouse metabolic cage usually collects urine and feces at the same time, which makes it difficult to separate them later. Even if a separation net is used to separate urine and feces, the removal and cleaning of the separation net require the metabolic cage and the metabolite collection rack to be disassembled and separated, which is a cumbersome operation.

[0005] (2) Technical solution

[0006] A mouse experimental device comprises a laboratory table, a transparent cover, a collection hopper, a solid-liquid separation device, and a receiving hopper. The collection hopper is vertically mounted on the surface of the laboratory table. A mesh plate is mounted on the top opening of the collection hopper. The transparent cover is mounted on the top opening of the collection hopper to cover the mesh plate. An inlet pipe for mice to enter is mounted on the transparent cover. A first horizontally arranged supporting plate is mounted on the laboratory table. The solid-liquid separation device is placed on the first supporting plate, and the discharge port of the collection hopper is located above the solid-liquid separation device.

[0007] A placement groove for placing the solid-liquid separation device is formed on the upper surface of the first supporting plate, and the solid-liquid separation device includes a cylinder, a truncated cone and an interception net, the truncated cone is arranged on the inner bottom wall of the cylinder, the interception net is vertically arranged on the side of the truncated cone, and an interception cavity for collecting mouse feces is formed between the interception net and the truncated cone, at least one water outlet is formed on the inner bottom wall of the cylinder, and at least one drainage hole corresponding to the water outlet is formed on the inner bottom wall of the placement groove, and the water outlet hole is connected to the corresponding drainage hole;

[0008] The receiving hopper is installed on the lower surface of the first supporting plate and is used to collect mouse urine flowing out of the drainage hole.

[0009] According to one embodiment of the present invention, an annular trough is installed on the side wall of the transparent cover close to the bottom surface thereof, and the annular space in the annular trough is divided into at least one feed trough for placing feed and at least one water trough for placing drinking water by a partition;

[0010] At least one feeder corresponding to the feed trough and at least one drinker corresponding to the water trough are installed outside the transparent cover.

[0011] According to one embodiment of the present invention, the water dispenser includes a connected water tank and a delivery pipe, wherein one end of the delivery pipe away from the water tank extends into the interior of the transparent cover and points to the water trough, and a valve body for controlling its on and off is installed on the delivery pipe.

[0012] According to one embodiment of the present invention, an inner flange is provided on the side surface of the top of the collecting bucket, and the grid plate is fixed to the inner flange by bolts.

[0013] According to an embodiment of the present invention, an outer flange is provided on the outer side of the inner flange, and a fixing flange is provided at the bottom end of the transparent cover to be matched with the outer flange.

[0014] According to one embodiment of the present invention, the experimental bench includes a support frame, a top plate is provided on the top of the support frame, the upper surface of the top plate forms the table top of the experimental bench, a second supporting plate is provided in the support frame, the second supporting plate is lower than the receiving hopper, a measuring cylinder is placed on the second supporting plate, and the measuring cylinder is used to receive mouse urine flowing out of the receiving hopper.

[0015] According to one embodiment of the present invention, a valve is installed at the bottom water outlet of the hopper.

[0016] According to one embodiment of the present invention, a gate is installed in the inlet pipe.

[0017] Beneficial effects of the utility model:

[0018] Open the inlet tube and put the experimental mice into the transparent cover. The mice move in the grid plate on the top of the collection bucket. During the metabolic experiment, the feces and urine discharged by the mice can pass through the grid plate and fall into the collection bucket, and then fall into the interception chamber of the solid-liquid separation device along the collection bucket. At this time, the mouse feces are intercepted by the interception net and remain in the interception net, while the urine flows along the cone surface and passes through the interception net and flows into the inner bottom wall of the cylinder. Then the urine flows out from the water outlet on the inner bottom wall of the cylinder and flows into the drainage hole of the placement trough. Finally, the urine drips from the drainage hole into the receiving hopper and flows out from the receiving hopper to the measuring cylinder below. After the experimental time is over, take out the mice and wait for a while until all the mouse urine is collected. Finally, the experimenter takes out the solid-liquid separation device and pours out the mouse feces in the interception chamber for weighing. Finally, rinse the solid-liquid separation device with clean water for use in the next experiment.

[0019] This experimental mouse device can collect mouse feces and mouse urine separately, realizing the effective separation of mouse feces and mouse urine. In the later stage, it is only necessary to take out the solid-liquid separation device and rinse it without opening the transparent cover. It is more convenient to use, has a simple structure and low cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the specific implementation methods of the utility model or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 A perspective view of an embodiment of the present invention;

[0022] Figure 2 A front view of an embodiment of the present utility model;

[0023] Figure 3 A three-dimensional diagram of a transparent cover provided in an embodiment of the present utility model;

[0024] Figure 4 A structural diagram of a collecting hopper and a solid-liquid separation device provided in an embodiment of the present utility model;

[0025] Figure 5 This is a structural diagram of the solid-liquid separation device provided in an embodiment of the present utility model.

[0026] Icons: 1. Laboratory table; 101. Roller; 102. First load-bearing plate; 103. Second load-bearing plate; 2. Collecting hopper; 201. Inner flange; 202. Outer flange; 3. Transparent cover; 301. Inlet pipe; 302. Annular trough; 303. Fixed flange; 4. Feeder; 5. Drinker; 6. Solid-liquid separation device; 601. Cylinder; 602. Cone; 603. Intercepting net; 604. Water outlet; 7. Receiving hopper; 8. Measuring cylinder; 9. Delivery pipe; 10. Grid plate; 11. Valve body. DETAILED DESCRIPTION

[0027] The following will clearly and completely describe the technical solutions of the present invention in conjunction with the embodiments. Obviously, the embodiments described are only a part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0028] like Figure 1-Figure 5 As shown, one embodiment of the present invention provides an experimental mouse device, including an experimental table 1, a transparent cover 3, a collecting hopper 2, a solid-liquid separation device 6 and a receiving hopper 7, the collecting hopper 2 is vertically installed on the table of the experimental table 1, the top opening of the collecting hopper 2 is installed with a grid plate 10, the transparent cover 3 is installed at the top opening of the collecting hopper 2 to cover the grid plate 10, and the transparent cover 3 is installed with an inlet pipe 301 for mice to enter; a first horizontally arranged carrying plate 102 is installed on the experimental table 1, the solid-liquid separation device 6 is placed on the first carrying plate 102, and the discharge port of the collecting hopper 2 is located above the solid-liquid separation device 6;

[0029] A placement groove for placing the solid-liquid separation device 6 is provided on the upper surface of the first supporting plate 102. The solid-liquid separation device 6 includes a cylinder 601, a frustum 602 and an interception net 603. The frustum 602 is provided on the inner bottom wall of the cylinder 601. The interception net 603 is vertically provided on the side of the frustum 602. An interception cavity for collecting mouse feces is formed between the interception net 603 and the frustum 602. At least one water outlet 604 is provided on the inner bottom wall of the cylinder 601. At least one drainage hole corresponding to the water outlet 604 is provided on the inner bottom wall of the placement groove. The water outlet 604 is connected to the corresponding drainage hole.

[0030] The receiving hopper 7 is mounted on the lower surface of the first supporting plate 102 and is used to collect the mouse urine flowing out of the drainage hole.

[0031] In this embodiment, the inlet pipe 301 is opened to place the experimental mouse inside the transparent cover 3. The mouse moves in the grid plate 10 on the top of the collection bucket 2. During the metabolic experiment, the feces and urine discharged by the mouse can pass through the grid plate 10 and fall into the collection bucket 2, and then fall into the interception chamber of the solid-liquid separation device 6 along the collection bucket 2. At this time, the mouse feces are intercepted by the interception net 603 and remain in the interception net 603, while the urine flows along the conical surface of the frustum 602 and passes through the interception net 603 and flows into the inner bottom wall of the cylinder 601. Then the urine flows out from the water outlet 604 on the inner bottom wall of the cylinder 601 and flows into the drain hole of the placement trough. Finally, the urine drips from the drain hole into the receiving hopper 7 and flows out from the receiving hopper 7 to the measuring cylinder 8 below. After the experimental time is over, the mouse is taken out and waits for a period of time until all the mouse urine is collected. Finally, the experimenter takes out the solid-liquid separation device 6 and pours out the mouse feces in the interception chamber for weighing. Finally, clean water is used to rinse the solid-liquid separation device 6 for use in the next experiment.

[0032] It can be seen that this experimental mouse device can collect mouse feces and mouse urine separately, realizing the effective separation of mouse feces and mouse urine. Later, it is only necessary to take out the solid-liquid separation device 6 and rinse it without opening the transparent cover 3. It is more convenient to use, has a simple structure and low cost.

[0033] As a specific embodiment, the experimental bench 1 includes a top plate and four supporting legs. The four supporting legs are fixed at the four corners of the bottom of the top plate. Two horizontally arranged supporting frames are provided between the four supporting legs. For the convenience of description, the supporting frame in a higher position is named as the first supporting frame, and the supporting frame in a lower position is named as the second supporting frame. A horizontally arranged first supporting plate 102 is provided on the first supporting frame, and the first supporting plate 102 is used to place the solid-liquid separation device 6. A horizontally arranged second supporting plate 103 is provided on the second supporting frame, and the second supporting plate 103 is used to place the measuring cylinder 8.

[0034] As a preferred embodiment, Figure 5 As shown, the solid-liquid separation device 6 includes a cylinder 601, and a frustum 602 is integrally formed on the inner bottom wall of the cylinder 601. The frustum 602 and the cylinder 601 are coaxially arranged, and an annular groove is provided on the conical surface of the frustum 602. The annular groove and the frustum 602 are coaxially arranged. The interception net 603 is wound in a tube network shape and vertically arranged in the annular groove. An interception cavity is formed inside the interception net 603. Furthermore, a plurality of water outlets 604 are provided, and the plurality of water outlets 604 are evenly arranged on the inner bottom wall of the cylinder 601 around the axis of the cylinder 601. Figure 2As shown, a placement groove is provided on the upper surface of the first supporting plate 102, adapted for the cylinder 601. The placement groove has multiple drainage holes corresponding one-to-one with the water outlet holes 604. A flange is provided on the top of the hopper 7, which is fixed to the lower surface of the first supporting plate 102. The diameter of the top opening of the hopper 7 is larger than the diameter of the placement groove to ensure that all urine flowing out of the drainage holes flows into the hopper 7.

[0035] Before the experiment begins, it is necessary to manually place the solid-liquid separation device 6 into the placement groove of the first supporting plate 102, and rotate the cylinder 601 so that the water outlet hole 604 on the cylinder 601 is aligned with the drain hole in the placement groove. Then, the mouse is placed into the transparent cover 3 and supplemented with food and drinking water, and then the timing is started. During the experiment, the feces and urine discharged by the mice pass through the grid plate 10 and enter the collecting hopper 2. The mouse urine and mouse feces flowing out of the collecting hopper 2 outlet directly fall onto the top side of the truncated cone 602, that is, fall into the interception chamber. The mouse feces are intercepted by the interception net 603 and remain in the interception chamber, while the mouse urine passes through the interception net 603 and flows along the conical surface of the truncated cone 602 into the inner bottom wall of the cylinder 601 and then flows out from the water outlet 604 into the drain hole, and finally flows out into the receiving hopper 7. The measuring cylinder 8 is located just below the receiving hopper 7 to collect the mouse urine flowing out from the receiving hopper 7. After the experiment time arrives, the mice are taken out, and wait for a period of time to ensure that all urine is collected. Finally, the solid-liquid separation device 6 is taken out to remove the mouse feces in the interception chamber. It can be seen that the solid-liquid separation device 6 in this embodiment can effectively separate mouse urine and mouse feces.

[0036] For example, a valve, preferably a butterfly valve, is installed at the bottom outlet of the collection hopper 2 to control its on / off function. Thus, at the beginning of the metabolic experiment, the mouse is placed in the transparent cover 3 and the butterfly valve is opened. When the experiment time is up, the butterfly valve is closed, which makes it more convenient to remove the mouse without having to take it away immediately.

[0037] As an optional embodiment, a circular hole is provided on the upper surface of the first supporting plate 102 for the cylinder 601 to pass through, and an ear plate is provided on the side of the cylinder 601. The cylinder 601 is placed in the circular hole of the first supporting plate 102, and the ear plate rests on the upper surface of the first supporting plate 102. A connecting flange is provided on the side of the cylinder 601 near its bottom, and the top flange of the hopper 7 is fixedly connected to the connecting flange on the cylinder 601. In this way, before the experiment begins, the hopper 7 and the cylinder 601 are placed from the top of the first supporting plate 102 into the circular hole of the first supporting plate 102 until the ear plate on the side of the cylinder 601 rests on the upper surface of the first supporting plate 102. After the mouse urine is collected, the hopper 7 and the solid-liquid separation device 6 are directly taken out together, and finally the mouse feces in the interception chamber are taken out using tools.

[0038] As a preferred embodiment, Figure 3 As shown, an annular trough 302 is installed on the side wall of the transparent cover 3 near its bottom surface. The annular trough 302 is divided into at least one feed trough for placing feed and at least one water trough for placing drinking water by a partition.

[0039] Furthermore, at least one feeder 4 corresponding to the feed trough and at least one waterer 5 corresponding to the water trough are installed on the outside of the transparent cover 3. The waterer 5 includes a connected water tank and a delivery pipe 9. One end of the delivery pipe 9 extends into the interior of the transparent cover 3, and the water outlet of the delivery pipe 9 is aligned with the water trough. The delivery pipe 9 is installed with a valve body 11 for controlling its on and off. It should be noted that the feeder 4 includes a feeding bucket and a delivery pipe. The feeding bucket is vertically installed on the outside of the transparent cover 3. One end of the delivery pipe is connected to the bottom opening of the feeding bucket, and the other end extends into the interior of the transparent cover 3 and is aligned with the feed trough. A material valve such as a gate valve or a discharger is installed on the delivery pipe. Unlike the conventional method of placing a feed box and a water box separately in the metabolic cage, this annular trough 302 will not be bumped by mice, and the problem of feed or drinking water being wasted due to the feed box and the water box being bumped by mice will not occur.

[0040] It should be noted that the annular space of the annular trough 302 can be reasonably divided according to actual conditions, for example, four partitions are used to divide the annular trough 302 into two feed troughs and two water troughs. Accordingly, two feeders 4 and two waterers 5 are required.

[0041] In order to facilitate subsequent cleaning of the experimental mouse device, the transparent cover 3 and the collecting bucket 2 are designed to be detachable, and the collecting bucket 2 can be detachably installed on the experimental table 1.

[0042] Specifically, such as Figure 2 and Figure 4 As shown, a circular hole is provided on the top plate of the experimental table 1, an inner flange 201 is provided on the side of the top of the collecting bucket 2, and a fixing plate is integrally formed on the edge of the grid plate 10. The fixing plate and the inner flange 201 are fixed by bolts, which makes it easy to remove the grid plate 10 for cleaning.

[0043] Furthermore, an outer flange 202 is provided on the outer side of the inner flange 201, the lower surfaces of the inner flange 201 and the outer flange 202 are flush, the upper surface of the outer flange 202 is lower than the upper surface of the inner flange 201, and a fixing flange 303 is provided at the bottom end of the transparent cover 3 to cooperate with the outer flange 202.

[0044] Since the outer diameter of the inner flange 201 is larger than the circular hole on the top plate of the experimental table 1, after the collecting bucket 2 is placed into the circular hole on the top plate of the experimental table 1, the inner flange 201 and the outer flange 202 are placed on the upper surface of the top plate to suspend the collecting bucket 2.

[0045] When assembling the transparent cover 3 and the collecting hopper 2, buckle the transparent cover 3 onto the collecting hopper 2 so that the fixing flange 303 at the bottom of the transparent cover 3 is aligned with the outer flange 202 on the top side of the collecting hopper 2. Finally, use bolts to fix the outer flange 202 and the fixing flange 303. This makes it easy to disassemble the transparent cover 3 and the collecting hopper 2 later, thereby facilitating the flushing of the transparent cover 3 and the collecting hopper 2.

[0046] In addition, if Figure 1 As shown, an inlet pipe 301 is installed on the outer wall of the transparent cover 3. The inlet pipe 301 and the interior of the transparent cover 3 are connected, and a socket is opened on the upper surface of the inlet pipe 301. A gate is installed in the socket. The gate is inserted from the socket on the upper surface of the inlet pipe 301 to prevent mice from drilling out of the transparent cover 3.

[0047] As an optional embodiment, a valve is installed at the bottom water outlet of the hopper 7.

[0048] As a preferred embodiment, rollers 101 are installed at the four corners of the bottom of the experimental table 1. The rollers 101 are universal wheels with brakes to improve the flexibility and convenience of the experimental mouse device.

[0049] In the description of this utility model, it should be noted that the terms "upper" and "lower" and other terms indicating orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely to facilitate the description of this utility model and simplify the description. They do not indicate or imply that the devices or components referred to must have a specific orientation, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0050] In the description of the present invention, it should be noted that, unless otherwise expressly specified or limited, the terms "installation", "connection", and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, an indirect connection through an intermediate medium, or a connection between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances. In addition, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0051] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An experimental mouse device, characterized in that: The invention comprises a laboratory table (1), a transparent cover (3), a collecting hopper (2), a solid-liquid separation device (6) and a receiving hopper (7), wherein the collecting hopper (2) is vertically mounted on the table of the laboratory table (1), a mesh plate (10) is mounted on the top opening of the collecting hopper (2), the transparent cover (3) is mounted at the top opening of the collecting hopper (2) to cover the mesh plate (10), and an inlet pipe (301) for mice to enter is mounted on the transparent cover (3); a first horizontally arranged supporting plate (102) is mounted on the laboratory table (1), the solid-liquid separation device (6) is placed on the first supporting plate (102), and the discharge port of the collecting hopper (2) is located above the solid-liquid separation device (6); The upper surface of the first supporting plate (102) is provided with a placement groove for placing the solid-liquid separation device (6), and the solid-liquid separation device (6) includes a cylinder (601), a frustum (602) and an interception net (603), the frustum (602) is provided on the inner bottom wall of the cylinder (601), the interception net (603) is vertically provided on the side of the frustum (602), and an interception cavity for collecting mouse feces is formed between the interception net (603) and the frustum (602), at least one water outlet (604) is provided on the inner bottom wall of the cylinder (601), and at least one drainage hole corresponding to the water outlet (604) is provided on the inner bottom wall of the placement groove, and the water outlet (604) is connected to the corresponding drainage hole; The receiving hopper (7) is mounted on the lower surface of the first supporting plate (102) and is used to collect mouse urine flowing out of the drainage hole.

2. The experimental mouse device according to claim 1, characterized in that An annular trough (302) is installed on the side wall of the transparent cover (3) close to the bottom surface thereof, and a partition is used to separate the annular space in the annular trough (302) into at least one feed trough for placing feed and at least one water trough for placing drinking water; At least one feeder (4) corresponding one-to-one to the feed trough and at least one drinker (5) corresponding one-to-one to the water trough are installed outside the transparent cover (3).

3. The experimental mouse device according to claim 2, characterized in that: The drinking fountain (5) comprises a water tank and a delivery pipe (9) connected to each other. An end of the delivery pipe (9) away from the water tank extends into the interior of the transparent cover (3) and points toward the water trough. A valve body (11) for controlling the on / off operation of the delivery pipe (9) is installed on the delivery pipe (9).

4. The experimental mouse device according to claim 1, characterized in that An inner flange (201) is provided on the side surface of the top of the collecting hopper (2), and the grid plate (10) is fixed to the inner flange (201) by means of bolts.

5. The experimental mouse device according to claim 4, characterized in that: An outer flange (202) is provided on the outer side surface of the inner flange (201), and a fixing flange (303) is provided at the bottom end of the transparent cover (3) and is connected to the outer flange (202).

6. The experimental mouse device according to claim 1, characterized in that: The experimental table (1) includes a support frame, a top plate is provided on the top of the support frame, and the upper surface of the top plate forms the table of the experimental table (1); a second supporting plate (103) is provided in the support frame, and the second supporting plate (103) is lower than the receiving hopper (7); a measuring cylinder (8) is placed on the second supporting plate (103), and the measuring cylinder (8) is used to receive mouse urine flowing out of the receiving hopper (7).

7. The experimental mouse device according to claim 1, characterized in that: A valve is installed at the bottom water outlet of the receiving hopper (7).

8. The experimental mouse device according to claim 1, characterized in that: A gate is installed in the inlet pipe (301).

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