Circulating tumor cell storage device

Abstract

The utility model provides a circulating tumor cell storage device which comprises a box body with a storage groove formed in the end face of the top end, a box cover arranged on the end face of the top end of the box body in a sealing mode and a refrigerating mechanism arranged in the storage groove and used for refrigerating reagent tubes. The reagent tube is movably arranged in the limiting hole in a penetrating manner; the refrigeration mechanism comprises a limiting pipe arranged in the storage groove in the vertical direction, a guide disc fixedly arranged at the bottom of an inner pipe of the limiting pipe, and a plurality of guide fan blades arranged on the end face of the top end of the guide disc through a rotating assembly, wherein the two ends of the limiting pipe are connected with the bottom wall of the storage groove and the opening position of the bottom end of the limiting hole correspondingly. The cooling assembly is arranged in the storage tank and is used for filling low-temperature air flow into the bottom end of the inner pipe of the limiting pipe; according to the utility model, the reagent tube can be conveniently positioned in a low-temperature environment, and circulating tumor cells placed in the reagent tube are prevented from deteriorating.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to a circulating tumor cell storage device. Background Art

[0002] Circulating tumor cells (CTCs) are a general term for various tumor cells present in peripheral blood. They are shed from solid tumor lesions either spontaneously or during diagnostic and treatment procedures. Most CTCs undergo apoptosis or are phagocytosed after entering the peripheral blood. A small number of CTCs escape and take root, developing into metastatic lesions and increasing the risk of death in patients with malignant tumors. CTC detection plays an important role in early diagnosis, treatment efficacy, and prognosis assessment. CTC detection kits are containers for CTC detection fluid and other chemical reagents used to detect chemical components, drug residues, and viral types.

[0003] In the prior art, circulating tumor cell detection kits do not have a cooling function. During the transportation of circulating tumor cell detection reagents and the implementation of detection technology, in order to prevent the reagents from deteriorating at room temperature, it is necessary to keep the relevant reagents in a low-temperature environment as much as possible. Utility Model Content

[0004] In response to the above technical problems, the present invention provides a circulating tumor cell storage device, which can conveniently place the reagent tube in a low-temperature environment, thereby avoiding the deterioration of circulating tumor cells placed in the reagent tube.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: a circulating tumor cell storage device, comprising a box body with a storage tank provided on the top end face, a box cover sealably arranged on the top end face of the box body, and a refrigeration mechanism arranged in the storage tank for refrigerating reagent tubes, a partition with a limiting hole provided on the opening position of the storage tank is fixedly provided, and the reagent tube can be movably passed through the limiting hole, the refrigeration mechanism comprises a limiting tube arranged in the storage tank along the vertical direction and with its two ends respectively connected to the bottom wall of the storage tank and the opening position of the bottom end of the limiting hole, a guide plate fixedly arranged at the bottom position of the inner tube of the limiting tube, a plurality of guide blades arranged on the top end face of the guide plate by a rotating component, and a cooling component arranged in the storage tank and filling the bottom end of the inner tube of the limiting tube with a low-temperature airflow.

[0006] Preferably, a support rod is fixedly provided inside the limiting tube and above the guide plate, and the middle part of the support rod body is a curved structure that matches the bottom end of the reagent tube.

[0007] Preferably, the cooling assembly includes a connecting rod fixedly arranged on the bottom wall of the storage tank and one end of which is connected to the bottom end of the side of the limiting tube, an air intake fan arranged on the top side of the connecting rod away from one end of the limiting tube, and a semiconductor refrigeration plate arranged on the connecting rod, a connecting channel that passes through the interior of the limiting tube is opened in the connecting rod, and an opening is opened on the connecting channel, and the opening is located at the position of the air intake fan; the cooling end of the semiconductor refrigeration plate is located in the connecting channel.

[0008] Preferably, multiple guide blades are arranged in a circular array above the guide plate through a rotating assembly, and after the airflow passes through the multiple guide blades, the multiple guide blades are driven to rotate around the axis of the guide plate; multiple guide holes are opened in a circular array on the end surface of the guide plate.

[0009] Preferably, the rotating assembly includes a slip ring that is rotatably arranged in an annular groove on the top end face of the guide plate, and the top of the slip ring is fixedly connected to the bottom ends of multiple guide blades; a plurality of discharge holes that are connected to the interior of the inner tube are opened at the top position of the side of the limiting tube.

[0010] The beneficial effects of the present invention are as follows: circulating tumor cells are stored through a reagent tube, and the reagent tube is placed in a storage tank through a limiting hole provided on a partition, at which time the reagent tube is passed through the limiting tube, and a low-temperature airflow is filled into the bottom wall of the limiting tube through a cooling assembly, and when the low-temperature airflow passes through a plurality of guide blades provided on a guide plate, the low-temperature airflow drives the plurality of guide blades to rotate, so that when the low-temperature airflow flows to the side of the test tube located in the limiting tube, the low-temperature airflow is driven to rotate in the reagent tube under the guidance of the plurality of guide blades, forming a spiral low-temperature airflow, which facilitates the circulating tumor cells in the reagent tube to be uniformly in a low-temperature state, and can conveniently place the reagent tube in a low-temperature environment, thereby avoiding the deterioration of circulating tumor cells placed in the reagent tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0012] Figure 1 This is a simplified structural diagram of the circulating tumor cell storage device proposed in the present invention.

[0013] Figure 2 This is a schematic diagram of the cross-sectional structure of the circulating tumor cell storage device proposed in the present invention.

[0014] Figure 3 This is a schematic structural diagram of the refrigeration mechanism of the present utility model.

[0015] Figure 4 This is a schematic diagram of the cross-sectional structure of the refrigeration mechanism of the present invention.

[0016] In the figure: 1. Box body; 2. Box cover; 3. Sealing ring; 4. Storage tank; 5. Partition; 6. Limit hole; 7. Reagent tube; 8. Limit tube; 9. Discharge hole; 10. Connecting rod; 11. Intake fan; 12. Guide plate; 13. Slip ring; 14. Guide fan blade; 15. Guide hole; 16. Support rod. DETAILED DESCRIPTION

[0017] In order to make the technical means, creative features, objectives and effects achieved by the present invention easier to understand, the present invention is further described below in conjunction with specific embodiments and drawings. However, the following embodiments are only preferred embodiments of the present invention and are not exhaustive. Based on the embodiments in the implementation manner, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present invention.

[0018] See also Figure 1-4 A circulating tumor cell storage device comprises a box body 1 with a storage tank 4 provided on the top end face, a box cover 2 which can be sealably arranged on the top end face of the box body 1, and a refrigeration mechanism arranged in the storage tank 4 to refrigerate the reagent tube 7. A partition 5 with a limiting hole 6 is fixedly provided at the opening position of the storage tank 4, and the reagent tube 7 can be movably passed through the limiting hole 6. The refrigeration mechanism comprises a limiting tube 8 which is arranged in the storage tank 4 in the vertical direction and whose two ends are respectively connected to the bottom wall of the storage tank 4 and the opening position of the bottom end of the limiting hole 6, a guide plate 12 fixedly arranged at the bottom position of the inner tube of the limiting tube 8, a plurality of guide blades 14 arranged on the top end face of the guide plate 12 by a rotating component, and a cooling component which is arranged in the storage tank 4 and fills the bottom end of the inner tube of the limiting tube 8 with a low-temperature airflow.

[0019] like Figure 1-4 As shown, circulating tumor cells are stored through the reagent tube 7, and the reagent tube 7 is passed through the limiting hole 6 and arranged in the limiting tube 8, and the bottom of the inner tube of the limiting tube 8 is filled with low-temperature airflow through the cooling component arranged in the storage tank 4. When the low-temperature airflow passes through the multiple guide blades 14 arranged on the guide plate 12, the low-temperature airflow will drive the multiple guide blades 14 arranged on the guide plate 12 through the rotating component to rotate, and when the low-temperature airflow passes through the multiple guide blades 14, the low-temperature airflow forms a spiral airflow in the inner tube of the limiting tube 8, so that the reagent tube 7 located in the inner tube is uniformly in a low-temperature environment, which can conveniently put the reagent tube 7 in a low-temperature environment, thereby avoiding the deterioration of circulating tumor cells placed in the reagent tube 7.

[0020] A support rod 16 is fixedly provided inside the limiting tube 8 and above the guide plate 12 , and the middle portion of the support rod 16 is a curved structure that matches the bottom end of the reagent tube 7 .

[0021] like Figure 4 As shown, when the reagent tube 7 is inserted into the limiting tube 8, the bottom end of the reagent tube 7 is located on the support rod 16. The support rod 16 facilitates supporting the reagent tube 7, thereby ensuring that the position of the reagent tube 7 in the limiting tube 8 is stable.

[0022] The cooling assembly includes a connecting rod 10 fixedly set on the bottom wall of the storage tank 4 and with one end connected to the bottom end of the side of the limiting tube 8, an air intake fan 11 arranged on the top side of the connecting rod 10 away from one end of the limiting tube 8, and a semiconductor refrigeration plate arranged on the connecting rod 10. A connecting channel that passes through the interior of the inner tube of the limiting tube 8 is opened in the connecting rod 10, and an opening is opened on the connecting channel, which is located at the position of the air intake fan 11; the cooling end of the semiconductor refrigeration plate is located in the connecting channel.

[0023] like Figure 3-4 As shown, when the reagent tube 7 is placed in the inner tube of the limiting tube 8, the air intake fan 11 rotates, driving the air in the storage tank 4 to enter the bottom end of the limiting tube 8 through the connecting channel, and when the air flow passes through the connecting channel, the air flow is cooled down by the cooling end of the semiconductor refrigeration plate located in the connecting channel and becomes a low-temperature air flow.

[0024] A plurality of guide blades 14 are arranged in a circular array above the guide plate 12 through a rotating assembly, and after the airflow passes through the plurality of guide blades 14, the plurality of guide blades 14 are driven to rotate around the axis direction of the guide plate 12; a plurality of guide holes 15 are opened in a circular array on the end surface of the guide plate 12.

[0025] The rotating assembly includes a slip ring 13 that is rotatably arranged in an annular groove on the top end face of the guide plate 12, and the top end of the slip ring 13 is fixedly connected to the bottom ends of multiple guide blades 14; a plurality of discharge holes 9 that are connected to the interior of the inner tube are opened at the top end of the side of the limiting tube 8.

[0026] like Figure 4 As shown, when the low-temperature airflow enters the bottom of the guide plate 12, when the low-temperature airflow moves upward through multiple guide holes 15, the low-temperature airflow passes through multiple guide blades 14, which on the one hand drives the slip ring 13 connected to the multiple guide blades 14 to rotate in the slide groove, thereby facilitating the conversion of the air entering the limiting tube 8 into a spiral low-temperature airflow, flowing to the side of the reagent tube 7, and discharged into the storage tank 4 through the discharge hole 9, so that the air circulates in the storage tank 4 and the limiting tube 8, so that the reagent tube 7 is in a uniform low-temperature environment, which can conveniently put the reagent tube 7 in a low-temperature environment, thereby avoiding the deterioration of circulating tumor cells placed in the reagent tube 7.

[0027] A sealing ring 3 is provided on the top end surface of the box body 1.

[0028] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely preferred examples of the present invention and are not intended to limit the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention, and such changes and improvements fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A circulating tumor cell storage device, comprising a box body (1) with a storage tank (4) provided on the top end face, a box cover (2) sealably arranged on the top end face of the box body (1), and a refrigeration mechanism arranged in the storage tank (4) for refrigerating a reagent tube (7), a partition (5) with a limiting hole (6) fixedly provided at the opening position of the storage tank (4), and the reagent tube (7) can be movably inserted into the limiting hole (6), characterized in that: The refrigeration mechanism comprises a limiting tube (8) vertically arranged in the storage tank (4) and having two ends respectively connected to the bottom wall of the storage tank (4) and the bottom opening position of the limiting hole (6), a guide plate (12) fixedly arranged at the bottom position of the inner tube of the limiting tube (8), a plurality of guide blades (14) arranged on the top end surface of the guide plate (12) via a rotating assembly, and a cooling assembly arranged in the storage tank (4) and charging a low-temperature airflow into the bottom end of the inner tube of the limiting tube (8).

2. The circulating tumor cell storage device according to claim 1, characterized in that: A support rod (16) is fixedly provided inside the inner tube of the limiting tube (8) and above the guide plate (12), and the middle portion of the support rod (16) presents a curved structure that matches the bottom end of the reagent tube (7).

3. The circulating tumor cell storage device according to claim 2, characterized in that: The cooling assembly comprises a connecting rod (10) fixedly arranged on the bottom wall of the storage tank (4) and having one end connected to the bottom end of the side of the limiting tube (8), an air intake fan (11) arranged on the top side of the connecting rod (10) away from one end of the limiting tube (8), and a semiconductor cooling plate arranged on the connecting rod (10); a connecting channel that passes through the interior of the inner tube of the limiting tube (8) is provided in the connecting rod (10), and an opening is provided in the connecting channel, and the opening is located at the position of the air intake fan (11); and the cooling end of the semiconductor cooling plate is located in the connecting channel.

4. A circulating tumor cell storage device according to any one of claims 1 to 3, characterized in that: A plurality of guide blades (14) are arranged in a circumferential array above the guide plate (12) through a rotating assembly, and after airflow passes through the plurality of guide blades (14), the plurality of guide blades (14) are driven to rotate around the axis direction of the guide plate (12); and a plurality of guide holes (15) are opened in a circumferential array on the end surface of the guide plate (12).

5. The circulating tumor cell storage device according to claim 4, characterized in that: The rotating assembly comprises a slip ring (13) rotatably arranged in an annular groove provided on the top end surface of the guide plate (12), and the top end of the slip ring (13) is fixedly connected to the bottom ends of a plurality of guide blades (14); a plurality of discharge holes (9) communicating with the interior of the inner tube are provided at the top end of the side surface of the limiting tube (8).

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