Adjustable small animal brain three-dimensional positioning auxiliary device

Abstract

The utility model discloses an adjustable small animal brain three-dimensional positioning auxiliary device which comprises three plate bodies and a bubble level, the three plate bodies are connected with an upper supporting rod through holes, and an upper layer track and a lower layer track are arranged on the first plate body; vertical lower supporting rods are arranged at the two ends of the second plate body and the third plate body, and positioning knobs are arranged at the bottoms of the lower supporting rods. Through the arrangement of the auxiliary device, the cranial crest of the small animal can be rapidly arranged and balanced, the experimental target site can be accurately positioned, and the experimental accuracy can be improved; different samples of the same model are processed through the same method, and measurement errors between individuals can be reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of medical research and medical equipment, in particular to an auxiliary device used on an adjustable small animal brain stereotactic operating table. Background Art

[0002] In recent years, small animal brain stereotaxic instruments have been widely used in animal experiments. They are important research equipment in the fields of neuroanatomy, neurophysiology, and neuropharmacology. They are used for targeted injection, stimulation, destruction, and potential guidance of specific brain structures. They are mostly used in the establishment of models of cerebral hemorrhage, Parkinson's disease, epilepsy, and brain tumors, as well as basic research on brain neural stem cell transplantation, cerebral ischemia, etc.

[0003] Diseases related to the central nervous system are an important research direction in clinical medicine, and the corresponding animal models have become an important factor limiting early pharmacological and efficacy research.

[0004] Disease models constructed using small animals are key to developing new drugs and studying pharmacological mechanisms. Currently, the commonly used small animal models that can be constructed using small animal brain stereotaxic devices include: cerebral hemorrhage model, cerebral stroke model, concussion model, brain in situ tumor-bearing model, etc. The problem is that the model construction operation is delicate, and the existing technology cannot guarantee that the operation points of each sample are completely consistent, which leads to poor consistency of the constructed models. At the same time, the delicate operation leads to a long time for model construction operation, which is difficult to support large-scale experiments. This has hindered the research on central nervous system-related diseases and the development of drugs to a certain extent. Therefore, there is a need for an adjustable small animal brain stereotaxic auxiliary device. Summary of the Invention

[0005] In order to solve the problems of long positioning adjustment time and inaccurate positioning of a small animal brain stereotaxic instrument, the utility model provides an adjustable small animal brain stereotaxic auxiliary device.

[0006] The utility model provides an adjustable small animal brain stereotactic positioning auxiliary device, which adopts the following technical solutions:

[0007] An adjustable small animal brain stereotactic positioning auxiliary device comprises three plates and a bubble level (1), wherein the three plates are connected to an upper support rod (7) via holes, the upper support rod being a threaded structure and being threadedly connected to a threaded outer sleeve (8), wherein the first plate (901) is provided with upper and lower rails (4); both ends of the second plate (902) and the third plate (903) are provided with vertical lower support rods (6), and the bottom of the lower support rod (6) is provided with a positioning knob (10).

[0008] In a specific embodiment, the bubble level (1) is fixedly placed on the top of the upper support rod (7).

[0009] In a specific embodiment, the bottom of the positioning knob (10) is provided with anti-slip material, and the length of the lower support rod can be adjusted by rotating the positioning knob (10).

[0010] In a specific feasible implementation scheme, the two layers of tracks are respectively set as an origin leveling ring track (5) and a positioning ring track (4), and are respectively provided with a supporting origin leveling ring limit knob (3) and a positioning ring limit knob (2), and the knobs are hollow and a long rod 1 (301) and a long rod 2 (201) are respectively inserted into the knobs, one end of which is connected to the origin leveling ring (302) and the positioning ring (202). The position of the long rod is fixed and adjusted by the limit knob and the track, and the track is a hollow structure in the first plate body.

[0011] In a specific possible implementation scheme, the origin leveling ring (3) is in the shape of a cross ring, and the position of the origin leveling ring (202) is adjusted by the origin leveling ring limit knob (3).

[0012] In a specific possible implementation scheme, the positioning ring (202) is designed as a miniature circular ring, and the position of the positioning ring (202) is adjusted by a limit knob (2) of the positioning ring (202).

[0013] In a specific embodiment, the device can be folded and stored in a rotating manner with the upper support rod (7) as the center.

[0014] In summary, the present invention has at least one of the following beneficial technical effects:

[0015] By assisting the small animal brain stereotaxic instrument to quickly balance the small animal's head and experimental site, the experimental time can be shortened, the difficulty of experimental operation can be reduced, the errors between different experimental subjects and operations can be reduced, and the operation efficiency can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a side view of the auxiliary structure.

[0017] Figure 2 It is a top view of the auxiliary structure.

[0018] Explanation of the accompanying symbols: 1. Bubble level; 2. Positioning ring limit knob; 201. Long rod two; 202. Positioning ring; 3. Origin leveling ring limit knob; 301. Long rod one; 302. Origin leveling ring; 4. Positioning ring track; 5. Origin leveling ring track; 6. Lower support rod; 7. Upper support rod; 8. Threaded sleeve; 901. First plate; 902. Second plate; 903. Third plate; 10. Positioning knob. DETAILED DESCRIPTION

[0019] The following is combined with Figure 1-2The utility model is described in further detail.

[0020] An auxiliary device for quickly leveling and positioning a small animal brain stereotaxic instrument comprises three plates and a bubble level (1). The three plates are connected to an upper support rod (7) through holes. The upper support rod is a threaded structure and is connected to a threaded outer sleeve (8) through threads. The first plate (901) is provided with an upper and lower track. The second plate (902) and the third plate (903) are provided with vertical lower support rods (6) at both ends, and the bottom of the lower support rods (6) are provided with positioning knobs (10). The bubble level (1) is fixed on the top of the upper support rod (7). The two tracks are respectively provided as an origin leveling ring track (5) and a positioning ring track (4), and are respectively provided with a support origin leveling ring limit knob (3) and a positioning ring limit knob (2). The hollow knobs are respectively inserted with a long rod 1 (301) and a long rod 2 (201) whose ends are connected to the origin leveling ring (302) and the positioning ring (202). The position of the long rod is fixed and adjusted by the limit knobs and the tracks. The origin leveling ring (3) is in the shape of a cross ring, and the position of the origin leveling ring (302) is adjusted by the origin leveling ring limit knob (3). The positioning ring (202) is designed as a miniature ring, and the position of the positioning ring (202) is adjusted by the positioning ring limit knob (2). The device can be folded and stored in a rotating manner with the upper support rod (7) as the center.

[0021] When using the auxiliary device, it is placed flat on the operating table of the small animal stereotaxic instrument. The upper support rod (7) and the threaded sleeve (8) are rotated from the folded storage state to the open state, and the threaded sleeve is then slid to stabilize the structure. The four-leg positioning knob (10) can be adjusted to cooperate with the bubble level positioner (1) to confirm whether it is in a horizontal state.

[0022] When using the auxiliary device, first, the small animal brain stereotactic auxiliary device of the utility model in the stored state is rotated and unfolded by taking the above support rod (7) as the center, and then placed in front of the animal placement table of the small animal brain stereotactic instrument after unfolding, and the four-leg positioning knobs are adjusted until the bubble level (1) is in a horizontal state, and then the entire auxiliary device is kept firmly placed.

[0023] The small animal can then be placed on the animal placement table of the brain stereotaxic instrument and fixed with the ear rods and opening rods provided with the instrument. The animal placement table is then moved so that the origin of the small animal's skull is directly below the origin leveling ring (202) of the auxiliary device of this embodiment. At this time, the threaded outer sleeve (8) connected to the upper support rod is adjusted, and the length of the upper support rod 7 is adjusted to adjust the height of the first plate (901). When the origin leveling ring (202) contacts the top of the small animal's skull, the central cross ring structure of the origin leveling ring (202) can clearly observe whether the top of the small animal's skull is in a horizontal state and where it deviates from the horizontal state, thereby adjusting the height of the ear rods or opening rods of the brain stereotaxic instrument to achieve horizontality.

[0024] After the top of the small animal's skull is adjusted to a horizontal level, the site of the experimental operation is located using a brain stereotaxic device. After the position is determined, the positioning ring (202) is adjusted to the target site through the positioning ring limit knob (2) and the positioning ring track and fixed. The size of the positioning ring (202) is approximately the size of the cranial drill bit. While facilitating cranial drill drilling, it eliminates the need to use a marker or other means to mark the target site, reducing the risk of the experimental animal suffering from additional trauma or infection. At the same time, the positioning ring track (4) where the positioning ring limit knob (202) is located is not placed on the same plane as the origin leveling ring track (5), reducing mutual interference between the two; at the same time, it also provides a height reference for cranial drill drilling, reducing the risk of cranial drill drilling too deep. In some cases, the origin leveling ring track (5) is placed below the positioning ring track (4).

[0025] The positioning ring knob (2) and the origin leveling ring knob (3) can be fixed on the corresponding track. After operating an animal, the same method is used to fix another animal and perform origin leveling. Then, the drilling operation can be performed directly at the positioning ring, which reduces the operation of re-searching the target site and reduces the measurement error between models.

[0026] After the experimental operation is completed, the auxiliary device of the utility model can be folded and stored in a rotational manner with the upper support rod (7) as the center.

[0027] The above are all preferred embodiments of the present invention, and are not intended to limit the scope of protection of the present invention. Therefore, any equivalent changes made based on the structure, shape, and principle of the present invention should be included in the scope of protection of the present invention.

Claims

1. An adjustable small animal brain stereotactic positioning auxiliary device, characterized by: The invention comprises three plates and a bubble level (1), wherein the three plates are connected to an upper support rod (7) through holes, wherein the first plate (901) is provided with an upper and lower track; lower support rods (6) are vertically provided at both ends of the second plate (902) and the third plate (903), and a positioning knob (10) is provided at the bottom of the lower support rod (6).

2. The adjustable small animal brain stereotactic positioning auxiliary device according to claim 1, characterized in that: The bubble level (1) is fixedly placed on the upper support rod (7) and the top of the first plate (901).

3. The adjustable small animal brain stereotactic positioning auxiliary device according to claim 1, characterized in that: The bottom of the positioning knob (10) is provided with anti-slip material, and the length of the lower support rod can be adjusted by rotating the positioning knob (10).

4. An adjustable small animal brain stereotactic positioning auxiliary device according to any one of claims 1 to 3, characterized in that: The two layers of tracks are respectively configured as an origin leveling ring track (5) and a positioning ring track (4), and are respectively provided with a supporting origin leveling ring limit knob (3) and a positioning ring limit knob (2), and a long rod 1 (301) and a long rod 2 (201) whose one end is connected to the origin leveling ring (302) and the positioning ring (202) are respectively inserted into the hollow of the button, and the position of the long rod is fixed and adjusted by the limit knob and the track.

5. The adjustable small animal brain stereotactic positioning auxiliary device according to claim 4, characterized in that The origin leveling ring (302) is in the shape of a cross ring, and the position of the origin leveling ring (302) is adjusted by the origin leveling ring limit knob (3) and the origin leveling ring track (5).

6. The adjustable small animal brain stereotactic positioning auxiliary device according to claim 4, characterized in that: The positioning ring (202) adopts a miniature circular ring design, and the position of the positioning ring (202) is adjusted through the positioning ring limit knob (2) and the positioning ring track (4).

7. The adjustable small animal brain stereotactic positioning auxiliary device according to claim 1, characterized in that: The device can be folded and stored in a rotational manner with the upper support rod (7) as the center.

8. The adjustable small animal brain stereotactic positioning auxiliary device according to claim 1, characterized in that: The upper support rod is a threaded structure and is connected to a threaded outer sleeve (8) via threads.

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