Multi-channel transcranial electrical stimulation system

Abstract

The multi-channel transcranial electrical stimulation system comprises a main control module, a stimulation module, a power supply module and an electrode switching module, the main control module receives and analyzes the control instruction, generates a control signal and sends the control signal to the stimulation module, and the stimulation module comprises a variable gain assembly and a current conversion assembly, generates a stimulation waveform based on the control signal, and obtains electrical stimulation information to adjust an electrical stimulation mode and slowly change a stimulation current; the electrode switching module receives the stimulation signal and switches the stimulation current to the stabbing electrode so as to transmit the stimulation current. According to the system, the treatment intensity of a subject can be continuously monitored and adjusted, discomfort of the subject caused by nervous system impact is reduced, and the comfort level and the treatment efficiency of the subject are improved; in addition, by adjusting the electrical stimulation mode, treatment schemes of subjects in different conditions can be optimized in a targeted mode.

Description

Technical Field

[0001] The present application relates to the field of neuromodulation, and in particular to a multi-channel transcranial electrical stimulation system. Background Art

[0002] Temporally Interfering (TI) electrical stimulation is a new type of non-invasive brain stimulation method. By generating multiple high-frequency pulse currents of different frequencies (such as 2.00kHz and 2.01kHz), the high-frequency current flows through the surface and deep areas of the brain, interfering in the deep brain to produce a low-frequency envelope (such as 10Hz). Since brain neurons do not respond to high-frequency (greater than 1.00kHz) electrical stimulation, the high-frequency current located on the surface of the brain does not produce a stimulating effect on the brain. The low-frequency envelope located deep in the brain stimulates the brain, which can achieve non-invasive stimulation of the deep brain without affecting the cerebral cortex.

[0003] Most traditional electrical stimulation devices do not support multi-channel stimulation, have low output signal accuracy, do not support pairing with stimulation electrodes, and can easily cause discomfort to patients during the process of adjusting the stimulation level, further affecting the treatment process. Compared with other stimulation devices, the multi-channel transcranial electrical stimulation system of this application supports the use of at least four stimulation channels for simultaneous output, and the stimulation waveform (waveform amplitude, frequency) of each channel is independently adjustable, and the stimulation mode is also adjustable, which improves the focusing accuracy of multi-channel stimulation. On this basis, it supports electrode recognition and can avoid electrode misuse.

[0004] In addition, the system described in the present application also optimizes the regulation of the stimulation process to reduce the impact of changes in stimulation intensity on the patient's nervous system, thereby improving treatment efficiency. Utility Model Content

[0005] To address the problems in the prior art, this application discloses a multi-channel transcranial electrical stimulation system that provides multiple independently adjustable stimulation channels, can slowly adjust the stimulation current intensity during brain stimulation therapy, and provides multiple stimulation modes. The technical solutions of this application are as follows:

[0006] A multi-channel transcranial electrical stimulation system, comprising:

[0007] Main control module 1, stimulation module 2, power supply module 3 and electrode adapter module 4;

[0008] The main control module 1 receives and analyzes the control instruction at the input end and generates a control signal. The output end of the main control module 1 is connected to the input end of the stimulation module 2, and the control signal is sent to the stimulation module 2 at the output end;

[0009] The stimulation module 2 generates stimulation voltage, stimulation current and obtains electrical stimulation information based on the control signal, and its output end is connected to the input end of the electrode adapter module 4;

[0010] The stimulation module 2 includes a variable gain component 23 and a current conversion component 24. The current conversion component 24 can generate stimulation current and adjust the electrical stimulation mode. The variable gain component 23 can change the stimulation voltage amplitude to control and slowly change the amplitude of the stimulation current generated by the current conversion component 24. The output end of the variable gain component 23 is connected to the input end of the current conversion component 24.

[0011] The power supply module 3 is used to provide power to the main control module 1 and the stimulation module 2. The power supply module 3 is electrically connected to the main control module 1 and the stimulation module 2 respectively;

[0012] The electrode adapter module 4 receives the stimulation signal from the stimulation module 2 and transfers the stimulation current to the electrodes disposed on the subject's scalp, thereby controlling the electrodes to deliver the stimulation current to the subject.

[0013] According to one embodiment of the present application, the stimulation module 2 further includes: a second execution unit 21 and a waveform generation component 22;

[0014] The second execution unit 21 receives the control instruction and controls the waveform generation component 22 to generate the stimulation voltage;

[0015] The waveform generation component 22 is used to generate a stimulation waveform, and its output end is connected to the input end of the variable gain component 23. The waveform generation component 22 transmits the generated stimulation waveform to the variable gain component 23 and can adjust the frequency of the stimulation waveform.

[0016] According to one embodiment of the present application, the stimulation waveform generated by the waveform generating component 22 is a sine wave, a square wave or a triangle wave; and

[0017] The number of waveform generating components 22 is 4 or 5 or more.

[0018] According to one embodiment of the present application, the variable gain component 23 includes:

[0019] Resistor R1, digital potentiometer R2, resistor R3, resistor R4 and voltage amplifier;

[0020] One end of the resistor R1 is connected to the output end of the waveform generating component, and the other end is connected in series with the digital potentiometer R2 and then grounded;

[0021] One end of the resistor R3 is connected to the output end of the voltage amplifier, and the other end is connected in series with the resistor R4 and then grounded;

[0022] The positive input terminal of the voltage amplifier is connected between the resistor R1 and the digital potentiometer R2, and the negative input terminal of the voltage amplifier is connected between the resistor R3 and the resistor R4;

[0023] The output terminal of the voltage amplifier is connected to the input terminal of the current conversion component.

[0024] According to one embodiment of the present application, the current conversion component 24 includes a current conversion unit 240 and a mode control unit 241. The current conversion unit 240 can generate a stimulation current based on the stimulation voltage, and the mode control unit 241 can adjust the flow direction of the stimulation current to adjust the electrical stimulation mode.

[0025] According to one embodiment of the present application, the current conversion unit 240 includes:

[0026] Resistor R5, resistor R6, resistor R7, resistor R8, resistor R9, first operational amplifier, resistor R10, resistor R11, resistor R12, resistor R13, resistor R14, second operational amplifier;

[0027] One end of the resistor R6 receives the stimulation voltage, and the other end is connected in series with the resistor R5 as the current positive output end;

[0028] One end of the resistor R8 is connected between the output terminal of the first operational amplifier and the resistor R9, and the other end is connected in series with the resistor R7 and then grounded;

[0029] The positive input terminal of the first operational amplifier is connected between the resistor R5 and the resistor R6, and the negative input terminal of the first operational amplifier is connected between the resistor R7 and the resistor R8;

[0030] The output terminal of the first operational amplifier is connected in series with the resistor R9 and then connected to the current positive output terminal;

[0031] One end of the resistor R10 serves as the current inverting input terminal, and the other end is connected in series with the resistor R11 and then grounded;

[0032] One end of the resistor R13 is connected between the output terminal of the second operational amplifier and the resistor R14, and the other end is connected in series with the resistor R12 to receive the stimulation voltage;

[0033] The positive input terminal of the second operational amplifier is connected between the resistor R10 and the resistor R11, and the negative input terminal of the second operational amplifier is connected between the resistor R12 and the resistor R13;

[0034] The output terminal of the second operational amplifier is connected in series with the resistor R14 and then connected to the current inverting input terminal.

[0035] According to one embodiment of the present application, the mode control unit 241 includes a first switch and a second switch, the first switch is connected to the current inverting input terminal, and the second switch is connected to the electrode switching module.

[0036] According to one embodiment of the present application, the stimulation module 2 further includes: a voltage conversion component 25, a single-ended conversion component 26 and a digital conversion unit 27;

[0037] The voltage conversion component 25 is used to collect the reflux stimulation current from the subject;

[0038] The single-ended conversion component 26 collects the differential voltage between the electrodes attached to the subject's scalp and converts the differential voltage signal into a single-ended voltage;

[0039] The digital conversion unit 27 receives the reflux stimulation current and the single-ended voltage, and generates a digital signal based on the reflux stimulation current and the single-ended voltage;

[0040] The second execution unit 21 is capable of receiving the digital signal and the return stimulation current, and calculating the contact impedance between the electrode and the subject's scalp based on the digital signal.

[0041] According to one embodiment of the present application, the main control module 1 includes: a serial port isolation component 12 and a first execution unit 11;

[0042] The first execution unit 11 is used to receive and analyze control instructions;

[0043] The first execution unit 11 is also connected to the second execution unit 21 through the serial port isolation component 12 to send control instructions to the second execution unit 21 and / or obtain contact impedance, digital signals and reflux stimulation current from the second execution unit 21.

[0044] According to one embodiment of the present application, the electrode adapter module 4 has an electrode adapter component 40, and the electrode adapter component 40 is used to receive the stimulation current and transfer the stimulation current to the electrode.

[0045] According to one embodiment of the present application, the electrode adapter module 4 further includes an accessory identification component 41 , which is electrically connected to the second execution unit 21 and sends an electrode identification signal to the second execution unit 21 ;

[0046] After the electrode identification signal is matched with the second execution unit 21 , the second execution unit 21 sends an electrode switching instruction to the electrode switching assembly 40 .

[0047] The multi-channel transcranial electrical stimulation system disclosed in this application utilizes a stimulation module to generate stimulation voltage and current, and to acquire electrical stimulation information. A variable gain component is used to adjust the stimulation voltage amplitude at a constant rate, allowing the stimulation current in each stimulation channel to vary at a relatively slow rate during the stimulation treatment. Consequently, when using this system for electrical stimulation therapy, the impact of rapid changes in stimulation on the subject's nervous system can be reduced by continuously monitoring electrical stimulation information and slowly adjusting the stimulation current intensity. This, in turn, reduces discomfort during treatment, improving subject comfort and enhancing treatment efficiency.

[0048] Furthermore, the multi-channel transcranial electrical stimulation system disclosed in this application can adjust the composition of stimulation pathways through current conversion components, providing a variety of electrical stimulation modes to meet the treatment needs of different subjects. By selecting appropriate stimulation modes, the therapeutic effect for different subjects can be optimized, while also improving the scalability and adaptability of the system.

[0049] Finally, the multi-channel transcranial electrical stimulation system disclosed in this application can use the electrode adapter module to achieve independent matching and identification of the electrodes used in each stimulation pathway, which can avoid misuse of electrodes, thereby improving treatment efficiency and reducing the occurrence of system failures and misoperations. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 This is a schematic structural diagram of a multi-channel transcranial electrical stimulation system of the present application in one embodiment;

[0051] Figure 2 1 is a circuit diagram of a variable gain component of the present application in one embodiment;

[0052] Figure 3 A circuit diagram of a current conversion component of the present application in one embodiment;

[0053] Figure 4 Flowchart of the transcranial electrical stimulation method of the present application in one embodiment.

[0054] Reference numerals

[0055] 1- Main control module 2- Stimulation module 3- Power module 4- Electrode adapter module

[0056] 11-First execution unit 12-Serial port isolation component 21-Second execution unit

[0057] 22- Waveform generation component 23- Variable gain component 24- Current conversion component

[0058] 25- voltage conversion component 26- single-ended conversion component 27- digital conversion unit

[0059] 40-Electrode conversion component 41-Accessory identification component 100-Main control module communication interface

[0060] 110-Control output interface 200-Stimulation module communication interface 210-Stimulation output interface

[0061] 310-AC unit 311-first step-down unit 320-isolated power supply

[0062] 321 - second step-down unit 322 - first charge pump 323 - second charge pump

[0063] 324-Boost unit 325-Negative pressure unit DETAILED DESCRIPTION

[0064] The following embodiments of the present application are intended only to illustrate specific implementation methods for implementing the present application and are not to be construed as limiting the present application. Any other changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principles of the present application are deemed equivalent replacements and fall within the scope of protection of the present application.

[0065] The multi-channel transcranial electrical stimulation system disclosed in this application, in one embodiment, comprises a main control module 1, a stimulation module 2, a power supply module 3 and an electrode adapter module 4. Figure 1 As shown. The main control module 1 is used to receive control instructions through the main control module communication interface 100, parse the control parameters and / or operation commands in the control instructions to generate control signals that can be executed by the stimulation module 2. The main control module 2 sends the control signals to the stimulation module 2 through the control output interface 110 to achieve control of the stimulation module 2. Specifically, the main control module has a serial port isolation component 12 and a first execution unit 11. The first execution unit 11 receives the control instructions input through the main control module communication interface 100, parses the control instructions and generates a control signal. The control signal is isolated from the current and interference signal through the serial port isolation component 12, and is sent to the second execution unit through the control output interface 110.

[0066] The control instructions received by the main control module 1 may include: stimulation current amplitude, stimulation current frequency value, electrical stimulation duration, electrical stimulation mode and / or stimulation voltage amplitude rise / fall time; in this application, the host computer that sends control instructions to the main control module can be exemplified by a computer, IPC, PLC, etc.

[0067] In one embodiment, the stimulation module 2 is used to receive control signals, generate stimulation voltages and currents, and obtain electrical stimulation information. The stimulation module includes a second execution unit 21, a waveform generation component 22, a variable gain component 23, and a current conversion component 24. The second execution unit 21 receives control signals through the stimulation module communication interface 200 and controls the waveform generation component 22 to generate stimulation waveforms. Under the control of the second execution unit 21, the waveform generation component 22 can generate stimulation voltages with waveforms of sine waves, square waves, or triangle waves. In the stimulation module 2, there are four waveform generation components 22, each of which is individually controlled by the second execution unit 21 and independently adjustable. In addition, under the control of the second execution unit 21, the waveform generation component 22 can adjust the frequency of the stimulation waveform it generates. Therefore, the waveform generation component 22 can generate stimulation waveforms that meet different electrical stimulation modes and electrical stimulation intensities, providing subjects with high-precision, personalized brain stimulation therapy.

[0068] The variable gain component 23 of the stimulation module 2 is used to obtain the stimulation waveform generated by the waveform generation component 22 and change the amplitude of the stimulation voltage. In one embodiment, the variable gain component 23 includes a resistor R1, a digital potentiometer R2, a resistor R3, a resistor R4 and a voltage amplifier (U1). One end of the resistor R1 is connected to the output end of the waveform generation component 22, and the other end is connected in series with the digital potentiometer R2 and then grounded; one end of the resistor R3 is connected to the output end of U1, and the other end is connected in series with the resistor R4 and then grounded; the positive input end of U1 is connected between the resistor R1 and the digital potentiometer R2, and the reverse input end of U1 is connected between the resistor R3 and the resistor R4; the output end of UI is connected to the input end of the current conversion component 24. When the stimulation voltage is transmitted to the resistor R1 through the waveform generation component 22, the variable gain component 23 changes the amplitude of the stimulation voltage and outputs the stimulation voltage after the amplitude change, as shown in the following formula:

[0069]

[0070] Among them, V i The amplitude of the stimulation waveform generated by the waveform generation component 22 is amplified / reduced accordingly by the variable gain component 23 according to the resistance values ​​of the resistor R1, the digital potentiometer R2, the resistor R3, and the resistor R4. It should be noted that the digital potentiometer R2 is electrically connected to the second execution unit 21. Under the control of the second execution unit 21, the digital potentiometer R2 can slowly change its own resistance. In this way, the variable gain component 23 can slowly change the amplitude of the generated stimulation voltage and adjust the stimulation voltage at a certain speed. In particular, when the stimulation module 2 receives the control signal for the first time and generates the stimulation voltage, the stimulation voltage V output by the variable gain component 23 is o , whose amplitude is greater than the stimulation waveform V generated by the waveform generating component 22i amplitude, that is, the variable gain component 23 realizes the amplification effect on the stimulation voltage, so that the stimulation voltage can generate a stimulation current suitable for brain stimulation treatment; and in the subsequent electrical stimulation process, by adjusting the resistance of the digital potentiometer R2, the amplitude of the stimulation voltage can be adjusted within a certain range to further change the amplitude of the stimulation current. In this adjustment process, the amplitude of the stimulation voltage can be amplified or reduced to better adjust the stimulation intensity, so that the system can better adapt to the treatment needs of the subject.

[0071] In one embodiment, the second execution unit 21 receives a control signal via the stimulation module communication interface 200, wherein the control signal includes the stimulation voltage amplitude and the stimulation voltage amplitude rise / fall time. The digital potentiometer R2 is controlled by the second execution unit 21 via the I2C interface and uniformly adjusts the resistance R2 to R2' during the stimulation voltage amplitude rise / fall time, so that the stimulation voltage output by the variable gain component 23 is uniformly adjusted from the existing amplitude to the stimulation voltage amplitude included in the control signal during the stimulation voltage amplitude rise / fall time. The resolution of the digital potentiometer R2 is set to 10 bits. For subjects receiving electrical stimulation, the stimulation voltage adjustment provided by the variable gain component 23 can effectively reduce the discomfort caused by the rapid adjustment of stimulation intensity by existing electrical stimulation devices, thereby improving the subject's comfort during treatment. In addition, this method of slowly adjusting the stimulation voltage amplitude helps medical personnel continuously monitor the subject's response and ensure the safety of the treatment process. By monitoring and recording stimulation parameters such as voltage and current during the stimulation voltage fluctuation process, the optimal treatment plan can be found, providing a long-term treatment plan suitable for different individuals.

[0072] In one embodiment, the current conversion component 24 generates a stimulation current based on the stimulation voltage, and adjusts the electrical stimulation mode. The current conversion component 24 includes a current conversion unit 240 and a mode control unit 241, wherein the current conversion unit 240 includes a resistor R5, a resistor R6, a resistor R7, a resistor R8, a resistor R9, and a first operational amplifier (U2A). One end of the resistor R6 receives the AC stimulation voltage, and the other end is connected in series with the resistor R5 as the current forward output end; one end of the resistor R8 is connected between the output end of U2A and the resistor R9, and the other end is connected in series with the resistor R7 and then grounded; the positive input end of U2A is connected between the resistor R5 and the resistor R6, and the reverse input end of U2A is connected between the resistor R7 and the resistor R8; the output end of U2A is connected in series with the resistor R9 and then connected to the current forward output end. In this way, the stimulation voltage output by the variable gain component 23 applied to the resistor R6 generates a corresponding stimulation current at one end of the resistor R5, and the stimulation current can be transferred to the electrode and used to generate a low-frequency envelope in deep brain interference.

[0073] The current conversion unit 240 also includes resistors R10, R11, R12, R13, R14, and a second operational amplifier (U2B). One end of resistor R10 serves as the current inverting input, and the other end is connected in series with resistor R11 and then to ground. One end of resistor R13 is connected between the output of U2B and resistor R14, and the other end is connected in series with resistor R12 to receive the stimulation voltage. The positive input of U2B is connected between resistors R10 and R11, and the negative input of U2B is connected between resistors R12 and R13. The output of U2B is connected in series with resistor R14 and then connected to the current inverting input. The stimulation current flows back to the current inverting input after passing through the subject and the electrode, forming a stimulation path.

[0074] It should be noted that, in this embodiment, any waveform generation component 22 forms a stimulation current generation path with a corresponding variable gain component 23 and a current conversion component 24. That is, in this embodiment, the number of variable gain components 23 and current conversion components 24 is four, and each stimulation current generation path is independently adjustable and controlled by the second execution unit 21. In this way, the system of the present application can generate stimulation currents with different waveforms, different amplitudes, different frequencies, and different amplitude rise / fall times, thereby improving the focusing accuracy and adjustability of multi-channel electrical stimulation, and providing a possible solution for subjects to receive high-efficiency and low-risk stimulation treatment.

[0075] In one embodiment, the mode control unit 241 is used to adjust the direction of the stimulation current to adjust the electrical stimulation mode. The mode control unit 241 includes a first switch (S1) and a second switch (S2), wherein S1 is connected to the current inverting input terminal of the current conversion unit 240, and KS is connected to the electrode adapter module 4. S1 and S2 can be dual-control switches, one end A of S1 is directly connected to one end A of S2, the other end B of S1 is connected to a reference point, and the other end B of S2 is connected to another reference point. Therefore, when S1 is connected to one end A and S2 is also connected to one end A, the stimulation current forms a return stimulation current after passing through the subject and the electrode, and the return stimulation current flows back to the current inverting input terminal through the path formed by S1 and S2, forming a conductive stimulation path, the current at the current forward output terminal and the current inverting input terminal have opposite phases, and the stimulation current generation paths including any current conversion component 24 are independent of each other; therefore, in this way, the present application can provide a stimulation mode of TI stimulation for the subject.

[0076] In another embodiment, when S1 is connected to its other end B and S2 is also connected to its other end B, the return stimulation current formed after the stimulation current passes through the subject and the electrode flows through S2 to the reference point connected to its other end B; the return stimulation current of any stimulation current generating path reaches the reference point connected to the other end B of S2, so that the four-lead stimulation paths converge at this reference point; therefore, in this way, a new stimulation path can be formed by combining the electrodes. When the stimulation current is alternating current, the present application can provide the subject with a stimulation mode of tACS stimulation, and when the stimulation current is direct current, the present application can provide the subject with a stimulation mode of tDCS stimulation. In summary, the electrical stimulation mode adjusted by the mode control unit 241 in the present application is TI stimulation, tACS stimulation and / or tDCS stimulation, which can adapt to the treatment needs of different subjects, optimize the treatment effect on different individual subjects by selecting an appropriate stimulation mode, and improve the scalability and adaptability of the system.

[0077] In one embodiment, the stimulation module further includes: a voltage conversion component 25, a single-ended conversion component 26, and a digital conversion unit 27. The voltage conversion component 25 is capable of acquiring the return stimulation current of any conductive stimulation pathway. Specifically, the voltage conversion component 25 acquires the voltage across a fixed resistor connected in series to any conductive stimulation pathway to obtain the return stimulation current flowing through the fixed resistor. The single-ended conversion component 26 is capable of acquiring the differential voltage across an electrode attached to the subject's scalp and converting the differential voltage into a single-ended voltage. The digital conversion unit 27 receives the return stimulation current and single-ended voltage of each conductive stimulation pathway and generates a digital signal based on the return stimulation current and single-ended voltage of each conductive stimulation pathway. The digital signal can be used to calculate the contact impedance between the electrode and the subject's scalp and reflect the waveform information of the stimulation current flowing through the subject's scalp. The digital conversion unit 27 sends the contact impedance, digital signal and the return stimulation current of each stimulation path to the second execution unit 21 through the control interface. The second execution unit 21 obtains electrical stimulation information based on the contact impedance, digital signal and the return stimulation current of each stimulation path, wherein the electrical stimulation information includes: contact impedance, digital signal, stimulation current amplitude, stimulation current waveform, stimulation current frequency and electrical stimulation mode.

[0078] In the present application, the digital conversion unit 27 can be exemplified by a single chip microcomputer with an ADC conversion chip, FPGA, DSP, and other microcontrollers.

[0079] The second execution unit 21 sends the acquired electrical stimulation information to the first execution unit 11 via the stimulation module communication interface 200, and the first execution unit 11 uploads the electrical stimulation information to the host computer via the main control module communication interface 100. In this way, medical personnel can use the system of the present application to monitor the contact impedance, voltage, current and other treatment parameters of the subject in real time during the electrical stimulation treatment process, so as to further protect the safety of the subject during treatment and provide data support for adjusting treatment parameters and improving treatment comfort.

[0080] Specifically, in one embodiment, the power module 3 may include an AC / DC power supply assembly 31 and a DC / DC power supply assembly 32. The AC / DC power supply assembly 31 includes an AC unit 310 and a first step-down unit 311. The AC unit 310 receives alternating current to generate a first intermediate power supply. After the first intermediate power supply is input into the first step-down unit 311, the first step-down unit 311 outputs a voltage, which is transmitted to the main control module 1 through a power interface to provide power to the main control module. Preferably, the output voltage of the first step-down unit 311 is 5V. The DC / DC power supply assembly 32 includes an isolated power supply 320, a second step-down unit 321, a first charge pump 322, a second charge pump 323, a boost unit 324 and a negative voltage unit 325; the isolated power supply 320 receives the first intermediate power supply to generate a second intermediate power supply, and inputs the second intermediate power supply into the second step-down unit 321, the first charge pump 322, and the second charge pump 323 respectively to generate a 5V DC voltage, a -12V DC voltage and a -12V AC voltage, which are respectively used to provide power to the stimulation module 2 through the power interface; in addition, the second intermediate power supply is input into the boost unit 324 to generate a 36V DC voltage, and the boost unit 324 inputs the boosted voltage into the negative voltage unit 325 to generate a -36V DC voltage, which is also used to provide power to the stimulation module 2.

[0081] In one embodiment, the electrode adapter module 4 includes an electrode adapter component 40 and an accessory identification component 41, which are used to receive the stimulation signal output by the stimulation module 2 and transfer the stimulation current to the electrode so that the electrode can provide stimulation current to the subject's brain after being attached to the subject's scalp. Specifically, the accessory identification component 41 is electrically connected to the second execution unit 21, and the accessory identification component 41 sends an electrode identification signal to the second execution unit 21, and the electrode identification signal is matched with the second execution unit 21; after the matching is completed, the second execution unit 21 sends an electrode transfer instruction to the electrode adapter component 40. When the stimulation module 2 outputs the stimulation current through the stimulation output interface 210, the electrode transfer instruction and the stimulation current constitute a stimulation signal, and the electrode adapter component 40 receives the stimulation signal and transfers the stimulation current to the electrode.

[0082] In particular, for the stimulation current output by any stimulation current generating path of the stimulation module 2, the electrode adapter assembly 40 transfers the stimulation current to two independent electrodes to form an independent single-channel stimulation path. In this way, the electrode adapter assembly 40 forms a total of four stimulation paths. For any single-channel stimulation path, the present application achieves independent matching and identification of electrodes through the electrode adapter module 4, which can avoid electrode misuse, thereby improving treatment efficiency and reducing the occurrence of system failures and malfunctions.

[0083] In one embodiment, the present application provides a transcranial electrical stimulation method for performing transcranial electrical stimulation therapy using the multi-channel transcranial electrical stimulation system of the present application, comprising:

[0084] Step S110: inputting a control instruction to the first execution unit 11, the first execution unit 11 generates a control signal after parsing the control instruction, and sends the control signal to the second execution unit 21 through the serial port isolation component 12;

[0085] Step S120: The second execution unit 21 controls the four waveform generation components 22 to generate stimulation waveforms based on the control signal, and the waveform generation components 22 transmit the stimulation waveforms to the corresponding variable gain components 23;

[0086] Step S130: The variable gain component 23 amplifies the stimulation voltage and transmits the stimulation voltage to the corresponding current conversion unit 240. The current conversion unit 240 generates a stimulation current. After the mode control unit 241 determines the electrical stimulation mode, the stimulation current is transmitted to the electrode adapter component 40.

[0087] Step S140: The accessory recognition component 41 sends an electrode recognition signal to the second execution unit 21. The second execution unit 21 matches the electrode recognition signal. After the match is successful, it sends an electrode switching instruction to the accessory recognition component 41. The electrode switching component 40 switches the stimulation current to the corresponding electrodes.

[0088] Step S150: Utilizing the voltage conversion component 25 and the single-ended conversion component 26 to obtain the reflux stimulation current and the single-ended voltage, obtaining a digital signal through the digital conversion unit 27, and transmitting the digital signal and the reflux stimulation current to the second execution unit 21 to calculate the contact impedance;

[0089] Step S160: The first execution unit 11 obtains and uploads at least one of the contact impedance, digital signal and reflux stimulation current to the host computer through the second execution unit 21. The host computer updates the control instructions and repeats steps S110-S150 to change at least one parameter of the stimulation current amplitude, stimulation current waveform, stimulation current frequency, stimulation voltage amplitude rise / fall time and electrical stimulation mode to improve the treatment effect and the comfort of the subject during the treatment process.

[0090] Although the embodiments of the present application are described above, the present application is not limited to the above-mentioned specific embodiments and application fields. The above-mentioned specific embodiments are merely illustrative and instructive, and not restrictive. A person of ordinary skill in the art, guided by this specification and without departing from the scope of protection of the claims of this application, may also devise various forms, all of which fall within the scope of protection claimed in this application.

Claims

1. A multi-channel transcranial electrical stimulation system, characterized in that: include: Main control module, stimulation module, power supply module and electrode adapter module; among them, The main control module receives and analyzes the control instruction at the input end to generate a control signal. The output end of the main control module is connected to the input end of the stimulation module, and the output end sends the control signal to the stimulation module. The stimulation module generates stimulation voltage, stimulation current and obtains electrical stimulation information based on the control signal, and its output end is connected to the input end of the electrode adapter module; wherein, The stimulation module includes a variable gain component and a current conversion component. The current conversion component is capable of generating stimulation current and adjusting the electrical stimulation mode. The variable gain component is capable of changing the stimulation voltage amplitude to control and slowly change the amplitude of the stimulation current generated by the current conversion component. The output end of the variable gain component is connected to the input end of the current conversion component. The power supply module is used to provide power supply to the main control module and the stimulation module, and the power supply module is electrically connected to the main control module and the stimulation module respectively; The electrode adapter module receives the stimulation signal from the stimulation module and transfers the stimulation current to the electrodes disposed on the subject's scalp, thereby controlling the electrodes to deliver the stimulation current to the subject.

2. The system according to claim 1, wherein: in, The stimulation module further includes: a second execution unit and a waveform generation component; The second execution unit receives the control instruction and controls the waveform generation component to generate a stimulation voltage; The waveform generating component is used to generate a stimulation waveform, and its output end is connected to the input end of the variable gain component. The waveform generating component transmits the generated stimulation waveform to the variable gain component and can adjust the frequency of the stimulation waveform.

3. The system according to claim 2, characterized in that in, The stimulation waveform generated by the waveform generating component is a sine wave, a square wave or a triangle wave; and The number of the waveform generating components is 4 or 5 or more.

4. The system according to claim 2, wherein: in, The variable gain component comprises: Resistor R1, digital potentiometer R2, resistor R3, resistor R4 and voltage amplifier; One end of the resistor R1 is connected to the output end of the waveform generating component, and the other end is connected in series with the digital potentiometer R2 and then grounded; One end of the resistor R3 is connected to the output end of the voltage amplifier, and the other end is connected in series with the resistor R4 and then grounded; The positive input terminal of the voltage amplifier is connected between the resistor R1 and the digital potentiometer R2, and the negative input terminal of the voltage amplifier is connected between the resistor R3 and the resistor R4; The output end of the voltage amplifier is connected to the input end of the current conversion component.

5. The system according to claim 4, characterized in that in, The current conversion component includes a current conversion unit and a mode control unit. The current conversion unit can generate a stimulation current based on a stimulation voltage. The mode control unit can adjust the flow direction of the stimulation current to adjust the electrical stimulation mode.

6. The system according to claim 5, characterized in that The current conversion unit includes: Resistor R5, resistor R6, resistor R7, resistor R8, resistor R9, first operational amplifier, resistor R10, resistor R11, resistor R12, resistor R13, resistor R14, second operational amplifier; One end of the resistor R6 receives the stimulation voltage, and the other end is connected in series with the resistor R5 as the current positive output end; One end of the resistor R8 is connected between the output end of the first operational amplifier and the resistor R9, and the other end is connected in series with the resistor R7 and then grounded; The positive input terminal of the first operational amplifier is connected between the resistor R5 and the resistor R6, and the negative input terminal of the first operational amplifier is connected between the resistor R7 and the resistor R8; The output end of the first operational amplifier is connected in series with the resistor R9 and then connected to the current positive output end; One end of the resistor R10 serves as the current inverting input terminal, and the other end is connected in series with the resistor R11 and then grounded; One end of the resistor R13 is connected between the output end of the second operational amplifier and the resistor R14, and the other end is connected in series with the resistor R12 to receive the stimulation voltage; The positive input terminal of the second operational amplifier is connected between the resistor R10 and the resistor R11, and the negative input terminal of the second operational amplifier is connected between the resistor R12 and the resistor R13; The output terminal of the second operational amplifier is connected in series with the resistor R14 and then connected to the current inverting input terminal.

7. The system according to claim 6, characterized in that in, The mode control unit includes a first switch and a second switch, the first switch is connected to the current inverting input terminal, and the second switch is connected to the electrode adapter module.

8. The system according to claim 2, wherein: in, The stimulation module further comprises: a voltage conversion component, a single-ended conversion component and a digital conversion unit; The voltage conversion component is used to collect the reflux stimulation current from the subject; The single-ended conversion component collects the differential voltage between the electrodes attached to the subject's scalp and converts the differential voltage signal into a single-ended voltage; The digital conversion unit receives the reflux stimulation current and the single-ended voltage, and generates a digital signal based on the reflux stimulation current and the single-ended voltage; The second execution unit is capable of receiving the digital signal and the return stimulation current, and calculating the contact impedance between the electrode and the subject's scalp based on the digital signal.

9. The system according to claim 8, characterized in that in, The main control module includes: a serial port isolation component and a first execution unit; The first execution unit is used to receive and parse the control instruction; The first execution unit is also connected to the second execution unit through the serial port isolation component to send the control instruction to the second execution unit and / or obtain the contact impedance, digital signal and reflux stimulation current from the second execution unit.

10. The system according to claim 2, wherein: in, The electrode adapter module has an electrode adapter component, and the electrode adapter component is used to receive the stimulation current and transfer the stimulation current to the electrode.

11. The system according to claim 10, wherein: in, The electrode adapter module further comprises an accessory identification component, the accessory identification component being electrically connected to the second execution unit and sending an electrode identification signal to the second execution unit; After the electrode identification signal is matched with the second execution unit, the second execution unit sends an electrode switching instruction to the electrode switching component.

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