Blood storage device and liver perfusion system

Abstract

The utility model provides a blood storage device and a liver perfusion system, and the blood storage device comprises a tank body which is provided with a blood storage cavity and two blood outlets; the upper cover is arranged on the tank body in a covering mode and seals the blood storage cavity, the upper cover is provided with a blood inlet and at least one exhaust port, and the exhaust port is communicated with the atmospheric environment; and the filtering mechanism is arranged in the blood storage cavity, is positioned between the blood inlet and the blood outlet, and is used for filtering the blood entering from the blood inlet and discharging the filtered blood from the blood outlet. The design of the single blood inlet and the double blood outlets is adopted, the liver physiological structure can be matched, the exhaust port communicated with the atmospheric environment is arranged, the negative pressure in front of the centrifugal pump can be balanced, and therefore the problem that the inferior vena cava sucks flat cannot occur. The blood can be filtered through the filtering mechanism after entering the blood storage device, and the filtered blood flows out through the two blood outlets respectively, so that the risk problem caused by the fact that thrombus flows back to the liver is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a blood storage device and a liver perfusion system. Background Art

[0002] End-stage liver disease (chronic liver failure) is a serious, life-threatening liver disease that may be caused by a variety of liver diseases, such as cirrhosis and liver cancer. Since there is currently no effective treatment clinically, patients generally require liver transplantation.

[0003] A liver transplant replaces a diseased liver with a healthy liver from another person. The entire liver or just a portion of it can be transplanted. In most cases, the healthy liver will come from a recently deceased organ donor. Sometimes, a healthy person will donate a portion of their liver.

[0004] The liver has three main blood vessels. Among them, the hepatic artery is a branch of the celiac artery, which is responsible for transporting oxygen-rich blood from the heart to the liver; the portal vein is responsible for collecting nutrient-rich venous blood from abdominal organs such as the gastrointestinal tract, spleen and pancreas, and transporting it to the liver for metabolism and detoxification; the hepatic vein is responsible for transporting the processed blood from the liver back to the inferior vena cava, and finally back to the heart.

[0005] The normothermic mechanical liver perfusion system perfuses the donor liver at near body temperature with a perfusion fluid containing nutrients and oxygen, mimicking normal physiological conditions. This perfusion method can effectively reduce non-ischemic heat damage to the organ, repair and improve the liver, assess organ viability, and effectively improve the success rate of liver transplantation.

[0006] In the existing normothermic mechanical perfusion circulation system for the liver, the circulation line is usually directly connected to the inferior vena cava. However, since negative pressure is generated in front of the pump when the centrifugal pump drives the blood flow, excessive negative pressure may cause the inferior vena cava to be flattened, posing the risk of obstruction of the liver blood channel. Utility Model Content

[0007] In order to solve the above problems, the utility model proposes a blood storage device and a liver perfusion system.

[0008] In a first aspect, the utility model proposes a blood storage device, comprising: a tank body, formed with a blood storage cavity and two blood outlets connected to the blood storage cavity; an upper cover, which is arranged on the tank body and encapsulates the blood storage cavity, and the upper cover has a blood inlet and at least one exhaust port connected to the blood storage cavity, and the exhaust port is connected to the atmospheric environment; and a filtering mechanism, which is arranged in the blood storage cavity and located between the blood inlet and the blood outlet, and is used to filter the blood entering from the blood inlet and enable the filtered blood to be discharged through the blood outlet.

[0009] Furthermore, the filtering mechanism includes: a support bracket, connected to the upper cover and forming a filter chamber with the upper cover, the filter chamber is used to receive blood entering from the blood inlet; a filter sponge, sleeved on the outside of the support bracket, used to perform a primary filter on the blood in the filter chamber; and a filter cloth, sleeved on the outside of the filter sponge, used to perform a secondary filter on the blood after being filtered by the filter sponge.

[0010] Furthermore, the filtering mechanism further includes a liquid separating column, which is disposed in the filtering cavity and connected to the supporting bracket.

[0011] Furthermore, the cross-sectional area of ​​the liquid separation column in the axial direction of the filter cavity is gradually increased in the direction from the upper cover toward the tank body.

[0012] Furthermore, the blood storage chamber includes a first cavity and a second cavity arranged in sequence along its axial direction, the second cavity is arranged away from the upper cover relative to the first cavity, and the cross-sectional area of ​​the second cavity in the axial direction of the blood storage chamber is gradually reduced in the direction from the upper cover toward the tank body.

[0013] Furthermore, the upper cover includes: a main body, which is covered on the tank body and encapsulates the blood storage cavity; a first channel member, which is connected to the main body and forms the blood inlet; and at least one second channel member, which is connected to the main body and forms the exhaust port.

[0014] Furthermore, the tank body includes: a main body, forming the blood storage cavity; two third channel members, each connected to the main body and forming a corresponding blood outlet; and a fourth channel member, connected to the main body and forming a drainage port communicating with the blood storage cavity.

[0015] Furthermore, a gas filter membrane is provided in the exhaust port, and the gas filter membrane is configured to allow gas to pass through but not allow liquid to pass through.

[0016] Furthermore, the first channel member is provided with a first sampling port, and at least one of the third channel members is provided with a second sampling port.

[0017] In a second aspect, the present invention proposes a liver perfusion system, which includes a first centrifugal pump, a second centrifugal pump, an oxygenator, and the blood storage device described above, wherein the blood inlet of the blood storage device is used to be connected to the inferior vena cava of the isolated liver, one blood outlet of the blood storage device is connected to the first centrifugal pump, and the other blood outlet is connected to the second centrifugal pump, the first centrifugal pump is used to be connected to the hepatic artery of the isolated liver via the oxygenator, and the second centrifugal pump is used to be connected to the portal vein of the isolated liver.

[0018] The beneficial effects of the utility model are as follows:

[0019] In the present application, the blood storage device adopts a single blood inlet and dual blood outlet design, which is adaptable to the physiological structure of the liver. The blood inlet of the blood storage device can be connected to the inferior vena cava of the isolated liver, and one of the blood outlets of the blood storage device is connected to the first centrifugal pump, and the other blood outlet is connected to the second centrifugal pump. Thus, the blood storage device realizes the connection between the inferior vena cava and the first and second centrifugal pumps. Since the blood storage device is also provided with an exhaust port connected to the atmospheric environment, it can balance the negative pressure before the pumps of the first and second centrifugal pumps, thereby preventing the negative pressure before the pumps from being transmitted to the inferior vena cava of the liver, thereby preventing the problem of the inferior vena cava of the liver from being flattened. In addition, after flowing out of the inferior vena cava and entering the blood storage device through the blood inlet, the blood can be filtered by the filtering mechanism to intercept thrombi or impurities generated in the liver. The filtered blood then flows out through the two blood outlets to the first and second centrifugal pumps, thereby avoiding the risk of thrombi flowing back into the liver.

[0020] The purpose of providing this summary is to introduce a selection of concepts in a simplified form, which will be further described in the detailed description below. This summary is not intended to identify key features or essential features of the present disclosure, nor is it intended to limit the scope of the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The above and other objects, features and advantages of the present disclosure will become more apparent through a more detailed description of exemplary embodiments of the present disclosure with reference to the accompanying drawings, wherein like reference numerals generally represent like components throughout the exemplary embodiments of the present disclosure.

[0022] Figure 1 Shows a schematic structural diagram of the liver perfusion system of the present invention;

[0023] Figure 2 Shows a three-dimensional view of the blood storage device of the present invention;

[0024] Figure 3 An exploded view of the blood storage device of the present invention is shown;

[0025] Figure 4 A schematic diagram of the internal structure of the blood storage device of the present invention at one viewing angle is shown;

[0026] Figure 5 A schematic diagram of the internal structure of the blood storage device of the present invention is shown from another perspective;

[0027] Figure 6Shows a three-dimensional view of the filter mechanism of the present invention;

[0028] Figure 7 A schematic diagram showing the connection between the support bracket and the liquid separation column of the filter mechanism of the present invention is shown.

[0029] The accompanying drawings are numerals as follows:

[0030] 1000. Liver perfusion device;

[0031] 100. Blood storage device;

[0032] 10. Tank body; 11. Main body; 12. Third channel member; 13. Fourth channel member; A. Blood storage chamber; A1. First cavity; A2. Second cavity; B2. Blood outlet; B4. Drain port; B6. Second sampling port;

[0033] 20. Upper cover; 21. Main body; 22. First channel member; 23. Second channel member; B1. Blood inlet; B3. Exhaust port; B4. Liquid drain port; B5. First sampling port;

[0034] 30. Filter mechanism; 31. Support bracket; 32. Filter sponge; 33. Filter cloth; C. Filter chamber; 34. Separating column;

[0035] 200, first centrifugal pump;

[0036] 300, second centrifugal pump;

[0037] 400, oxygenator;

[0038] G, isolated liver. DETAILED DESCRIPTION

[0039] Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided to make the present disclosure more thorough and complete, and to fully convey the scope of the present disclosure to those skilled in the art.

[0040] As used herein, the term "including" and its variations represent open inclusion, i.e., "including but not limited to." Unless otherwise stated, the term "or" means "and / or." The term "based on" means "based at least in part on." The terms "an example embodiment" and "an embodiment" mean "at least one example embodiment." The term "another embodiment" means "at least one additional embodiment." The terms "first," "second," etc. may refer to different or the same objects. Other explicit and implicit definitions may also be included below.

[0041] Refer to the followingFigures 1-7 The blood storage device and liver perfusion system according to the embodiments of the present application are described.

[0042] Reference Figure 1 The liver perfusion system 1000 in the embodiment of the present application includes a blood storage device 100 , a first centrifugal pump 200 , a second centrifugal pump 300 and an oxygenator 400 .

[0043] Among them, the blood inlet of the blood storage device 100 is used to connect to the inferior vena cava of the isolated liver G, one blood outlet is connected to the first centrifugal pump 200, and the other blood outlet is connected to the second centrifugal pump 300. The first centrifugal pump 200 is used to connect to the hepatic artery of the isolated liver G via the oxygenator 400, and the second centrifugal pump 300 is used to connect to the portal vein of the isolated liver G.

[0044] Specifically, after the blood in the isolated liver G flows out from the inferior vena cava, it flows into the blood storage device 100 through the blood inlet of the blood storage device 100. The blood storage device 100 processes the blood therein and then circulates back to the liver in two ways. One of the blood paths is driven by the first centrifugal pump 200 and flows through the oxygenator 400. After gas exchange occurs in the oxygenator 400, the venous blood is converted into arterial blood, and the arterial blood flows back to the liver through the hepatic artery of the isolated liver G; the other blood path is driven by the second centrifugal pump 300 and flows directly back to the liver through the portal vein of the isolated liver G.

[0045] Therefore, the liver perfusion system 1000 of the present application can be used to perfuse the donor liver with a perfusion fluid containing nutrients and oxygen at a temperature close to body temperature to simulate the normal physiological state of the liver, thereby effectively reducing non-ischemic heat damage to the liver, repairing and improving the liver, and evaluating the activity of the liver, thereby effectively improving the success rate of liver transplantation.

[0046] Reference Figures 2 to 7 The blood storage device 100 in the embodiment of the present application includes a tank body 10 , an upper cover 20 and a filtering mechanism 30 .

[0047] The tank body 10 is formed with a blood storage chamber A and two blood outlets B2 communicating with the blood storage chamber A.

[0048] The upper cover 20 is disposed on the tank body 10 and encapsulates the blood storage chamber A. The upper cover 20 has a blood inlet B1 communicating with the blood storage chamber A and at least one exhaust port B3 communicating with the atmospheric environment.

[0049] The filtering mechanism 30 is disposed in the blood storage chamber A and located between the blood inlet B1 and the blood outlet B2 , and is used for filtering the blood entering from the blood inlet B1 and allowing the filtered blood to be discharged through the blood outlet B2 .

[0050] In this embodiment, the blood storage device 100 has a single blood inlet B1 and a double blood outlet B2 design, which can adapt to the physiological structure of the liver. The blood inlet B1 of the blood storage device 100 can be connected to the inferior vena cava of the isolated liver G, and one of the blood outlets of the blood storage device 100 is connected to the first centrifugal pump 200, and the other blood outlet is connected to the second centrifugal pump 300. Thus, the connection between the inferior vena cava and the first centrifugal pump 200 and the second centrifugal pump 300 is achieved through the blood storage device 100. Since the blood storage device 100 is also provided with an exhaust port B3 connected to the atmospheric environment, it can balance the pre-pump negative pressure of the first centrifugal pump 200 and the second centrifugal pump 300, thereby avoiding the pre-pump negative pressure from being transmitted to the inferior vena cava of the liver, and thus the problem of flattening of the inferior vena cava of the liver will not occur.

[0051] Furthermore, after blood flows out of the inferior vena cava and enters the blood storage device 100 through the blood inlet B1, it is filtered by the filter mechanism 30 to intercept thrombi or impurities in the liver. The filtered blood then flows out through the two blood outlets B2 to the first centrifugal pump 200 and the second centrifugal pump 300, respectively, thereby avoiding the risk of thrombi flowing back into the liver. Furthermore, the blood storage device 100 of the present application has a small volume and is particularly suitable for use with liver perfusion flow rates.

[0052] Reference Figures 4 to 6 The filter mechanism 30 includes a support bracket 31, a filter sponge 32 and a filter cloth 33. Specifically, the material of the filter sponge 32 is polyurethane, and the material of the filter cloth 33 is polyamide.

[0053] The support bracket 31 is connected to the upper cover 20 and forms a filter chamber C with the upper cover 20. The filter chamber C is used to receive blood entering from the blood inlet B1. The filter sponge 32 is mounted on the outside of the support bracket 31 and is used to perform a primary filter on the blood in the filter chamber C. The filter cloth 33 is mounted on the outside of the filter sponge 32 and is used to perform a secondary filter on the blood after being filtered by the filter sponge 32.

[0054] Among them, the support bracket 31 is connected to the upper cover 20 in the blood storage chamber A and forms a filter chamber C with the upper cover 20. The blood flowing out of the inferior vena cava will directly enter the filter chamber C of the blood storage device 100 through the blood inlet B1, and then be filtered in turn through the filter sponge 32 and the filter cloth 33. The filtered blood enters the blood storage chamber A for storage and then flows out to the first centrifugal pump 200 and the second centrifugal pump 300 through the two blood outlets B2 respectively.

[0055] Therefore, in this embodiment, the support bracket 31 is mainly used to provide support for the filter sponge 32 and the filter cloth 33, and the filter sponge 32 and the filter cloth 33 are mainly used to filter out impurities such as blood clots in the blood, and also have a certain bubble elimination effect, thereby avoiding the risk of blood clots flowing back to the liver.

[0056] Reference Figures 4 to 7 The filtering mechanism 30 further includes a liquid separation column 34 , which is disposed in the filtering cavity C and connected to the supporting bracket 31 .

[0057] In this embodiment, based on the setting of the separatory column 34, the blood entering the filter chamber C of the blood storage device 100 through the blood inlet B1 will first contact the separatory column 34. On the one hand, the separatory column 34 can effectively alleviate the kinetic energy of the blood, thereby preventing the blood from directly impacting the wall surfaces corresponding to the support bracket 31 and the filter sponge 32 and causing greater blood damage; on the other hand, the separatory column 24 can also slow down the blood flow velocity when the blood enters the blood liquid surface in the blood storage device 100, thereby effectively reducing the generation of bubbles.

[0058] Reference Figure 4 and Figure 5 The cross-sectional area of ​​the liquid separation column 34 in the axial direction of the filter cavity C is gradually increased from the upper cover 20 toward the tank body 10.

[0059] In this embodiment, since the cross-sectional area of ​​the separatory column 34 in the axial direction of the filter chamber C is gradually increased in the direction from the upper cover 20 toward the tank body 10, the blood entering the filter chamber C of the blood storage device 100 through the blood inlet B1 will flow downward along the outer surface of the separatory column 34, which can effectively slow down the blood flow velocity when the blood enters the blood liquid surface in the blood storage device 100, thereby reducing the kinetic energy of the blood, avoiding the blood directly impacting the corresponding wall surfaces of the support bracket 31 and the filter sponge 32 to cause greater blood damage, and can also effectively reduce the generation of bubbles.

[0060] Reference Figure 5 The blood storage chamber A includes a first cavity A1 and a second cavity A2 arranged in sequence along its axial direction. The second cavity A2 is arranged away from the upper cover 20 relative to the first cavity A1, and the cross-sectional area of ​​the second cavity A2 in the axial direction of the blood storage chamber A is gradually reduced in the direction from the upper cover 20 toward the tank body 10.

[0061] In this embodiment, since the cross-sectional area of ​​the second cavity A2 in the axial direction of the blood storage chamber A is gradually reduced in the direction from the upper cover 20 toward the tank body 10, after the blood flows out of the filtering chamber C, based on the structure of the blood storage chamber A which is wide at the top and narrow at the bottom, it can quickly converge into the second cavity A2 and flow out through the blood outlet B2, which helps to increase the outflow speed of blood from the blood storage chamber A.

[0062] ReferenceFigures 2 to 5 The upper cover 20 includes a body 21 , a first channel member 22 and at least one second channel member 23 .

[0063] The main body 21 is covered on the tank body 10 and encloses the blood storage chamber A. The first channel member 22 is connected to the main body 21 and forms a blood inlet B1. Each second channel member 23 is connected to the main body 21 and forms an exhaust port B3 communicating with the blood storage chamber A.

[0064] Reference Figures 2 to 5 The tank body 10 includes a main body 11 , two third channel members 12 and a fourth channel member 13 .

[0065] The main body 11 forms a blood storage cavity A. The two third channel members 12 are respectively connected to the main body 11 and form a corresponding blood outlet B2. The fourth channel member 13 is connected to the main body 11 and forms a drainage port B4 communicating with the blood storage cavity A.

[0066] Specifically, the two third channel members 12 are arranged at the bottom of the main body 11 , which is also the bottom of the blood storage chamber A, thereby facilitating the outflow of blood from the blood storage chamber A.

[0067] In some embodiments, a gas filter membrane is provided in the exhaust port B3, and the gas filter membrane is configured to allow gas to pass through but not liquid to pass through.

[0068] During use of the blood storage device 100 of the present application, in order to achieve the purpose of balancing the negative pressure before the first centrifugal pump 200 and the second centrifugal pump 300, the exhaust port B3 is in a normally open state. Since the gas filter membrane in the exhaust port B3 only allows gas to pass through but not liquid, it will not affect the normal circulation process of the blood.

[0069] Reference Figure 2 The first channel member 22 is provided with a first sampling port B5 , and the at least one third channel member 12 is provided with a second sampling port B6 .

[0070] During use of the blood storage device 100 of the present application, the first sampling port B5 and the second sampling port B6 are normally closed and only need to be opened for sampling and testing. Specifically, the first sampling port B5 is used to sample and test blood before it enters the filter chamber C (i.e., blood that has not been filtered by the filter mechanism 30), while the second sampling port B6 is used to sample and test blood after it flows out of the filter chamber C (i.e., blood that has been filtered by the filter mechanism 30).

[0071] While various embodiments of the present disclosure have been described above, the foregoing description is intended to be illustrative, non-exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is selected to best explain the principles of the embodiments, their practical applications, or technological improvements in the marketplace, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A blood storage device (100), characterized in that: include: A tank body (10) is formed with a blood storage cavity (A) and two blood outlets (B2) communicating with the blood storage cavity (A); an upper cover (20) disposed on the tank body (10) and encapsulating the blood storage chamber (A), wherein the upper cover (20) has a blood inlet (B1) communicating with the blood storage chamber (A) and at least one exhaust port (B3), wherein the exhaust port (B3) is communicated with the atmospheric environment; and A filtering mechanism (30) is provided in the blood storage chamber (A) and located between the blood inlet (B1) and the blood outlet (B2), and is used for filtering the blood entering from the blood inlet (B1) and allowing the filtered blood to be discharged through the blood outlet (B2).

2. The blood storage device (100) according to claim 1, characterized in that: The filtering mechanism (30) comprises: a support bracket (31), connected to the upper cover (20) and enclosing a filter cavity (C) with the upper cover (20), wherein the filter cavity (C) is used to receive blood entering from the blood inlet (B1); A filter sponge (32) is sleeved on the outside of the support bracket (31) and is used to filter the blood in the filter cavity (C) once; and The filter cloth (33) is sleeved on the outside of the filter sponge (32) and is used for secondary filtering of the blood after being filtered through the filter sponge (32).

3. The blood storage device (100) according to claim 2, characterized in that: The filtering mechanism (30) further comprises a liquid separation column (34), wherein the liquid separation column (34) is arranged in the filtering cavity (C) and connected to the supporting bracket (31).

4. The blood storage device (100) according to claim 3, characterized in that: The cross-sectional area of ​​the liquid separation column (34) in the axial direction of the filter cavity (C) is gradually increased in a direction from the upper cover (20) toward the tank body (10).

5. The blood storage device (100) according to any one of claims 1-4, characterized in that: The blood storage chamber (A) comprises a first cavity (A1) and a second cavity (A2) arranged in sequence along its axial direction; The second cavity (A2) is arranged away from the upper cover (20) relative to the first cavity (A1), and the cross-sectional area of ​​the second cavity (A2) in the axial direction of the blood storage cavity (A) is gradually reduced in a direction from the upper cover (20) toward the tank body (10).

6. The blood storage device (100) according to claim 1, characterized in that: The upper cover (20) comprises: A main body (21) is disposed on the tank body (10) and encapsulates the blood storage cavity (A); a first channel member (22), connected to the body (21) and forming the blood inlet (B1); and At least one second channel member (23) is connected to the body (21) and forms the exhaust port (B3).

7. The blood storage device (100) according to claim 6, characterized in that: The tank body (10) comprises: A main body (11) is formed with the blood storage cavity (A); Two third channel members (12), each connected to the main body (11) and forming a corresponding blood outlet (B2); and A fourth channel member (13) is connected to the main body (11) and forms a liquid discharge port (B4) communicating with the blood storage chamber (A).

8. The blood storage device (100) according to claim 7, characterized in that: A gas filter membrane is provided in the exhaust port (B3), and the gas filter membrane is configured to allow gas to pass through but not allow liquid to pass through.

9. The blood storage device (100) according to claim 7, characterized in that: The first channel member (22) is provided with a first sampling port (B5), and at least one of the third channel members (12) is provided with a second sampling port (B6).

10. A liver perfusion system, characterized in that: Comprising a first centrifugal pump (200), a second centrifugal pump (300), an oxygenator (400), and the blood storage device (100) according to any one of claims 1 to 9; The blood inlet (B1) of the blood storage device (100) is used to connect to the inferior vena cava of the isolated liver (G), one blood outlet (B2) is connected to the first centrifugal pump (200), and the other blood outlet (B2) is connected to the second centrifugal pump (300); The first centrifugal pump (200) is used to connect to the hepatic artery of the isolated liver (G) via the oxygenator (400), and the second centrifugal pump (300) is used to connect to the portal vein of the isolated liver (G).

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