Salting reaction device for pharmacy
By introducing multiple annular array water spray pipes and nozzles into the salt-forming reaction device, combined with the synergistic effect of the motor-driven rotating shaft and stirring blades, the problem of uneven mixing was solved, achieving full contact and mixing between the salt-forming agent and the main drug, improving product quality and production efficiency, and reducing the scrap rate.
Patent Information
- Application Number
- CN202422905748.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-27
- Publication Date
- 2025-10-24
- Estimated Expiration
- 2034-11-27
AI Technical Summary
Existing salt-forming reaction devices suffer from poor stirring effects due to their single stirring method. Some salt-forming agents fail to fully contact the active pharmaceutical ingredient, resulting in incomplete reactions that affect product purity and quality. Furthermore, excessively high local concentrations may damage the active pharmaceutical ingredient, leading to increased scrap rates and production costs.
Multiple annular array water spray pipes and nozzles were designed at the top of the reaction tank. Combined with the synergistic action of the rotating shaft, rotating rod, driven gear, and stirring blades driven by the first motor, the salt-forming agent was ensured to be sprayed evenly and stirred thoroughly. The uniform distribution and efficient mixing of materials were achieved through the motor-driven stirring blades and gas control system of the storage tank.
It improves the efficiency of salt formation reaction and product quality, ensures uniform distribution and thorough mixing of materials in the reaction vessel, reduces scrap rate, and enhances production efficiency and product stability.
Smart Images
Figure CN223464826U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of pharmaceutical industry production, in particular to a salt formation reaction device for pharmaceutical industry. BACKGROUND
[0002] In the production of pharmaceutical industry, the main equipment for salt formation synthesis production is a salt formation reaction tank and a salt formation agent storage tank. The production process includes processes such as cooling of liquid medicine, stirring of liquid medicine, and salt formation reaction. The injection water is cooled to a specified temperature in the salt formation tank, the main medicine is added to the reaction tank, and the salt formation agent is added while stirring to perform salt formation reaction with the main medicine. In the actual production process, the addition speed and mode of the salt formation agent directly affect various quality indicators of the product, thereby determining the product quality.
[0003] However, the existing salt formation reaction device may have poor stirring effect due to the single stirring mode, resulting in that part of the salt formation agent cannot fully contact the main medicine, causing incomplete reaction, affecting the purity of the product. If the stirring is uneven, the local concentration of the salt formation agent in some areas may be too high, thereby damaging the main medicine and affecting the quality and utility of the product. Due to unstable product quality, the waste product rate may increase, thereby increasing the production cost. CONTENT OF THE UTILITY MODEL
[0004] In view of the deficiencies of the prior art, the present application provides a salt formation reaction device for pharmaceutical industry, which has the advantages of improving production efficiency, and solves the problems of the existing salt formation reaction device, such as poor stirring effect due to the single stirring mode, resulting in that part of the salt formation agent cannot fully contact the main medicine, causing incomplete reaction, affecting the purity of the product, and if the stirring is uneven, the local concentration of the salt formation agent in some areas may be too high, thereby damaging the main medicine and affecting the quality and utility of the product. Due to unstable product quality, the waste product rate may increase, thereby increasing the production cost.
[0005] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a salt formation reaction device for pharmaceutical industry, comprising a reaction tank and a storage tank, a plurality of water spray pipes arranged in a ring array are arranged through the upper end of the reaction tank, a plurality of spray heads are fixedly connected to one side of the upper end of the reaction tank through the plurality of water spray pipes, a water distribution ring is fixedly connected to the upper end of the plurality of water spray pipes, a water inlet pipe is fixedly connected to one side of the outer wall of the water distribution ring, a first motor is fixedly connected to the upper end of the reaction tank, a first rotating shaft is rotatably connected to the upper end of the reaction tank, a rotating rod is fixedly connected to the outer wall of the first rotating shaft, a second rotating shaft is rotatably connected to the inner side of each of the two sides of the rotating rod, a driven gear is fixedly connected to the upper end of each of the two second rotating shafts, four first stirring blades arranged in a straight line are fixedly connected to the outer part of each of the two second rotating shafts, a gear ring is fixedly connected to the upper end of the inner part of the reaction tank, a water outlet pipe is fixedly connected to the bottom end of the storage tank, and a connecting pipe is fixedly connected to the end of the water outlet pipe away from the reaction tank.
[0006] Through the above scheme, through the design of the water spraying pipe and the nozzle arranged in multiple annular arrays at the upper end of the reaction tank, it is ensured that the salting agent can be sprayed to every corner in the reaction tank in a uniform manner, which helps to realize sufficient contact and mixing of the salting agent and the reaction material, thereby improving the efficiency of the salting reaction and the product quality. Through the cooperation of the first rotating shaft, the rotating rod and the second rotating shaft driven by the first motor, and the driven gear and the first stirring blade, sufficient stirring of the material in the reaction tank is realized, the stirring efficiency is improved, and uniform distribution of the material in the reaction tank is also ensured, which is beneficial to the salting reaction. The device has the advantages of uniform spraying and high-efficiency stirring.
[0007] Further, the bottom end of the reaction tank is fixedly connected with a discharge pipe, and a first adjusting valve is sleeved on the outer wall of the discharge pipe.
[0008] Through the above scheme, the discharge pipe is used to discharge the reacted material, and the first adjusting valve is installed on the outer wall of the discharge pipe to control the opening and closing of the discharge pipe and adjust the discharge rate of the material.
[0009] Further, a feeding pipe is fixedly connected to one side of the outer wall of the reaction tank, a turnover cover is rotatably connected to the end of the feeding pipe away from the reaction tank through a hinge, and a handle is fixedly connected to one side of the upper end of the turnover cover.
[0010] Through the above scheme, the feeding pipe is a pipeline connecting the outside and the inside of the reaction tank, allowing the material required for the reaction to be added from the outside to the reaction tank. The turnover cover is rotatably connected to the end of the feeding pipe away from the reaction tank through a hinge, and is used to close or open the feeding port. When the material needs to be added, the turnover cover can be opened; when the reaction is carried out, the turnover cover remains closed to ensure the sealing of the reaction tank. The handle is fixed to one side of the upper end of the turnover cover, which is convenient for the operator to open or close the turnover cover.
[0011] Further, a second motor is fixedly connected to the upper end of the storage tank, a third rotating shaft is rotatably connected to the upper end of the inside of the storage tank, a second stirring blade is fixedly connected to the bottom end of the third rotating shaft, and the output end of the second motor is fixedly connected with the third rotating shaft through a shaft coupling.
[0012] Through the above scheme, the second motor serves as the power source of the stirring system, provides rotary power through the output shaft, drives the third rotating shaft and the second stirring blade thereon to rotate, and stirs the material in the storage tank.
[0013] Further, an air inlet pipe is fixedly connected to one side of the outer wall of the storage tank, a second adjusting valve is sleeved on the outer wall of the air inlet pipe, an injection pipe is fixedly connected to one side of the upper end of the storage tank, and a sealing cover is threadedly connected to the side away from the storage tank of the injection pipe.
[0014] Through the above scheme, the design of the gas inlet pipe allows the convenient introduction of the required gas to adjust the gas pressure in the storage tank, the introduction of the second regulating valve allows the flow of the gas to be accurately controlled, and the amount of gas entering the storage tank can be flexibly adjusted by adjusting the opening of the regulating valve. The design of the liquid injection pipe allows the operator to inject the salting agent into the storage tank when needed. The threaded sealing cover not only ensures the sealing of the liquid injection port to prevent liquid leakage, but also improves the convenience of operation.
[0015] Further, the end of the connecting pipe away from the water outlet pipe is fixedly connected with the water inlet pipe.
[0016] Through the above scheme, the salting agent is transported into the water inlet pipe through the water outlet pipe by the pressure inside the storage tank, and is distributed through the water distribution ring.
[0017] Further, the output end of the first motor is fixedly connected with the first rotating shaft through a shaft coupling.
[0018] Through the above scheme, the power output by the first motor is stably and efficiently transmitted to the first rotating shaft, which in turn drives the stirring blades to rotate, thereby achieving the stirring effect.
[0019] Further, the two driven gears are engaged with the toothed ring.
[0020] Through the above scheme, when the two driven gears are engaged with the toothed ring, the two driven gears will rotate at the same speed, thereby ensuring that the devices or components connected thereto can work synchronously, and thereby making the two stirring devices rotate simultaneously while revolving, thereby improving the stirring effect.
[0021] Compared with the prior art, the technical scheme of the present application has the following beneficial effects:
[0022] The pharmaceutical salting reaction device can ensure that the salting agent is sprayed uniformly into every corner of the reaction tank, which helps to realize the full contact and mixing of the salting agent and the reaction material, thereby improving the efficiency of the salting reaction and the product quality. The first rotating shaft, the rotating rod and the second rotating shaft driven by the first motor, and the driven gears and the first stirring blades work together to realize the full stirring of the material in the reaction tank, improve the stirring efficiency, and ensure the uniform distribution of the material in the reaction tank, which is beneficial to the salting reaction. The device has the advantages of uniform spraying and high-efficiency stirring. BRIEF DESCRIPTION OF DRAWINGS
[0023] Figure 1 The overall structure of the structure of the present application is shown in the figure;
[0024] Figure 2 The internal structure of the reaction tank of the structure of the present application is shown in the figure;
[0025] Figure 3 The structure diagram of the reaction tank stirring device of the present application;
[0026] Figure 4 The structure diagram of the inside structure of the storage tank of the present application.
[0027] In the figure:
[0028] 1, reaction tank; 2, water spraying pipe; 3, spray head; 4, water distribution ring; 5, water inlet pipe; 6, first motor; 7, first rotating shaft; 8, rotating rod; 9, second rotating shaft; 10, driven gear; 11, first stirring blade; 12, gear ring; 13, storage tank; 14, water outlet pipe; 15, connecting pipe; 16, discharge pipe; 17, first regulating valve; 18, feed pipe; 19, overturning cover; 20, handle; 21, second motor; 22, third rotating shaft; 23, second stirring blade; 24, air inlet pipe; 25, second regulating valve; 26, liquid injection pipe; 27, sealing cover. DETAILED DESCRIPTION
[0029] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.
[0030] Please refer to Figure 1 , Figure 2 and Figure 3The embodiment relates to a salt formation reaction device for pharmaceuticals, which comprises a reaction tank 1 and a storage tank 13. A plurality of water spraying pipes 2 in annular array are arranged through the upper end of the reaction tank 1. A plurality of nozzles 3 are fixedly connected to one side of the upper end of the reaction tank 1. A water distribution ring 4 is fixedly connected to the upper end of the plurality of water spraying pipes 2. A water inlet pipe 5 is fixedly connected to one side of the outer wall of the water distribution ring 4. The plurality of water spraying pipes 2 and the nozzles 3 arranged in annular array at the upper end of the reaction tank 1 ensure that the salt formation agent can be sprayed in a uniform manner to each corner in the reaction tank 1, which helps to realize sufficient contact and mixing of the salt formation agent and the reaction material, thereby improving the efficiency of the salt formation reaction and the product quality. A first motor 6 is fixedly connected to the upper end of the reaction tank 1. A first rotating shaft 7 is rotatably connected to the inner upper end of the reaction tank 1. A rotating rod 8 is fixedly connected to the outer wall of the first rotating shaft 7. A second rotating shaft 9 is rotatably connected to the inner wall of the rotating rod 8. A driven gear 10 is fixedly connected to the upper end of the second rotating shaft 9. Four first stirring blades 11 arranged in a straight line are fixedly connected to the outer wall of the second rotating shaft 9. A gear ring 12 is fixedly connected to the inner upper end of the reaction tank 1. The first rotating shaft 7, the rotating rod 8 and the second rotating shaft 9 driven by the first motor 6, and the driven gear 10 and the first stirring blades 11 realize sufficient stirring of the material in the reaction tank 1, improve the stirring efficiency, and ensure uniform distribution of the material in the reaction tank 1, which is beneficial to the salt formation reaction. A water outlet pipe 14 is fixedly connected to the bottom end of the storage tank 13. A connecting pipe 15 is fixedly connected to the end of the water outlet pipe 14 away from the reaction tank 1.
[0031] Please refer to Figure 1 and Figure 4The bottom end of the reaction tank 1 is fixedly connected with a discharge pipe 16, the outer wall of the discharge pipe 16 is sleeved with a first adjusting valve 17, the discharge pipe 16 is used for discharging the material after reaction, the first adjusting valve 17 is installed on the outer wall of the discharge pipe 16 and is used for controlling the opening and closing of the discharge pipe 16 and adjusting the discharging rate of the material, one side of the outer wall of the reaction tank 1 is fixedly connected with a feeding pipe 18, the end of the feeding pipe 18 away from the reaction tank 1 is hingedly connected with a turnover cover 19, the upper end of the turnover cover 19 is fixedly connected with a handle 20 on one side, the feeding pipe 18 is a pipeline connecting the inside and outside of the reaction tank 1 and allows the material required for reaction to be added from the outside into the reaction tank 1, the turnover cover 19 is hingedly connected at the end of the feeding pipe 18 away from the reaction tank 1 and is used for closing or opening the feeding port, when the material needs to be added, the turnover cover 19 can be opened, when the reaction is carried out, the turnover cover 19 remains closed to ensure the sealing of the reaction tank 1, the handle 20 is fixed on the upper end of the turnover cover 19 on one side and is convenient for the operator to open or close the turnover cover 19, the upper end of the storage tank 13 is fixedly connected with a second motor 21, the inside of the storage tank 13 is rotatably connected with a third rotating shaft 22, the bottom end of the third rotating shaft 22 is fixedly connected with a second stirring blade 23, the output end of the second motor 21 is fixedly connected with the third rotating shaft 22 through a shaft coupling, the second motor 21 serves as a power source of the stirring system and provides rotary power through an output shaft to drive the third rotating shaft 22 and the second stirring blade 23 thereon to rotate and stir the material in the storage tank 13.
[0032] Please refer to Figure 1 , Figure 3 and Figure 4The outer wall of the storage tank 13 is fixedly connected with an air inlet pipe 24 on one side, the outer wall of the air inlet pipe 24 is sleeved with a second regulating valve 25, the upper end of the storage tank 13 is fixedly connected with a liquid injection pipe 26 on one side, the side away from the storage tank 13 of the liquid injection pipe 26 is threadedly connected with a sealing cover 27, the design of the air inlet pipe 24 allows the required gas to be conveniently introduced to adjust the air pressure in the storage tank 13, the introduction of the second regulating valve 25 allows the flow of the gas to be accurately controlled, and the amount of gas entering the storage tank 13 can be flexibly adjusted by adjusting the opening of the regulating valve, the design of the liquid injection pipe 26 allows the operator to inject the salting agent into the storage tank 13 when needed, the threadedly connected sealing cover 27 not only ensures the sealing of the liquid injection port to prevent liquid leakage, but also improves the convenience of operation, and the end of the connecting pipe 15 away from the water outlet pipe 14 is fixedly connected with the water inlet pipe 5, the salting agent is conveyed into the water inlet pipe 5 through the water outlet pipe 14 by the pressure in the storage tank 13, and is branched through the water distribution ring 4, the output end of the first motor 6 is fixedly connected with the first rotating shaft 7 through a shaft coupling, the power output by the first motor 6 is stably and efficiently transmitted to the first rotating shaft 7, and then drives the stirring blades to rotate, so that the stirring effect is realized, the two driven gears 10 are engaged with the gear ring 12, when the two driven gears 10 are engaged with the gear ring 12, the two driven gears 10 will rotate at the same speed, so as to ensure that the devices or components connected therewith can work synchronously, and then the two stirring devices are simultaneously revolved and rotated, so as to improve the stirring effect.
[0033] In the embodiment, the water injection pipe 2 and the spray head 3 arranged in an annular array on the upper end of the reaction tank 1 ensure that the salting agent can be sprayed into each corner of the reaction tank 1 in a uniform manner, which is helpful to realize the full contact and mixing of the salting agent and the reaction material, thereby improving the efficiency of the salting reaction and the product quality, the first rotating shaft 7, the rotating rod 8 and the second rotating shaft 9 driven by the first motor 6, and the driven gear 10 and the first stirring blade 11 work cooperatively to realize the full stirring of the material in the reaction tank 1, improve the stirring efficiency, and also ensure the uniform distribution of the material in the reaction tank 1, which is beneficial to the salting reaction. The device has the advantages of uniform spraying and high-efficiency stirring.
[0034] It should be noted that the device mainly consists of two parts, the reaction tank 1 and the storage tank 13, the reaction tank 1 is used for salting reaction, and the storage tank 13 is used for storing the salting agent required for processing, and the two are connected through the connecting pipe 15.
[0035] The working principle of the above embodiment is as follows:
[0036] First, the appropriate amount of salt-forming agent is injected into the storage tank 13 through the injection pipe 26, and the sealing cover 27 is screwed tightly to ensure the sealing, the gas inlet pipe 24 is connected and the second regulating valve 25 is opened, the flow of gas is adjusted as needed to maintain the appropriate gas pressure in the storage tank 13, the turnover cover 19 is opened, and the required materials for the reaction are added to the reaction tank 1 through the feeding pipe 18, the second motor 21 is started, and the third rotating shaft 22 and the second stirring blade 23 thereon are driven to rotate in the storage tank 13 through the shaft coupling, so as to pre-stir or maintain the uniform state of the salt-forming agent, the first motor 6 is started, and the power is transmitted to the first rotating shaft 7 through the shaft coupling, thereby driving the rotating rod 8 and the second rotating shaft 9 to rotate, since the driven gear 10 is engaged with the gear ring 12, the two second rotating shafts 9 will rotate at the same speed, and at the same time drive the first stirring blade 11 to stir the materials in the reaction tank 1, then the salt-forming agent in the storage tank 13 is transported to the water distribution ring 4 through the connecting pipe 15 and the water outlet pipe 14, the water distribution ring 4 uniformly distributes the salt-forming agent into the plurality of water spraying pipes 2, and sprays the salt-forming agent in the form of mist or fine stream into the materials in the reaction tank 1 through the spray head 3, the sprayed salt-forming agent fully contacts and mixes with the materials in the reaction tank 1, and the salt-forming reaction is carried out, during the reaction process, the first motor 6 continuously drives the stirring system to ensure the uniform distribution and sufficient stirring of the materials in the reaction tank 1, when the reaction is completed, the first motor 6 and the second motor 21 are turned off, the stirring is stopped, and the first regulating valve 17 on the discharge pipe 16 is opened, so that the reacted materials are discharged from the reaction tank 1.
[0037] It should be noted that the relational terms herein such as first and second and the like are used solely to distinguish one entity or action from another, without necessarily requiring or implying any such actual relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element preceded by "comprises... " does not, without more limitations, foreclose the existence of
[0038] Although embodiments of the present application have been shown and described, it is to be understood that various modifications, substitutions, replacements and changes can be made to these embodiments without departing from the principles and spirit of the present application, and the scope of the present application is defined by the appended claims and their equivalents.
Claims
1. A pharmaceutical salt formation reaction apparatus comprising a reaction tank (1) and a storage tank (13), characterized by: The upper end of the reaction tank (1) is provided with a plurality of annular array water spray pipes (2), a plurality of the water spray pipes (2) are fixedly connected with nozzles (3) on one side of the upper end of the reaction tank (1), a plurality of the water spray pipes (2) are fixedly connected with water distribution rings (4), the water distribution rings (4) are fixedly connected with water inlet pipes (5) on one side of the outer wall, the reaction tank (1) is fixedly connected with a first motor (6), the first motor (6) is rotatably connected with a first rotating shaft (7) on the upper end of the reaction tank (1), the first rotating shaft (7) is fixedly connected with rotating rods (8), the rotating rods (8) are rotatably connected with second rotating shafts (9) on both sides, the second rotating shafts (9) are fixedly connected with driven gears (10) on the upper end, the second rotating shafts (9) are fixedly connected with four first stirring blades (11) which are arranged in a straight line on the outer part, the reaction tank (1) is fixedly connected with a gear ring (12) on the upper end, the storage tank (13) is fixedly connected with a water outlet pipe (14) on the bottom, and the water outlet pipe (14) is fixedly connected with a connecting pipe (15) away from the reaction tank (1).
2. The salt formation reaction apparatus for pharmaceutical use according to claim 1, characterized by: The bottom of the reaction tank (1) is fixedly connected with a discharge pipe (16), and the discharge pipe (16) is sleeved with a first adjusting valve (17) on the outer wall.
3. The salt formation reaction apparatus for pharmaceutical use according to claim 1, characterized by: The outer wall of the reaction tank (1) is fixedly connected with a feed pipe (18) on one side, and the feed pipe (18) is rotatably connected with a turnover cover (19) away from the reaction tank (1) through a hinge, and the turnover cover (19) is fixedly connected with a handle (20) on one side of the upper end.
4. The salt formation reaction apparatus for pharmaceutical use according to claim 1, characterized by: The upper end of the storage tank (13) is fixedly connected with a second motor (21), and the third rotating shaft (22) is rotatably connected with the third rotating shaft (22) on the upper end of the storage tank (13), and the third rotating shaft (22) is fixedly connected with a second stirring blade (23) on the bottom.
5. The salt formation reaction apparatus for pharmaceutical use according to claim 4, characterized by: The outer wall of the storage tank (13) is fixedly connected with an air inlet pipe (24) on one side, and the air inlet pipe (24) is sleeved with a second adjusting valve (25) on the outer wall, and the storage tank (13) is fixedly connected with a liquid injection pipe (26) on one side of the upper end, and the liquid injection pipe (26) is threadedly connected with a sealing cover (27) away from the storage tank (13).
6. The salt formation reaction apparatus for pharmaceutical use according to claim 4, characterized by: The connecting pipe (15) is fixedly connected with the water inlet pipe (5) away from the water outlet pipe (14).
7. The apparatus for salt formation according to claim 2, wherein: The output end of the first motor (6) is fixedly connected with the first rotating shaft (7) through a shaft coupling.
8. The apparatus for salt formation according to claim 3, wherein: The two driven gears (10) are engaged with the gear ring (12).