Plasma mixing device for tetanus human immune globulin

Through the coordinated design of the driving component and the guide component, the plasma can be reciprocated in the bottle, solving the problem of low efficiency of the traditional mixing method and improving the mixing effect and product quality of tetanus human immunoglobulin.

CN223474863UActive Publication Date: 2025-10-28BANGHE PHARMA CO LTD
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Patent Information

Application Number
CN202422940973.5
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-11-30
Publication Date
2025-10-28
Estimated Expiration
2034-11-30

AI Technical Summary

Technical Problem

In the existing production process of tetanus human immunoglobulin, the mixing effect is poor, resulting in unsatisfactory product purity and effect, and the traditional stirring or shaking method is inefficient.

Method used

The design of the driving component and the guide component is adopted to realize the reciprocating forward and reverse rotation of the cylinder driven by the transmission rod. Combined with the motor drive, automatic operation is realized. Through the staged engagement of the inner and outer ring gears with the spur gears, irregular flow of plasma in the bottle is achieved, thereby improving the mixing effect.

Benefits of technology

It improves the plasma mixing efficiency, reduces manual intervention, lowers the difficulty of operation, enhances the mixing effect, and ensures product quality and effect.

✦ Generated by Eureka AI based on patent content.

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Abstract

The plasma mixing device for tetanus human immune globulin comprises a bottom plate, a sliding table is slidably connected to the top of the bottom plate, a driving assembly is arranged in the sliding table, a supporting rod is arranged at the top of the driving assembly and rotatably connected with the sliding table, a guiding assembly is arranged at the top of the supporting rod, and the guiding assembly is rotatably connected with the sliding table. A transmission rod is arranged at the top of the guide assembly, a supporting table is rotationally connected to the outer side of the transmission rod, the bottom of the supporting table is fixedly connected with the top of the sliding table, a cylinder is fixedly connected to the top of the transmission rod, a screw cap is in threaded connection with the top of the cylinder, and a disc is arranged on the rear side of the driving assembly. A cylindrical rod is arranged on the rear side of the disc, a limiting frame is connected to the rear side of the cylindrical rod in a sliding mode, and the problems that a simple stirring or shaking mode is mostly adopted in an existing uniform mixing device and method, the efficiency of the mode is low, uneven distribution of components in plasma is easily caused, and the quality and the effect of a final product are affected are effectively solved.
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Description

Technical Field

[0001] This utility model relates to the field of plasma mixing technology, and in particular to a plasma mixing device for tetanus immunoglobulin. Background Art

[0002] Tetanus is a serious infectious disease caused by toxins produced by Clostridium tetani. Timely administration of tetanus immunoglobulin is a key measure for the prevention and treatment of tetanus, especially after injury. Timely administration of immunoglobulin can effectively prevent fatal tetanus infection. However, the supply of tetanus immunoglobulin in China has always been insufficient. This is mainly due to the complex extraction process of traditional immunoglobulins and poor mixing, which often results in unsatisfactory purity and efficacy of the product.

[0003] In the traditional production process of tetanus immunoglobulin, plasma homogenization is a crucial step. The quality of homogenization directly affects the purity and activity of the immunoglobulin. Most existing homogenization devices and methods use simple stirring or shaking, which is not only inefficient but also prone to uneven distribution of plasma components, thus affecting the quality and efficacy of the final product. Tetanus is a serious infectious disease caused by toxins produced by Clostridium tetani. Timely injection of tetanus immunoglobulin is a key measure for the prevention and treatment of tetanus, especially after injury. Timely administration of immunoglobulin can effectively prevent fatal tetanus infection. However, the domestic supply of tetanus immunoglobulin has always been insufficient. This is mainly due to the complex extraction process of traditional immunoglobulins and poor homogenization, which often results in unsatisfactory product purity and efficacy. Utility Model Content

[0004] In view of the above situation and to overcome the defects of the prior art, this utility model provides a plasma mixing device for tetanus human immunoglobulin. This design effectively solves the problem that most existing mixing devices and methods adopt simple stirring or shaking methods, which are not only inefficient, but also easily lead to uneven distribution of components in the plasma, thereby affecting the quality and effect of the final product.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] This utility model includes a base plate, a slide table slidably connected to the top of the base plate, a drive assembly inside the slide table, a support rod on the top of the drive assembly, the support rod rotatably connected to the slide table, a guide assembly on the top of the support rod, a transmission rod on the top of the guide assembly, a support platform rotatably connected to the outside of the transmission rod, the bottom of the support platform being fixedly connected to the top of the slide table, a cylinder fixedly connected to the top of the transmission rod, a screw cap threadedly connected to the top of the cylinder, a disc on the rear side of the drive assembly, a cylindrical rod on the rear side of the disc, a limit frame slidably connected to the rear side of the cylindrical rod, and the bottom of the limit frame being fixedly connected to the base plate.

[0007] Preferably, the drive assembly includes a motor, a first bevel gear is fixedly connected to the rear side of the motor, a second bevel gear meshes with the top of the first bevel gear, and the top of the second bevel gear is fixedly connected to the bottom of the support rod.

[0008] Preferably, a shaft is fixedly connected to the rear side of the first bevel gear, the shaft is rotatably connected to the inside of the slide, and the rear side of the shaft is fixedly connected to the disk.

[0009] Preferably, the guide assembly includes a turntable, the bottom of which is fixedly connected to the top of the support rod, and the interior of the turntable has a groove.

[0010] Preferably, an external gear ring is provided on the outer side of the groove, and an internal gear ring is provided on the inner side of the groove. A spur gear is fitted between the internal gear ring and the external gear ring, and the top of the spur gear is fixedly connected to the transmission rod.

[0011] Compared with the prior art, the beneficial effects of the present invention are:

[0012] Through the cooperation of the drive and guide components, the transmission rod drives the cylinder to reciprocate in both forward and reverse directions. This periodic rotation effectively improves the mixing efficiency of plasma in the bottle. The entire device is driven by a motor, achieving automated operation, reducing manual intervention, improving work efficiency, and lowering the difficulty of operation. The turntable design in the guide component, through the staged meshing of the internal and external gear rings with the spur gear, realizes the forward and reverse rotation of the transmission rod. The different numbers of forward and reverse rotations create irregularities in the flow of plasma in the bottle, thereby improving the mixing effect. While the slide moves back and forth on the base plate, the cylinder also performs periodic forward and reverse rotations. This composite motion further enhances the mixing effect of the plasma. Attached Figure Description

[0013] Figure 1 It is a schematic diagram of the overall structure of the utility model.

[0014] Figure 2 This is a cross-sectional schematic diagram of the slide table of this utility model.

[0015] Figure 3 This is a schematic diagram of the cooperation structure between the turntable and the transmission rod of this utility model.

[0016] Figure 4 This is a schematic diagram of the structure of the motor and the cylindrical rod of this utility model.

[0017] The following are the labels in the diagram: 1. Screw cap; 2. Cylinder body; 3. Support platform; 4. Slide table; 5. Base plate; 6. Turntable; 7. External gear ring; 8. Internal gear ring; 9. Spur gear; 10. Motor; 11. Transmission rod; 12. First bevel gear; 13. Second bevel gear; 14. Support rod; 15. Shaft; 16. Disc; 17. Cylindrical rod; 18. Limiting frame. DETAILED DESCRIPTION

[0018] The following is in conjunction with the appendix Figures 1-4 The specific embodiments of this utility model will be described in further detail.

[0019] This utility model includes a base plate 5, which is placed on a workbench. A slide table 4 is slidably connected to the top of the base plate 5, allowing the slide table 4 to move left and right on the top of the base plate 5. A drive assembly is located inside the slide table 4, and a support rod 14 is located at the top of the drive assembly. The drive assembly can drive the support rod 14 to rotate. The support rod 14 is rotatably connected to the slide table 4. A guide assembly is located at the top of the support rod 14, and a transmission rod 11 is located at the top of the guide assembly. The support rod 14 can drive the guide assembly to achieve the reciprocating forward and reverse rotation of the transmission rod 11. A support platform 3 is rotatably connected to the outside of the transmission rod 11, and the bottom of the support platform 3 is fixedly connected to the top of the slide table 4. The support platform 3 supports the rotation of the transmission rod 11. A cylinder 2 is fixedly connected to the top of the transmission rod 11, and a cap 1 is threadedly connected to the top of the cylinder 2. The inside of the cylinder 2 can be used to store a blood plasma container. By rotating the cap 1, the cap 1 moves downward to fix the container inside the cylinder 2. 1. The drive assembly drives the cylinder 2 to reciprocate in both forward and reverse directions to mix the plasma inside. A disc 16 is located on the rear side of the drive assembly, and a cylindrical rod 17 is located on the rear side of the disc 16. A limit frame 18 is slidably connected to the rear side of the cylindrical rod 17. The bottom of the limit frame 18 is fixedly connected to the base plate 5. The drive assembly drives the disc 16 to rotate, which in turn drives the cylindrical rod 17 to rotate in a circle. Since the base plate 5 and the limit frame 18 are fixedly connected, the position of the limit frame 18 is fixed. The rotation of the disc 16 compresses the inside of the limit frame 18 through the cylindrical rod 17. When the disc 16 rotates clockwise, it drives the cylindrical rod 17 to rotate clockwise. Under the action of the limit frame 18, the disc 16 and the slide table 4 are pushed to the left. As the disc 16 continues to rotate, the slide table 4 can move back and forth. At this time, the cylinder 2 will periodically rotate forward and reverse as it moves back and forth with the slide table 4, which improves the efficiency of plasma mixing.

[0020] The drive assembly includes a motor 10, a first bevel gear 12 fixedly connected to the rear side of the motor 10, a second bevel gear 13 meshing with the top of the first bevel gear 12, and the top of the second bevel gear 13 fixedly connected to the bottom of the support rod 14. When the motor 10 rotates, it drives the fixedly connected first bevel gear 12 to rotate, and the rotation of the first bevel gear 12 drives the meshing second bevel gear 13 to rotate, and the second bevel gear 13 drives the support rod 14 to rotate.

[0021] The first bevel gear 12 is fixedly connected to the rear side of the shaft 15, which is rotatably connected to the inside of the slide table 4. The rear side of the shaft 15 is fixedly connected to the disc 16. The first bevel gear 12 drives the rear shaft 15 to rotate, and the shaft 15 drives the fixedly connected disc 16 to rotate.

[0022] The guiding assembly includes a turntable 6, the bottom of which is fixedly connected to the top of a support rod 14. The support rod 14 can drive the turntable 6 to rotate. The turntable 6 has a groove inside, an external gear ring 7 on the outside of the groove, and an internal gear ring 8 on the inside of the groove. A spur gear 9 is engaged between the internal gear ring 8 and the external gear ring 7. The spur gear 9 can mesh with the external gear ring 7 or the internal gear ring 8 in stages. When the turntable 6 rotates circumferentially, the internal gear ring 8 first meshes with the spur gear 9, driving the spur gear 9 to rotate. After the turntable 6 rotates 180 degrees, the internal gear ring 8 will disengage from the spur gear 9, and then the external gear ring 7 will begin to mesh with the spur gear 9, driving the spur gear 9 to rotate in the opposite direction. The stroke of the external gear ring 7 is longer than that of the internal gear ring 8. The number of forward and reverse rotations of the spur gear 9 are not the same, which makes the flow of the internal plasma irregular and better mixed. The top of the spur gear 9 is fixedly connected to a transmission rod 11, which drives the cylinder 2 to rotate.

[0023] In use, the drive assembly and guide assembly work together to achieve the reciprocating forward and reverse rotation of the cylinder 2 driven by the transmission rod 11. This periodic rotation effectively improves the mixing efficiency of plasma in the bottle. The entire device is driven by the motor 10, realizing automated operation, reducing manual intervention, improving work efficiency, and reducing the difficulty of operation. The turntable 6 in the guide assembly is designed to achieve the forward and reverse rotation of the transmission rod 11 through the staged meshing of the internal gear ring 8 and the external gear ring 7 with the spur gear 9. The different number of forward and reverse rotations make the flow of plasma in the bottle irregular, thereby improving the mixing effect. While the slide table 4 moves back and forth on the base plate 5, the cylinder 2 also performs periodic forward and reverse rotation. This compound motion further enhances the mixing effect of plasma.

[0024] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A plasma mixing device for tetanus human immunoglobulin, comprising a base plate (5), characterized in that, The top of the base plate (5) is slidably connected to a slide table (4). The slide table (4) is equipped with a drive assembly. The top of the drive assembly is equipped with a support rod (14). The support rod (14) is rotatably connected to the slide table (4). The top of the support rod (14) is equipped with a guide assembly. The top of the guide assembly is equipped with a transmission rod (11). The outside of the transmission rod (11) is rotatably connected to a support platform (3). The bottom of the support platform (3) is fixedly connected to the top of the slide table (4). The top of the transmission rod (11) is fixedly connected to a cylinder (2). The top of the cylinder (2) is threadedly connected to a cap (1). The rear side of the drive assembly is equipped with a disc (16). The rear side of the disc (16) is equipped with a cylindrical rod (17). The rear side of the cylindrical rod (17) is slidably connected to a limit frame (18). The bottom of the limit frame (18) is fixedly connected to the base plate (5).

2. The plasma mixing device for tetanus immunoglobulin according to claim 1, characterized in that, The drive assembly includes a motor (10), a first bevel gear (12) is fixedly connected to the rear side of the motor (10), a second bevel gear (13) is meshed with the top of the first bevel gear (12), and the top of the second bevel gear (13) is fixedly connected to the bottom of the support rod (14).

3. The plasma mixing device for tetanus immunoglobulin according to claim 2, characterized in that, The first bevel gear (12) is fixedly connected to a shaft (15) on its rear side. The shaft (15) is rotatably connected to the slide (4) and the rear side of the shaft (15) is fixedly connected to a disc (16).

4. The plasma mixing device for tetanus immunoglobulin according to claim 1, characterized in that, The guide assembly includes a turntable (6), the bottom of which is fixedly connected to the top of a support rod (14), and the interior of the turntable (6) is provided with a groove.

5. The plasma mixing device for tetanus immunoglobulin according to claim 4, characterized in that, An external gear ring (7) is provided on the outer side of the groove, and an internal gear ring (8) is provided on the inner side of the groove. A spur gear (9) is fitted between the internal gear ring (8) and the external gear ring (7). The top of the spur gear (9) is fixedly connected to the transmission rod (11).