Dialysis equipment for cross-linked sodium hyaluronate gel

Abstract

The utility model relates to dialysis equipment for cross-linked sodium hyaluronate gel. The dialysis equipment comprises a tank body, and a buffer solution discharge port and a stirring motor are arranged at the lower end of the tank body; the two sides of the tank top cover are connected with hydraulic lifting devices respectively, the hydraulic lifting devices drive the tank top cover to do lifting motion above the tank body, and a buffer solution feeding opening is formed in the tank top cover; the hanging bracket comprises a hanging plate and a hanging rod, the lower end of the hanging rod is connected with the hanging plate, the upper end of the hanging rod is fixedly connected with the tank top cover, a hanging hole is formed in the hanging plate and is a stepped hole, a dialysis filter cartridge is arranged in each hanging hole, a flange edge is formed at the upper end of each dialysis filter cartridge, and the dialysis filter cartridges are hung in the hanging holes through the flange edges; and a cylinder cover is arranged on each dialysis filter cylinder. Compared with a traditional dialysis bag, the dialysis filter cartridge is large in capacity, high in dialysis efficiency, convenient to assemble and disassemble, not prone to floating and damage and capable of being repeatedly used.

Description

Technical Field

[0001] This utility model relates to a dialysis device for cross-linked sodium hyaluronate gel. Background Technology

[0002] Sodium hyaluronate (HA) is a linear high-molecular-weight polysaccharide that is cross-linked with cross-linking agents such as 1,4-butanediol diglycidyl ether or divinyl sulfone under alkaline conditions to form cross-linked sodium hyaluronate gel. The gel prepared by cross-linking not only retains the good biocompatibility of HA, but also has a significantly extended retention time in vivo, and has now become the most commonly used tissue filler in clinical practice.

[0003] Because residual cross-linking agents are toxic to the human body, unreacted cross-linking agents must be removed after sodium hyaluronate cross-linking is completed. Currently, a common method is to cut the cross-linked gel into fixed sizes, place it into dialysis bags made of semi-permeable membranes, close the ends of the dialysis bags with clips, and immerse the dialysis bags in injectable water or buffered saline solution for dialysis.

[0004] The process of loading the gel into the dialysis bag requires two people to work together. The bagging process is slow and the operators are prone to touching the material, causing unnecessary contamination. In addition, the density of the gel is close to that of the dialysate, so the dialysis bag is prone to floating or shaking and being torn by the agitator during dialysis. During dialysis, the gel expands due to absorbing water and stretches the dialysis clamp, resulting in material loss. Semi-permeable membrane dialysis has low efficiency and often requires a long dialysis time to remove free cross-linking agents, resulting in low production efficiency. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the shortcomings of the prior art and provide a dialysis device for cross-linked sodium hyaluronate gel, thereby solving the technical problem of low dialysis efficiency of cross-linked sodium hyaluronate gel in the past.

[0006] The technical solution adopted by this utility model to solve its technical problem is:

[0007] A dialysis device for cross-linked sodium hyaluronate gel is provided, comprising:

[0008] The tank body has a buffer solution discharge port and a stirring motor at its lower end;

[0009] The tank top cover has hydraulic lifting devices connected to both sides. The hydraulic lifting devices drive the tank top cover to move up and down above the tank body. A buffer filling port is provided on the tank top cover.

[0010] The hanger includes a hanging plate and a hanging rod. The lower end of the hanging rod is connected to the hanging plate, and the upper end of the hanging rod is fixedly connected to the top cover of the tank. The hanging plate has a lifting hole, which is a stepped hole. Each lifting hole is equipped with a dialysis filter cartridge. The upper end of the dialysis filter cartridge forms a flange edge, and it is suspended in the lifting hole through the flange edge. Each dialysis filter cartridge is equipped with a cartridge cover.

[0011] Furthermore, both the lifting hole and the dialysis filter cartridge have hexagonal cross-sections.

[0012] Furthermore, the various lifting holes are distributed in a matrix-like honeycomb pattern on the hanging plate.

[0013] Furthermore, filter holes are provided on the cap and the dialysis filter cartridge.

[0014] Furthermore, the tank is mounted on a weighing device.

[0015] Furthermore, a jacket and a temperature probe are provided on the outer wall of the tank, and both the jacket (11) and the temperature probe (23) are connected to the electrical control unit.

[0016] The beneficial effects of this utility model are:

[0017] Compared with traditional dialysis bags, the dialysis filter cartridge of this invention has a larger capacity, higher dialysis efficiency, is easier to load and unload, is less prone to floating and breakage, and can be reused.

[0018] The gaps between the various dialysis filter cartridges facilitate the passage of buffer solution and increase the dialysis area.

[0019] The dialysis filter cartridges are arranged in a honeycomb matrix, allowing the hanging platform to hold more cartridges and dialyze more gel. For the same capacity dialysis tank, the gel throughput is greater, which is beneficial for large-scale industrial production.

[0020] Honeycomb matrix dialysis filter cartridges have a maximized specific surface area, which speeds up the dialysis process, shortens dialysis time, and improves production efficiency.

[0021] Compared to dialysis bags, filling is quick and easy, reduces personnel contact with materials during the filling process, reduces material contamination, and improves the pass rate.

[0022] Compared to dialysis bags, filter cartridges have larger pores, allowing for faster liquid exchange between the inside and outside of the cartridge and improving dialysis efficiency. Heating can be achieved through a jacket, accelerating the movement between molecules and further improving dialysis efficiency.

[0023] It enables online CIP / SIP, and the filter cartridge can be reused, reducing production costs. Attached Figure Description

[0024] The present invention will be further described below with reference to the accompanying drawings.

[0025] Figure 1 This is a schematic diagram of the dialysis device of this utility model;

[0026] Figure 2 This is a top view of the suspended platform;

[0027] Figure 3 This is a schematic diagram showing the various dialysis filter cartridges distributed on the hanger;

[0028] Figure 4 This is a schematic diagram of a dialysis filter cartridge;

[0029] Among them, 1. tank body, 11. jacket, 12. buffer solution discharge port, 13. stirring motor;

[0030] 2. Tank top cover; 21. Buffer solution inlet; 22. Hydraulic lifting device; 23. Temperature probe;

[0031] 3. Hanger; 31. Hanging plate; 32. Hanging rod; 33. Hanging hole;

[0032] 4. Dialysis filter cartridge; 41. Flange edge;

[0033] 5. Weighing equipment. Detailed Implementation

[0034] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0035] This application provides a dialysis device for cross-linked sodium hyaluronate gel, which will be described in detail below. It should be noted that the order of description of the following embodiments is not intended to limit the preferred order of the embodiments of this application. Furthermore, the descriptions of each embodiment have their own emphasis; parts not described in detail in a certain embodiment can be referred to in the relevant descriptions of other embodiments.

[0036] To address the low dialysis efficiency of cross-linked sodium hyaluronate gel in existing technologies, one embodiment of this application provides a dialysis device using cross-linked sodium hyaluronate gel. This is described in detail below.

[0037] like Figures 1 to 4 As shown, a dialysis device for cross-linked sodium hyaluronate gel includes...

[0038] Tank 1, with a buffer solution discharge port 12 and a stirring motor 13 at the lower end of the tank 1;

[0039] The tank top cover 2 is connected to hydraulic lifting devices 22 on both sides. The hydraulic lifting devices 22 drive the tank top cover 2 to move up and down above the tank body 1. A buffer filling port 21 is opened on the tank top cover 2.

[0040] The hanger 3 includes a hanging plate 31 and a hanging rod 32. The lower end of the hanging rod 32 is connected to the hanging plate 31, and the upper end of the hanging rod 32 is fixedly connected to the tank top cover 2. The hanging plate 31 has a hanging hole 33, which is a stepped hole. Each hanging hole 33 is equipped with a dialysis filter cartridge 4. The upper end of the dialysis filter cartridge 4 forms a flange edge 41, and it is suspended in the hanging hole 33 through the flange edge 41. Each dialysis filter cartridge 4 is provided with a cartridge cover.

[0041] In this embodiment, the distance between the hanging plate 31 and the tank top cover 2 ensures that the dialysis filter cartridge 4 can be placed into the hanging hole 33.

[0042] Specifically, as an optional implementation method in this embodiment, such as Figure 1 As shown, the hydraulic lifting device 22 uses a hydraulic cylinder, but it can also use an electric cylinder or a pneumatic cylinder.

[0043] Specifically, as an optional implementation of this embodiment, two hydraulic lifting devices 22 are distributed on the left and right sides, driving the tank top cover 2 to lift or close the tank body 11.

[0044] Specifically, as an optional implementation of this embodiment, the hanging plate 31 has a circular structure, see [reference]. Figure 2 As shown.

[0045] Specifically, as an optional implementation of this embodiment, both the lifting hole 33 and the dialysis filter cartridge 4 have hexagonal cross-sections.

[0046] Specifically, as an optional implementation method in this embodiment, such as Figure 2 As shown, the various lifting holes 33 are distributed in a matrix honeycomb pattern on the hanging plate 31.

[0047] Specifically, as an optional implementation of this embodiment, filter holes are provided on the cylinder cover.

[0048] Specifically, as an optional implementation method in this embodiment, such as Figure 1 As shown, the tank 1 is mounted on the weighing device 5. In this embodiment, the weighing device 54 is a weighbridge.

[0049] Specifically, as an optional implementation method in this embodiment, such as Figure 1 As shown, a jacket 11 and a temperature probe 23 are provided on the outer wall of the tank 1. Both the jacket 11 and the temperature probe 23 are connected to the electronic control unit. The electronic control unit heats the buffer solution inside the tank 1 through the jacket 11, and the temperature probe 23 detects the temperature of the buffer solution. The jacket 11 stops heating after the predetermined temperature is reached.

[0050] In this embodiment, the dialysis filter cartridge 4 and the cartridge cover are made of 316L stainless steel, and the filter pore size is 0.5mm.

[0051] During operation, the top cover 2 of the tank is opened, and the hanger 3 is lifted together with the top cover 2. Then, the dialysis filter cartridge 4 containing gel is manually inserted into the lifting hole 33. Then, the cover is closed, and the hanger 3 is installed into the tank body 1 through the lifting device.

[0052] The buffer solution in tank 1 is added through the buffer solution inlet 21 at the top and discharged through the buffer solution outlet 12 at the bottom. During dialysis, the buffer solution is driven by the stirring motor 13 to flow within tank 1 and between the various dialysis filter cartridges 4, thereby achieving gel dialysis.

[0053] This invention relates to a dialysis device that uses cartridge dialysis. It selectively allows water, free cross-linking agents, and uncross-linked sodium hyaluronate to pass through. The honeycomb matrix of individual dialysis cartridges 4 fully utilizes the space within the dialysis tank, accommodating more gel. The multifaceted structure of the cartridges 4 increases the exchange efficiency between the gel and the dialysate. Simultaneously, the jacket 11 enables thermal dialysis, further improving dialysis efficiency. In production, this significantly shortens dialysis time, quickly reaching the dialysis endpoint and increasing production efficiency. Compared to dialysis bags, cartridge loading is simpler, reducing personnel contact with materials and improving the yield rate. The fixed volume of the cartridges allows for controllable volume and weight of the gel after complete swelling, effectively controlling the final dialysis gel content and facilitating product quality control. The entire tank 11 can be cleaned and sterilized online, and the cartridges are reusable, reducing production costs.

[0054] All the devices (parts whose specific structures are not specified) selected in this application are general standard parts or parts known to those skilled in the art. Their structures and principles can be learned by those skilled in the art through technical manuals or conventional experimental methods.

[0055] In the description of the embodiments of this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0056] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0057] In the several embodiments provided in this application, it should be understood that the disclosed systems, apparatuses, and methods can be implemented in other ways. The apparatus embodiments described above are merely illustrative. For example, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. Furthermore, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Additionally, the shown or discussed mutual couplings, direct couplings, or communication connections may be through some communication interfaces; indirect couplings or communication connections between devices or units may be electrical, mechanical, or other forms.

[0058] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment according to actual needs.

[0059] In addition, in the various embodiments of this utility model, each functional unit can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit.

[0060] Based on the above-described preferred embodiments of this utility model, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the technical concept of this utility model. The technical scope of this utility model is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A dialysis device for cross-linked sodium hyaluronate gel, characterized in that, include The tank (1) has a buffer discharge port (12) and a stirring motor (13) at its lower end; The tank top cover (2) is connected to hydraulic lifting devices (22) on both sides. The hydraulic lifting devices (22) drive the tank top cover (2) to move up and down above the tank body (1). The tank top cover (2) has a buffer filling port (21). The hanger (3) includes a hanging plate (31) and a hanging rod (32). The lower end of the hanging rod (32) is connected to the hanging plate (31), and the upper end of the hanging rod (32) is fixedly connected to the tank top cover (2). The hanging plate (31) is a circular structure with a hanging hole (33) on it. The hanging hole (33) is a stepped hole. Each hanging hole (33) is equipped with a dialysis filter cartridge (4). The upper end of the dialysis filter cartridge (4) forms a flange edge (41), and it is suspended in the hanging hole (33) through the flange edge (41). Each dialysis filter cartridge (4) is equipped with a cap.

2. The dialysis device for cross-linked sodium hyaluronate gel according to claim 1, characterized in that, Both the lifting hole (33) and the dialysis filter cartridge (4) have hexagonal cross-sections.

3. The dialysis device for cross-linked sodium hyaluronate gel according to claim 1, characterized in that, The various lifting holes (33) are distributed in a matrix honeycomb pattern on the hanging plate (31).

4. The dialysis device for cross-linked sodium hyaluronate gel according to claim 1, characterized in that, The cylinder cover has filter holes.

5. The dialysis device for cross-linked sodium hyaluronate gel according to claim 1, characterized in that, The tank (1) is mounted on the weighing device (5).

6. The dialysis device for cross-linked sodium hyaluronate gel according to claim 1, characterized in that, The outer wall of the tank (1) is provided with a jacket (11) and a temperature probe (23), both of which are connected to the electrical control unit.

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