Sample application device for batch preparation of thin-layer chromatography

Abstract

The utility model discloses a sample application device for batch preparation of thin-layer chromatograms. The sample application device comprises a supporting assembly, a sliding assembly arranged on the supporting assembly in a sliding manner and a sample application needle arranged on the sliding assembly, the sliding assembly comprises a cover plate, a sliding block and a sliding plate; the cover plate is arranged on the sliding plate, a cavity used for containing the sliding block is formed between the cover plate and the sliding plate, the sliding block is arranged on the sliding plate in a sliding mode, a boss is arranged on the side, away from the sliding plate, of the sliding block, the cover plate is provided with a first limiting sliding way matched with the boss in size and identical with the sliding direction of the sliding block, and the boss penetrates through the first limiting sliding way. A groove is formed in the contact face of the sliding block and the sliding plate, one end of the sample application needle is arranged in the groove in a sliding mode, and the other end of the sample application needle penetrates through the second limiting slide way. The sample application device provided by the utility model can simultaneously complete the preparation of a plurality of thin-layer chromatography samples, and solves the problems of poor sample application effect, low efficiency and long consumed time existing in manual sample application in the prior art.

Description

Technical Field

[0001] This utility model relates to the field of chemical experimental equipment technology, and in particular to a spotting device for batch preparation of thin-layer chromatography. Background Technology

[0002] High-throughput chemical synthesis is a method for efficient, rapid, and high-yield chemical synthesis. By utilizing automated and high-throughput laboratories, it can simultaneously process reactions of thousands of different reactants, significantly increasing the yield and rate of compound production. This method is widely used in various fields such as medicine, materials science, chemical biology, and organic chemistry, accelerating the development of new materials and drugs. Compared to traditional manual synthesis methods, high-throughput synthesis offers greater automation, standardization, and the ability to operate without multiple personnel, reducing the cost and risk of chemical experiments.

[0003] High-throughput chemical synthesis products often involve sample separation and purification. Preparative thin-layer chromatography (PTC) is an important separation method, especially crucial for the preparation of highly reactive trace components. Efficient preparative TLC not only saves separation and purification time but also yields compounds with novel structures, thus promoting the rapid development of high-throughput chemical synthesis research. It is noteworthy that sample loading is a vital and critical step in preparative TLC. However, current methods typically involve repeatedly applying sample solution to the preparative TLC plate using a glass capillary tube, which suffers from poor spotting quality, low efficiency, and time-consuming processing.

[0004] In summary, there is an urgent need for a spotting device for batch preparation of thin-layer chromatography to solve the problems existing in related technologies. Utility Model Content

[0005] To address the aforementioned problems, this utility model discloses a spotting device for batch preparation of thin-layer chromatography, comprising a support assembly, a sliding assembly slidably disposed on the support assembly, and a spotting needle disposed on the sliding assembly;

[0006] The sliding assembly includes a cover plate, a sliding block, and a sliding plate. The cover plate is disposed on the sliding plate, and a cavity for accommodating the sliding block is formed between the two. The sliding block is slidably disposed on the sliding plate, and a boss is provided on the side of the sliding block away from the sliding plate. The cover plate is provided with a limiting slide first that matches the size of the boss and is in the same sliding direction as the sliding block. The boss passes through the limiting slide first. A limiting slide second is provided on the sliding plate. A groove is provided on the contact surface between the sliding block and the sliding plate. One end of the sampling needle is slidably disposed in the groove, and the other end passes through the limiting slide second. The size of one end of the limiting slide second matches the reaction plate, and the size of the other end matches the thin-layer chromatography silica gel plate.

[0007] Preferably, it further includes a limiting component disposed on the support assembly for limiting the position of the thin-layer chromatography silica gel plate. The limiting component includes a plurality of limiting members, each of which includes a movable block, a connecting arm, and a limiting block. The movable block is slidably disposed on the support assembly, and the two ends of the connecting arm are respectively hinged to the movable block and the limiting block.

[0008] Preferably, the support assembly includes several support members, each including a support column and a spring; one end of the support column passes through a sliding plate and a cover plate in sequence and is limited by bolts, and the other end of the support column is provided with a base; the movable block is slidably disposed on the support column, and the sliding plate and the movable block, as well as the movable block and the base, are connected by springs.

[0009] Preferably, it includes at least two sets of limiting members and four sets of supporting members. The four sets of supporting members are respectively disposed at the four corners of the sliding plate, and the two sets of limiting members are respectively disposed on two of the supporting members. The combination of the two sets of limiting members realizes the limiting of the thin-layer chromatography silica gel plate.

[0010] Preferably, the contact section between the support column and the movable block is a hexagonal prism.

[0011] Preferably, one end of the sampling needle is provided with a cylinder that matches the size of the groove in the sliding block, and the other end is provided with a liquid collection groove.

[0012] Preferably, the sliding plate is provided with a sliding groove, and the bottom of the sliding groove is provided with a plurality of limiting slide rails; the depth of the sliding groove matches the height of the sliding block, and the sliding block is disposed in the sliding groove.

[0013] Preferably, rolling bearings are provided at both ends of the sliding block.

[0014] Preferably, the cover plate and the sliding plate are bolted together.

[0015] Preferably, the number of the sampling needles and the number of the limiting slides are matched, and the sampling needles and the limiting slides are set in a one-to-one correspondence.

[0016] The advantages of this application compared to the prior art are as follows:

[0017] (1) The present invention provides a sample spotting device for batch preparation of thin-layer chromatography. This device enables batch preparation of thin-layer chromatography. During use, the sliding block is first slid to the end of the limiting slide that matches the reaction plate, and then slid downwards along the support assembly. The spotting needle dips into the liquid in the reaction plate and resets, then slides along the limiting slide to the end that matches the thin-layer chromatography silica gel plate, and then slides downwards along the support assembly, allowing the spotting needle to complete the spotting on the thin-layer chromatography silica gel plate. By setting multiple spotting needles, multiple batches of thin-layer chromatography can be prepared, solving the problems of poor spotting effect, low efficiency, and long time consumption in the prior art of manual spotting.

[0018] (2) Through the technical solution of this utility model, a limiting component is also provided on the support component. When at least two sets of limiting components slide down along the support column, the thin-layer chromatographic silica gel plate located between the two sets of limiting components is clamped to ensure that the thin-layer chromatographic silica gel plate does not shake during the spotting process of the spotting needle.

[0019] (3) Through the technical solution of this utility model, the contact section between the support column and the movable block is set to a hexagonal prism shape, so that the spring action of the movable block can slide down along the support column when the sliding plate slides down, without deflection, ensuring that the limiting block can accurately limit the thin-layer chromatography silica gel plate.

[0020] (4) Through the technical solution of this utility model, rolling bearings are also provided at both ends of the sliding block, so that the sliding block can slide smoothly from one end of the limiting slide to the other end, reducing the friction between the sliding block and the cover plate or the sliding plate, and reducing the wear of the components.

[0021] The preferred embodiments of this application will be described in more detail below with reference to the accompanying drawings, so as to facilitate an understanding of the features and advantages of this application. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the original state of the sampling device according to an embodiment of this application;

[0024] Figure 2 for Figure 1 A schematic diagram of the midpoint sampling device without the cover plate;

[0025] Figure 3 for Figure 1 A schematic diagram of the midpoint sampling device in the downward pressure state;

[0026] Figure 4 for Figure 1 A schematic diagram of the support assembly of the midpoint sampling device with movable blocks (spring not shown);

[0027] Figure 5 for Figure 1 A schematic diagram of the sliding plate of the midpoint sampling device.

[0028] Among them, 1-cover plate; 2-sliding block; 3-sliding plate; 4-support component; 5-moving block; 6-connecting arm; 7-limiting block; 8-thin-layer chromatography silica gel plate; 9-sampling needle; 10-rolling bearing; 11-limiting slide rail II. Detailed Implementation

[0029] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. The application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0030] In the embodiments of this application, directional indicators such as up, down, left, right, front, back, etc. are only used to explain the relative positional relationship and movement of the components in a specific posture as shown in the attached figure. If the specific posture changes, the directional indicator will also change accordingly.

[0031] Furthermore, the use of terms such as "first" and "second" in this application is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features.

[0032] Example 1, see Figure 1 and Figure 2 This application discloses a spotting device for batch preparation of thin-layer chromatography, including a support component 4, a sliding component slidably disposed on the support component 4, and a spotting needle 9 disposed on the sliding component;

[0033] The sliding assembly includes a cover plate 1, a sliding block 2, and a sliding plate 3. The cover plate 1 is disposed on the sliding plate 3, forming a cavity between them to accommodate the sliding block 2. The sliding block 2 is slidably disposed on the sliding plate 3, and a protrusion is provided on the side of the sliding block 2 away from the sliding plate 3. The cover plate 1 is provided with a limiting slide first that matches the size of the protrusion and is in the same sliding direction as the sliding block 2, and the protrusion passes through the limiting slide first. The sliding plate 3 is provided with a limiting slide second 11, and a groove is provided on the contact surface between the sliding block 2 and the sliding plate 3. One end of the sampling needle 9 is slidably disposed in the groove, and the other end passes through the limiting slide second 11. The size of one end of the limiting slide second 11 matches the reaction plate, and the size of the other end matches the thin-layer chromatography silica gel plate 8. It should be noted that in this embodiment, a total of 8 sampling needles 9 and 8 limiting slide second 11s are provided, with each sampling needle 9 corresponding to a limiting slide second 11.

[0034] In this embodiment, a limiting component for limiting the position of the thin-layer chromatography silica gel plate 8 is also included on the support assembly 4. The limiting component includes two sets of limiting members, each including a movable block 5, a connecting arm 6, and a limiting block. The support assembly 4 includes four sets of support members, each including a support column and a spring. The four sets of support members are respectively disposed at the four corners of the sliding plate 3, and the two sets of limiting members are respectively disposed on two of the support members. The two sets of limiting members combine to limit the position of the thin-layer chromatography silica gel plate 8. One end of the support column passes through the sliding plate 3 and the cover plate 1 sequentially and is limited by bolts. The other end of the support column is provided with a base. The movable block 5 is slidably disposed on the support column. Both ends of the connecting arm 6 are hinged to the movable block 5 and the limiting block, respectively. The sliding plate 3 and the movable block 5, as well as the movable block 5 and the base, are connected by springs. See also Figure 3 When the sliding plate 3 is subjected to downward pressure, it slides down along the support column. At this time, the spring is compressed, and the force is applied to the movable block 5. The movable block 5 is subjected to force and slides down along the support column, causing the connecting arm 6 to drive the limiting block 7 to move towards the thin-layer chromatography silica gel plate 8. When the sliding plate 3 reaches the lowest position, the movable block 5 also reaches the lowest position. At this time, the limiting block 7 just abuts against the thin-layer chromatography silica gel plate 8. The two limiting blocks 7 just achieve the limiting of the thin-layer chromatography silica gel plate 8.

[0035] In this embodiment, see Figure 4 The contact section between the support column and the movable block 5 is a hexagonal prism. In this embodiment, the support column with the movable block 5 includes a circumscribed hexagonal prism of diameter a, an inscribed hexagonal prism of diameter b (i.e., the contact section with the movable block 5, which is a hexagonal prism), and a cylinder of diameter c connected in sequence. The free end of the circumscribed hexagonal prism of diameter a passes through the sliding plate 3 and the cover plate 1 in sequence and is provided with an M4 thread. A nut is tightened to limit its position. The free end of the cylinder of diameter c is connected to a base of diameter d, wherein diameter a... <b<c<d。

[0036] In this embodiment, one end of the sampling needle 9 is provided with a cylinder that matches the size of the groove of the sliding block 2, and the other end is provided with a liquid collection groove.

[0037] In this embodiment, see Figure 5 The sliding plate 3 is provided with a sliding groove, and a plurality of limiting slide rails are provided at the bottom of the sliding groove; the depth of the sliding groove matches the height of the sliding block 2, and a limiting slide rail 11 is provided at the bottom of the sliding groove, and the sliding block 2 is disposed in the sliding groove.

[0038] In this embodiment, rolling bearings 10 are provided at both ends of the sliding block 2.

[0039] In this embodiment, the cover plate 1 and the sliding plate 3 are bolted together.

[0040] The present application has been further described above with reference to specific embodiments. However, it should be understood that the specific descriptions herein should not be construed as limiting the substance and scope of the present application. Various modifications made by those skilled in the art to the above embodiments after reading this specification are all within the scope of protection of the present application.

Claims

1. A spotting device for batch preparation of thin-layer chromatography, characterized in that, It includes a support component (4), a sliding component that is slidably disposed on the support component (4), and a sampling needle (9) disposed on the sliding component; The sliding assembly includes a cover plate (1), a sliding block (2), and a sliding plate (3); the cover plate (1) is disposed on the sliding plate (3) and a cavity for accommodating the sliding block (2) is formed between the two; the sliding block (2) is slidably disposed on the sliding plate (3) and a boss is provided on the side of the sliding block (2) away from the sliding plate (3); the cover plate (1) is provided with a limiting slide first that matches the size of the boss and has the same sliding direction as the sliding block (2); the boss passes through the limiting slide first; a limiting slide second (11) is provided on the sliding plate (3); a groove is provided on the contact surface between the sliding block (2) and the sliding plate (3); one end of the spotting needle (9) is slidably disposed in the groove, and the other end passes through the limiting slide second (11); the size of one end of the limiting slide second (11) matches the reaction plate, and the size of the other end matches the thin-layer chromatography silica gel plate.

2. The sampling device according to claim 1, characterized in that, It also includes a limiting component disposed on the support assembly (4) for limiting the position of the thin-layer chromatography silica gel plate. The limiting component includes several limiting elements, including a movable block (5), a connecting arm (6) and a limiting block (7). The movable block (5) is slidably disposed on the support assembly (4), and the two ends of the connecting arm (6) are hinged to the movable block (5) and the limiting block (7) respectively.

3. The sampling device according to claim 2, characterized in that, The support assembly (4) includes several support members, including a support column and a spring; one end of the support column passes through the sliding plate (3) and the cover plate (1) in sequence and is limited by bolts, and the other end of the support column is provided with a base; the movable block (5) is slidably disposed on the support column, and the sliding plate (3) and the movable block (5) and the movable block (5) are connected by springs.

4. The sampling device according to claim 3, characterized in that, It includes at least two sets of limiting components and four sets of supporting components. The four sets of supporting components are respectively set at the four corners of the sliding plate (3). The two sets of limiting components are respectively set on two of the supporting components. The combination of the two sets of limiting components realizes the limiting of the thin-layer chromatography silica gel plate.

5. The sampling device according to claim 3, characterized in that, The contact section between the support column and the movable block (5) is a hexagonal prism.

6. The sampling device according to claim 1, characterized in that, One end of the sampling needle (9) is provided with a cylinder that matches the size of the groove of the sliding block (2), and the other end is provided with a liquid collection groove.

7. The sampling device according to claim 1, characterized in that, The sliding plate (3) is provided with a sliding groove, and a number of limiting slide rails (11) are provided at the bottom of the sliding groove; the depth of the sliding groove matches the height of the sliding block (2), and the sliding block (2) is set in the sliding groove.

8. The sampling device according to claim 7, characterized in that, Rolling bearings (10) are provided at both ends of the sliding block (2).

9. The sampling device according to claim 1, characterized in that, The cover plate (1) and the sliding plate (3) are bolted together.

10. The sampling device according to any one of claims 1-9, characterized in that, The number of the sampling needles (9) matches the number of the limiting slides 2, and the sampling needles are set in a one-to-one correspondence with the limiting slides 2.

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