Gastric spasmolysis drug anisodamine hydrobromide extraction equipment

Abstract

The utility model discloses extraction equipment for a gastric spasmolysis drug anisodamine hydrobromide. The extraction equipment comprises a bottom frame, an extraction tank fixedly mounted on one side of the top of the bottom frame, a pressurizing and shunting tank fixedly mounted on one side of the extraction tank, and an electric cabinet fixedly mounted on the top of the bottom frame and positioned between the extraction tank and the pressurizing and shunting tank. And a conveying pump and a material guide pump are fixedly mounted at the bottom of the electric control box on the bottom frame. A material pumping pipe and a material discharging pipe are mounted at the two ends of the material guiding pump respectively, and one end of the material discharging pipe is in butt joint with the extraction tank. The two ends of the delivery pump are in butt joint with the extraction tank and the pressurizing flow dividing tank respectively. Discharging pipes with different heights are installed on the two sides of the pressurizing flow dividing tank in a penetrating mode. According to the utility model, the density of the residual liquid in the pressurized shunting tank is changed according to the adjustment of the pressure intensity. And the sewage passes through the biological filter membrane and is discharged from the cleaning holes. It is guaranteed that no liquid remains in the pressurizing flow dividing tank, and extraction of the next group of medicine is not affected.

Description

Technical Field

[0001] This utility model belongs to the field of pharmaceutical extraction technology, specifically relating to an extraction device for the gastric antispasmodic drug anisodamine hydrobromide. Background Technology

[0002] Scopolamine hydrobromide is an organic compound and an anticholinergic drug that blocks M-cholinergic receptors. Its effects are similar to or slightly weaker than atropine, including relaxing smooth muscles, relieving vasospasm, improving microcirculation, and providing analgesia. However, its mydriatic and glandular secretion-inhibiting effects are weaker, and it rarely causes central nervous system excitation symptoms. Scopolamine hydrobromide solution is a colorless, odorless, and transparent liquid.

[0003] Domestic utility model patent application number 202323521512.6 discloses a separation and extraction device for pharmaceutical production, including a base. A centrifuge tank is embedded in the top side of the base, and the top of the centrifuge tank is covered with a sealing cap. The upper part of the interior of the centrifuge tank has an upper fixing groove, and the lower part of the interior of the centrifuge tank has a lower fixing groove. The bottom end of the upper fixing groove and the top end of the lower fixing groove extend and connect to form an inner cylinder, and a drug-carrying bag is wedged between the bottom end of the upper fixing groove and the lower fixing groove. An extraction tank is embedded in the top other side of the base. This device uses centrifugal separation and air pressure filtration to purify the medicinal liquid of Chinese medicinal materials. This device can obtain a medicinal liquid with fewer impurities, while also ensuring that the medicinal liquid content in the residue is low, thus obtaining more medicinal liquid to a certain extent. The centrifugal mechanism of this device has multiple drug-carrying bags into which the boiled medicinal materials are poured before centrifugation. The aforementioned utility model uses centrifugation to filter and separate drugs. However, this separation method generally has limited effectiveness, and centrifugation cannot be used for extraction of liquids miscible with the drug. When extracting a liquid containing anisodamine hydrobromide, a solvent separation process is required to separate the components in the mixture. A selected solvent that is immiscible (or slightly miscible) with the anisodamine hydrobromide liquid mixture is added, utilizing the different solubilities of the components in the solvent to achieve separation or extraction. However, after separation, during the transfer of the liquid, some liquid residue may remain at the separation site. Utility Model Content

[0004] To address the aforementioned technical problems, this utility model provides an extraction device for the gastric antispasmodic drug anisodamine hydrobromide, comprising a base frame, an extraction tank fixedly installed on one side of the top of the base frame, a pressurization and diversion tank fixedly installed on one side of the extraction tank, and an electrical control box fixedly installed on the top of the base frame between the extraction tank and the pressurization and diversion tank. A delivery pump and a feed pump are fixedly installed on the base frame at the bottom of the electrical control box. A suction pipe and a discharge pipe are respectively installed at both ends of the feed pump, with one end of the discharge pipe connected to the extraction tank. Both ends of the delivery pump are connected to the extraction tank and the pressurization and diversion tank, respectively. Discharge pipes of different heights are installed through both sides of the pressurization and diversion tank.

[0005] After calculating the required volume of scopolamine hydrobromide liquid for extraction, it is introduced into the extraction tank from the top, and the extraction solvent is added according to the specific capacity. After the reaction has proceeded for a period of time, it is then pumped into a pressurized splitter tank and discharged.

[0006] As a further preferred technical solution of this utility model, four sets of wheels are fixedly installed at the bottom of the base frame. The top of the extraction tank supports a top cover, and the bottom of the extraction tank is fixedly installed to the top of the base frame through four sets of support frames. A feeding pipe is installed through the extraction tank at the bottom of the top cover on one side, and the bottom of the feeding pipe is connected to the top of the discharge pipe through a metering pipe.

[0007] By using a metering tube, the amount of solvent added can be observed, ensuring the accuracy of the operation.

[0008] As a further preferred technical solution of this utility model; a feed pipe is installed at the bottom of the extraction tank, and a three-pronged connecting pipe is connected to the end of the feed pipe; a conveying pipe is installed at the top of the conveying pump; and three-pronged guide pipes are installed between the three-pronged connecting pipe and the conveying pump, and at one end of the conveying pipe. The three-pronged guide pipe is connected to the booster and diversion tank via a three-pronged connecting pipe.

[0009] The extracted liquid at the bottom of the extraction tank is transported by a transfer pump. After extraction, two branches on a three-way feed pipe transfer different liquids, thereby reducing the possibility of mixing due to different liquids being transported through the same set of pipes.

[0010] As a further preferred technical solution of this utility model, solenoid valves are installed on the feeding pipe, the three-pronged guide pipe, the discharge pipe, and the outlet pipe. The bottom of the three-pronged connecting pipe, the three-pronged guide pipe, and the three-pronged connecting pipe are all supported by support columns.

[0011] The solenoid valves are set and controlled by the electrical control box to ensure smooth pipeline transportation in the extraction equipment.

[0012] As a further preferred technical solution of this utility model; a top plate is welded and installed on the top of the pressurization diversion tank, four sets of support rods are fixedly installed on the bottom of the top plate, and a hydraulic cylinder is fixedly installed on the top plate. A telescopic rod is installed through the bottom of the hydraulic cylinder and a piston block is fixedly installed at the bottom of the telescopic rod. A biofilter membrane is fixedly installed inside the pressurization diversion tank. A cleaning hole penetrating the base frame is opened at the bottom of the pressurization diversion tank, and a plug is snapped into the bottom of the cleaning hole.

[0013] The piston block moves up and down inside the pressurized diversion tank by extending and retracting the telescopic rod at the bottom of the hydraulic cylinder. This changes the density of the residual liquid inside the tank according to the pressure adjustment, forcing it through the biofilter membrane and out through the cleaning port. This ensures that there is no liquid residue inside the pressurized diversion tank, preventing it from affecting the extraction of the next batch of drugs.

[0014] As a further preferred technical solution of this utility model, the discharge pipes are respectively connected and installed at the top and bottom positions of the biofilter membrane.

[0015] Two sets of discharge pipes at different locations separate the liquid from the top and bottom of the biofiltration membrane.

[0016] Beneficial effects

[0017] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0018] 1. The piston block moves up and down inside the pressurized diversion tank by extending and retracting the telescopic rod at the bottom of the hydraulic cylinder. This changes the density of the residual liquid inside the tank according to the pressure adjustment, allowing it to pass through the biofilter membrane and be discharged through the cleaning port. This ensures that there is no liquid residue inside the pressurized diversion tank, preventing it from affecting the extraction of the next batch of drugs.

[0019] 2. The extracted liquid at the bottom of the extraction tank is transported by a transfer pump. After extraction, two branches on the three-way feed pipe transfer different liquids, thereby reducing the possibility of mixing due to different liquids being transported through the same set of pipes. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the structure of this utility model;

[0021] Figure 2 for Figure 1 Enlarged structural diagram at point A;

[0022] Figure 3 for Figure 1 Enlarged structural diagram at point B;

[0023] Figure 4 This is a cross-sectional structural diagram of the pressurized diversion tank of this utility model.

[0024] In the diagram: 1. Base frame; 11. Wheels; 12. Support column; 2. Extraction tank; 21. Support frame; 22. Top cover; 23. Feeding pipe; 24. Metering pipe; 25. Discharge pipe; 26. Three-way connecting pipe; 3. Electrical control box; 4. Conveying pump; 41. Conveying pipe; 42. Three-way guide pipe; 5. Guide pump; 51. Extraction pipe; 52. Discharge pipe; 6. Solenoid valve; 7. Booster and diverter tank; 71. Three-way connecting pipe; 72. Top plate; 73. Support rod; 74. Hydraulic cylinder; 75. Telescopic rod; 76. Piston block; 77. Cleaning hole; 78. Discharge pipe; 79. Biofiltration membrane. Detailed Implementation

[0025] This specific embodiment is an extraction device for the gastric antispasmodic drug anisodamine hydrobromide.

[0026] The aforementioned utility model uses centrifugation to filter and separate drugs. However, this separation method generally has limited effectiveness, and centrifugation cannot be used for extraction of liquids miscible with the drug. When extracting a liquid containing anisodamine hydrobromide, a solvent separation process is required to separate the components in the mixture. A selected solvent that is immiscible (or slightly miscible) with the anisodamine hydrobromide liquid mixture is added, utilizing the different solubilities of the components in the solvent to achieve separation or extraction. However, after separation, during the transfer of the liquid, some liquid residue may remain at the separation site.

[0027] Its structural diagram is as follows Figures 1-4As shown. An extraction device for the gastric antispasmodic drug anisodamine hydrobromide includes a base frame 1, an extraction tank 2 fixedly installed on one side of the top of the base frame 1, a pressurization and diversion tank 7 fixedly installed on one side of the extraction tank 2, and an electrical control box 3 fixedly installed on the top of the base frame 1 between the extraction tank 2 and the pressurization and diversion tank 7. A delivery pump 4 and a feed pump 5 are fixedly installed on the base frame 1 at the bottom of the electrical control box 3. A suction pipe 51 and a discharge pipe 52 are respectively installed at both ends of the feed pump 5, and one end of the discharge pipe 52 is connected to the extraction tank 2. Four sets of wheels 11 are fixedly installed at the bottom of the base frame 1. The top of the extraction tank 2 is supported by a top cover 22, and the bottom of the extraction tank 2 is fixedly installed to the top of the base frame 1 through four sets of support frames 21. A feed pipe 23 is installed through one side of the extraction tank 2 at the bottom of the top cover 22, and the bottom of the feed pipe 23 is connected to the top of the discharge pipe 52 through a metering pipe 24. The metering tube 24 allows for monitoring of solvent levels during addition, ensuring operational accuracy. The transfer pump 4 is connected to the extraction tank 2 and the pressurized distribution tank 7 at both ends. A discharge pipe 25 is connected to the bottom of the extraction tank 2, with a three-way connecting pipe 26 at one end. A delivery pipe 41 is connected to the top of the transfer pump 4. Three-way guide pipes 42 are connected between the three-way connecting pipe 26 and the transfer pump 4, and at one end of the delivery pipe 41. The three-way guide pipe 42 is connected to the pressurized distribution tank 7 via a three-way connecting pipe 71. The transfer pump 4 transports the extracted liquid from the bottom of the extraction tank 2. After extraction, the two branches on the three-way guide pipe 42 transfer different liquids, reducing mixing caused by using the same set of pipes. Solenoid valves 6 are installed on the discharge pipe 25, the three-way guide pipe 42, the discharge pipe 78, and the discharge pipe 52. The bottoms of the three-way connecting pipe 26, the three-way feed pipe 42, and the three-way connecting pipe 71 are all supported by support columns 12. The solenoid valve 6 is controlled by the electrical control box 3 to ensure smooth pipeline transport in the extraction equipment. Discharge pipes 78 of different heights are installed through both sides of the pressurized diversion tank 7. A top plate 72 is welded to the top of the pressurized diversion tank 7. Four sets of support rods 73 are fixedly installed at the bottom of the top plate 72, and a hydraulic cylinder 74 is fixedly installed on the top plate 72. A telescopic rod 75 is installed through the bottom of the hydraulic cylinder 74, and a piston block 76 is fixedly installed at the bottom of the telescopic rod 75. A bio-filter membrane 79 is fixedly installed inside the pressurized diversion tank 7. A cleaning hole 77 penetrating the base frame 1 is opened at the bottom of the pressurized diversion tank 7, and a plug is snapped into the bottom of the cleaning hole 77. The piston block 76 moves up and down inside the pressurized diversion tank 7 by extending and retracting the telescopic rod 75 at the bottom of the hydraulic cylinder 74, thereby changing the density of the residual liquid inside the pressurized diversion tank 7 according to the pressure adjustment. This allows the liquid to pass through the biofilter membrane 79 and be discharged through the cleaning port 77. This ensures that there is no liquid residue inside the pressurized diversion tank 7, preventing it from affecting the extraction of the next batch of drugs. The discharge pipes 78 are respectively connected to the top and bottom positions of the biofilter membrane 79.Two sets of discharge pipes 78 at different locations separate the liquid at the top and bottom of the biofiltration membrane 79 for discharge.

[0028] After calculating the required volume of scopolamine hydrobromide liquid for extraction, it is introduced into extraction tank 2 from the top. Extraction solvent is added via extraction pipe 51 according to the specific capacity, and the solvent volume is controlled via metering pipe 24. A selected solvent that is immiscible or slightly miscible with the scopolamine hydrobromide liquid mixture is added, utilizing the different solubilities of the components in the solvent to achieve separation or extraction. After a period of reaction, the separated bottom layer solution is discharged via discharge pipe 25 and pumped into pressurized diversion tank 7 by transfer pump 4. The scopolamine hydrobromide liquid is then filtered through biofiltration membrane 79 and discharged via discharge pipe 78. The liquid located at the stratification point inside extraction tank 2 is filtered in this manner, ensuring the purity of the extracted scopolamine hydrobromide liquid. When the extraction of this drug is completed and another drug is used for extraction, the inside of the extraction tank 2 is rinsed with clean water, and the clean water is delivered by the delivery pump 4 to clean the inside of the pressurized diversion tank 7 a second time. The cleaning hole 77 at the bottom of the pressurized diversion tank 7 is opened, and the piston block 76 is pushed by the hydraulic cylinder 74 to ensure that the liquid inside the pressurized diversion tank 7 is discharged from the cleaning hole 77 without residue, thereby ensuring the multiple uses of the extraction equipment.

[0029] All technical features in this embodiment can be freely combined according to actual needs.

[0030] The above embodiments are preferred implementations of this utility model. In addition, this utility model can also be implemented in other ways. Any obvious substitutions without departing from the concept of this technical solution are within the protection scope of this utility model.

Claims

1. An extraction device for anisodamine hydrobromide, a gastric antispasmodic drug, characterized in that, The system includes a base frame (1), an extraction tank (2) fixedly installed on one side of the top of the base frame (1), a pressure boosting and diversion tank (7) fixedly installed on one side of the extraction tank (2), and an electrical control box (3) fixedly installed on the top of the base frame (1) between the extraction tank (2) and the pressure boosting and diversion tank (7). A delivery pump (4) and a feed pump (5) are fixedly installed on the base frame (1) at the bottom of the electrical control box (3). The feed pump (5) has a suction pipe (51) and a discharge pipe (52) installed at both ends, and one end of the discharge pipe (52) is connected to the extraction tank (2). The two ends of the delivery pump (4) are connected to the extraction tank (2) and the pressure boosting and diversion tank (7), respectively. The pressure boosting and diversion tank (7) has discharge pipes (78) of different heights installed through both sides.

2. The extraction equipment for the gastric antispasmodic drug anisodamine hydrobromide according to claim 1, characterized in that: The bottom of the base frame (1) is fixedly installed with four sets of walking wheels (11). The top of the extraction tank (2) is supported by a top cover (22). The bottom of the extraction tank (2) is fixedly installed to the top of the base frame (1) through four sets of support frames (21). A feeding pipe (23) is installed through one side of the extraction tank (2) at the bottom position of the top cover (22). The bottom of the feeding pipe (23) is connected to the top of the discharge pipe (52) through a metering pipe (24).

3. The extraction equipment for the gastric antispasmodic drug anisodamine hydrobromide according to claim 2, characterized in that: The bottom of the extraction tank (2) is connected to a feed pipe (25), and the end of the feed pipe (25) is connected to a three-way connecting pipe (26). The top of the delivery pump (4) is connected to a delivery pipe (41). The three-way connecting pipe (26) and the delivery pump (4) are connected to a three-way guide pipe (42), and one end of the delivery pipe (41) is connected to the three-way guide pipe (42). The three-way guide pipe (42) is connected to the pressurized diversion tank (7) through a three-way connecting pipe (71).

4. The extraction equipment for the gastric antispasmodic drug anisodamine hydrobromide according to claim 3, characterized in that: Solenoid valves (6) are installed on the feeding pipe (25), the three-pronged guide pipe (42), the discharge pipe (78), and the discharge pipe (52). The bottom of the three-pronged connecting pipe (26), the three-pronged guide pipe (42), and the three-pronged connecting pipe (71) are all supported by support columns (12).

5. The extraction equipment for the gastric antispasmodic drug anisodamine hydrobromide according to claim 4, characterized in that: The top of the pressurized diversion tank (7) is welded and installed with a top plate (72). Four sets of support rods (73) are fixedly installed at the bottom of the top plate (72). A hydraulic cylinder (74) is fixedly installed on the top plate (72). A telescopic rod (75) is installed through the top plate (72) at the bottom of the hydraulic cylinder (74). A piston block (76) is fixedly installed at the bottom of the telescopic rod (75). A bio-filter membrane (79) is fixedly installed inside the pressurized diversion tank (7). A cleaning hole (77) is opened at the bottom of the pressurized diversion tank (7) through the base frame (1). A plug is snapped into the bottom of the cleaning hole (77).

6. The extraction equipment for the gastric antispasmodic drug anisodamine hydrobromide according to claim 5, characterized in that: The discharge pipe (78) is respectively connected to the top and bottom positions of the biofilter membrane (79).

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