Mixing granulator for preparing temozolomide capsules
By designing a mixing granulator with a linkage mechanism and transmission components, the problems of uneven mixing and low efficiency in the preparation of temozolomide capsules were solved, achieving all-round mixing and circulating mixing, thus improving the mixing quality and efficiency.
Patent Information
- Application Number
- CN202423017173.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-09
- Publication Date
- 2025-11-11
- Estimated Expiration
- 2034-12-09
AI Technical Summary
The existing temozolomide capsule preparation equipment has a simple structure and a small stirring range, which results in the raw materials at the bottom and along the wall not being stirred, leading to uneven mixing and low efficiency.
The mixing and granulation machine, designed with a linkage mechanism and transmission components, includes a mixing drum, linkage mechanism, transmission components and screw rod, to achieve multi-directional and circulating mixing. Combined with electric heating function, it ensures that the raw materials are fully mixed.
It achieves all-around, no-dead-angle mixing, improves mixing efficiency and quality, reduces human error, and avoids raw material waste.
Smart Images
Figure CN223530368U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of mixing equipment technology, and in particular to a mixing and granulation machine for preparing temozolomide capsules. Background Technology
[0002] Temozolomide capsules are a novel oral alkylating agent antitumor drug, primarily used to treat gliomas.
[0003] In the preparation process, temozolomide powder needs to be stirred and mixed with the formulation, including temozolomide, mannitol, citric acid, polysorbate-80, sodium citrate and hydrochloric acid.
[0004] Common temozolomide capsule raw material mixing devices only use a stirring shaft and stirring frame to stir the raw materials. Their structure is simple, the stirring range in the chamber is small, and they cannot achieve multi-directional stirring. This will result in the raw materials at the bottom and along the walls of the mixing chamber not being stirred, which will affect the quality. Moreover, if the stirring effect is not good in a single time, the raw materials need to be discharged from the outlet and then manually poured back into the inlet, which is also inefficient.
[0005] Therefore, we propose a mixing granulator for the preparation of temozolomide capsules to solve the above problems. Utility Model Content
[0006] This invention provides a mixing and granulation machine for preparing temozolomide capsules, which solves the technical problems mentioned in the background art.
[0007] To solve the above-mentioned technical problems, the present invention provides a mixing and granulation machine for preparing temozolomide capsules, including a mixing cylinder. A linkage mechanism is installed inside the mixing cylinder, comprising a connecting rod, a rotating rod, and mixing blades. A protrusion is installed at one end of the connecting rod, and the end of the protrusion away from the connecting rod meshes with the tooth groove of a first gear installed inside the mixing cylinder. A second rotating rod is inserted inside the first gear. A first turntable and a second turntable are respectively inserted at the bottom and top of the second rotating rod. The end of the connecting rod and the protrusion connected to each other is fixedly installed on the outer wall of the first turntable. A fixing plate is connected to the second turntable. A second gear is rotatably connected to the inner wall of the fixing plate. A rack is slidably inserted into the inner wall of the fixing plate, and the tooth groove of the rack meshes with the tooth groove of the second gear.
[0008] The outer wall of the fixed plate is rotatably connected to a rotating shaft. A partition is fixedly installed at the top of the rotating shaft. A transmission assembly is provided on the partition. The transmission assembly includes a first transmission wheel and a second transmission wheel. A track is drivingly connected between the first transmission wheel and the second transmission wheel. A first rotating rod is rotatably connected to the lower end of the second transmission wheel. A fixing block is rotatably connected to the outer wall of the first rotating rod. The outer wall of the fixing block is inserted into the partition. A receiving rod is rotatably connected to the end of the first rotating rod away from the second transmission wheel. The receiving rod is rotatably connected to a rack at the end away from the first rotating rod.
[0009] Preferably, a conveying pipe is inserted into one side of the mixing cylinder, a screen is installed at one end of the conveying pipe, a feed inlet is provided below the screen, a screw rod is rotatably connected inside the conveying pipe, and a first discharge port and a second discharge port are provided through the bottom of the mixing cylinder.
[0010] Preferably, the outer wall of the mixing cylinder is fixedly fitted with glass.
[0011] Preferably, the outer wall of the mixing cylinder is connected to a control panel that is electrically connected to the screw rod.
[0012] Preferably, a water storage tank is fixedly installed at the bottom of the mixing cylinder, and an electric heating rod is fixedly installed on the outer wall of the water storage tank.
[0013] Preferably, a storage box is provided directly below the second discharge port.
[0014] Preferably, a baffle is installed between the linkage mechanism and the transmission component inside the mixing cylinder, and the baffle has multiple holes through a ring near the inner wall of the mixing cylinder.
[0015] Compared with related technologies, the mixing and granulation machine for preparing temozolomide capsules provided by this utility model has the following beneficial effects:
[0016] 1. In this utility model, the second transmission wheel drives the receiving rod to rotate the rack through the first rotating rod. The tooth groove on one side of the rack meshes with the tooth groove on the surface of the second gear, thereby driving the second gear to rotate the second turntable. At the same time, multiple linkage mechanisms installed on the outer wall of the second turntable rotate. Meanwhile, the protrusion meshing with the tooth groove of the first gear drives multiple linkage mechanisms to rotate around the first turntable, resulting in a larger stirring range and realizing multi-directional stirring and mixing, which is beneficial to ensure the full mixing of temozolomide powder and prescription raw materials.
[0017] 2. In this utility model, temozolomide raw material is poured into the inlet and enters the conveying pipe through the screen. It is then carried upward into the mixing cylinder by the screw rod and stirred by multiple internal linkage mechanisms. By opening the first outlet, the temozolomide raw material can be poured back into the inlet for circulation and stirring. When repeated stirring is no longer needed, the second outlet is opened to allow it to flow out. This ensures the mixing degree of the raw material. At the same time, if the single mixing effect is not good, a second mixing can be performed directly, which helps to improve the mixing efficiency. Attached Figure Description
[0018] Figure 1 Internal structure diagram of a mixing granulator for preparing temozolomide capsules;
[0019] Figure 2 for Figure 1 Enlarged view of the structure at point A in the middle;
[0020] Figure 3 for Figure 1 Enlarged view of the structure at point B;
[0021] Figure 4 An overall external schematic diagram of a mixing granulator used for the preparation of temozolomide capsules.
[0022] Labels in the diagram: 1. Mixing cylinder; 2. Glass; 3. Control panel; 4. Water tank; 5. Heating rod; 6. Second discharge port; 7. Storage box; 8. Feed inlet; 9. Conveying pipe; 10. First discharge port; 11. Screw rod; 12. Screen; 13. Mixing blade; 14. Rotating rod; 15. Connecting rod; 16. Hole; 17. Track; 18. First drive wheel; 19. Second drive wheel; 20. Rack; 21. Fixing plate; 22. Fixing block; 23. First rotating rod; 24. Receiving rod; 25. Rotating shaft; 26. First gear; 27. Second rotating rod; 28. Protrusion; 29. First turntable; 30. Second gear; 31. Second turntable; 32. Motor. Detailed Implementation
[0023] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.
[0024] Example 1, by Figure 1-4A mixing granulator for preparing temozolomide capsules is provided, comprising a mixing cylinder 1. A linkage mechanism is installed inside the mixing cylinder 1, including a connecting rod 15, a rotating rod 14, and a mixing blade 13. A protrusion 28 is installed at one end of the connecting rod 15. The end of the protrusion 28 away from the connecting rod 15 meshes with the tooth groove of a first gear 26 installed inside the mixing cylinder 1. A second rotating rod 27 is inserted inside the first gear 26. A first rotating disk 29 and a second rotating disk 31 are respectively inserted into the bottom and top of the second rotating rod 27. The end of the connecting rod 15 and the protrusion 28 connected to each other is fixedly installed on the outer wall of the first rotating disk 29. A fixing plate 21 is connected to the second rotating disk 31. A second gear 30 is rotatably connected to the inner wall of the fixing plate 21. A rack 20 is slidably inserted into the inner wall of the fixing plate 21, and the tooth groove of the rack 20 meshes with the tooth groove of the second gear 30.
[0025] A rotating shaft 25 is rotatably connected to the outer wall of the fixed plate 21. A partition is fixedly installed at the top of the rotating shaft 25. A transmission assembly is provided on the partition, which includes a first transmission wheel 18, a track 17, a second transmission wheel 19, and a motor 32. The track 17 is connected between the first transmission wheel 18 and the second transmission wheel 19. A first rotating rod 23 is rotatably connected to the lower end of the second transmission wheel 19. A fixing block 22 is rotatably connected to the outer wall of the first rotating rod 23. The outer wall of the fixing block 22 is inserted into the partition. A receiving rod 24 is rotatably connected to the end of the receiving rod 24 away from the second drive wheel 19. The end of the receiving rod 24 away from the first rotating rod 23 is rotatably connected to the rack 20. When the temozolomide raw material is transported into the mixing drum 1 by the conveying pipe 9, the end of the receiving rod 24 is driven by the second drive wheel 19, causing the rack 20 to rotate by meshing with the second gear 30. At the same time, the second gear 30, the second turntable 31, the fixing plate 21, and the first turntable 29 are all horizontally inserted into the outside of the second rotating rod 27. The rotation of the second gear 30 causes multiple linkage mechanisms fixedly installed on the outer wall of the second turntable 31 to rotate synchronously. The rotating rod 14 in the linkage mechanism can also drive the mixing blade 13 to rotate through one end of the connecting rod 15. The outer wall of the first turntable 29 is also fixedly installed with multiple linkage mechanisms. The tooth groove of the first gear 26 drives the protrusion 28, causing it and the inner wall of the first turntable 29 to rotate around the inner wall of the second rotating rod 27. The connecting rod 15 of the linkage mechanism fixedly installed on the outer wall of the first turntable 29 is shorter and has a smaller range, and is used for stirring in the central area inside the mixing drum 1. The connecting rod 15 of the multiple linkage mechanisms fixedly installed on the outer wall of the second turntable 31 is longer and has a larger range, and is used for stirring in the position close to the inner wall inside the mixing drum 1. The whole can perform all-round stirring without dead angles inside the mixing drum 1, preventing uneven stirring. The water tank 4 installed at the bottom of the mixing drum 1 heats the water inside through the inserted electric heating rod 5, which heats the raw materials inside the mixing drum 1.
[0026] In addition, a baffle is installed between the linkage mechanism and the transmission component inside the mixing cylinder 1. The baffle has multiple holes 16 that run through it around the inner wall of the mixing cylinder 1. The baffle is used to separate the linkage mechanism and the transmission component, and to fix the overall structure inside the mixing cylinder 1 to ensure normal operation. The smaller holes 16 around the baffle can pass through to prevent the raw materials from drying out too much during the stirring process. Temozolomide also needs to be dried later, so this will not affect the preparation process of temozolomide.
[0027] In addition, a storage box 7 is provided directly below the second discharge port 6. The storage box 7 is located directly below the second discharge port 6 to facilitate the collection of raw materials that have been internally mixed and flow out of the second discharge port 6, so as to prevent them from spilling onto the ground and affecting the effect.
[0028] In addition, a water tank 4 is fixedly installed at the bottom of the mixing drum 1, and an electric heating rod 5 is fixedly installed on the outer wall of the water tank 4. The water tank 4 stores water, and the water inside is heated by the inserted electric heating rod 5, so that the temperature is transferred to the raw materials inside the mixing drum 1. Since the raw materials will accumulate at the bottom of the mixing drum 1, the position of the water tank 4 can better heat the raw materials.
[0029] Example 2, based on Example 1, with reference to Appendix Figure 1 and 4 A conveying pipe 9 is inserted into one side of the mixing drum 1. A screen 12 is installed at one end of the conveying pipe 9. A feed inlet 8 is provided below the screen 12. A screw rod 11 is rotatably connected inside the conveying pipe 9. A first discharge port 10 and a second discharge port 6 are opened through the bottom of the mixing drum 1. The raw material is poured into the inside of the feed inlet 8, passes through the screen 12 and enters the inside of the conveying pipe 9. The screw rod 11 inside the conveying pipe 9 continuously rotates and conveys the raw material upward to the inside of the mixing drum 1. At this time, the relevant personnel can observe the conveying of the raw material inside through the glass 2 and turn off the screw rod 11 to stop the conveying. After the raw material is stirred, it can be opened through the first discharge port 10 and flow back into the inside of the feed inlet 8. It is then conveyed back into the mixing drum 1 through the conveying pipe 9 for circulation and stirring. After the stirring is completed, the second discharge port 6 can be opened to let it flow out and then stored in the storage box 7.
[0030] In addition, the outer wall of the mixing cylinder 1 is connected to a control panel 3 that is electrically connected to the screw rod 11, which allows relevant personnel to drive the screw rod 11 and control the conveying of raw materials inside the mixing cylinder 1. Based on the conveying of raw materials inside the mixing cylinder 1, the control panel can be switched on and off in a timely manner, eliminating the need for relevant personnel to manually pour in raw materials, thus avoiding spillage due to human negligence and preventing unnecessary waste.
[0031] In addition, a glass 2 is fixedly installed on the outer wall of the mixing cylinder 1. After the raw materials are transported into the mixing cylinder 1 through the conveying pipe 9, relevant personnel can observe the conveying status of the raw materials through the glass 2 from the outside, so as to prevent the mixing effect from being affected by too much or too little.
[0032] Working principle:
[0033] When stirring inside mixing drum 1:
[0034] When the temozolomide raw material is conveyed into the mixing drum 1 through the conveying pipe 9, one end of the receiving rod 24 is driven by the second transmission wheel 19, causing the rack 20 to mesh with the second gear 30, thus rotating the second gear 30. Simultaneously, the second gear 30, the second turntable 31, the fixed plate 21, and the first turntable 29 are all horizontally inserted into the outer wall of the second rotating rod 27. The rotation of the second gear 30 causes multiple linkage mechanisms fixedly installed on the outer wall of the second turntable 31 to rotate synchronously. The rotating rod 14 in the linkage mechanism can also drive the mixing blade 13 to rotate through one end of the connecting rod 15. The outer wall of the first turntable 29 also has multiple linkage mechanisms fixedly installed, which are connected by the teeth of the first gear 26. The groove drives the protrusion 28, causing it and the inner wall of the first turntable 29 to rotate around the inner wall of the second rotating rod 27. The linkage mechanism fixedly installed on the outer wall of the first turntable 29 has a shorter connecting rod 15 and a smaller range, which is used for stirring in the central area inside the mixing drum 1. The multiple linkage mechanisms fixedly installed on the outer wall of the second turntable 31 have a longer connecting rod 15 and a larger range, which are used for stirring in the position close to the inner wall inside the mixing drum 1. The whole can perform all-round stirring without dead angles inside the mixing drum 1, preventing uneven stirring. The water tank 4 installed at the bottom of the mixing drum 1 heats the water inside through the inserted electric heating rod 5, which serves to heat the raw materials inside the mixing drum 1.
[0035] When conveying temozolomide raw material into mixing cylinder 1:
[0036] The raw materials are poured into the inlet 8 and pass through the screen 12 into the conveying pipe 9. The screw 11 inside the conveying pipe 9 continuously rotates and conveys the raw materials upward into the mixing drum 1. At this time, the relevant personnel can observe the conveying of the raw materials inside through the glass 2 and turn off the screw 11 to stop the conveying. After stirring, the raw materials can be opened through the first outlet 10 and flow back into the inlet 8. They are then conveyed back into the mixing drum 1 through the conveying pipe 9 for circulation and stirring. After stirring is completed, the second outlet 6 can be opened to let the raw materials flow out. The materials are then collected in the storage box 7 and then subjected to refining, washing and drying operations. After completion, the materials can be granulated by subsequent granulation equipment.
[0037] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A mixing and granulating machine for preparing temozolomide capsules, comprising a mixing cylinder (1), characterized in that, The mixing cylinder (1) is equipped with a linkage mechanism, which includes a connecting rod (15), a rotating rod (14), and a mixing blade (13). A protrusion (28) is installed at one end of the connecting rod (15). The end of the protrusion (28) away from the connecting rod (15) meshes with a first gear (26) installed inside the mixing cylinder (1). A second rotating rod (27) is inserted inside the first gear (26). A first turntable (29) and a second turntable (31) are inserted at the bottom and top of the second rotating rod (27), respectively. The end of the connecting rod (15) and the protrusion (28) connected to each other is fixedly installed on the first turntable (29). A fixing plate (21) is connected to the second turntable (31). A second gear (30) is rotatably connected to the inner wall of the fixing plate (21). A rack (20) is inserted into the inner wall of the fixing plate (21). The rack (20) meshes with the second gear (30). The outer wall of the fixed plate (21) is rotatably connected to a rotating shaft (25). A partition is fixedly installed at the top of the rotating shaft (25). A transmission assembly is provided on the partition. The transmission assembly includes a first transmission wheel (18) and a second transmission wheel (19). A track (17) is connected between the first transmission wheel (18) and the second transmission wheel (19). The lower end of the second transmission wheel (19) is rotatably connected to a first rotating rod (23). A fixing block (22) is rotatably connected to the outer wall of the first rotating rod (23). The outer wall of the fixing block (22) is inserted into the partition. A receiving rod (24) is rotatably connected to the end of the first rotating rod (23) away from the second transmission wheel (19). The end of the receiving rod (24) away from the first rotating rod (23) is rotatably connected to a rack (20).
2. The mixing and granulating machine for preparing temozolomide capsules according to claim 1, characterized in that, A conveying pipe (9) is inserted into one side of the mixing cylinder (1). A screen (12) is installed at one end of the conveying pipe (9). An inlet (8) is provided below the screen (12). A screw rod (11) is rotatably connected inside the conveying pipe (9). A first outlet (10) and a second outlet (6) are provided through the bottom of the mixing cylinder (1).
3. The mixing and granulating machine for preparing temozolomide capsules according to claim 2, characterized in that, The outer wall of the mixing cylinder (1) is fixedly fitted with glass (2).
4. The mixing and granulating machine for preparing temozolomide capsules according to claim 3, characterized in that, The outer wall of the mixing cylinder (1) is connected to a control panel (3) that is electrically connected to the screw rod (11).
5. The mixing and granulating machine for preparing temozolomide capsules according to claim 4, characterized in that, A water storage tank (4) is fixedly installed at the bottom of the mixing cylinder (1), and an electric heating rod (5) is fixedly installed on the outer wall of the water storage tank (4).
6. The mixing and granulating machine for preparing temozolomide capsules according to claim 5, characterized in that, A storage box (7) is provided directly below the second discharge port (6).
7. The mixing and granulating machine for preparing temozolomide capsules according to claim 6, characterized in that, A baffle is installed between the linkage mechanism and the transmission component inside the mixing cylinder (1), and multiple holes (16) are opened through the baffle near the inner wall of the mixing cylinder (1).