Material taking device for fixing mouse tissues

By designing the assembly structure of the dish body, dish base, and silicone base, the problem of easy breakage of the mouse tissue sampling device was solved, achieving stable fixation and flexible observation.

CN223542025UActive Publication Date: 2025-11-14FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202422339119.3
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-09-25
Publication Date
2025-11-14
Estimated Expiration
2034-09-25

AI Technical Summary

Technical Problem

Existing mouse tissue sampling devices are prone to rupture during repeated punctures, making it impossible to effectively fix mouse tissue.

Method used

A material-taking device comprising a dish body and a dish base was designed. The inner wall of the dish body has a substrate, and the dish base contains a base. A stable connection is achieved through an assembly mechanism and a holding mechanism. The base, made of silicone, can be punctured multiple times without breaking and is equipped with a handle and guide rail structure for flexible rotation and observation.

Benefits of technology

This device enables stable fixation and flexible rotation observation of mouse tissues, improving their practicality and reliability while avoiding tissue damage.

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Abstract

The utility model discloses a sampling device for fixing mouse tissue, which relates to the field of mouse tissue sampling, comprises a dish body and a dish seat, and is characterized in that a base plate is arranged between the inner side walls of the dish body and at the bottom end, a base is arranged in the dish seat, an assembling mechanism is arranged between the dish body and the dish seat, and the dish seat is provided with a clamping mechanism. A holding mechanism is arranged on the outer side wall of the dish base, a second partition plate is arranged on the outer side wall of the dish base and located at the top position, the assembling mechanism comprises a first partition plate, and a plurality of sets of screw rings are arranged at the upper end of the first partition plate at equal intervals; the sampling device has the advantages that the fixing needle penetrates through the base plate and then is inserted into the base, the base is made of silica gel and can be repeatedly punctured without being broken, the base plate punctured for multiple times can be replaced, the practicability of the sampling device can be improved, a mouse fixed in the dish body can be rotated flexibly and quickly, and the sampling device is convenient to use. Different parts of the mouse can be conveniently observed.
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Description

Technical Field

[0001] This utility model relates to the field of mouse tissue sampling, and in particular to a sampling device for fixing mouse tissue. Background Technology

[0002] This sampling device can repeatedly fix tissues such as those from mice with fixation needles, and can also fix fresh tissues, such as fixing the entire spine with spinal cord, and dissecting the spinal cord.

[0003] However, in the existing technology, the sampling device used to fix mouse tissue needs to fix different mice and different mouse tissues, which leads to repeated punctures, which in turn makes it easy to break and makes it impossible to effectively fix the mouse. Utility Model Content

[0004] The purpose of this invention is to provide a sampling device for fixing mouse tissue, so as to solve the problems mentioned in the background art.

[0005] To solve the above-mentioned technical problems, the technical solution of this utility model is a sampling device for fixing mouse tissue, comprising a dish body and a dish base, characterized in that: a base plate is provided between the inner sidewalls of the dish body and at the bottom position; a base is provided inside the dish base; an assembly mechanism is provided between the dish body and the dish base; a holding mechanism is provided on the outer sidewall of the dish base; and a second partition is provided on the outer sidewall of the dish base at the top position.

[0006] As a further embodiment of this utility model: the assembly mechanism includes a first partition plate, and a plurality of sets of spiral rings are equidistantly arranged on the upper end of the first partition plate, and a screw is spirally arranged inside the spiral rings.

[0007] As a further embodiment of this utility model: a threaded groove for threaded connection with the screw is provided at the upper end of the second partition plate and below the screw ring.

[0008] As a further embodiment of this utility model: the dish body is placed on the upper end of the dish base through the first partition and the second partition, and the substrate is located on the upper surface of the base. The bottom of the screw is disposed in the screw groove in the second partition through the threaded ring passing through the first partition.

[0009] As a further embodiment of this utility model: the holding mechanism includes a base plate, and guide rails are provided at the bottom end of the second partition and the upper end of the base plate. A handle is provided between the second partition and the base plate through the guide rails. Several sets of inclined grooves are equidistantly opened on the outer side wall of the handle, and sliding grooves are opened at both the upper and lower ends of the handle.

[0010] As a further embodiment of this utility model: the slide groove is sleeved on the guide rail, and the handle is rotatably positioned between the second partition and the bottom plate through the slide groove in cooperation with the guide rail.

[0011] As a further embodiment of this utility model: the base is made of silicone derived from dissolved silicone powder, and the base and the dish are tightly bonded together.

[0012] The above technical solution involves placing the dish body on the upper end of the dish base, rotating the dish body to rotate the first partition on the upper end of the second partition, rotating the screw ring to the corresponding screw groove, and then inserting the screw through the screw ring into the screw groove in the second partition to fix the first and second partitions together. The dish body and dish base are then assembled together. The mouse is placed on the upper end of the dish body, and the operator can then use a fixing needle to puncture and fix the mouse through the base plate. The fixing needle penetrates the base plate and inserts into the interior of the base. Since the base is made of silicone, it can be repeatedly punctured without breaking, and the base plate can be replaced after multiple punctures, thus improving the practicality of the sampling device.

[0013] Holding the second partition and the base plate, pick up the base of the sampling device to observe the mouse located in the dish. When it is necessary to observe different parts of the mouse, move your finger from the base plate to the handle. The inclined groove can increase the friction between the finger and the handle to prevent slippage. At this time, move the dish to drive the base to rotate through the guide rail and the sliding groove, thereby driving the mouse inside the dish to rotate. The rotation of the mouse fixed inside the dish is more flexible and quick, making it easier to observe different parts of the mouse. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of a tissue sampling device for fixing mouse tissue.

[0015] Figure 2 A schematic diagram of the structure of a sampling device for fixing mouse tissue;

[0016] Figure 3 A schematic diagram of the tray and base of a sampling device for fixing mouse tissue;

[0017] Figure 4 This is a schematic diagram of the structure of a sampling device for fixing mouse tissue.

[0018] In the figure: 1. Dish body; 2. Substrate; 3. Assembly mechanism; 4. First partition plate; 5. Threaded ring; 6. Second partition plate; 7. Threaded groove; 8. Threaded rod; 9. Dish seat; 10. Holding mechanism; 11. Base plate; 12. Guide rail; 13. Handle; 14. Inclined groove; 15. Slide groove; 16. Base. Detailed Implementation

[0019] The specific embodiments of this utility model will be further described below with reference to the accompanying drawings. It should be noted that these descriptions are for the purpose of aiding understanding of this utility model, but do not constitute a limitation thereof. Furthermore, the technical features involved in the various embodiments of this utility model described below can be combined with each other as long as they do not conflict with each other.

[0020] Example 1

[0021] Please see Figures 1-4 This utility model provides a technical solution: a sampling device for fixing mouse tissue, including a dish body 1 and a dish base 9. A base plate 2 is provided between the inner sidewalls of the dish body 1 and at the bottom position. A base 16 is provided inside the dish base 9. An assembly mechanism 3 is provided between the dish body 1 and the dish base 9. A holding mechanism 10 is provided on the outer sidewall of the dish base 9. A second partition 6 is provided on the outer sidewall of the dish base 9 and at the top position.

[0022] Please see Figure 2 and Figure 3 The assembly mechanism 3 includes a first partition 4, and several sets of screw rings 5 ​​are equidistantly arranged on the upper end of the first partition 4. A screw 8 is spirally arranged inside the screw rings 5.

[0023] The second partition plate 6 has a threaded groove 7 at its upper end and below the screw ring 5, which is threaded to the screw rod 8.

[0024] The dish body 1 is placed on the upper end of the dish base 9 through the first partition 4 and the second partition 6, and the substrate 2 is located on the upper surface of the base 16. The bottom of the screw 8 passes through the first partition 4 through the screw ring 5 and is set in the screw groove 7 in the second partition 6.

[0025] In use, place the dish body 1 on the upper end of the dish base 9, rotate the dish body 1 to make the first partition 4 rotate on the upper end of the second partition 6, rotate the screw ring 5 to the upper end of the corresponding screw groove 7, and then put the screw 8 through the screw ring 5 through the first partition 4 into the screw groove 7 in the second partition 6 to fix the first partition 4 and the second partition 6 together. Then assemble the dish body 1 and the dish base 9 together, place the mouse on the upper end of the dish body 1, and the operator can then puncture and fix the mouse by penetrating the mouse and the base plate 2. This can fix fresh tissues, such as the entire spine with the spinal cord, and dissect the spinal cord. The silicone is non-toxic and harmless and will not damage fresh tissues. The fixation needle penetrates the base plate 2 and inserts into the base 16. Since the base 16 is made of silicone, it can be punctured repeatedly without breaking. The base plate 2 can be replaced after multiple punctures, which can improve the practicality of the sampling device.

[0026] Example 2

[0027] Please see Figures 1-4This utility model provides a technical solution: a sampling device for fixing mouse tissue, including a dish body 1 and a dish base 9. A base plate 2 is provided between the inner sidewalls of the dish body 1 and at the bottom position. A base 16 is provided inside the dish base 9. An assembly mechanism 3 is provided between the dish body 1 and the dish base 9. A holding mechanism 10 is provided on the outer sidewall of the dish base 9. A second partition 6 is provided on the outer sidewall of the dish base 9 and at the top position.

[0028] Please see Figure 3 and Figure 4 The holding mechanism 10 includes a base plate 11. Guide rails 12 are provided at the bottom end of the second partition 6 and the top end of the base plate 11. A handle 13 is provided between the second partition 6 and the base plate 11 through the guide rails 12. Several sets of inclined grooves 14 are provided at equal intervals on the outer side wall of the handle 13. Sliding grooves 15 are provided at both the upper and lower ends of the handle 13.

[0029] The slide groove 15 is fitted onto the guide rail 12, and the handle 13 is rotated between the second partition 6 and the base plate 11 via the slide groove 15 and the guide rail 12.

[0030] The base 16 is made of silicone derived from dissolved silicone powder, and the base 16 and the dish 9 are tightly bonded together.

[0031] Specifically, the staff member holds the second partition 6 and the base plate 11 and picks up the base 16 of the sampling device to observe the mouse located in the dish 1. When it is necessary to observe different parts of the mouse, the finger is moved from the base plate 11 to the handle 13. The inclined groove 14 can increase the friction between the finger and the handle 13 to prevent slippage. At this time, the dish 1 is turned to drive the base 16 to rotate through the guide rail 12 and the sliding groove 15, thereby driving the mouse inside the dish 1 to rotate. The rotation of the mouse fixed inside the dish 1 is more flexible and quick, which is convenient for observing different parts of the mouse.

[0032] Working principle: Place dish 1 on top of dish base 9. Rotate dish 1 to rotate the first partition 4 above the second partition 6, rotating the screw ring 5 above the corresponding screw groove 7. Then, insert the screw 8 through the screw ring 5 into the screw groove 7 in the second partition 6, fixing the first partition 4 and the second partition 6 together. This assembles dish 1 and dish base 9 together. Place the mouse on top of dish 1. At this point, the operator can insert a fixation needle through the mouse and base plate 2 to puncture and fix the mouse. This can fix fresh tissues, such as the entire spine with spinal cord, allowing for dissection of the spinal cord. The silicone is non-toxic and harmless and will not damage fresh tissue. The staff can hold the second partition 6 and the base plate 11 to pick up the base 16 of the sampling device and observe the mouse located in the dish 1. When it is necessary to observe different parts of the mouse, the fingers are moved from the base plate 11 to the handle 13. The inclined groove 14 can increase the friction between the fingers and the handle 13 to prevent slippage. At this time, the dish 1 is turned to drive the base 16 to rotate through the guide rail 12 and the sliding groove 15, thereby driving the mouse inside the dish 1 to rotate. The rotation of the mouse fixed inside the dish 1 is more flexible and quick, which is convenient for observing different parts of the mouse.

[0033] The embodiments of this utility model have been described in detail above with reference to the accompanying drawings, but this utility model is not limited to the described embodiments. For those skilled in the art, various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of this utility model, and these variations still fall within the protection scope of this utility model.

Claims

1. A sampling device for fixing mouse tissue, comprising a dish body (1) and a dish base (9), characterized in that: A base plate (2) is provided between the inner sidewalls of the dish body (1) and at the bottom position. A base (16) is provided inside the dish seat (9). An assembly mechanism (3) is provided between the dish body (1) and the dish seat (9). A holding mechanism (10) is provided on the outer sidewall of the dish seat (9). A second partition (6) is provided on the outer sidewall of the dish seat (9) and at the top position. The assembly mechanism (3) includes a first partition (4), and a number of sets of screw rings (5) are equidistantly arranged on the upper end of the first partition (4), and a screw (8) is spirally arranged inside the screw rings (5); The second partition (6) has a threaded groove (7) at its upper end and below the screw ring (5) for threaded connection with the screw rod (8); The base (16) is made of silicone derived from dissolved silicone powder, and the base (16) and the dish (9) are tightly bonded together.

2. The sampling device for fixing mouse tissue according to claim 1, characterized in that: The dish body (1) is placed on the upper end of the dish base (9) through the first partition (4) and the second partition (6), and the substrate (2) is located on the upper surface of the base (16). The bottom of the screw (8) passes through the first partition (4) through the screw ring (5) and is set in the screw groove (7) in the second partition (6).

3. The sampling device for fixing mouse tissue according to claim 1, characterized in that: The gripping mechanism (10) includes a base plate (11), and guide rails (12) are provided at the bottom end of the second partition (6) and the top end of the base plate (11). A handle (13) is provided between the second partition (6) and the base plate (11) through the guide rails (12). Several sets of inclined grooves (14) are provided at equal intervals on the outer side wall of the handle (13), and sliding grooves (15) are provided at both the upper and lower ends of the handle (13).

4. The sampling device for fixing mouse tissue according to claim 3, characterized in that: The slide groove (15) is fitted onto the guide rail (12), and the handle (13) is rotated between the second partition (6) and the bottom plate (11) through the slide groove (15) in cooperation with the guide rail (12).