Targeted drug delivery sampling capsule driven by double magnets

Abstract

The utility model relates to the technical field of minimally invasive medical instruments, and discloses a double-magnet-driven targeted drug delivery sampling capsule, a drug delivery module comprises a drug bin shell, one end of the drug bin shell is connected with a guide shell, the other end of the drug bin shell is provided with a piston, a push rod connected with the piston is arranged in the drug bin shell, one end of the push rod extends into the guide shell, and the other end of the push rod extends into the guide shell. A first radial magnetization annular magnet used for driving the push rod to move in the axial direction is installed in the guide shell. The sampling module comprises a sampling shell connected with the guide shell, a guide groove is formed in the inner side of the sampling shell, a sampler and a cam transmission mechanism are arranged in the guide groove, and a second radial magnetization annular magnet is arranged on the outer side of the sampling shell; according to the capsule, the drug release function and the puncture sampling function are integrated, control over the drug release function and the puncture sampling function is achieved through double-magnet partition driving, mutual interference of sampling and drug administration actions is avoided, and action predictability and remote control precision are remarkably improved.

Description

Technical Field

[0001] This utility model relates to the field of minimally invasive medical device technology, specifically to a targeted drug delivery and sampling capsule driven by dual magnets. Background Technology

[0002] Magnetically controlled microcapsules, relying on the interaction between an external magnetic field and an internal magnet, can achieve remote positioning and attitude control within body cavities (such as the gastrointestinal tract). They have been gradually applied and validated in minimally invasive procedures such as gastric visualization, targeted drug delivery, and biopsy / sampling. Clinical and engineering studies have shown that magnetically controlled capsules can achieve precise docking and orientation without wires, significantly improving the visualization rate of gastric anatomical landmarks, and possessing good safety and feasibility.

[0003] While existing magnetically controlled capsules can achieve precise positioning within cavities, they generally suffer from problems when performing procedures such as punctures or drug releases. These problems include complex structures, low utilization of internal space, trigger actions that are mostly one-time and difficult to reset, limitations on multiple actions, significant influence of posture and gap changes on mechanical output, and insufficient real-time linkage with external magnetic fields. These shortcomings not only reduce the success rate of operations but also limit the application of capsules in multifunctional, long-duration in vivo tasks. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a dual-magnet driven targeted drug delivery and sampling capsule, which can achieve a multi-functional integrated operation of stable puncture and precise targeted drug release at the target site, and can be repeatedly triggered.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0006] A dual-magnet-driven targeted drug delivery sampling capsule includes a sampling module and a drug delivery module connected to each other. The drug delivery module includes a drug chamber shell, one end of which is connected to a guide shell, and the other end of which is provided with a piston for sealing the drug chamber. Inside the drug chamber shell, a push rod connected to the piston is provided, one end of which extends into the guide shell, and a first radially magnetized annular magnet for driving the push rod to move axially is installed in the guide shell. The sampling module includes a sampling shell connected to the guide shell. A guide groove is formed on the inner side of the sampling shell, and a sampler and a cam transmission mechanism for driving the sampler to reciprocate radially are provided in the guide groove. A second radially magnetized annular magnet for driving the cam transmission mechanism to rotate is provided on the outer side of the sampling shell. The second radially magnetized annular magnet is connected to the cam transmission mechanism through a one-way transmission assembly, and the second radially magnetized annular magnet is also used to drive the first radially magnetized annular magnet to move axially.

[0007] Optionally, the cam transmission mechanism includes a camshaft, one end of which extends to the outside of the sampling housing and is connected to the one-way transmission assembly, and the other end is rotatably mounted in the guide groove. A cam body for driving the linear motion of the sampler is eccentrically mounted on the camshaft.

[0008] Optionally, the sampler has a sliding hole, and the cam body is embedded in the sliding hole to drive one end of the sampler to extend to the outside of the sampling shell.

[0009] Optionally, the sampling shell has a notch on its side wall that communicates with the guide groove, and the end of the sampler extends through the notch to the outside of the sampling shell.

[0010] Optionally, at least one sampler is provided, and the number of notches and cam bodies corresponds to the number of samplers.

[0011] Optionally, the unidirectional transmission assembly includes a transmission housing connected to the sampling housing. The transmission housing contains a ratchet and a pawl for driving the ratchet to rotate unidirectionally. The ratchet is fixedly connected to the camshaft. A contact post is fixedly connected to the side of the pawl opposite to the ratchet. One end of the contact post extends to the outside of the transmission housing and is connected to the second radially magnetized annular magnet.

[0012] Optionally, a guide rail is installed inside the guide shell, the first radially magnetized annular magnet is slidably sleeved on the guide rail, a guide hole is opened inside the guide rail, a base support for supporting the first radially magnetized annular magnet is provided in the guide hole, and one end of the push rod is embedded in the guide hole and connected to the base support.

[0013] Optionally, an installation groove is provided on the side wall of the guide hole, the base includes a core and a support, the core is slidably embedded in the guide hole and abuts against the push rod, and the side of the core passes through the installation groove and is connected to the support, the support is slidably sleeved on the guide rail, and the first radially magnetized annular magnet is installed on the top of the support.

[0014] Optionally, a boss is provided on the inner wall of the medicine container shell, and a base plate is fixedly installed at the bottom of the guide slide rail. The base plate overlaps the boss, and the push rod extends through the base plate into the guide hole.

[0015] Optionally, the first radially magnetized annular magnet and the second radially magnetized annular magnet are coaxially distributed.

[0016] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0017] (1) In this utility model, the drug release and puncture sampling functions are integrated into one, and the two are controlled by dual magnet partition drive, avoiding mutual interference between sampling and drug administration actions, and significantly improving the predictability of actions and remote control accuracy.

[0018] (2) In this utility model, the rotational motion generated by the second radially magnetized ring magnet is converted into linear puncture and retraction action by using a cam transmission mechanism. Compared with the direct push structure, it can achieve stable puncture and sampling control, effectively reduce the risk of tissue damage and improve the sampling success rate.

[0019] (3) In this utility model, ratchet and pawl are used as unidirectional transmission components, which only allow the second radial magnetized ring magnet to drive the cam transmission mechanism in the set direction, effectively avoiding the problem of false triggering under attitude disturbance or magnetic field interference. At the same time, this structural design can prevent fatigue wear caused by repeated actions between the sampler and the cam body, thereby improving the life and reliability of the device. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the structure of the dual-magnet driven targeted drug delivery sampling capsule in this embodiment of the present invention;

[0021] Figure 2 yes Figure 1 Schematic diagram of the cross-sectional structure at section AA;

[0022] Figure 3 This is an exploded structural diagram of the push rod, guide rail, base and first radially magnetized annular magnet in an embodiment of this utility model;

[0023] Figure 4 This is a schematic diagram of the assembly structure of the base and the guide rail in an embodiment of this utility model;

[0024] Figure 5 This is a schematic diagram of the internal structure of the sampling shell in an embodiment of this utility model;

[0025] Figure 6 This is a schematic diagram of the structure of the cam transmission mechanism and the one-way transmission assembly in the embodiment of this utility model;

[0026] Figure 7 This is a schematic diagram of the positional structure of the cam body and the sliding hole in an embodiment of this utility model;

[0027] Figure 8 This is a schematic diagram of the sampler in an embodiment of this utility model;

[0028] Among them, 1. Medicine compartment shell; 101. Piston; 102. Push rod;

[0029] 2. Guide housing; 201. Guide slide rail; 211. Guide hole; 212. Mounting groove; 202. Base plate; 203. Base support; 231. Support part; 232. Core column;

[0030] 3. Sampling housing; 301. Guide groove; 302. Sampler; 321. Drive unit; 322. Actuator; 323. Sliding hole; 303. Cam transmission mechanism; 331. Camshaft; 332. Cam body;

[0031] 4. Transmission housing; 401. Ratchet; 402. Claw plate; 403. Contact post; 404. Contact shaft; 405. Spring;

[0032] 5. First radially magnetized ring magnet; 6. Second radially magnetized ring magnet. Detailed Implementation

[0033] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments. These drawings are simplified schematic diagrams, which are only used to illustrate the basic structure of the present invention in a schematic manner, and therefore only show the components related to the present invention.

[0034] Example 1, as Figure 1 and Figure 2 As shown, a dual-magnet-driven targeted drug delivery and sampling capsule includes a drug delivery module and a sampling module, both integrated into the same capsule structure. The respective actions are controlled by a first radially magnetized annular magnet 5 and a second radially magnetized annular magnet 6, which are coaxially distributed. This capsule integrates drug release and puncture sampling functions, and achieves control of both through dual-magnet zoned drive, avoiding interference between sampling and drug delivery actions, and significantly improving the predictability of actions and remote control accuracy.

[0035] In this design, both the first radially magnetized annular magnet 5 and the second radially magnetized annular magnet 6 are radially magnetized. The same magnet has two poles, N and S, along its axial center plane; that is, both N and S poles exist simultaneously on the end face of the magnet. The second radially magnetized annular magnet 6 can rotate around its axial direction under the control of an external magnetic field. A cam transmission mechanism 303 drives the actuator 322 inside the capsule to reciprocate radially, achieving puncture and / or sampling. The cam transmission mechanism 303 converts the rotational motion of the second radially magnetized annular magnet 6 into linear insertion and retraction actions. Compared to a direct-push structure, this allows for stable puncture and sampling control, effectively reducing the risk of tissue damage and improving the sampling success rate. The medication is stored in the drug compartment of the drug delivery module. Driven by the second radially magnetized annular magnet 6, the first radially magnetized annular magnet 5 can move linearly along its axial direction, thereby opening the drug compartment and releasing the medication. When the opposite magnetic poles of the end faces of the second radially magnetized annular magnet 6 and the first radially magnetized annular magnet 5 are opposite to each other, they attract each other, and the first radially magnetized annular magnet 5 drives the piston 101 to close the medicine chamber through the push rod 102; when the like magnetic poles of the end faces are opposite to each other, they generate a repulsive force, thereby pushing the first radially magnetized annular magnet 5 to move away from the second radially magnetized annular magnet 6 along the axial direction and opening the medicine chamber.

[0036] Furthermore, the second radially magnetized annular magnet 6 is connected to the cam transmission mechanism 303 via a one-way transmission assembly. The one-way transmission assembly limits the rotation direction of the cam transmission mechanism 303, allowing the second radially magnetized annular magnet 6 to drive the cam transmission mechanism 303 only in the set direction (counterclockwise or clockwise rotation). This effectively avoids the problem of false triggering under attitude disturbance or magnetic field interference. At the same time, this structural design can prevent fatigue wear caused by repeated movements between the actuator 322 and the cam body 332, thereby improving the life and reliability of the device.

[0037] This solution employs dual magnets, one at the front and one at the rear, to drive both puncture and drug delivery functions, unlike existing methods that use a single magnet to drive both functions simultaneously. The movement direction, force transmission path, and functional modules of the front and rear magnets are physically isolated, avoiding the problem in existing technologies where switching magnetic field direction or intensity might trigger multiple actions simultaneously, thus improving the predictability of system control and the safety of execution.

[0038] Example 2: Based on Example 1, this utility model proposes a specific structure for the drug delivery module.

[0039] like Figures 1-4As shown, the drug delivery module includes a drug tank shell 1 with a drug compartment inside, the drug compartment being used to store liquid medicine. One end of the drug tank shell 1 is fixedly connected to a guide shell 2, and the other end has a nozzle communicating with the drug compartment. A piston 101 for sealing the drug compartment is installed at the nozzle, and a push rod 102 is provided inside the drug tank shell 1. One end of the push rod 102 is fixedly connected to the piston 101, and the other end extends into the guide shell 2.

[0040] The guide shell 2 is fixedly installed with a guide slide rail 201. The first radially magnetized annular magnet 5 is hollow inside and slidably sleeved on the guide slide rail 201. It can move along the axial direction of the guide slide rail 201, thereby driving the push rod 102 to move along the axial direction to push the piston 101 open, so that the liquid medicine in the medicine chamber can be released to the outside through the nozzle.

[0041] The guide rail 201 has a guide hole 211 inside, and a base 203 for supporting the first radially magnetized annular magnet 5 is set inside the guide hole 211. One end of the push rod 102 is embedded in the guide hole 211 and connected to the base 203. The periphery of the base 203 extends to the outside of the guide hole 211 to support the first radially magnetized annular magnet 5. The inner core of the base 203 is connected to the push rod 102. When the first radially magnetized annular magnet 5 moves axially towards the medicine chamber under the control of an external magnetic field, the base 203 pushes the push rod 102 to push the piston 101 out of the nozzle, thereby opening the medicine chamber.

[0042] Specifically, a mounting groove 212 is provided on the side wall of the guide hole 211. The base 203 includes a core 232 located in the middle and a support part 231 located on the periphery. The side of the core 232 passes through the mounting groove 212 and is fixedly connected to the support part 231. The core 232 is slidably embedded in the guide hole 211 and abuts against the push rod 102. The support part 231 is slidably sleeved on the outside of the guide rail 201 in a circular shape. The first radially magnetized annular magnet 5 is fixedly installed on the top of the support part 231. The linear drive of the push rod 102 is realized through the support part 231 and the core 232. This structure can improve the guiding accuracy and stability of the movement of the first radially magnetized annular magnet 5.

[0043] Furthermore, to facilitate the installation of the guide rail 201, an annular boss is provided on the inner wall of the medicine container shell 1. A base plate 202 is fixedly installed at the bottom of the guide rail 201. The edge of the base plate 202 overlaps the boss to separate the inner cavities of the medicine container shell 1 and the guide shell 2, so as to achieve the independence and sealing of the medicine container. The push rod 102 extends through the base plate 202 into the guide hole 211.

[0044] The guide shell 2 and the drug chamber shell 1 are interconnected by a threaded connection and a medical silicone sealing ring is provided at the joint surface to prevent liquid from seeping in. At the same time, the push rod 102 is also coaxial with the guide shell 2 and the drug chamber shell 1. The guide slide rail 201 is perpendicular to the base plate 202 and fixedly connected. The cross-section of the two is T-shaped, which can provide precise linear guidance for the first radial magnetized annular magnet 5 and the drug release mechanism (push rod 102 and piston 101) to prevent swaying.

[0045] Drug administration process: The external magnetic field first controls the rotation of the second radial magnetized annular magnet 6, so that the magnetic poles of the second radial magnetized annular magnet 6 are gradually adjusted to form the same pole opposite to the near end of the first radial magnetized annular magnet 5, thereby generating a repulsive force, pushing the first radial magnetized annular magnet 5 to move along the guide slide rail 201 towards the medicine chamber; the first radial magnetized annular magnet 5 drives the push rod 102 to push the piston 101 forward through the base 203, releasing the preset dose of liquid medicine through the nozzle to the target site. The release stroke is limited by the contact between the end of the base 203 and the base plate 202 to ensure that the release amount is consistent each time.

[0046] When the medicine compartment is closed, the N pole of the first radially magnetized annular magnet 5 is opposite to the S pole of the second radially magnetized annular magnet 6, and the S pole of the former is opposite to the N pole of the latter. A magnetic attraction force is generated between them, and the second radially magnetized annular magnet 6 attracts the first radially magnetized annular magnet 5, thus closing the medicine compartment. When the second radially magnetized annular magnet 6 rotates 180 degrees around its own axis under the control of an external magnetic field, the N pole of the second radially magnetized annular magnet 6 is opposite to the N pole of the first radially magnetized annular magnet 5, and the S pole of the former is opposite to the S pole of the latter. The repulsive force generated between them pushes the first radially magnetized annular magnet 5 to move axially to open the medicine compartment.

[0047] In Example 3, based on Example 2, this utility model also proposes a specific structure for the sampling module.

[0048] like Figures 1-2 , Figures 5-8 As shown, the sampling module includes a sampling shell 3 connected to the guide shell 2. A guide groove 301 is provided on the inner side of the sampling shell 3. A sampler 302 and a cam transmission mechanism 303 are arranged in the guide groove 301. The cam transmission mechanism 303 is used to drive the sampler 302 to reciprocate radially, so as to extend radially to the outside of the sampling shell 3 to achieve puncture, or retract into the sampling shell 3 to complete sample collection. A second radially magnetized annular magnet 6 is arranged on the outside of the sampling shell 3 and is used to drive the cam transmission mechanism 303 to rotate so as to drive the sampler 302 to perform puncture or sampling actions.

[0049] As described above, the cam transmission mechanism 303 includes a camshaft 331. One end of the camshaft 331 extends axially to the outside of the sampling housing 3 and is connected to the one-way transmission component. The other end is rotatably installed in the guide groove 301. A cam body 332 for driving the sampler 302 to move radially linearly is eccentrically mounted on the camshaft 331.

[0050] The sampler 302 has a sliding hole 323. The cam body 332, as an eccentric circular profile segment connected to the cam shaft 331, is embedded in the sliding hole 323. The two slide against each other, and the eccentricity is controlled at 0.5mm. This converts the rotational motion into linear motion, driving one end of the sampler 302 to extend to the outside of the sampling housing 3. The side wall of the sampling housing 3 has a notch communicating with the guide groove 301. Driven by the cam transmission mechanism 303, the end of the sampler 302 can extend to the outside of the sampling housing 3 through the notch.

[0051] Specifically, the second radially magnetized annular magnet 6 can rotate around the axis under the control of an external magnetic field. The torque is transmitted to the cam transmission mechanism 303 through a one-way transmission component. Then, through the cooperation of the cam transmission mechanism 303 and the sliding hole 323, the rotational motion is converted into the linear motion of the sampler 302, so that its end can pass through the notch and extend to the outside of the sampling shell 3 for puncture / sampling operation.

[0052] Compared to traditional direct magnetic drive needles, this invention uses a rotating magnetic field to drive a cam system, converting rotational motion into linear reciprocating motion. The output direction is stable and the amplitude is fixed, avoiding the problem of inconsistent puncture depth caused by torque jitter or eccentricity in the prior art. This improves the consistency and integrity of the sampled tissue and facilitates histological analysis.

[0053] Furthermore, the sampler 302 includes a drive unit 321 and an execution unit 322. The execution unit 322 is located at one end of the drive unit 321. The two are detachably connected by a threaded connection. A sliding hole 323 is formed on the drive unit 321, and the drive unit 321 is slidably embedded in the guide groove 301. Under the constraint of the side wall of the guide groove 301, it can be driven by the cam transmission mechanism 303 to achieve linear displacement.

[0054] When the sampler 302 uses a puncture needle, the drive unit 321 is a rectangular slider structure with a sliding hole 323 on it. The actuator 322 is a needle-shaped structure with its outer end extending through a notch to the outside of the capsule. Simultaneously, when the needle retracts, it completely enters the guide groove 301 to prevent scratching or puncturing tissue when not in operation. The puncture needle pierces the tissue to obtain a tissue sample when extended and carries the sample into the capsule when retracted.

[0055] When the sampler 302 uses sampling forceps, the drive unit 321 also has a rectangular slider structure, with a sliding hole 323 formed on the rectangular slider. The actuator 322 has an ∈-shaped structure, with its middle part connected to the rectangular slider and both ends bent towards one side of the slider, allowing for tissue sample collection during retraction. The sampling forceps scrape the tissue surface when extended and bring the tissue sample into the guide groove 301 when retracted, thus achieving tissue sampling.

[0056] Sampling process: An external magnetic field control system generates a rotating magnetic field that acts on the second radially magnetized annular magnet 6. The second radially magnetized annular magnet 6 rotates around the axis of the capsule, driving the camshaft 331 to rotate unidirectionally via a one-way transmission assembly. The eccentric section of the camshaft 331 (i.e., the cam body 332) drives the sampler 302 to reciprocate radially, achieving periodic puncture sampling of intestinal wall tissue. Both puncture needles and sampling forceps can be used to obtain tissue samples. Sampling forceps are suitable for scraping samples from the surface, while puncture needles are suitable for obtaining samples from deep tissues.

[0057] In Example 4, based on Example 3, at least one sampler 302 is provided, and the number of notches and cam bodies 332 corresponds to the number of samplers 302.

[0058] Two samplers 302 are provided here, one a puncture needle and the other a sampling clamp. They are placed overlappingly in the guide groove 301. The puncture needle is close to the first radially magnetized annular magnet 5, and the sampling clamp is close to the second radially magnetized annular magnet 6. The actuators 322 of the two are arranged opposite each other. Similarly, two notches and two cam bodies 332 are provided. The two notches are opened opposite each other on the outside of the sampling shell 3 and are stacked. The two cam bodies 332 are arranged opposite each other on the camshaft 331, so that the camshaft 331 has two overlapping eccentric sections.

[0059] In embodiment five, the second radially magnetized annular magnet 6 in this utility model is connected to the cam transmission mechanism 303 through a one-way transmission assembly. The one-way transmission mechanism can ensure that the camshaft 331 rotates only in a specified direction (counterclockwise or clockwise). Compared with the existing structure, it can effectively block the mechanism from malfunctioning due to magnetic field noise, accidental reverse rotation, etc., extend the life of the device, and reduce the risk of patient tissue damage in case of emergencies.

[0060] like Figure 2 and Figure 6 As shown, the unidirectional transmission assembly includes a transmission housing 4 connected to the sampling housing 3. A ratchet 401 and a pawl for driving the ratchet 401 to rotate in one direction are provided inside the transmission housing 4. The ratchet 401 is fixedly connected to the camshaft 331. A contact post 403 is fixedly connected to the side of the pawl opposite to the ratchet 401. One end of the contact post 403 extends axially to the outside of the transmission housing 4 and is fixedly connected to the second radially magnetized annular magnet 6.

[0061] The second radially magnetized annular magnet 6 adopts a hollow cylindrical structure and is fixedly sleeved on the section of the contact post 403 extending to the outside of the transmission housing 4. The contact post 403 is rotatably connected to the transmission housing 4 through a bearing. The ratchet 401 and the camshaft 331 are fixedly connected by an interference fit, and a radial locating pin hole is provided at the connection between the two to ensure the stability of torque transmission and the concentricity of assembly.

[0062] As described above, the ratchet 401 has multiple ratchet teeth, which are arranged in a circular array around the axis of the ratchet 401 on the end face of the ratchet 401 near the pawl. The cross-section of the ratchet teeth is approximately triangular, and their inclined surfaces are helical curved surfaces. The pawl includes a pawl disc 402 fixedly connected to the contact post 403. Two contact shafts 404 corresponding to the ratchet teeth are fixedly installed on the end face of the pawl disc 402 near the ratchet 401. A spring 405 is fixedly sleeved on the contact shaft 404. The lower end of the spring 405 is embedded in the gap between two adjacent ratchet teeth. The spring 405 is made of rigid material, meaning that its shaft end will contract when subjected to force, while its circumferential side will not undergo excessive deformation when subjected to force.

[0063] Specifically, under the control of an external magnetic field, the second radially magnetized annular magnet 6 rotates around the axis of the capsule and drives the pawl to rotate synchronously in the same direction through the contact post 403. When the contact post 403 drives the pawl disk 402 to rotate in the working direction, the lower part of the spring 405 contacts the side of the ratchet. Due to the small radial deformation, the ratchet can drive the ratchet wheel 401 to rotate, thereby driving the camshaft 331 to rotate in the working direction. Conversely, when the contact post 403 drives the pawl disk 402 to rotate in the opposite direction to the working direction, the lower end of the spring 405 moves to the inclined surface of the ratchet and contacts it, so that the lower end of the spring 405 is subjected to axial force. The contraction of the spring 405 does not generate driving force on the ratchet. Therefore, when the second radially magnetized annular magnet 6 rotates in this direction, it cannot drive the camshaft 331 to rotate through the ratchet wheel 401.

[0064] For example, clockwise rotation is set as the working direction of the second radial magnetized annular magnet 6. When the second radial magnetized annular magnet 6 rotates clockwise, it can drive the camshaft 331 to rotate through the one-way transmission component, thereby driving the sampler 302 to achieve radial extension and retraction. When the second radial magnetized annular magnet 6 rotates counterclockwise, the end of the spring 405 is compressed and does not drive the ratchet 401 to rotate. The pawl rotates freely, which can avoid misoperation.

[0065] Example 6, as Figure 1 and Figure 2As shown, in this utility model, the targeted drug delivery sampling capsule includes a drug chamber shell 1, a guide shell 2, a sampling shell 3, and a transmission shell 4 connected coaxially in sequence. A first radially magnetized annular magnet 5 is installed inside the guide shell 2, and a second radially magnetized annular magnet 6 is installed at the end of the transmission shell 4. Both magnets adopt a hollow cylindrical structure and are coaxial with each shell.

[0066] The sampling shell 3 includes a first shell and a first shell cover. The first shell cover is fixedly fitted onto the first shell. The guide groove 301 and the notch are both opened on the first shell. One end of the guide shell 2 is fixedly connected to the bottom of the first shell, and one end of the guide slide rail 201 also abuts against the bottom of the first shell.

[0067] The transmission housing 4 includes a second housing and a second housing cover. The second housing cover is also fixedly fitted onto the second housing, and the bottom of the second housing is fixedly connected to the first housing cover. One end of the camshaft 331 passes through the first housing cover and the second housing in sequence and is fixedly connected to the ratchet 401. The ratchet pawl is connected to the second housing cover through the contact post 403 and the bearing.

[0068] In summary, the dual-magnet-driven targeted drug delivery and sampling capsule proposed in this invention has its components arranged sequentially along the capsule's axis to form a compact, integrated structure, which facilitates patient swallowing and internal propulsion and has the potential for mass production. Simultaneously, it can stably achieve multiple punctures and targeted release without relying on complex electronic components and high-power drives, significantly reducing the risk of mechanism failure and enhancing the capsule's operational capabilities in complex environments such as the digestive tract and gastrointestinal tract. This provides a more efficient, safe, and controllable execution solution for minimally invasive surgery, targeted drug delivery, and biopsy sampling.

[0069] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0070] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0071] Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0072] Based on the preferred embodiments of this utility model described above, those skilled in the art can make various changes and modifications without departing from the technical concept of this utility model. The technical scope of this utility model is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A dual-magnet-driven targeted drug delivery and sampling capsule, characterized in that: The device includes a sampling module and a drug delivery module connected to each other. The drug delivery module includes a drug chamber shell, one end of which is connected to a guide shell, and the other end is provided with a piston for sealing the drug chamber. Inside the drug chamber shell, there is a push rod connected to the piston. One end of the push rod extends into the guide shell, and a first radially magnetized annular magnet for driving the push rod to move axially is installed inside the guide shell. The sampling module includes a sampling shell connected to the guide shell. A guide groove is provided on the inner side of the sampling shell. A sampler and a cam transmission mechanism for driving the sampler to reciprocate radially are disposed in the guide groove. A second radially magnetized annular magnet for driving the cam transmission mechanism to rotate is disposed on the outer side of the sampling shell. The second radially magnetized annular magnet is connected to the cam transmission mechanism through a one-way transmission assembly, and the second radially magnetized annular magnet is also used to drive the first radially magnetized annular magnet to move axially.

2. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 1, characterized in that: The cam transmission mechanism includes a camshaft, one end of which extends to the outside of the sampling housing and is connected to the one-way transmission assembly, and the other end is rotatably mounted in the guide groove. A cam body for driving the linear motion of the sampler is eccentrically mounted on the camshaft.

3. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 2, characterized in that: The sampler has a sliding hole, and the cam body is embedded in the sliding hole to drive one end of the sampler to extend to the outside of the sampling shell.

4. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 3, characterized in that: The sampling shell has a notch on its side wall that communicates with the guide groove, and the end of the sampler extends through the notch to the outside of the sampling shell.

5. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 4, characterized in that: At least one sampler is provided, and the number of notches and cam bodies corresponds to the number of samplers.

6. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 2, characterized in that: The unidirectional transmission assembly includes a transmission housing connected to the sampling housing. A ratchet and a pawl for driving the ratchet to rotate unidirectionally are provided inside the transmission housing. The ratchet is fixedly connected to the camshaft. A contact post is fixedly connected to the side of the pawl opposite to the ratchet. One end of the contact post extends to the outside of the transmission housing and is connected to the second radially magnetized annular magnet.

7. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 1, characterized in that: The guide shell is equipped with a guide slide rail. The first radially magnetized annular magnet is slidably sleeved on the guide slide rail. The guide slide rail is provided with a guide hole. A base support for supporting the first radially magnetized annular magnet is provided in the guide hole. One end of the push rod is embedded in the guide hole and connected to the base support.

8. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 7, characterized in that: An installation groove is provided on the side wall of the guide hole. The base includes a core and a support. The core is slidably embedded in the guide hole and abuts against the push rod. The side of the core passes through the installation groove and is connected to the support. The support is slidably sleeved on the guide rail. The first radially magnetized annular magnet is installed on the top of the support.

9. The dual-magnet driven targeted drug delivery and sampling capsule according to claim 8, characterized in that: The inner wall of the medicine container shell is provided with a boss, and a base plate is fixedly installed at the bottom of the guide slide rail. The base plate overlaps the boss, and the push rod extends through the base plate into the guide hole.

10. The dual-magnet-driven targeted drug delivery sampling capsule according to any one of claims 1-9, characterized in that: The first radially magnetized annular magnet and the second radially magnetized annular magnet are coaxially distributed.

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