Laboratory mouse fixing device

Abstract

The utility model discloses a laboratory mouse fixing device which comprises a fixing cylinder and a supporting base, a mouse tail groove extending in the length direction of the fixing cylinder is formed in the fixing cylinder, and the mouse tail groove extends to the center position of the tail end of the fixing cylinder; the supporting base comprises an annular support with a notch, the annular support is arranged on the outer side of the fixing cylinder in a sleeving mode, the fixing cylinder can rotate in the annular support, the laboratory mouse fixing device can rotate the laboratory mouse by rotating the fixing cylinder after fixing the laboratory mouse, the obvious degree of veins on the two sides of the mouse tail can be observed in the process of rotating the fixing cylinder, and puncture points can be selected; the experiment operation is convenient.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and more specifically, to a mouse restraint device. Background Technology

[0002] Tail vein injection in laboratory mice is a commonly used drug administration method in biological, medical, and pharmaceutical experiments. However, mice are difficult to control during tail vein injection, requiring immobilization. In current techniques, this immobilization process is complex and challenging, and it's impossible to change the mouse's position in real time after immobilization, affecting the accuracy of the injection at the tail vein injection point during the experimental procedure. Utility Model Content

[0003] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes a mouse restraint device. After the mouse is restrained, it can be rotated by rotating the restraint cylinder. During the rotation of the cylinder, the prominence of the veins on both sides of the mouse's tail can be observed, allowing for the selection of puncture points and facilitating experimental operations.

[0004] To achieve the above objectives, an experimental mouse restraint device is proposed according to an embodiment of the present invention. The experimental mouse restraint device includes: a fixing cylinder, on which a mouse tail groove is provided extending along the length direction of the fixing cylinder, the mouse tail groove extending to the center position of the tail end of the fixing cylinder; and a support base, the support base including an annular bracket with a notch, the annular bracket being sleeved on the outside of the fixing cylinder, and the fixing cylinder being rotatable within the annular bracket.

[0005] According to the experimental mouse fixation device of this utility model embodiment, after fixing the experimental mouse, the experimental mouse can be rotated by rotating the fixation cylinder. During the rotation of the fixation cylinder, the visibility of the veins on both sides of the mouse tail can be observed, and the puncture point can be selected, which facilitates the experimental operation.

[0006] In addition, the experimental mouse restraint device according to the above embodiments of this utility model may also have the following additional technical features:

[0007] According to one embodiment of the present invention, the fixed cylinder includes a mating part, the annular bracket is sleeved on the outside of the mating part, the mating part is provided with a limiting flange, and the limiting flange is in a stop-fitting engagement with the end of the annular bracket;

[0008] And / or, when the fixed cylinder cooperates with the annular bracket, the fixed cylinder is inclined and its tail end faces downward.

[0009] According to one embodiment of the present invention, the fixing cylinder includes:

[0010] A cylindrical body that defines a receiving space, wherein the tail end of the cylindrical body is closed and the head end forms an inlet for the receiving space;

[0011] A stop member is movably disposed in the accommodating space and divides the accommodating space into a first space and a second space. The first space is located on the side of the stop member facing away from the inlet and is used to accommodate laboratory mice.

[0012] According to one embodiment of the present invention, the rat-tail groove is formed in the cylinder, the rat-tail groove extends to the inlet and is open at the inlet.

[0013] According to one embodiment of the present invention, a guide groove is provided on the cylinder body extending along the length direction of the cylinder body, the guide groove extends to the inlet and is open at the inlet, and at least a portion of the stop member cooperates with the guide groove.

[0014] According to one embodiment of the present invention, the stop member includes:

[0015] The main body is disposed in the accommodating space and is used to divide the accommodating space;

[0016] A fixing part, which cooperates with the cylinder to fix the main body to the cylinder.

[0017] According to one embodiment of the present invention, the fixing part includes a fixing knob, which is threadedly engaged with the main body. The knob head is located on the outside of the cylinder. When the fixing knob rotates relative to the main body, it moves closer to or further away from the main body along the radial direction of the cylinder.

[0018] According to one embodiment of the present invention, the fixing cylinder further includes a spacer insert, which cooperates with the inner wall of the cylinder to limit the internal space of the accommodating space.

[0019] According to one embodiment of the present invention, the stop member is provided with a clearance hole, and the occupant insert passes through the clearance hole and engages with the inner wall of the cylinder.

[0020] According to one embodiment of the present invention, the support base includes:

[0021] The chassis is equipped with suction cups and anti-slip pads at the bottom;

[0022] A support arm, the bottom of which is fixedly mounted on the chassis, and an annular bracket mounted on the top of the support arm.

[0023] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0024] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0025] Figure 1 This is a schematic diagram of the structure of the experimental mouse restraint device according to an embodiment of the present invention;

[0026] Figure 2 This is a partial structural schematic diagram of the experimental mouse restraint device according to an embodiment of the present utility model;

[0027] Figure 3 This is a schematic diagram of the structure of the cylindrical body of the experimental mouse restraint device according to an embodiment of the present utility model;

[0028] Figure 4 This is a schematic diagram of the structure of the stop member of the experimental mouse fixing device according to an embodiment of the present utility model;

[0029] Figure 5 This is a schematic diagram of the spacer insert of the experimental mouse fixation device according to an embodiment of the present invention.

[0030] Figure label:

[0031] Laboratory mouse restraint device 100, restraint tube 10,

[0032] Cylinder body 1, guide groove 111, rat tail groove 121, inlet 13, vent 14, mating part 15, limiting flange 151.

[0033] Stop 20, main body 21, clearance hole 211, fixing knob 23,

[0034] Baffle 21, connecting part 22, limiting member 23, limiting part 231, limiting surface 2311, guide surface 1312.

[0035] Support base 30, chassis 31, suction cup 311, anti-slip pad 312, support arm 32, ring bracket 321, spacer insert 40, buckle 401, drive unit 402. Detailed Implementation

[0036] This application is based on the inventor's discoveries and understanding of the following facts and problems:

[0037] Tail vein injection in laboratory mice is a commonly used drug administration method in biological, medical, and pharmaceutical experiments. However, mice are difficult to control during tail vein injection, requiring immobilization. In current techniques, this immobilization process is complex and challenging, and it's impossible to change the mouse's position in real time after immobilization, affecting the accuracy of the injection at the tail vein injection point during the experimental procedure.

[0038] Therefore, this utility model embodiment designs a fixing device that can fix the experimental mouse and extend the mouse's tail. After fixing the experimental mouse, the experimental mouse can be easily rotated. The experimental mouse is fixed in posture inside the fixing tube 10. The degree of prominence of the veins on both sides of the mouse's tail can be observed by rotating the fixing tube 10, and the puncture point can be selected, which facilitates the experimental operation.

[0039] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0040] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," etc., indicating the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, features defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0041] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0042] The experimental mouse restraint device 100 according to an embodiment of the present invention is described below with reference to the accompanying drawings.

[0043] like Figures 1-5 As shown, the experimental mouse fixing device 100 according to an embodiment of the present invention includes: a fixing cylinder 10 and a support base 30.

[0044] The fixing cylinder 10 has a tail groove 121 extending along its length, reaching the center of the tail end of the fixing cylinder 10. The tail of the experimental mouse fixed inside the fixing cylinder 10 can pass through the tail groove 121 and emerge from the center of the tail end of the fixing cylinder 10. The support base 30 can fix the fixing cylinder 10 at a certain height above the experimental table or other carrier, freeing the experimenter's hands. The experimenter does not need to control the fixing cylinder 10 during injection and can complete the injection step with both hands, which is convenient for the experimenter's operation.

[0045] The support base 30 includes an annular bracket 321 with a notch. When the support base 30 is used to control the fixing cylinder 10, the annular bracket 321 is sleeved on the outside of the fixing cylinder 10. The fixing cylinder 10 can rotate inside the annular bracket 321. Thus, before intravenous injection into the tail of the experimental rat, the obviousness of the veins on both sides of the tail can be observed by rotating the fixing cylinder 10 located inside the annular bracket 321, and the puncture point can be selected, which facilitates the experimental operation.

[0046] According to the experimental mouse fixation device 100 of this utility model embodiment, after fixing the experimental mouse, the experimental mouse can be rotated by rotating the fixation cylinder 10. During the rotation of the fixation cylinder 10, the obviousness of the veins on both sides of the mouse tail can be observed, and the puncture point can be selected, which facilitates the experimental operation.

[0047] like Figure 1 As shown, the fixed cylinder 10 includes a mating part 15, and an annular bracket 321 is sleeved on the outside of the mating part 15. Thus, the mating position on the fixed cylinder 10 for mating with the annular bracket 321 is fixed. That is, the fixed cylinder 10 is mated with the annular bracket 321 by the mating part 15. The mating part 15 on the fixed cylinder 10 and other structural parts can be designed separately. The mating part 15 can be designed to be smoother to facilitate mating with the annular bracket 321, so as to facilitate the rotation of the fixed cylinder 10 relative to the annular bracket 321. Other structural parts can be designed with more pores or patterns for the breathing of laboratory mice or to improve the aesthetics of their appearance.

[0048] When the frictional force between the mating part 15 of the annular support 321 and the fixed cylinder 10 is insufficient to limit the fixed cylinder 10, in order to ensure the stability of the fixed cylinder 10 on the annular support 321, a limiting flange 151 is provided at the end of the mating part 15. The limiting flange 151 is engaged with the end of the annular support 321 to restrict the position of the fixed cylinder 10, ensuring that the relative position between the fixed cylinder 10 and the annular support 321 in the axial direction remains unchanged. The fixed cylinder 10 can only rotate relative to the annular support 321, thus preventing the fixed cylinder 10 from detaching from the annular support 321 and causing injury to the experimental mouse or damage to the fixed cylinder 10.

[0049] like Figure 1 As shown, when the fixing tube 10 is engaged with the ring bracket 321, the fixing tube 10 is tilted and the tail end faces downward. At this time, the experimental mouse is in the fixing tube 10 with its head facing upward and its tail facing downward, and its tail extends out of the fixing tube 10 from the tail end. This posture is more suitable for finding the veins on both sides of the experimental mouse's tail.

[0050] Furthermore, since the fixed cylinder 10 is inclined and its tail end faces downward when it is engaged with the annular bracket 321, the limiting flange 151 is located at the end of the mating part 15 away from the tail end of the fixed cylinder 10. Thus, the limiting flange 151 and the end of the annular bracket 321 can be engaged and the fixed cylinder 10 can be limited by gravity at the same time, which simplifies the structure of the fixed cylinder 10 while ensuring the stability of the fixed cylinder 10.

[0051] The support base 30 also includes a chassis 31 and a support arm 32. The chassis 31 is located at the bottom of the support base 30 and is used to support the entire support base 30 and the fixing cylinder 10 mounted on the support base 30. The chassis 31 can increase the contact area between the support base 30 and the carrier, such as a desktop or laboratory bench, to ensure the overall stability of the support base 30 and lower the center of gravity. The bottom of the chassis 31 is provided with a suction cup 311 and an anti-slip pad 312. The suction cup 311 can connect the chassis 31 to the carrier to ensure the stability of the support base 30, and the anti-slip pad 312 can increase the friction between the chassis 31 and the carrier to ensure the stability of the chassis 31.

[0052] The bottom of the support arm 32 is fixedly mounted on the chassis 31, and the ring bracket 321 is mounted on the top of the support arm 32. The support arm 32 can raise the height of the ring bracket 321, so that the height of the fixed cylinder 10 and the experimental mouse fixed inside the fixed cylinder 10 is appropriate, which facilitates the movement of the experimental personnel and the injection of drugs.

[0053] Combination Figures 1-4In the embodiment shown, the fixing cylinder 10 includes a cylinder body 1 and a stop member 20. The cylinder body 1 defines a receiving space. The first end of the cylinder body 1 forms an inlet 13 for the receiving space, and the tail end of the cylinder body 1 is closed. The experimenter can send the experimental mouse into the receiving space through the inlet 13. At this time, the body of the experimental mouse is located in the receiving space, and the tail of the experimental mouse passes through the tail groove 121 and is located outside the fixing cylinder 10. After the experimental mouse is sent into the receiving space, dragging the tail of the experimental mouse can move the experimental mouse located at the first end of the cylinder body 1 to the tail end of the cylinder body 1. After the experimental mouse reaches the tail, the head of the experimental mouse faces the first end of the cylinder body 1, the tail of the experimental mouse faces the tail end of the cylinder body 1, and the tail end of the experimental mouse fits into the tail end structure of the cylinder body 1. The tail of the experimental mouse is led out through the tail groove 121 at the center of the tail end of the fixing cylinder 10.

[0054] Reference Figure 2 and Figure 3 The axial cross section of the tail end of the cylinder 1 is arc-shaped to better fit the curve of the mouse's tail, restrict the mouse's movement, and prevent the accumulation of the mouse's feces and urine, making it easier to clean.

[0055] The stop 20 is movably disposed within the receiving space. After the laboratory mouse is moved to the tail end of the cylinder 1 by the experimenter, the stop 20 can be placed within the receiving space through the inlet 13. The stop 20 divides the receiving space into a first space and a second space. The first space is located on the side of the stop 20 facing away from the inlet 13, and the first space is used to house the laboratory mouse, i.e., the laboratory mouse is located within the first space. The surface of the stop 20 facing the first space is formed as a conical surface to prevent the laboratory mouse's head from twisting.

[0056] Specifically, when the stop 20 moves towards the side closer to the tail end of the cylinder 1, the size of the first space gradually decreases until the stop 20 and the cylinder 1 together restrict a first space in which the experimental mouse cannot move. Under the restriction of the stop 20 and the cylinder 1, the experimental mouse cannot move relative to the cylinder 1 and its tail is fixed, which is convenient for the experimenter to operate. Before intravenous injection into the tail of the experimental mouse, the obviousness of the veins on both sides of the tail can be observed by rotating the fixed cylinder 10 to select the puncture point, which is convenient for experimental operation.

[0057] Combination Figures 1-4 In the embodiment shown, the stop 20 and / or the cylinder 1 are provided with a vent 14 for the breathing of the experimental mouse fixed in the fixed cylinder 10, so as to prevent the experimental mouse from suffocating.

[0058] like Figure 3As shown, a tail groove 121 is formed in the cylinder 1, and extends to the inlet 13 and is open at the inlet 13. Thus, when the experimenter moves the experimental mouse by dragging its tail, the base of the experimental mouse's tail, which is outside the containment space, can be dragged into the tail groove 121 through the open opening at the inlet 13. At this time, the experimental mouse's body is inside the containment space, and its tail passes through the tail groove 121 and is outside the containment space. By dragging the experimental mouse along the tail groove 121, the position of the experimental mouse in the containment space can be moved, and the tail of the experimental mouse is always outside the containment space for moving the experimental mouse or injecting drugs.

[0059] like Figures 1-3 As shown, a guide groove 111 extending along the length of the cylinder 1 is provided on the cylinder body 1. The guide groove 111 extends to the inlet 13 and opens at the inlet 13. At least a portion of the stop member 20 cooperates with the guide groove 111. The stop member 20 can move axially along the cylinder body 1 under the guidance of the guide groove 111.

[0060] Specifically, after the experimental mouse moves to the tail end of the cylinder 1, the position of the experimental mouse can be fixed by installing a stop 20 on the cylinder 1. At this time, the part of the stop 20 that cooperates with the guide groove 111 can be moved into the guide groove 111 through the open opening at the inlet 13 of the guide groove 111. At this time, part of the structure of the stop 20 is located in the receiving space, dividing the receiving space into a first space and a second space. The first space is located on the side of the stop 20 facing away from the inlet 13. The first space is used to hold the experimental mouse. The other part of the structure of the stop 20 passes through the guide groove 111 and is located outside the receiving space. The experimenter can drive the stop 20 to move towards the tail end of the cylinder 1 under the guidance of the guide groove 111 by driving the part of the structure located outside the guide groove 111, gradually reducing the size of the first space until the experimental mouse is fixed in the narrow first space.

[0061] The rat tail groove 121 and the guide groove 111 can be the same groove opened on the cylinder 1, or two grooves opened on the cylinder 1 respectively.

[0062] like Figure 1 and Figure 4As shown, the stop 20 includes a main body 21 and a fixing part. The main body 21 is disposed in the receiving space and is used to divide the receiving space. While blocking the inlet 13 of the cylinder 1, it divides the receiving space into a closed first space and a second space communicating with the inlet 13. The first space is used to fix the experimental mouse. When the stop 20 moves to the point where it can completely restrict the movement of the experimental mouse in the first space defined by it and the cylinder 1, the stop 20 cooperates and is fixed to the cylinder 1 to ensure that the stop 20 can be fixed in this position to restrict the movement of the experimental mouse at all times during the entire experimental operation, and to prevent the experimental mouse from running around during the experiment. The stop 20 is fixed to the cylinder 1 through the cooperation of the fixing part with the cylinder 1, and the fixing part fixes the main body 21 to the cylinder 1.

[0063] Specifically, the fixing part includes a fixing knob 23, which is threadedly engaged with the main body 21. The fixing knob 23 includes a knob head and a threaded rod. The main body 21 has a threaded hole, and the knob head is fixedly connected to the threaded rod, which is threadedly engaged with the threaded hole.

[0064] Therefore, when the fixing knob 23 rotates counterclockwise or clockwise relative to the main body 21, the fixing knob 23 will move closer to or further away from the main body 21. The knob head of the fixing knob 23 is located on the outside of the cylinder 1. The threaded rod cooperates with the guide groove 111 to pass through the cylinder 1 and connect the main body 21 and the knob head located inside and outside the cylinder 1. When the fixing knob 23 rotates relative to the main body 21, it moves closer to or further away from the main body 21 in the radial direction of the cylinder 1. At the same time as the fixing knob 23 moves closer to the main body 21, the knob head of the fixing knob 23 and the main body 21 clamp the cylinder wall of the cylinder 1. As the fixing knob 23 is tightened, the pressure between the knob head of the fixing knob 23 and the cylinder 1 and the pressure between the main body 21 and the cylinder 1 continuously increase. The friction between the cylinder wall of the cylinder 1 and the main body 21 and the friction between the cylinder wall of the cylinder 1 and the knob head of the fixing knob 23 fix the stop 20 to the cylinder 1, thereby realizing the fixation of the stop 20.

[0065] Reference Figure 1 , Figure 2 and Figure 5 The fixed cylinder 10 also includes a spacer insert 40, which fits into the inner wall of the cylinder 1. The spacer insert 40 occupies part of the space inside the containment space to limit the cross-sectional size of the space inside the containment space, thereby achieving the purpose of accommodating experimental mice of different sizes.

[0066] like Figure 1 As shown, the spacer insert 40 can be fixed on the inner wall of the cylinder 1. Due to the setting of the spacer insert 40, the internal space of the accommodating space is compressed, which can fix a smaller experimental mouse. Depending on the size of the experimental mouse, different numbers of spacer inserts 40 can be selected to fix in order to control the cross-sectional size of the accommodating space, ensure that the experimental mouse can be fixed, and prevent the experimental mouse from rotating in the accommodating space.

[0067] The radial cross-section of the side surface of the spacer insert 40 facing the accommodating space is formed in an arc shape to avoid causing harm to the experimental mice.

[0068] Reference Figure 1 and Figure 4 The stop 20 has a clearance hole 211. The spacer insert 40 passes through the clearance hole 211 and engages with the inner wall of the cylinder 1. The clearance hole 211 avoids interference between the spacer insert 40 and the stop 20, ensuring that the spacer insert 40 and the stop 20 can be placed in the accommodating space at the same time and can move along the axial direction of the cylinder 1.

[0069] The placeholder insert 40 has a buckle 401 on the side opposite to the tail end of the cylinder 1. The edge structure of the cylinder 1 at the inlet 13 can be inserted into the buckle 401 and cooperate with it, thereby fixing the tail end of the placeholder insert 40 to the edge of the inlet 13 of the cylinder 1. The buckle 401 has a driving part 402. The experimenter can open the buckle 401 by pressing the driving part 402 so that the placeholder insert 40 can be pulled out from the receiving space.

[0070] In some embodiments, the fixed cylinder 10 is provided with a slot extending along the length of the cylinder 1, the slot extends to the inlet 13 and is open at the inlet 13, the placeholder insert 40 is provided with a protrusion, the side of the protrusion away from the body of the placeholder insert 40 has a limiting part 231, the limiting part 231 is spaced apart from the body of the placeholder insert 40, when the placeholder insert 40 is installed on the cylinder 1, the protrusion cooperates with the slot, the limiting part 231 is located outside the receiving space, and the body of the placeholder insert 40 is located inside the receiving space.

[0071] During the installation of the spacer insert 40, the protrusion can be guided into the slot through the open opening at the inlet 13 to cooperate with the slot, and the spacer insert 40 can be driven along the extension direction of the slot until the spacer insert 40 reaches the limit position within the accommodating space. The spacer insert 40 reduces the accommodating space and the range of motion of the experimental mouse by occupying part of the accommodating space defined by the cylinder 1.

[0072] An embodiment of the present invention will now be described with reference to the accompanying drawings.

[0073] The experimental mouse fixation device 100 includes a spacer insert 40, a fixing cylinder 10, and a support base 30. The fixing cylinder 10 includes a cylinder body 1 and a stop 20. The support base 30 includes a base 31, a suction cup 311, an anti-slip pad 312, a support arm 32, and a ring bracket 321 with a notch.

[0074] The cylinder 1 defines the receiving space. The first end of the cylinder 1 forms the inlet 13 of the receiving space. The tail end of the cylinder 1 is closed. The axial cross section of the tail end of the cylinder 1 is arc-shaped. The stop 20 is movably disposed in the receiving space. A groove extending along the length of the cylinder 1 is provided on the cylinder 1. The groove extends to the inlet 13 and opens at the inlet 13. The groove also cooperates with part of the structure of the stop 20 and the root of the rat tail.

[0075] The stop 20 includes a main body 21 and a fixed knob 23. The fixed knob 23 includes a knob head and a threaded rod. The main body 21 has a threaded hole. The knob head is fixedly connected to the threaded rod, and the threaded rod is threaded into the threaded hole. When the stop 20 is engaged with the cylinder 1, the knob head is located on the outside of the cylinder 1, the threaded rod is engaged with the groove, and the main body 21 is located on the inside of the cylinder 1.

[0076] The stop 20 has a clearance hole 211 on its main body 21, and the occupant strip 40 passes through the clearance hole 211 and engages with the inner wall of the cylinder 1.

[0077] The placeholder insert 40 has a buckle 401 on the side opposite to the tail end of the cylinder 1. The edge structure of the cylinder 1 at the inlet 13 can be inserted into the buckle 401 and cooperate with it, thereby fixing the tail end of the placeholder insert 40 to the edge of the inlet 13 of the cylinder 1. The buckle 401 has a driving part 402. The experimenter can open the buckle 401 by pressing the driving part 402 so that the placeholder insert 40 can be pulled out from the receiving space. The fixed cylinder 10 has a slot extending along the length of the cylinder 1. The slot extends to the inlet 13 and is open at the inlet 13. The placeholder insert 40 has a protrusion. The side of the protrusion away from the body of the placeholder insert 40 has a limiting part 231. The limiting part 231 is spaced apart from the body of the placeholder insert 40. When the placeholder insert 40 is installed on the cylinder 1, the protrusion and the slot cooperate. The limiting part 231 is located outside the receiving space, and the body of the placeholder insert 40 is located inside the receiving space.

[0078] During the experiment, the size of the experimental mouse determines whether to insert a spacer strip 40 into the cylinder 1. When the experimental mouse is large, the spacer strip 40 may not be inserted. When the experimental mouse is small, one spacer strip 40, two spacer strips 40, or three spacer strips 40 may be inserted. By fixing different numbers of spacer strips 40, the space occupied by different sizes of space can be controlled to have different widths of cross-section, so that the experimental mouse fixing device 100 can be used to fix experimental mice of different sizes, and to prevent smaller experimental mice from having extra space to move within the space.

[0079] During the fixing process of the spacer strip 40, one end of the spacer strip 40 can be inserted into the receiving space. The protrusion of the spacer strip 40 is guided into the slot through the opening at the inlet 13 and engages with the slot. The spacer strip 40 is then driven along the extension direction of the slot until it reaches the limit position within the receiving space. The buckle 401 at the tail end of the spacer strip 40 is then engaged at the edge of the inlet 13 of the cylinder 1, thus fixing the spacer strip.

[0080] Furthermore, the experimenter can grasp the tail of the experimental mouse and drag it to the inlet 13 of the cylinder 1. The base of the mouse's tail, which is outside the containment space, is then pulled into the tail groove 121 through the open opening at the inlet 13. The experimental mouse is then sent into the containment space through the inlet 13. At this time, the body of the experimental mouse is in the containment space, and the tail of the experimental mouse passes through the tail groove 121 and is located outside the fixed cylinder 10. After the experimental mouse is sent into the containment space, dragging the tail of the experimental mouse can move the experimental mouse located at the head end of the cylinder 1 to the tail end of the cylinder 1. When the experimental mouse reaches the tail end, the head of the experimental mouse faces the head end of the cylinder 1, and the tail of the experimental mouse faces the tail end of the cylinder 1, with the tail end of the experimental mouse fitting against the structure of the tail end of the cylinder 1. The tail of the experimental mouse is then led out through the tail groove 121 at the center of the tail end of the fixed cylinder 10.

[0081] After the experimenter moves the experimental mouse to the tail end of the cylinder 1 by dragging its tail, the stop 20 can be placed in the receiving space through the inlet 13. The threaded rod of the stop 20 moves into the groove through the guide groove 111 at the open opening at the inlet 13. At this time, the main body 21 of the stop 20 is located in the receiving space, dividing the receiving space into a first space and a second space. The first space is located on the side of the stop 20 facing away from the inlet 13. The first space is used to hold the experimental mouse. The button of the stop 20 is located outside the receiving space. The button drives the entire stop 20 to move towards the side closer to the tail end of the cylinder 1 under the guidance of the groove, gradually reducing the size of the first space until the experimental mouse is fixed in the narrow first space.

[0082] When the stop 20 moves to a position where the first space defined by it and the cylinder 1 can completely restrict the movement of the experimental mouse, the stop 20 and the cylinder 1 are fixed together. When the fixing knob 23 rotates relative to the main body 21, it moves closer to or away from the main body 21 along the radial direction of the cylinder 1. As the fixing knob 23 moves closer to the main body 21, the knob head of the fixing knob 23 and the main body 21 clamp the cylinder wall of the cylinder 1. As the fixing knob 23 is tightened, the pressure between the knob head of the fixing knob 23 and the cylinder 1 and the pressure between the main body 21 and the cylinder 1 continuously increase. The friction between the cylinder wall of the cylinder 1 and the main body 21 and the friction between the cylinder wall of the cylinder 1 and the knob head of the fixing knob 23 fix the stop 20 to the cylinder 1, thereby achieving the fixation of the stop 20.

[0083] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0084] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. An experimental mouse fixing device, characterized by, The application relates to a mouse tail slot fixing cylinder and a support base. The fixing cylinder comprises a fitting part, the annular support is arranged outside the fitting part, the fitting part is provided with a limiting flange, and the limiting flange is in abutting fit with the end part of the annular support. The fixing cylinder comprises:

2. The experimental mouse immobilization device of claim 1, wherein, The cylinder body defines a containing space, the tail end of the cylinder body is closed, and the head end is formed into an inlet of the containing space; The stopper is movably arranged in the containing space and divides the containing space into a first space and a second space, the first space is located on the side of the stopper away from the inlet, and the first space is used for accommodating a laboratory mouse.

3. The experimental mouse immobilization device of claim 1, wherein, The mouse tail slot is arranged on the cylinder body, extends to the inlet and is open at the inlet. The cylinder body is provided with a guide slot extending along the length direction of the cylinder body, the guide slot extends to the inlet and is open at the inlet, and at least a part of the stopper is in fit with the guide slot. The stopper comprises:

4. The experimental mouse immobilization device of claim 3, wherein, The main body is arranged in the containing space and is used for dividing the containing space; 5. The experimental mouse immobilization device of claim 3, wherein, The fixing part is in fit with the cylinder body so as to fix the main body at different depths in the containing space.

6. The experimental mouse immobilization device of claim 5, wherein, The fixing part comprises a fixing knob, the fixing knob is in screw fit with the main body, the knob head of the fixing knob is arranged outside the cylinder body, and the fixing knob is rotated relative to the main body and approaches or moves away from the main body along the radial direction of the cylinder body. The fixing cylinder further comprises an occupying plug, the occupying plug is in fit with the inner wall of the cylinder body so as to limit the internal space of the containing space. The stopper is provided with a avoiding hole, the occupying plug passes through the avoiding hole and is in fit with the inner wall of the cylinder body.

7. The experimental mouse immobilization device of claim 6, wherein, The support base comprises:

8. The experimental mouse immobilization device of claim 3, wherein, The bottom disc is provided with a suction disc and an anti-skid pad at the bottom; 9. The experimental mouse immobilization device of claim 8, wherein, The support arm is fixedly arranged at the top of the support arm.

10. The experimental mouse immobilization device of claim 1, wherein, ​ ​ ​

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