Hemodynamics in-vitro simulation device for jugular arteriovenous tumor

Abstract

The utility model discloses a hemodynamics in-vitro simulation device for jugular arteriovenous tumors, which relates to the technical field of in-vitro models and comprises a profiling blood vessel, a pulse pressure pump, a storage, a pressing block and a data acquisition system. The profiling blood vessel is used for simulating a neck blood vessel and comprises a blood vessel body, a first connector and a second connector, and the first connector and the second connector are located at the two ends of the blood vessel body respectively. The pulse pressure pump is used for conveying blood to the profiling blood vessel, and the storage device is used for storing blood. The pressing block is used for simulating tumors and presses the blood vessel body. The data acquisition system comprises a flow velocity probe, a pressure strain gauge and a data acquisition unit. The flow velocity probe is inserted into the blood vessel body and used for detecting the blood flow velocity. The pressure strain gauge is attached to the inner wall of the blood vessel body and used for detecting blood pressure changes. Compared with the prior art, the external simulation device disclosed by the utility model can simulate the influence of tumor tissues on the flowing condition of jugular artery and vein blood in different states.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of in-vitro model, in particular to a carotid artery and vein tumor hemodynamics in-vitro simulation device. BACKGROUND

[0002] The internal carotid artery is a blood vessel that supplies blood to the intracranial, and its blood flow velocity and spectrum are often observed for changes. The external carotid artery supplies the structure of the neck, and its flow resistance is higher than that of the internal carotid artery. The vertebral arteries converge upward to form the basilar artery, which is responsible for the posterior circulation of the brain. The related technology generally calculates the pressure and flow rate in the carotid artery and vein by constructing a numerical model, but the numerical model simplifies the complex carotid vascular structure, and the calculation result is often not accurate enough. SUMMARY

[0003] The utility model discloses a carotid artery and vein tumor hemodynamics in-vitro simulation device to solve the problems existing in the above-mentioned related technology, simulate the influence of tumor tissue on the blood flow of carotid artery and vein under different conditions.

[0004] To achieve the above-mentioned purpose, the utility model provides the following scheme:

[0005] The utility model discloses a carotid artery and vein tumor hemodynamics in-vitro simulation device, comprising:

[0006] A profiled blood vessel for simulating carotid artery and vein, the profiled blood vessel comprises a blood vessel body, a first interface and a second interface, and the first interface and the second interface are located at two ends of the blood vessel body respectively;

[0007] A pulse pressure pump for delivering blood to the profiled blood vessel, and the outlet of the pulse pressure pump is communicated with the first interface;

[0008] A storage device for storing blood, and the outlet of the storage device is communicated with the inlet of the pulse pressure pump, and the inlet of the storage device is communicated with the second interface;

[0009] A pressure block for simulating tumor, and the pressure block is used for pressing the blood vessel body;

[0010] A data acquisition system for detecting blood flow changes, comprising a flow velocity probe, a pressure strain gauge and a data acquisition device, the flow velocity probe and the pressure strain gauge are electrically connected to the data acquisition device, the flow velocity probe is inserted into the blood vessel body for detecting blood flow velocity, and the pressure strain gauge is attached to the inner wall of the blood vessel body for detecting blood pressure changes.

[0011] Preferably, the blood vessel body is made of hydrogel material.

[0012] Preferably, the blood vessel body is prepared by 3D printing.

[0013] Preferably, the carotid arteriovenous tumor hemodynamics in-vitro simulation device further comprises a whole frame for maintaining the shape of the profiled blood vessel, and the profiled blood vessel is connected to the whole frame.

[0014] Preferably, the whole frame comprises a mounting rack, and the first interface and the second interface are both fixedly connected through the mounting rack, and the pressing block is fixedly connected to the mounting rack and is adjustable in the mounting position on the mounting rack.

[0015] Preferably, the whole frame further comprises a first sleeve and a second sleeve, the first interface is slidably connected through the first sleeve, the second interface is slidably connected through the second sleeve, and the first sleeve and the second sleeve are fixedly connected to the mounting rack, and the first interface is fixedly connected to the first sleeve, and the second interface is fixedly connected to the second sleeve.

[0016] Preferably, the first interface is fixedly connected to the first sleeve by a bolt, and the second interface is fixedly connected to the second sleeve by a bolt.

[0017] Preferably, the whole frame further comprises a positioning support fixedly connected to the mounting rack, and the positioning support is provided with a positioning hole for positioning the blood vessel body to define the position of the blood vessel body.

[0018] Preferably, the positioning support is provided in a plurality of numbers to position different positions of the blood vessel body respectively.

[0019] Preferably, the carotid arteriovenous tumor hemodynamics in-vitro simulation device further comprises an ultrasonic detector for dynamic imaging detection of the profiled blood vessel.

[0020] The utility model discloses relative to relevant technology has obtained following technical effect:

[0021] In the utility model, the profiled blood vessel is used for simulating the blood vessel of the neck, the pressing block is used for pressing the blood vessel body, and is used for simulating the compression of the tumor to the blood vessel. The flow velocity probe is used for detecting the flow velocity of the blood in the blood vessel body, and the pressure strain gauge is used for detecting the change of the blood pressure of the blood in the blood vessel body. Therefore, the data acquisition system can collect the hemodynamics related parameters. By changing the compression position and compression degree of the pressing block, the influence of the tumor on the hemodynamics related parameters when the tumor compresses in different positions and when the compression degree of the tumor changes can be simulated.

[0022] In the preferred scheme of the utility model, the blood vessel body is of hydrogel material. The hydrogel has certain permeability, can directly show the blood flow condition and provides materials for subsequent image recognition training. The carotid arteriovenous tumor hemodynamics in-vitro simulation device further comprises an ultrasonic detector, which is used for dynamic imaging detection on the profiled blood vessel. The thickness, hardness and elastic modulus of the hydrogel tissue can be adjusted according to the human tissue blood vessel condition, and the real condition can be greatly simulated when ultrasonic imaging is performed. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or related technologies, the following will briefly introduce the drawings needed to be used in the embodiments. Obviously, the drawings in the following description are only some embodiments of the utility model, and other drawings can be obtained by those skilled in the art without creative labor.

[0024] Figure 1 It is a schematic view of the carotid arteriovenous tumor hemodynamics in-vitro simulation device of the utility model embodiment.

[0025] In the figure: 1 - storage; 2 - pulse pressure pump; 3 - data collector; 4 - first interface; 5 - bolt; 6 - flow rate probe; 7 - pressure strain gauge; 8 - positioning support; 9 - pressing block; 10 - second interface; 11 - catheter; 12 - mounting bracket; 13 - blood vessel body. DETAILED DESCRIPTION

[0026] The technical scheme in the utility model embodiments will be described clearly and completely in combination with the drawings in the utility model embodiments. Obviously, the described embodiments are only some embodiments of the utility model, not all embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the utility model.

[0027] The utility model aims at providing a kind of carotid arteriovenous tumor hemodynamics in-vitro simulation device, to solve the problems of the above-mentioned related technologies, simulate the influence of tumor tissue on carotid arteriovenous blood flow condition under different states.

[0028] In order to make the above-mentioned purposes, features and advantages of the utility model more obvious and easy to understand, the following will be further described in detail to the utility model in combination with drawings and specific embodiments.

[0029] REFERENCE Figure 1 The embodiment provides a kind of carotid arteriovenous tumor hemodynamics in-vitro simulation device, including profiled blood vessel, pulse pressure pump 2, storage 1, pressing block 9 and data acquisition system.

[0030] A prosthetic blood vessel is used to simulate neck blood vessels. The prosthetic blood vessel includes a blood vessel body 13, a first interface 4, and a second interface 10, located at opposite ends of the blood vessel body 13. A pulse pressure pump 2 is used to deliver blood to the prosthetic blood vessel; the outlet of the pulse pressure pump 2 is connected to the first interface 4. A reservoir 1 is used to store blood; the outlet of the reservoir 1 is connected to the inlet of the pulse pressure pump 2, and the inlet of the reservoir 1 is connected to the second interface 10. A pressure block 9 is used to simulate a tumor, compressing the blood vessel body 13. A data acquisition system is used to detect changes in blood flow. The data acquisition system includes a flow velocity probe 6, a pressure strain gauge 7, and a data acquisition unit 3. Both the flow velocity probe 6 and the pressure strain gauge 7 are electrically connected to the data acquisition unit 3. The flow velocity probe 6 is inserted into the blood vessel body 13 to detect blood flow velocity. The pressure strain gauge 7 is attached to the inner wall of the blood vessel body 13 to detect changes in blood pressure.

[0031] The working principle of the in vitro simulation device for carotid artery and vein tumor hemodynamics in this embodiment is as follows:

[0032] The pulse pressure pump 2 pumps blood from the reservoir 1 to the first interface 4 via the conduit 11 at a preset flow rate. The blood then flows along the vessel body 13 to the second interface 10, and then back to the reservoir 1 via the conduit 11, completing blood circulation. The pressure block 9 compresses the vessel body 13 to simulate tumor compression of the blood vessel; the compression of the pressure block 9 affects blood pressure and blood flow velocity. The flow velocity probe 6 is used to detect the blood flow velocity in the vessel body 13, and the pressure strain gauge 7 is used to detect changes in blood pressure in the vessel body 13. Therefore, the data acquisition system can collect hemodynamic parameters. By changing the compression position and degree of the pressure block 9, the effects of tumor compression at different locations and changes in the degree of tumor compression on hemodynamic parameters can be simulated. The shape of the vessel body 13 should conform to the course of the corresponding carotid artery or jugular vein (e.g., internal carotid artery, external carotid artery, or vertebral artery) to simulate the corresponding carotid artery or jugular vein.

[0033] As a possible example, in this embodiment, the blood vessel body 13 is made of hydrogel. Hydrogel has a certain degree of permeability, which can visually display the blood flow situation and provide material for subsequent image recognition training.

[0034] As a possible example, in this embodiment, the blood vessel body 13 is prepared by 3D printing, thereby obtaining a complex, high-fidelity, and mechanically adjustable wet-slip hydrogel soft tissue organ. The 3D printing substrate is a solution of N-carboxyethyl chitosan and oxidized hyaluronic acid, which are combined to obtain the hydrogel.

[0035] The CT cross-sectional images of healthy patients are processed by graphic software (for example, Mimics software), and the carotid artery and vein and the surrounding anatomical structure are displayed in three dimensions, and the vascular terminations are simplified and modified, so as to obtain the 3D printing model of the vascular body 13.

[0036] As a possible example, in the embodiment, the carotid artery and vein tumor hemodynamics in vitro simulation device further comprises a whole frame for maintaining the shape of the profiled blood vessel, and the profiled blood vessel is connected to the whole frame, so as to position the profiled blood vessel.

[0037] As a possible example, in the embodiment, the whole frame comprises a mounting frame 12, and the first interface 4 and the second interface 10 are both connected to the mounting frame 12. The pressing block 9 is fixedly connected to the mounting frame 12, and the mounting position of the mounting frame 12 on the mounting frame 12 is adjustable, so as to adjust the degree of compression of the pressing block 9 to the vascular body 13.

[0038] As a possible example, in the embodiment, the whole frame further comprises a first sleeve and a second sleeve. The first interface 4 is slidably connected to the first sleeve, and the second interface 10 is slidably connected to the second sleeve. The first sleeve and the second sleeve are both fixedly connected to the mounting frame 12. The first interface 4 is fixedly connected to the first sleeve, and the second interface 10 is fixedly connected to the second sleeve. By connecting the first interface 4 to the first sleeve and connecting the second interface 10 to the second sleeve, the first interface 4 and the second interface 10 are quickly positioned. For example, the mounting frame 12 comprises a bottom plate and two vertical plates, and the first sleeve and the second sleeve are respectively fixed to the two vertical plates.

[0039] As a possible example, in the embodiment, the first interface 4 is fixedly connected to the first sleeve by a bolt 5, and the second interface 10 is fixedly connected to the second sleeve by a bolt 5. However, the actual implementation is not limited thereto. For example, the first interface 4 can also be fixedly connected to the first sleeve by a positioning pin, and the second interface 10 can also be fixedly connected to the second sleeve by a positioning pin.

[0040] As a possible example, in the embodiment, the whole frame further comprises a positioning support 8, and the positioning support 8 is fixedly connected to the mounting frame 12. The positioning support 8 is provided with a positioning hole for positioning the vascular body 13, so as to limit the position of the vascular body 13. It should be noted that if only the two ends of the profiled blood vessel are positioned, the vascular body 13 is prone to shaking. In the embodiment, the positioning support 8 is further provided, and the vascular body 13 is positioned by the positioning support 8, so as to improve the position stability of the vascular body 13.

[0041] As a possible example, in the embodiment, the number of the positioning supports 8 is multiple, so as to position different positions of the vascular body 13, thereby reducing the local shaking of the vascular body 13, and further improving the position stability of the vascular body 13.

[0042] As a possible example, in the embodiment, the carotid tumor hemodynamics in vitro simulation device further comprises an ultrasonic detector for dynamic imaging detection of the profiled blood vessel. The thickness, hardness, elastic modulus and the like of the hydrogel tissue can be adjusted according to the human tissue blood vessel condition, and when ultrasonic imaging is performed, the real situation can be greatly simulated.

[0043] The principle and implementation mode of the specific examples are described in the utility model, and the above embodiment is only used for helping to understand the method and core idea of the utility model; meanwhile, for the general technical personnel in the field, the specific implementation mode and application range will be changed according to the idea of the utility model. In conclusion, the content of the specification should not be understood as the limitation of the utility model.

Claims

1. An in vitro simulation device for hemodynamics of carotid artery and vein tumors, characterized in that, include: A sculpted blood vessel for simulating neck blood vessels, the sculpted blood vessel includes a blood vessel body, a first interface and a second interface, the first interface and the second interface being located at both ends of the blood vessel body, respectively; A pulse pressure pump for delivering blood to the prosthetic blood vessel, the outlet of the pulse pressure pump being connected to the first interface; A reservoir for storing blood, the outlet of which is connected to the inlet of the pulse pressure pump, and the inlet of which is connected to the second interface; A pressure block used to simulate a tumor, the pressure block being used to compress the blood vessel body; A data acquisition system for detecting changes in blood flow includes a flow velocity probe, a pressure strain gauge, and a data acquisition unit. The flow velocity probe and the pressure strain gauge are both electrically connected to the data acquisition unit. The flow velocity probe is inserted into the blood vessel body to detect blood flow velocity. The pressure strain gauge is attached to the inner wall of the blood vessel body to detect changes in blood pressure.

2. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 1, characterized in that: The blood vessel body is made of hydrogel material.

3. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 2, characterized in that: The blood vessel body is prepared by 3D printing.

4. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 1, characterized in that: It also includes an overall frame for maintaining the shape of the prosthetic blood vessel, the prosthetic blood vessel being connected to the overall frame.

5. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 4, characterized in that: The overall frame includes a mounting bracket; both the first interface and the second interface pass through and are fixedly connected to the mounting bracket; the pressure block is fixedly connected to the mounting bracket, and its installation position on the mounting bracket is adjustable.

6. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 5, characterized in that: The overall frame also includes a first sleeve and a second sleeve; the first interface slides through the first sleeve, the second interface slides through the second sleeve, and both the first sleeve and the second sleeve are fixedly connected to the mounting bracket; the first interface is fixedly connected to the first sleeve, and the second interface is fixedly connected to the second sleeve.

7. The in vitro hemodynamic simulation device for carotid artery and vein tumors according to claim 6, characterized in that: The first interface is fixedly connected to the first sleeve by bolts, and the second interface is fixedly connected to the second sleeve by bolts.

8. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 5, characterized in that: The overall frame also includes a positioning bracket, which is fixedly connected to the mounting bracket; the positioning bracket is provided with a positioning hole for positioning the blood vessel body to define the position of the blood vessel body.

9. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 8, characterized in that: The number of positioning stents is multiple, each positioned at a different location on the blood vessel body.

10. The in vitro simulation device for carotid artery and vein tumor hemodynamics according to claim 1, characterized in that: It also includes an ultrasound detector for dynamic imaging detection of the shaped blood vessel.

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