Safety protection system based on electroencephalogram closed-loop phase interference stimulator

Abstract

The utility model discloses a safety protection system based on an electroencephalogram closed-loop phase interference stimulator, which comprises an electroencephalogram acquisition module, a signal processing and analyzing module, a phase interference module, a stimulation output module and a safety monitoring module which are connected in sequence, wherein the safety monitoring module is connected with the signal processing and analyzing module and the stimulation output module. The beneficial effects of the utility model are that through the arrangement of the safety monitoring module, the electrode-skin impedance and the output current value are monitored in real time during the operation of the system, the output is cut off in time under abnormal conditions, and the operation safety of the system is ensured.

Description

Technical Field

[0001] This utility model relates to the field of brain stimulation technology, and in particular to a safety protection system based on a closed-loop phase interference stimulator for brain. Background Technology

[0002] Phase interference electric field stimulation is a low-frequency envelope wave stimulation, which is generated by two high-frequency alternating currents with a small difference frequency to form a low-frequency envelope stimulation electric field. Some existing devices have EEG monitoring functions, but they have not achieved effective closed-loop control and the application of phase interference technology. Therefore, it is of great significance to develop a device that can adjust stimulation parameters according to real-time EEG signals and a protection system to ensure the safe operation of the device. Utility Model Content

[0003] The purpose of this invention is to provide a safety protection system based on a closed-loop phase interference stimulator for EEG, ensuring the safe operation of EEG stimulation equipment.

[0004] The objective of this utility model is achieved through the following technical solution:

[0005] The safety protection system based on the EEG closed-loop phase interference stimulator includes an EEG acquisition module, a signal processing and analysis module, a phase interference module, a stimulation output module, and a safety monitoring module connected in sequence, wherein the safety monitoring module is connected to the signal processing and analysis module and the stimulation output module.

[0006] Furthermore, the safety monitoring module includes a current detection unit, an impedance detection unit, and an abnormal control unit. The current detection unit is connected to the stimulation output module, and the impedance detection unit is connected to the signal processing and analysis module.

[0007] Furthermore, the signal processing and analysis module includes a real-time filtering unit, a feature extraction unit, and an EEG rhythm analysis unit. The real-time filtering unit preprocesses the EEG signals from the EEG acquisition module. The feature extraction unit extracts the time-frequency characteristic parameters of the EEG signals. The EEG rhythm analysis unit is connected to the impedance detection unit and separates and analyzes EEG rhythms in different frequency bands.

[0008] Furthermore, the stimulation output module includes a waveform generator, a waveform synthesizer, and an ADC converter. The ADC converter generates an analog signal based on stimulation parameters. The waveform synthesizer is used to synthesize multiple analog signals and generate a stimulation signal waveform through the waveform generator. The current detection unit is connected to the waveform generator.

[0009] Furthermore, the signal processing and analysis module is connected to a data storage unit, and a display and input module is connected between the signal processing and analysis module and the phase interference module.

[0010] This utility model has the following advantages:

[0011] The safety monitoring module is set up to monitor the electrode-skin impedance and output current value in real time during system operation, and cut off the output in time under abnormal conditions to ensure the safe operation of the system. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the structure of this utility model.

[0013] Figure 2 This is a schematic diagram of the system's operation process. Detailed Implementation

[0014] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can typically be arranged and designed in various different configurations.

[0015] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0016] It should be noted that, where there is no conflict, the embodiments and features in the embodiments of this utility model can be combined with each other.

[0017] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0018] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this utility model is in use, or the orientation or positional relationship commonly understood by those skilled in the art. They are only used for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. In addition, the terms "first," "second," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0019] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0020] refer to Figure 1 As shown in Figure 2, one embodiment of this utility model is as follows:

[0021] The safety protection system based on the EEG closed-loop phase interference stimulator includes an EEG acquisition module, a signal processing and analysis module, a phase interference module, a stimulation output module, and a safety monitoring module connected in sequence, wherein the safety monitoring module is connected to the signal processing and analysis module and the stimulation output module.

[0022] Specifically, the safety monitoring module includes a current detection unit, an impedance detection unit, and an abnormal control unit. The current detection unit is connected to the stimulation output module, and the impedance detection unit is connected to the signal processing and analysis module.

[0023] The signal processing and analysis module includes a real-time filtering unit, a feature extraction unit, and an EEG rhythm analysis unit. The real-time filtering unit preprocesses the EEG signals from the EEG acquisition module. The feature extraction unit extracts the time-frequency characteristic parameters of the EEG signals. The EEG rhythm analysis unit is connected to the impedance detection unit and separates and analyzes EEG rhythms in different frequency bands.

[0024] The stimulation output module includes a waveform generator, a waveform synthesizer, and an ADC converter. The ADC converter generates an analog signal based on stimulation parameters. The waveform synthesizer is used to synthesize multiple analog signals and generate a stimulation signal waveform through the waveform generator. The current detection unit is connected to the waveform generator.

[0025] The impedance detection unit connects to the EEG rhythm unit and monitors the electrode-skin impedance in real time by injecting small signals while analyzing the EEG rhythm. In case of abnormalities such as impedance exceeding the threshold or change rate exceeding 50% / s, a protection mechanism is triggered, and the output of the stimulation output module is cut off through the abnormal control unit. During system operation, the current of the waveform generator is monitored in real time by the current detection unit, and waveform distortion is detected. When the current exceeds the preset threshold, the output of the stimulation output module is immediately cut off through the abnormal control unit to ensure the safe operation of the system.

[0026] Furthermore, the signal processing and analysis module is connected to a data storage unit, and a display and input module is connected between the signal processing and analysis module and the phase interference module.

[0027] The data storage unit not only stores treatment process data but also records and stores abnormal data for later troubleshooting.

[0028] The interactive display and operation module is used for parameter setting and operation commands, and can display operation information, remaining stimulation duration, stimulation mode, and resistance value. When the current approaches the threshold, an alarm connected to the system will issue a prompt, allowing the operator to decide whether to manually stop or continue treatment based on the actual situation.

[0029] In treatment, the EEG acquisition module specifically includes a multi-lead electrode module, a signal amplification module, and an analog-to-digital converter module connected in sequence. The analog-to-digital converter module is connected to the signal processing and analysis module. The multi-lead electrode module has multiple independently configured signal acquisition channels, and the connected electrode pads are Ag / AgCl. EEG signals from the target brain region are acquired through the electrode pads connected to the multi-lead electrode module, which are placed on the scalp. The acquired signals are amplified by the signal amplification module, and then converted from analog signals to digital signals by a 24-bit high-precision analog-to-digital converter before being transmitted to the signal processing and analysis module.

[0030] The signal processing and analysis module includes a real-time filtering unit, a feature extraction unit, and an EEG rhythm analysis unit. The real-time filtering unit includes a digital filter bank: an FIR bandpass filter, an IIR notch filter, and an adaptive filter. This unit preprocesses the received EEG signals, including power frequency interference suppression, baseline drift correction, and high-frequency noise removal. Subsequently, the feature extraction unit extracts the time-frequency characteristic parameters of the EEG signals. The extraction process can utilize Hilbert transform mathematical tools, specifically including: time-domain feature extraction (mean calculation, variance analysis, zero-crossing rate detection); and frequency-domain feature extraction (power spectral density estimation, band energy calculation, and phase feature extraction). Finally, the EEG rhythm analysis unit uses wavelet analysis and other methods to separate and analyze EEG rhythms in different frequency bands (δ, θ, α, β, and γ) to provide the basis data for subsequent phase interference control module calculations.

[0031] The phase interference control module includes a phase detection unit, an interference pattern calculation unit, a parameter optimization unit, and a feedback control unit. The phase detection unit performs real-time phase extraction from EEG data, including: real-time phase calculation (Hilbert transform); instantaneous phase extraction; and phase synchronization analysis. A phase tracking system is also included, employing phase-locked loop design, phase prediction algorithm, and phase correction mechanism. Subsequently, the interference pattern calculation unit, based on the extracted phase information, uses neural oscillation theory and phase synchronization principles to calculate the stimulation pattern that produces the optimal interference effect, deriving specific stimulation parameters, including: interference pattern generation (single-frequency interference pattern; multi-frequency interference pattern; and adaptive interference pattern). During this process, the system continuously monitors the neural activity state and phase synchronization degree of the target brain region by real-time acquisition and analysis of the subject's EEG signals. Based on the monitoring results, the parameter optimization unit optimizes and adjusts the stimulation parameters of the stimulation pattern, including stimulation intensity, frequency, and phase, using real-time optimization strategies such as gradient descent, genetic algorithm, and particle swarm optimization. Performance evaluation indicators include: phase synchronization degree; energy efficiency; and stability assessment. During system operation, the feedback control unit of the phase interference control module continuously monitors the neural activity state and phase synchronization degree of the target brain region. Based on the monitoring results, a PID adaptive control algorithm is used to adjust the stimulation parameters in real time to achieve closed-loop control. In addition, the stimulation effect is evaluated by calculating quantitative indicators such as the phase-locked value (PLV). Based on the evaluation results, machine learning algorithms are used to continuously optimize the control strategy to achieve the best stimulation and therapeutic effects.

[0032] In the stimulation output module, the ADC converter generates an analog signal based on stimulation parameters, including stimulation waveform, frequency, phase, and amplitude. A waveform synthesizer combines multiple analog signals and generates a stimulation signal waveform via the waveform generator, which is then applied to the subject through electrode pads connected to the stimulation output channel. Specific parameters of the stimulation output system include: output current range of 0-2mA with an accuracy better than 0.1mA; frequency range of 0.1-100Hz with an adjustable step size of 0.1Hz; phase adjustment range of 0-360° with an accuracy better than 1°; multiple output waveforms such as sine, square, and triangle waves; 8-16 output channels, independently controllable; overcurrent protection; and a response time of less than 1ms.

[0033] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A safety protection system based on a closed-loop phase interference stimulator for electroencephalography, characterized in that: It includes an EEG acquisition module, a signal processing and analysis module, a phase interference module, a stimulus output module, and a safety monitoring module connected in sequence, wherein the safety monitoring module is connected to the signal processing and analysis module and the stimulus output module.

2. The safety protection system based on a closed-loop phase interference stimulator according to claim 1, characterized in that: The safety monitoring module includes a current detection unit, an impedance detection unit, and an abnormal control unit. The current detection unit is connected to the stimulation output module, and the impedance detection unit is connected to the signal processing and analysis module.

3. The safety protection system based on the EEG closed-loop phase interference stimulator according to claim 2, characterized in that: The signal processing and analysis module includes a real-time filtering unit, a feature extraction unit, and an EEG rhythm analysis unit. The real-time filtering unit preprocesses the EEG signals from the EEG acquisition module. The feature extraction unit extracts the time-frequency characteristic parameters of the EEG signals. The EEG rhythm analysis unit is connected to the impedance detection unit and separates and analyzes EEG rhythms in different frequency bands.

4. The safety protection system based on the EEG closed-loop phase interference stimulator according to claim 3, characterized in that: The stimulation output module includes a waveform generator, a waveform synthesizer, and an ADC converter. The ADC converter generates an analog signal based on stimulation parameters. The waveform synthesizer is used to synthesize multiple analog signals and generate a stimulation signal waveform through the waveform generator. The current detection unit is connected to the waveform generator.

5. The safety protection system based on a closed-loop phase interference stimulator according to claim 1, characterized in that: The signal processing and analysis module is connected to a data storage unit, and a display and input module is connected between the signal processing and analysis module and the phase interference module.

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