Modeling auxiliary device for mouse knee osteoarthritis

Abstract

The utility model relates to the field of modeling auxiliary devices, and discloses a mouse knee osteoarthritis modeling auxiliary device which comprises a rearing cage, a cover plate is arranged on the top of the rearing cage, a belt conveyor is installed in the rearing cage, a fixing box is fixedly connected to the bottom of the right end of the rearing cage, the belt conveyor is installed in the fixing box, and an inserting groove is formed in the position, on one side of the fixing box, of the top of the rearing cage. A door opening is formed in the lower portion of the middle of the fixing plate, L-shaped limiting strips are fixedly connected to the upper portions of the side faces of the ends, close to each other, of the fixing plate, an opening is formed in the left end of the rearing cage, a baffle is movably installed at the position of the opening in the rearing cage, and a through groove is formed in the bottom face of the rearing cage; and a mesh plate is mounted on the inner side of the through groove. Due to the arrangement of the fixing plate and the limiting plate, the belt conveyor can be kept clean and sanitary; meanwhile, through the arrangement of a mesh plate and a collecting basin, excrement of the mice can be conveniently collected, and the interior of the rearing cage can be conveniently kept clean and sanitary.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of moulding auxiliary device, specifically is a mouse knee osteoarthritis moulding auxiliary device. BACKGROUND

[0002] Mice are important animal models for studying the pathogenesis, risk factors and treatment methods of osteoarthritis due to their small size, large-scale reproduction, short life cycle and gene knockout advantages. The current knee osteoarthritis modeling methods applied to mice mainly include spontaneous models and artificially induced models.

[0003] The utility model patent with publication number CN209030822U discloses a mouse knee osteoarthritis molding auxiliary device, which comprises a feeding cage for providing activity space for mice and a diet cage for providing food and drink for mice, and the diet cage is arranged in the feeding cage and can be adjusted in position. The feeding cage comprises a cage bottom and a cage wall surrounding the cage bottom, and the cage wall and the cage bottom form a cavity for the mice to move. A partition plate seals and separates the inner cavity into a feed chamber for holding food and a water chamber for holding water. The diet cage is detachably fixed to the inner wall of the feeding cage through a connecting device. The connecting device comprises a plug row arranged on the outer wall of the diet cage, and further comprises a set of plug holes arranged on the cage wall of one side of the feeding cage. The diet cage is detachably fixed to the inner wall of the feeding cage through the cooperation of the plugs and the plug holes. The utility model can simulate the upright state of human knee joint and better study the pathogenesis and process of knee osteoarthritis.

[0004] However, in actual application, the feeding and movement of mice are all located in the feeding cage, and the feces of mice can contaminate the track, and the rotation of the track can cause the space in the whole feeding cage to be contaminated, which is unhygienic and difficult to clean, and needs to be improved. UTILITY MODEL CONTENT

[0005] The technical problem to be solved by the utility model is to overcome the above technical defects and provide a mouse knee osteoarthritis molding auxiliary device.

[0006] In order to solve the above problems, the technical scheme of the utility model is as follows: a mouse knee osteoarthritis molding auxiliary device, comprising a feeding cage, a cover plate is arranged at the top of the feeding cage, a belt machine for the movement of mice is installed inside, a fixed box is fixedly connected to the bottom of the right end of the feeding cage, the belt machine is installed in the fixed box, a slot is formed in one side of the fixed box at the top of the feeding cage, a limiting plate is inserted into the slot, a fixed plate is fixedly connected to one side of the limiting plate inside the feeding cage, a door hole is formed in the middle lower part of the fixed plate, an L-shaped limiting strip is fixedly connected to the upper part of the side surface of one end of the feeding cage, an opening is formed in the left end of the feeding cage, a baffle is movably installed at the opening inside the feeding cage, a through slot is formed in the bottom surface of the feeding cage, and a mesh plate is installed on the inner side of the through slot.

[0007] Furthermore, the top surface of the belt conveyor is flush with the inner bottom surface of the feeding cage.

[0008] Furthermore, a feeding trough is placed inside the breeding cage.

[0009] Furthermore, L-shaped limiting strips are symmetrically fixed to the upper part of both sides of the door opening on the side of the fixing plate, and limiting grooves are formed between the limiting strips and the fixing plate. The two ends of the limiting plate are inserted into the two limiting grooves.

[0010] Furthermore, a horizontal plate is fixedly connected to the top of the limiting plate, and a handle is provided on the top of the horizontal plate.

[0011] Furthermore, two T-shaped strips are installed on both the front and rear sides of the inside of the breeding cage, and handles are fixed to the outside of the baffles, with slots at both ends that are adapted to the T-shaped strips.

[0012] Furthermore, the left end of the feeding cage has a through hole above the opening, and a threaded post that passes through the through hole is fixed to the upper part of the side of the baffle, and a wing nut is installed on the threaded post.

[0013] Furthermore, a fixed frame is fixedly connected to the bottom of the feeding cage below the through groove, and a collection basin is placed inside the fixed frame.

[0014] The advantages of this invention compared to existing technologies are as follows: the fixed plate and limiting plate help keep the conveyor belt clean and hygienic; at the same time, the mesh plate and collection basin facilitate the collection of mouse feces, making it easier to keep the inside of the breeding cage clean and hygienic. Attached Figure Description

[0015] Figure 1 This is a three-dimensional representation of the present invention. Figure 1 .

[0016] Figure 2 This is a three-dimensional representation of the present invention. Figure 2 .

[0017] Figure 3 This is a cross-sectional view of the present invention.

[0018] Figure 4 This is a connection structure diagram of the limiting plate of this utility model.

[0019] Figure 5 This is a connection structure diagram of the baffle of this utility model.

[0020] As shown in the figure: 1. Feeding cage; 2. Cover plate; 3. Belt conveyor; 4. Fixing box; 5. Limiting plate; 6. Fixing plate; 7. Limiting strip; 8. Baffle; 9. Mesh plate; 10. Feeding trough; 11. Horizontal plate; 12. Handle; 13. T-shaped strip; 14. Handle; 15. Threaded post; 16. Fixing frame; 17. Collection basin. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0022] like Figures 1 to 3 As shown, an auxiliary device for modeling knee osteoarthritis in mice includes a feeding cage 1, a cover plate 2 on the top of the feeding cage 1, a belt conveyor 3 for mouse movement installed inside the cage 1, a fixed box 4 fixed to the bottom right end of the feeding cage 1, the belt conveyor 3 installed inside the fixed box 4, and the top surface of the belt conveyor 3 is flush with the inner bottom surface of the feeding cage 1. A feeding trough 10 is placed inside the feeding cage 1.

[0023] When the mouse moves onto the belt conveyor 3, the belt conveyor 3 is turned on to induce the mouse to perform joint walking movements. By controlling the rotation speed and the duration of operation of the belt conveyor 3, the amount of movement of the mouse can be controlled. The state of the human knee joint is simulated from both mechanical and movement characteristics, thus more closely resembling the pathogenesis of knee osteoarthritis in humans. This allows for better research into the pathogenesis and progression of knee osteoarthritis, thereby better assisting in the modeling of knee osteoarthritis in mice.

[0024] The feeding trough 10 is placed in the feeding cage 1 only when feeding the mice and is removed after feeding to avoid contamination of the feeding trough 10.

[0025] like Figure 1 , Figure 3 and Figure 4 As shown, the top of the feeding cage 1 has a slot on one side of the fixed box 4, and a limiting plate 5 is inserted into the slot. A fixed plate 6 is fixedly connected to one side of the limiting plate 5 inside the feeding cage 1. A doorway is opened in the lower middle part of the fixed plate 6. L-shaped limiting strips 7 are symmetrically fixed to the upper part of both sides of the doorway on the side of the fixed plate 6. A limiting groove is formed between the limiting strips 7 and the fixed plate 6. The two ends of the limiting plate 5 are inserted into the two limiting grooves. A horizontal plate 11 is fixedly connected to the top of the limiting plate 5. A handle 12 is provided on the top of the horizontal plate 11.

[0026] The fixed plate 6 and the limiting plate 5 divide the interior of the cage 1 into a living area and an exercise area, allowing the mice to engage in different activities in different areas, such as resting, eating, and exercising. This helps maintain the mice's physical and mental health and also helps keep the exercise area clean and hygienic. By pulling the limiting plate 5 upwards with the handle 12, the mice can move through the doorway to the top of the conveyor belt 3.

[0027] like Figure 1 , Figure 3 and Figure 5 As shown, the rearing cage 1 has an opening at the left end, and a baffle 8 is movably installed inside the rearing cage 1 at the opening. Two T-shaped bars 13 are installed on both the front and rear sides of the rearing cage 1. A handle 14 is fixed to the outside of the baffle 8, and slots that fit the T-shaped bars 13 are opened at both ends. A through hole is opened above the opening at the left end of the rearing cage 1. A threaded post 15 that passes through the through hole is fixed to the upper side of the baffle 8, and a wing nut is installed on the threaded post 15.

[0028] When artificial intervention in mouse movement is required, remove the limiting plate 5, then remove the wing nut, and push the baffle 8 to move by pushing the handle 14. The baffle 8 slides along the T-shaped strip 13 and gradually approaches the fixed plate 6, thereby prompting the mouse to move above the belt conveyor 3.

[0029] The bottom surface of the feeding cage 1 is provided with a through groove, and a mesh plate 9 is installed inside the through groove. A fixed frame 16 is fixedly connected to the bottom of the feeding cage 1 below the through groove, and a collection basin 17 is placed inside the fixed frame 16.

[0030] The mesh plate 9 and the collection basin 17 facilitate the collection of mouse feces, making it easier to keep the inside of the breeding cage 1 clean and hygienic.

[0031] In practical use, the mesh plate 9 and the collection basin 17 facilitate the collection of mouse feces, keeping the inside of the breeding cage 1 clean and hygienic; by removing the limiting plate 5, the mouse can move through the doorway to the top of the conveyor belt 3, and the conveyor belt 33 can be turned on to move; when it is necessary to manually intervene in the movement of the mouse, the wing nut is removed, and the baffle 8 is moved by pushing the handle 14. The baffle 8 slides along the T-shaped strip 13 and gradually approaches the fixed plate 6, thereby prompting the mouse to move to the top of the conveyor belt 3.

[0032] The parts not disclosed in this utility model are all prior art, and their specific structures and working principles will not be described in detail.

[0033] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0034] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

[0035] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention; the actual structure is not limited thereto. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the inventive spirit of the present invention, such designs should fall within the protection scope of the present invention.

Claims

1. An auxiliary device for modeling knee osteoarthritis in mice, comprising a feeding cage (1), wherein the feeding cage (1) is provided with a cover plate (2) on the top, and a belt conveyor (3) for providing exercise for mice is installed inside, characterized in that: The bottom right end of the feeding cage (1) is fixedly connected to a fixed box (4), the belt conveyor (3) is installed inside the fixed box (4), the top of the feeding cage (1) is provided with a slot on one side of the fixed box (4), a limiting plate (5) is inserted into the slot, a fixed plate (6) is fixedly connected to one side of the limiting plate (5) inside the feeding cage (1), a door opening is provided in the lower middle part of the fixed plate (6), an opening is provided at the left end of the feeding cage (1), and a baffle (8) is movably installed at the opening inside the feeding cage (1), a through groove is provided on the bottom surface of the feeding cage (1), and a mesh plate (9) is installed inside the through groove.

2. The auxiliary device for establishing a mouse knee osteoarthritis model according to claim 1, characterized in that: The top surface of the belt conveyor (3) is flush with the inner bottom surface of the feeding cage (1).

3. The auxiliary device for modeling knee osteoarthritis in mice according to claim 1, characterized in that: The feeding cage (1) contains a feeding trough (10).

4. The auxiliary device for modeling knee osteoarthritis in mice according to claim 1, characterized in that: The fixed plate (6) has L-shaped limiting strips (7) symmetrically fixed to the upper part of both sides of the door opening. The limiting strips (7) and the fixed plate (6) form a limiting groove. The two ends of the limiting plate (5) are inserted into the two limiting grooves.

5. The auxiliary device for modeling knee osteoarthritis in mice according to claim 4, characterized in that: A horizontal plate (11) is fixedly connected to the top of the limiting plate (5), and a handle (12) is provided on the top of the horizontal plate (11).

6. The auxiliary device for modeling knee osteoarthritis in mice according to claim 1, characterized in that: The rearing cage (1) has two T-shaped bars (13) installed on both the front and back sides inside. The baffle (8) has a handle (14) fixed to the outside and slots at both ends that are compatible with the T-shaped bars (13).

7. The auxiliary device for modeling knee osteoarthritis in mice according to claim 6, characterized in that: The left end of the feeding cage (1) has a through hole above the opening, and a threaded post (15) that passes through the through hole is fixed to the upper side of the baffle (8). A wing nut is installed on the threaded post (15).

8. The auxiliary device for modeling knee osteoarthritis in mice according to claim 1, characterized in that: The bottom of the feeding cage (1) is fixedly connected to a fixed frame (16) below the through groove, and a collection basin (17) is placed inside the fixed frame (16).

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