Residual impurity cleaning device convenient for anion exchange chromatography filler

Abstract

The utility model provides a device convenient for cleaning residual impurities of anion exchange chromatography filler, which relates to an anion exchange layer cleaning device and comprises a cleaning assembly, the cleaning assembly comprises a support, the top end of the cleaning assembly is fixedly connected with a cleaning box, and one side, far away from the cleaning assembly, of the top end of the cleaning assembly is fixedly connected with a recovery assembly. The cleaning assembly comprises a sodium hydroxide tank, the top end of the sodium hydroxide tank is fixedly connected to a support, a sodium chloride tank is fixedly connected to the top end of the support, an isopropanol tank is fixedly connected to the top end of the cleaning assembly, and an acetic acid tank is fixedly connected to the top end of the support. By means of the design, appropriate cleaning agents can be selected according to different types of pollutants, waste liquid is shunted through the independent recycling box, cross contamination of chemical reagents is reduced, the recycling rate of the waste liquid is increased, and the regeneration frequency of the filler is effectively reduced. In addition, the purity control of the waste liquid is realized through the split-flow design of each recycling box, and the treatment difficulty and the cleaning cost are reduced.

Description

TECHNICAL FIELD

[0001] The utility model relates to anion exchange layer cleaning device especially relates to a residual impurity cleaning device convenient for anion exchange chromatography filler. BACKGROUND

[0002] Anion exchange chromatography uses positively charged resin or medium, these media can combine with anion in solution, form stable complex, when different anion in sample and medium's combination ability are different, can realize separation through changing elution condition.

[0003] In anion exchange process, impurity can be gradually adsorbed on the surface of filler or enter the pore of filler, and long-term accumulation of these impurities can affect the binding site of filler, reduce its anion exchange capacity, thereby making separation effect worse.

[0004] Therefore, the utility model provides a residual impurity cleaning device convenient for anion exchange chromatography filler. UTILITY MODEL CONTENT

[0005] The utility model discloses a residual impurity cleaning device convenient for anion exchange chromatography filler.

[0006] In order to realize the above-mentioned purpose, the utility model discloses the following technical scheme: a residual impurity cleaning device convenient for anion exchange chromatography filler, including cleaning subassembly, the cleaning subassembly includes support, the top fixedly connected with cleaning box of cleaning subassembly, the top of cleaning subassembly is fixedly connected with recovery subassembly on the side away from the cleaning assembly,

[0007] The washing assembly includes a sodium hydroxide tank, the top of the sodium hydroxide tank is fixedly connected on the support, the top of the support is fixedly connected with a sodium chloride tank, the top of the cleaning assembly is fixedly connected with an isopropyl alcohol tank, the top of the support is fixedly connected with an acetic acid tank, the top of the support is fixedly connected with a phosphoric acid tank, the top of the support is fixedly connected with a water tank, and the top of the water tank is fixedly connected with a water pump.

[0008] As a preferred implementation, the recovery assembly includes a sodium hydroxide recovery tank and a water outlet pipe, the bottom of the sodium hydroxide recovery tank is fixedly connected on the cleaning assembly, the top of the support is fixedly connected with a sodium chloride recovery tank, the top of the support is fixedly connected with an isopropyl alcohol recovery tank, the top of the support is fixedly connected with an acetic acid recovery tank, and the inside of the cleaning assembly is fixedly connected with a discharge port.

[0009] The technical effects of the above technical scheme are: the residual impurities in the filler surface and pores can be effectively removed, the anion exchange capacity of the filler is restored, the design of the recovery assembly not only improves the utilization rate of the cleaning liquid, but also reduces environmental pollution and meets environmental protection requirements.

[0010] As a preferred embodiment, the top end of the bracket is fixedly connected with a cleaning box, and the inside of the cleaning box is fixedly connected with a membrane filter.

[0011] The technical effects of the above technical scheme are: the use of the membrane filter can effectively remove the small particles and impurities in the cleaning liquid, avoiding the pollution of these substances to the filler again.

[0012] As a preferred embodiment, the top end of the sodium hydroxide tank is fixedly connected to the cleaning box, and the top end of the sodium chloride tank is fixedly connected to the cleaning box.

[0013] The technical effects of the above technical scheme are: the rapid preparation and replenishment of the cleaning liquid can be realized, and the concentration and pH value of the cleaning liquid during the cleaning process can be maintained at the optimal state.

[0014] As a preferred embodiment, the top end of the isopropyl alcohol tank is fixedly connected to the cleaning box, the top end of the acetic acid tank is fixedly connected to the cleaning box, and the top end of the phosphoric acid tank is fixedly connected to the cleaning box.

[0015] The technical effects of the above technical scheme are: a variety of chemical reagents, including isopropyl alcohol, acetic acid, and phosphoric acid tanks, can be provided for the cleaning process. These reagents can be selected and used according to different cleaning needs. Isopropyl alcohol helps to dissolve organic matter, acetic acid can adjust the pH value, and the phosphoric acid tank is used to remove metal ions.

[0016] As a preferred embodiment, the inner wall bottom end of the cleaning box is fixedly connected to the sodium hydroxide recovery tank, and the inner wall bottom end of the cleaning box is fixedly connected to the sodium chloride recovery tank.

[0017] The technical effects of the above technical scheme are: effective recovery of used sodium hydroxide and sodium chloride can be realized, reducing the waste of chemical reagents and reducing environmental pollution.

[0018] As a preferred embodiment, the inner wall bottom end of the cleaning box is fixedly connected to the isopropyl alcohol recovery tank, and the inner wall bottom end of the cleaning box is fixedly connected to the acetic acid recovery tank.

[0019] The technical effects of the above technical scheme are: effective recovery of used isopropyl alcohol and acetic acid can be realized, further improving the utilization rate of chemical reagents and reducing the potential impact on the environment.

[0020] Compared with the prior art, the advantages and positive effects of the utility model lie in,

[0021] The utility model discloses a different cleaning reagent tank in the cleaning assembly is injected into the cleaning box in turn, and the organic matter, mineral matter and grease impurities in the filler surface or aperture are contacted and dissolved with the filler, the membrane filter filters the fine impurity particles generated in the cleaning liquid, and finally the waste liquid is shunted to the respective recovery tank, so that the design can select the appropriate cleaning agent for different types of pollutants, and the waste liquid is shunted through the independent recovery tank, the cross -contamination of chemical reagent is reduced, the recovery utilization rate of waste liquid is improved, and the filler regeneration frequency is effectively reduced. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 A perspective view of a residual impurity cleaning device for anion exchange chromatography filler convenient for the utility model is provided;

[0023] Figure 2 A synchronous drive assembly structure schematic view of a residual impurity cleaning device for anion exchange chromatography filler convenient for the utility model is provided;

[0024] Figure 3 A stirring assembly structure schematic view of a residual impurity cleaning device for anion exchange chromatography filler convenient for the utility model is provided;

[0025] Figure 4 A transmission column structure schematic view of a residual impurity cleaning device for anion exchange chromatography filler convenient for the utility model is provided.

[0026] LEGEND:

[0027] 1, cleaning assembly;11, support;12, cleaning tank;13, membrane filter;

[0028] 2, cleaning assembly;21, sodium hydroxide tank;22, sodium chloride tank;23, isopropanol tank;24, acetic acid tank;25, phosphoric acid tank;26, water tank;27, water pump;

[0029] 3, recovery assembly;31, sodium hydroxide recovery tank;32, sodium chloride recovery tank;33, isopropanol recovery tank;34, acetic acid recovery tank;35, water outlet pipe;36, discharge port. DETAILED DESCRIPTION

[0030] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of the present application.

[0031] As shown in Figure 1 - Figure 3 The present embodiment provides a technical solution: a residual impurity cleaning device for anion exchange chromatography filler, which comprises a cleaning assembly 1, the cleaning assembly 1 comprises a support 11, the top end of the cleaning assembly 1 is fixedly connected with a cleaning box 12, the top end of the support 11 is fixedly connected with the cleaning box 12, the inside of the cleaning box 12 is fixedly connected with a membrane filter 13, and the top end of the cleaning assembly 1 is fixedly connected with a recovery assembly 3 away from one side of the cleaning assembly 2;

[0032] The cleaning assembly 1 is the basis of the device, supported by the support 11, and the cleaning box 12 is installed at the top end thereof. The cleaning box 12 is stable through the design structure of the fixed support 11, and is provided with the membrane filter 13 for filtering fine impurity particles generated in the cleaning process;

[0033] The cleaning assembly 2 comprises a sodium hydroxide tank 21, the top end of the sodium hydroxide tank 21 is fixedly connected to the cleaning box 12, the top end of the sodium hydroxide tank 21 is fixedly connected to the support 11, the top end of the support 11 is fixedly connected with a sodium chloride tank 22, the top end of the sodium chloride tank 22 is fixedly connected to the cleaning box 12, the top end of the cleaning assembly 1 is fixedly connected with an isopropyl alcohol tank 23, the top end of the isopropyl alcohol tank 23 is fixedly connected to the cleaning box 12, the top end of the support 11 is fixedly connected with an acetic acid tank 24, the top end of the acetic acid tank 24 is fixedly connected to the cleaning box 12, the top end of the support 11 is fixedly connected with a phosphoric acid tank 25, the top end of the phosphoric acid tank 25 is fixedly connected to the cleaning box 12, the top end of the support 11 is fixedly connected with a water tank 26, and the top end of the water tank 26 is fixedly connected with a water pump 27;

[0034] The cleaning assembly 2 comprises a plurality of cleaning agent tanks, namely a sodium hydroxide tank 21, a sodium chloride tank 22, an isopropyl alcohol tank 23, an acetic acid tank 24, a phosphoric acid tank 25 and a water tank 26, which are respectively connected with the cleaning tank 12. Each of the agent tanks is connected to the cleaning tank 12 through a dedicated pipeline, so as to quantitatively deliver different agents according to the cleaning requirements. The sodium hydroxide solution can effectively remove organic contamination, while the sodium chloride and acetic acid are respectively used for dissolving different types of impurity deposits. The isopropyl alcohol tank 23 can be used for removing grease contamination, the phosphoric acid tank 25 is used for removing specific mineral deposits, and the water tank 26 is connected with a water delivery pump 27 for providing the final rinse and dilution of the cleaning liquid. The multi-agent combined cleaning method makes the device have high cleaning flexibility, and the cleaning agent can be adjusted according to the specific contaminant, so as to achieve efficient and thorough cleaning effect.

[0035] Further, as shown in Figure 1 、 Figure 3 and Figure 4 : the recovery assembly 3 comprises a sodium hydroxide recovery tank 31 and a water outlet pipe 35, the inner wall bottom end of the cleaning tank 12 is fixedly connected to the sodium hydroxide recovery tank 31, the bottom end of the sodium hydroxide recovery tank 31 is fixedly connected to the cleaning assembly 1, the top end of the support 11 is fixedly connected with a sodium chloride recovery tank 32, the inner wall bottom end of the cleaning tank 12 is fixedly connected to the sodium chloride recovery tank 32, the top end of the support 11 is fixedly connected with an isopropyl alcohol recovery tank 33, the inner wall bottom end of the cleaning tank 12 is fixedly connected to the isopropyl alcohol recovery tank 33, the top end of the support 11 is fixedly connected with an acetic acid recovery tank 34, the inner wall bottom end of the cleaning tank 12 is fixedly connected to the acetic acid recovery tank 34, and the inside of the cleaning assembly 1 is fixedly connected with a discharge port 36;

[0036] The sodium hydroxide recovery tank 31 is located in the bottom end inner wall of the cleaning tank 12, and is stably connected through the fixed support 11. During the cleaning process, the waste liquid containing sodium hydroxide will first pass through the filter of the cleaning tank 12, flow into the sodium hydroxide recovery tank 31, and be discharged through the bottom water outlet pipe 35 for further storage or treatment. This layered design can effectively avoid cross contamination of the cleaning liquid, enable the sodium hydroxide waste liquid to be recycled, reduce the consumption of chemical reagents during the cleaning process, and facilitate the guidance and storage of the waste liquid. The sodium chloride recovery tank 32 is fixed at the top end of the support 11 and connected with the bottom end inner wall of the cleaning tank 12, so as to ensure the purity of the cleaning liquid and ensure that the waste liquid can be stored and processed without being contaminated by mixed reagents. The isopropyl alcohol recovery tank 33 is also connected with the inner wall of the cleaning tank 12 and stably located at the top of the support 11. It is specially designed to collect organic waste liquid containing isopropyl alcohol, so that the organic solvent can be independently recycled and reused, effectively reducing the cleaning cost and reducing the pressure of chemical waste liquid treatment. The acetic acid recovery tank 34 is located at the bottom end of the inner wall of the cleaning tank 12 and is fixed by the support 11, so that the waste liquid containing acetic acid can flow into and be stored separately. The process of the cleaning tank 12 diverting various waste liquids to the specific recovery tank realizes classified collection and management, avoids mutual contamination of the cleaning waste liquid, and the device is also provided with a discharge port 36 for regularly discharging solid impurities and suspended particles generated during the cleaning process, to ensure the purity of the liquid in the cleaning tank 12 and the recovery tanks.

[0037] Working principle:

[0038] As shown in Figure 1 - Figure 4 :

[0039] In use: when cleaning, sodium hydroxide solution is first injected to effectively remove organic residues in the filler; then, according to the type of specific pollutants, sodium chloride, acetic acid and isopropyl alcohol are used in turn to dissolve different impurities and grease deposits, and phosphoric acid is used to remove mineral deposits. During the cleaning process, various cleaning solutions enter the cleaning tank 12 in turn and come into contact with the filler, and then the membrane filter 13 arranged in the cleaning tank 12 filters the fine impurity particles generated during the cleaning process, and the filtered waste liquid is shunted to the corresponding recovery tank. At this time, the sodium hydroxide waste liquid will flow into the sodium hydroxide recovery tank 31 at the bottom of the cleaning tank 12 and be discharged through the water outlet pipe 35 at the bottom, and be stored or treated; similarly, the waste liquid containing sodium chloride is guided to the sodium chloride recovery tank 32, the isopropyl alcohol waste liquid flows into the isopropyl alcohol recovery tank 33, the waste liquid containing acetic acid enters the acetic acid recovery tank 34, and the shunt design can ensure the purity of various waste liquids and avoid cross contamination between reagents. The clean water in the water tank 26 is sent to the cleaning tank 12 by the water pump 27 to complete the final rinsing and dilution of the cleaning area, so as to ensure that the liquid in the cleaning tank 12 is pure and further avoid impurity residues. The discharge port 36 in the device is used to regularly discharge the solid impurities deposited at the bottom of the cleaning tank 12 and each recovery tank to avoid blockage and secondary pollution.

[0040] The above is only a preferred embodiment of the present application, and is not intended to limit the present application in other forms. Any skilled person in the art can modify or change the above disclosed technical content to equivalent embodiments applied to other fields, but any simple modification, equivalent change and modification of the above embodiments without departing from the technical scheme of the present application, according to the technical essence of the present application, still belongs to the protection scope of the technical scheme of the present application.

Claims

1. A device for facilitating cleaning of residual impurities from anion exchange chromatography packing, comprising a cleaning assembly (1) comprising a holder (11), characterized in that, The top end of the cleaning assembly (1) is fixedly connected with a cleaning box (12), and the top end of the cleaning assembly (1) is fixedly connected with a recycling assembly (3) away from the side of the cleaning assembly (2). The cleaning assembly (2) comprises a sodium hydroxide tank (21), the top end of the sodium hydroxide tank (21) is fixedly connected to the bracket (11), the top end of the bracket (11) is fixedly connected with a sodium chloride tank (22), the top end of the cleaning assembly (1) is fixedly connected with an isopropyl alcohol tank (23), the top end of the bracket (11) is fixedly connected with an acetic acid tank (24), the top end of the bracket (11) is fixedly connected with a phosphoric acid tank (25), the top end of the bracket (11) is fixedly connected with a water tank (26), and the top end of the water tank (26) is fixedly connected with a water pump (27).

2. A device for cleaning residual impurities from anion exchange chromatography packing material according to claim 1, characterized in that: The recycling assembly (3) comprises a sodium hydroxide recycling tank (31) and a water outlet pipe (35), the bottom end of the sodium hydroxide recycling tank (31) is fixedly connected to the cleaning assembly (1), the top end of the bracket (11) is fixedly connected with a sodium chloride recycling tank (32), the top end of the bracket (11) is fixedly connected with an isopropyl alcohol recycling tank (33), the top end of the bracket (11) is fixedly connected with an acetic acid recycling tank (34), and the inside of the cleaning assembly (1) is fixedly connected with a discharge port (36).

3. A device for cleaning residual impurities from anion exchange chromatography packing material according to claim 2, characterized in that: The top end of the bracket (11) is fixedly connected with a cleaning box (12), and the inside of the cleaning box (12) is fixedly connected with a membrane filter (13).

4. A device for cleaning residual impurities from anion exchange chromatography packing material according to claim 1, characterized in that: The top end of the sodium hydroxide tank (21) is fixedly connected to the cleaning box (12), and the top end of the sodium chloride tank (22) is fixedly connected to the cleaning box (12).

5. A device for cleaning residual impurities from anion exchange chromatography packing material according to claim 1, characterized in that: The top end of the isopropyl alcohol tank (23) is fixedly connected to the cleaning box (12), the top end of the acetic acid tank (24) is fixedly connected to the cleaning box (12), and the top end of the phosphoric acid tank (25) is fixedly connected to the cleaning box (12).

6. A device for cleaning residual impurities from anion exchange chromatography packing material according to claim 2, characterized in that: The inner wall bottom of the cleaning box (12) is fixedly connected to the sodium hydroxide recycling tank (31), and the inner wall bottom of the cleaning box (12) is fixedly connected to the sodium chloride recycling tank (32).

7. A device for cleaning residual impurities from anion exchange chromatography packing material according to claim 2, characterized in that: The inner wall bottom of the cleaning box (12) is fixedly connected to the isopropyl alcohol recycling tank (33), and the inner wall bottom of the cleaning box (12) is fixedly connected to the acetic acid recycling tank (34).

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