Detection consumable and nucleic acid detection equipment

Abstract

The utility model provides a detection consumable and nucleic acid detection equipment, which comprises a consumable tube, a flexible deformation piece and a pressing piece, and the consumable tube is provided with a consumable cavity with an outlet; the flexible deformation piece is provided with a deformation cavity communicated with the consumable cavity; the pressing piece is connected to the pressing end of the consumable pipe through the flexible deformation piece, the pressing end and the outlet are arranged at the two ends of the consumable pipe in the pipe length direction of the consumable pipe correspondingly, the pressing piece is used for extruding the flexible deformation piece and enabling the flexible deformation piece to deform, and a pressing feedback structure for resisting the pressing piece is arranged on the consumable pipe. According to the detection consumable, the pressing piece and the flexible deformation piece are arranged on the top, the situation that in the prior art, a cover is repeatedly opened for liquid taking can be avoided, meanwhile, the pressing feedback structure is arranged on the consumable pipe, the visual rough judgment mode in the prior art can be replaced, whether liquid taking is in place or not can be accurately controlled, in-place liquid taking can be more visually fed back, and the detection accuracy is improved. And the operation convenience of the detection consumables is greatly improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of detection instrument, especially, relate to a kind of detection consumables and nucleic acid detection equipment. BACKGROUND

[0002] Detection consumables are increasingly widely used in sample detection fields such as nucleic acid detection. Nucleic acid detection is a commonly used method for detecting biomolecules. It determines whether specific pathogens or genetic sequences exist by detecting nucleic acid molecules in samples. In the medical field, nucleic acid detection is often used to detect the presence and quantity of viruses, bacteria, fungi and other microorganisms to help diagnose and monitor infectious diseases. Nucleic acid detection has high sensitivity and specificity, and can detect the presence of pathogens at an early stage, and even detect genetic variations of pathogens. Therefore, it has wide application in epidemiological investigation, epidemic monitoring, clinical diagnosis and other aspects.

[0003] Currently, the detection of consumables on the market requires opening the cover and manually transferring the liquid, which is very inconvenient to operate. It also requires manual visual inspection of the liquid transfer amount, which is less convenient to use. In addition, repeated opening of the detection consumables can easily contaminate the detection consumables, resulting in poor detection accuracy. SUMMARY

[0004] The main purpose of the utility model is to provide a kind of detection consumables and nucleic acid detection equipment, to solve the technical problem of the detection consumables of prior art inconvenient operation and easy to be contaminated.

[0005] To achieve the above purpose, the utility model provides a kind of detection consumables, the detection consumables include: consumable tube, is provided with the consumable cavity with outlet;Flexible deformation part, is provided with and the deformation cavity of the consumable cavity intercommunication;Pressing piece, is connected to the pressing end of the consumable tube by the flexible deformation part, the pressing end and the outlet are along the pipe length direction of the consumable tube and are arranged at both ends of the consumable tube, the pressing piece is used for extruding the flexible deformation part and makes the flexible deformation part deformation, the pressing feedback structure of the consumable tube is set to resist the pressing piece.

[0006] In the utility model embodiment, the pressing piece includes: pressing part, the side away from the consumable tube is provided with pressing surface;Connecting part, one end connects the pressing part side towards the consumable tube, the other end connects the flexible deformation part, and the connecting part is hollowly arranged.

[0007] In the utility model embodiment, the flexible deformation part includes: first connecting barrel, is sleeved in the connecting part outside;Second connecting barrel, is connected with the first connecting barrel, the consumable tube is provided with positioning part, the second connecting barrel is sleeved in the positioning part outside, and the pressing feedback structure penetrates the second connecting barrel.

[0008] In the embodiment of the utility model, the positioning part is provided with a positioning notch, and the second connecting barrel is provided with a positioning protrusion matched with the positioning notch.

[0009] In the embodiment of the utility model, the detection consumable further comprises a tube cover connected with the consumable tube, the tube cover is provided with a flow guide section and a leak-proof dripper connected with the flow guide section, an inner wall of the flow guide section is provided with a drainage taper surface for guiding the leak-proof dripper, and a small end of the drainage taper surface is arranged close to the leak-proof dripper.

[0010] In the embodiment of the utility model, the detection consumable further comprises a tube cover connected with the consumable tube, the tube cover is provided with a flow guide section and a leak-proof dripper connected with the flow guide section, an inner wall of the flow guide section is provided with a drainage taper surface for guiding the leak-proof dripper, and a small end of the drainage taper surface is arranged close to the leak-proof dripper.

[0011] In the embodiment of the utility model, the leak-proof dripper comprises a connecting section connected with the flow guide section at one end, an outer thread of the connecting section is provided with an outer thread for screwing with the tube cap; and a lengthened leak-proof section, the other end of the connecting section is connected with the lengthened leak-proof section, and the length of the lengthened leak-proof section is longer than that of the connecting section.

[0012] In the embodiment of the utility model, the tube cap is provided with a plurality of guide protrusions, and the plurality of guide protrusions enclose a guide groove for guiding the lengthened leak-proof section.

[0013] In the embodiment of the utility model, the consumable tube, the flexible deformation piece and the pressing piece are integrally formed; and / or, the number of the pressing feedback structures is at least two, and the at least two pressing feedback structures are arranged at intervals along the circumference of the consumable tube.

[0014] The utility model further provides a nucleic acid detection equipment, the nucleic acid detection equipment includes movable magnetic attraction piece and the detection consumable as described above, the movable magnetic attraction piece is used for magnetically attracting the magnetic beads in the detection consumable, the tube cover of the detection consumable is provided with the flow guide section for guiding the magnetic beads, and the movable magnetic attraction piece can be moved close to the flow guide section.

[0015] Through the above technical scheme, the detection consumable provided by the embodiment of the utility model has the following beneficial effects:

[0016] In nucleic acid detection using the detection consumable, the flexible deformation piece and the pressing piece are sealingly connected to the top of the consumable tube, the consumable cavity can accommodate reagent and sample solution, when it is needed to discharge the solution in the consumable cavity, the pressing piece can be pressed towards the direction close to the consumable tube, so that the pressing piece extrudes the flexible deformation piece, the deformation cavity is compressed, and the air pressure in the consumable cavity connected with the deformation cavity changes, so that the solution in the consumable cavity is discharged to the outlet under the action of air pressure, the magnetic beads can be smoothly guided, the magnetic beads are guided out of the consumable cavity, the application range of the detection consumable is increased, and the sensitivity of the magnetic bead detection is improved, the pressing feedback structure on the consumable tube can resist the pressing piece and feed back to the operator when the pressing piece is pressed in place, so that manual visual judgment whether the liquid discharge is in place can be avoided. The detection consumable in the utility model can avoid the repeated opening of the cover to take liquid in the prior art, facilitate the liquid taking operation, avoid the pollution of the external environment to the detection consumable, and replace the visual rough judgment mode in the prior art, accurately control whether the liquid taking is in place, more intuitively feed back the liquid taking in place, and greatly improve the operation convenience of the detection consumable.

[0017] Other features and advantages of the present application will be described in detail in the following specific embodiments. BRIEF DESCRIPTION OF DRAWINGS

[0018] The accompanying drawings are included to provide a further understanding of the present application, and constitute a part of the specification, and are used together with the following specific embodiments to explain the present application, but do not constitute a limitation on the present application. In the drawings:

[0019] Figure 1 is a structure schematic view of the detection consumable according to an embodiment of the present application;

[0020] Figure 2 is a sectional structure schematic view of the detection consumable according to an embodiment of the present application;

[0021] Figure 3 is an exploded structure schematic view of the detection consumable according to an embodiment of the present application;

[0022] Figure 4 is a cap structure schematic view of the detection consumable according to an embodiment of the present application;

[0023] Figure 5 is a partial structure sectional schematic view of the detection consumable according to an embodiment of the present application.

[0024] BRIEF DESCRIPTION OF DRAWINGS

[0025] DETAILED DESCRIPTION

[0026] The specific embodiments of the utility model are described in detail below in combination with the drawings. It should be understood that the specific embodiments described herein are only used to illustrate and explain the utility model, and are not used to limit the utility model.

[0027] The detection consumable according to the utility model is described below with reference to the drawings.

[0028] As Figures 1 to 5 shown, in the embodiment of the utility model, the detection consumable 100 includes a consumable tube 1, a flexible deformation member 2 and a pressing member 3, the consumable tube 1 is provided with a consumable cavity 11 with an outlet; the flexible deformation member 2 is provided with a deformation cavity in communication with the consumable cavity 11; the pressing member 3 is connected to the pressing end of the consumable tube 1 through the flexible deformation member 2, the pressing end and the outlet are arranged at two ends of the consumable tube 1 along the tube length direction of the consumable tube 1, the pressing member 3 is used to extrude the flexible deformation member 2 and make the flexible deformation member 2 deform, and the consumable tube 1 is provided with a pressing feedback structure 12 resisting the pressing member 3.

[0029] Understandably, the detection consumable 100 in the embodiment is mainly used for nucleic acid detection, the consumable tube 1 and the pressing member 3 in the embodiment can adopt PP hard glue member, and the flexible deformation member 2 can adopt soft glue member. The pressing feedback structure 12 can be a sheet-shaped protrusion, and the sheet-shaped protrusion extends along the tube length direction. The tube length direction of the consumable tube 1 can be the up-down direction in the drawing, the pressing end is located at the top of the consumable tube 1, and the outlet can be located at the bottom of the consumable tube 1.

[0030] The pressing member 3, the flexible deformation member 2 and the consumable tube 1 in the embodiment can be connected in sequence along the tube length direction of the consumable tube 1. The extension directions of the pressing member 3, the flexible deformation member 2 and the consumable tube 1 are consistent, the consumable cavity 11 can accommodate reagent or sample solution, in the case of needing to transfer the solution in the consumable cavity 11, the pressing member 3 can be pressed in the direction close to the pressing end, so that the pressing member 3 extrudes the flexible deformation member, the flexible deformation member deforms under the pressing action, the volume of the deformation cavity is compressed, the air pressure in the consumable cavity 11 in communication with the deformation cavity changes, and the liquid in the consumable cavity 11 can flow out through the outlet under the action of the air pressure until the pressing feedback structure 12 on the consumable tube 1 resists the pressing member 3, and the pressing feedback structure 12 is used to generate the in-place feedback of the pressing in place. In an embodiment, the pressing feedback structure 12 is used to resist the pressing member 3 and generate sound feedback as in-place feedback, in another embodiment, the pressing feedback structure 12 is used to resist the pressing member 3 and generate tactile feedback as in-place feedback, in still another embodiment, the pressing feedback structure 12 resists the pressing member 3 and generates sound feedback and tactile feedback as in-place feedback, and in other embodiments, the pressing feedback structure 12 resists the pressing member 3 and can generate other forms of in-place feedback, and the utility model does not limit the form of in-place feedback.

[0031] In the nucleic acid detection using the detection consumable 100 in the embodiment, the flexible deformation piece 2 and the pressing piece 3 are sealingly connected to the top of the consumable tube 1, and the consumable cavity 11 can accommodate reagent and sample solution. When it is necessary to discharge the solution in the consumable cavity 11, the pressing piece 3 can be pressed in the direction close to the consumable tube 1, so that the pressing piece 3 extrudes the flexible deformation piece 2, the deformation cavity is compressed, the air pressure in the consumable cavity 11 connected with the deformation cavity is changed, and the solution in the consumable cavity 11 is discharged to the outlet under the action of the air pressure. In the scenario of the magnetic bead method for detecting nucleic acid, the magnetic beads can be smoothly guided and discharged from the consumable cavity 11, the application range of the detection consumable 100 is increased, and the sensitivity of the magnetic bead method for detecting is improved. The pressing feedback structure 12 on the consumable tube 1 can resist the pressing piece 3 and provide in-place feedback to the operator when the pressing piece 3 is pressed in place, so that manual visual judgment of whether the liquid is discharged in place can be avoided. The detection consumable 100 in the embodiment can avoid the repeated opening of the cover to take liquid in the prior art, which facilitates the liquid taking operation and avoids the pollution of the external environment to the detection consumable 100. Meanwhile, the pressing feedback structure 12 provided on the consumable tube 1 can replace the visual rough judgment mode in the prior art, accurately control whether the liquid is taken in place, more intuitively feedback whether the liquid is taken in place, and greatly improve the operation convenience of the detection consumable 100.

[0032] As shown in Figure 5 In an embodiment, the pressing piece 3 includes a pressing part 31 and a connecting part 32. The pressing part 31 is provided with a pressing surface 311 on the side away from the consumable tube 1. One end of the connecting part 32 is connected to the side of the pressing part 31 facing the consumable tube 1, and the other end is connected to the flexible deformation piece 2. The connecting part 32 is hollow. The top surface of the pressing part 31 in the embodiment is an arc-shaped pressing surface 311, which can be adapted to the shape of the hand of the operator, facilitating the positioning of the operator, and ensuring that the operator has enough contact area with the pressing part 31, thereby improving the operation convenience. The connecting part 32 in the embodiment can be a hollow columnar structure. The cross-sectional size of the pressing part 31 is greater than that of the connecting part 32. The pressing part 31 can be a flat plate structure, which is simple in structure and easy to produce.

[0033] Specifically, as shown in Figure 3As shown, the flexible deformation piece 2 comprises a first connecting cylinder 21 and a second connecting cylinder 22, the first connecting cylinder 21 is sleeved outside the connecting portion 32; the second connecting cylinder 22 is connected with the first connecting cylinder 21, the consumable tube 1 is provided with a positioning portion 13, the second connecting cylinder 22 is sleeved outside the positioning portion 13, and the pressing feedback structure 12 penetrates through the second connecting cylinder 22. The first connecting cylinder 21 and the second connecting cylinder 22 in the embodiment are both hollow columnar structures, the first connecting cylinder 21 is connected to the top of the second connecting cylinder 22, and the cross-sectional size of the first connecting cylinder 21 is smaller than that of the second connecting cylinder 22. The first connecting cylinder 21 and the second connecting cylinder 22 can be coaxially arranged, the pressing feedback structure 12 is located below the pressing portion 31 after penetrating through the second connecting cylinder 22, and the pressing feedback structure 12 can resist the pressing portion 31 in the case that the pressing portion 31 extrudes the flexible deformation piece 2 downwards, so that the structure is simple and convenient for production.

[0034] As shown in the drawings, Figure 5 In an embodiment, the second connecting cylinder 22 can comprise a deformation portion 222 located at the upper portion and a main body portion 223 connected to the lower end of the deformation portion 222, the wall thickness of the deformation portion 222 is smaller than that of the main body portion 223, the main body portion 223 is connected with the first connecting cylinder 21 through the deformation portion 222, and the positioning protrusion 221 is arranged on the inner wall of the main body portion 223. By arranging the deformation portion 222 with a smaller wall thickness at the upper end of the second connecting cylinder 22, the deformation smoothness of the flexible deformation piece 2 can be ensured, and the connection stability between the flexible deformation piece 2 and the consumable tube 1 can be ensured at the same time by cooperating with the main body portion 223 at the lower portion.

[0035] In the embodiment of the utility model, the positioning portion 13 is provided with a positioning gap 131, and the second connecting cylinder 22 is provided with a positioning protrusion 221 which is positioned and matched with the positioning gap 131. As shown in the drawings, Figure 3 The positioning portion 13 is arranged at the top of the tube body 14, and the cross-sectional size of the positioning portion 13 is smaller than that of the tube body 14, the cross-sectional size of the second connecting cylinder 22 matches that of the tube body 14, and the outer surface of the second connecting cylinder 22 is flush with the outer surface of the tube body 14 in the case that the second connecting cylinder 22 is sleeved outside the positioning portion 13. The number of the positioning gap 131 can be multiple, the multiple positioning gaps 131 can be arranged at intervals along the circumference of the positioning portion 13, the number of the positioning protrusion 221 and the positioning gap 131 is consistent and one-to-one correspondence, and the connection precision between the flexible deformation piece 2 and the consumable tube 1 can be ensured by the clamping cooperation of the positioning gap 131 and the positioning protrusion 221.

[0036] Specifically, the detection consumable 100 further comprises a tube cover 4 connected with the consumable tube 1, the tube cover 4 is provided with a flow guide section 41 and a leak-proof drip head 42 connected with the flow guide section 41, an inner wall of the flow guide section 41 is provided with a flow guide taper surface for guiding the leak-proof drip head 42, and a small end of the flow guide taper surface is arranged close to the leak-proof drip head 42. In the embodiment, the tube cover 4 is connected to an outlet end (which can be a lower end) of the tube body 14, a bottom of the leak-proof drip head 42 can be arranged at a drip port, the flow guide section 41 is conical with a large upper end and a small lower end, and the flow guide section 41 is arranged to be inclined inward from top to bottom, so as to concentrate and guide the magnetic beads, and the flow guide taper surface can facilitate the movement of the enriched magnetic beads to the drip port of the tube cover 4.

[0037] As shown in Figures 1 to 4 , the detection consumable 100 further comprises a tube cap 5 sealing the leak-proof drip head 42, and the tube cap 5 is provided with a leak-proof protrusion 51 for plugging the leak-proof drip head 42. In the embodiment, the leak-proof protrusion 51 protrudes upward and can extend into the leak-proof drip head 42, which can effectively prevent the liquid in the detection consumable 100 from leaking during transportation or reaction, and can improve the sealing performance of the detection consumable 100.

[0038] In an embodiment, the leak-proof drip head 42 comprises a connecting section 421 and an elongated leak-proof section 422, one end of the connecting section 421 is connected with the flow guide section 41, and an outer side of the connecting section 421 is provided with external threads for screwing with the tube cap 5; the other end of the connecting section 421 is connected with the elongated leak-proof section 422, and the length of the elongated leak-proof section 422 is longer than that of the connecting section 421. Figure 2 and Figure 3 As shown in , the elongated leak-proof section 422 is arranged at the bottom of the leak-proof drip head 42, and the elongated leak-proof section 422 is arranged to be elongated, which can buffer the downward flow of the solution and avoid the situation that the liquid drips out when the tube cap 5 is opened.

[0039]

[0040] As shown in Figure 4As shown, the cap 5 has multiple guide protrusions 52 inside, which form a guide groove for the extended leak-proof section 422. In this embodiment, the guide protrusions 52 protrude inward from the inner wall of the cap 5, and the multiple guide protrusions 52 are spaced apart circumferentially along the cap 5. The multiple guide protrusions 52 surround the leak-proof protrusion 51, which is located at the bottom of the cap 5 and protrudes upward, extending into the extended leak-proof section 422 and sealing it. In this embodiment, the multiple guide protrusions 52 of the cap 5 guide the extended leak-proof section 422 of the cap 4, ensuring the accuracy and stability of the assembly between the cap 5 and the cap 4, and preventing misalignment between the cap 5 and the cap 4. In one embodiment, the outer walls of the tube cap 4 and the tube cap 5 may both be provided with anti-slip structures. The tube cap 4 and the tube cap 5 are threaded together, and the tube cap 4 and the consumable tube 1 are threaded together. The anti-slip structure facilitates the rotation operation of the tube cap 4 and the tube cap 5. The anti-slip structure may be multiple strip-shaped vertical protrusions. In other embodiments, the anti-slip structure may adopt other anti-slip designs.

[0041] In one embodiment, the consumable tube 1 includes a tube body 14 and a threaded section 15 and a stop portion 16 disposed on the tube body 14. The threaded section 15 is threadedly connected to the tube cap 4, and the stop portion 16 is disposed near the threaded section 15 and is used to stop the tube cap 4. In this embodiment, the stop portion 16 is a flat annular plate, which is arranged around the outside of the tube body 14. The threaded section 15 is disposed below the stop portion 16 and has external threads. The tube cap 4 has internal threads that are compatible with the external threads. The tube cap 4 and the consumable tube 1 are connected by threads. The structure is simple and edge-fitted. The flow guiding section 41 is disposed below the threaded section 15, which facilitates flow guiding.

[0042] It should be noted that the consumable tube 1, the flexible deformable component 2, and the pressing component 3 are integrally molded; furthermore, the number of pressing feedback structures 12 is at least two, and the at least two pressing feedback structures 12 are arranged at intervals along the circumference of the consumable tube 1. In this embodiment, the consumable tube 1, the flexible deformable component 2, and the pressing component 3 can be injection molded integrally, which can ensure the sealing of the detection consumable 100 and avoid the solution in the consumable cavity 11 being contaminated by the external environment, such as... Figure 3 As shown, in one embodiment, there are two pressure feedback structures 12, which are arranged opposite each other radially along the consumable tube 1. In other embodiments, the consumable tube 1, the flexible deformable element 2, and the pressing element 3 can be integrally formed using other processes, and this utility model does not limit them.

[0043] This utility model also proposes a nucleic acid detection device, which includes a movable magnetic suction component and the detection consumable 100 as described above. The movable magnetic suction component is used to magnetically attract magnetic beads inside the detection consumable 100. The tube cap 4 of the magnetically attracted detection consumable 100 is provided with a flow guiding section 41 for guiding the magnetic beads. The movable magnetic suction component can move close to the flow guiding section 41. The specific structure of the detection consumable 100 is as described in the above embodiments. Since the detection consumable 100 adopts all the technical solutions of all the above embodiments, it has at least all the beneficial effects brought about by the technical solutions of the above embodiments, which will not be described in detail here.

[0044] The nucleic acid detection device in this embodiment is mainly used for magnetic bead nucleic acid detection. A movable magnetic suction component, which can be a magnet, can be installed on the outside of the tube cap 4. After the magnetic bead reaction solution in the detection consumable 100 is fully mixed with the sample (using ultrasound), the movable magnetic suction component moves close to the upper part of the tube cap 4. Driven by a driving component (such as a motor), the movable magnetic suction component can slowly move downward. Under the traction of the magnetic force, and in conjunction with the flow guide cone surface of the flow guide section 41, the magnetic beads enriched with nucleic acid from the sample are gathered towards the leak-proof dropper 42 below. The tube cap 5 is opened, and the volume of the consumable cavity 11 is compressed by the flexible deformation component 2 driven by the pressing component 3, so that the magnetic bead reaction solution is discharged from the leak-proof dropper 42. Existing reagent tubes are only suitable for one-step nucleic acid detection and cannot effectively realize magnetic bead-based nucleic acid detection, thus limiting its application expansion. However, the detection consumable 100 in this embodiment, with a pressing component 3 and a flexible deformation component 2 at the top, facilitates pressing operation at the top. At the same time, the flow guiding section 41 and the extended leak-proof section 422 at the bottom facilitate the downward flow of magnetic beads and prevent liquid leakage without external force. With a movable magnetic suction component near the bottom, the reaction liquid with magnetic beads can flow smoothly out of the detection consumable 100. This allows the detection consumable 100 to be used in magnetic bead-based nucleic acid detection. Moreover, the detection consumable 100 has a simple structure, is easy to manufacture, and does not require a complex detection process. With the movable magnetic suction component, the efficiency of nucleic acid detection can be improved.

[0045] In the description of this utility model, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0046] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0047] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0048] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A detection consumable, characterized in that, The detection consumable (100) comprises: a consumable tube (1) provided with a consumable cavity (11) with an outlet; a flexible deformation piece (2) provided with a deformation cavity in communication with the consumable cavity (11); a pressing piece (3) connected to a pressing end of the consumable tube (1) through the flexible deformation piece (2), the pressing end and the outlet being arranged at two ends of the consumable tube (1) along the tube length direction of the consumable tube (1), the pressing piece (3) being used for extruding and deforming the flexible deformation piece (2), and the consumable tube (1) being provided with a pressing feedback structure (12) resisting the pressing piece (3).

2. The test consumable of claim 1, wherein, The pressing piece (3) comprises: a pressing part (31) provided with a pressing surface (311) on the side away from the consumable tube (1); a connecting part (32) connected to the pressing part (31) on the side towards the consumable tube (1) at one end and connected to the flexible deformation piece (2) at the other end, and the connecting part (32) being hollow.

3. The test consumable of claim 2, wherein, The flexible deformation piece (2) comprises: a first connecting cylinder (21) sleeved outside the connecting part (32); a second connecting cylinder (22) connected with the first connecting cylinder (21), the consumable tube (1) being provided with a positioning part (13), the second connecting cylinder (22) being sleeved outside the positioning part (13), and the pressing feedback structure (12) penetrating through the second connecting cylinder (22).

4. The test consumable of claim 3, wherein, The positioning part (13) is provided with a positioning notch (131), and the second connecting cylinder (22) is provided with a positioning protrusion (221) positioned and matched with the positioning notch (131).

5. The test consumable of any one of claims 1 to 4, wherein, The detection consumable (100) further comprises a tube cover (4) connected with the consumable tube (1), the tube cover (4) being provided with a flow guide section (41) and a leak-proof dripper (42) connected with the flow guide section (41), an inner wall of the flow guide section (41) being provided with a flow guide taper surface guiding flow to the leak-proof dripper (42), and a small end of the flow guide taper surface being arranged close to the leak-proof dripper (42).

6. The test consumable of claim 5, wherein, The detection consumable (100) further comprises a tube cap (5) sealing the leak-proof dripper (42), the tube cap (5) being provided with a leak-proof protrusion (51) plugging the leak-proof dripper (42) inside.

7. The test consumable of claim 6, wherein, The leak-proof dripper (42) comprises: a connecting section (421) connected with the flow guide section (41) at one end, an outer side of the connecting section (421) being provided with an outer thread threadedly connected with the tube cap (5); an elongated leak-proof section (422) connected with the connecting section (421) at the other end of the connecting section (421), the elongated leak-proof section (422) being longer than the connecting section (421).

8. The test consumable of claim 7, wherein, The tube cap (5) is provided with a plurality of guide protrusions (52) inside, the plurality of guide protrusions (52) surrounding a guide groove guiding the elongated leak-proof section (422).

9. The test consumable of any one of claims 1 to 4, wherein, The consumable tube (1), the flexible deformation piece (2) and the pressing piece (3) are integrally formed; and / or, The number of the pressing feedback structures (12) is at least two, and the at least two pressing feedback structures (12) are arranged at intervals along the circumference of the consumable tube (1).

10. A nucleic acid detection device, characterized by, The nucleic acid detection device comprises a movable magnetic attraction piece and the detection consumable (100) according to any one of claims 1 to 9, the movable magnetic attraction piece is used for magnetically attracting magnetic beads in the detection consumable (100), a flow guide section (41) for guiding the magnetic beads is arranged on a tube cover (4) of the detection consumable (100), and the movable magnetic attraction piece can be moved close to the flow guide section (41).

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