Fluorescence immunoassay detector device

Abstract

The utility model provides a fluorescence immunoassay detector device which comprises a detector and a fluorescent reagent strip, and the detector is used for detecting the fluorescent reagent strip; a tooth-shaped structure is arranged at the bottom of the fluorescent reagent strip; the detector comprises an objective table, a reagent strip insertion opening, a detection device, a transmission gear and a clockwork spring device, wherein the detection device is provided with at least one detection site on the objective table; the reagent strip insertion opening allows the fluorescent reagent strip to enter or come out, the transmission gear is rotationally arranged on the objective table and is meshed with a tooth-shaped structure at the bottom of the fluorescent reagent strip, and the clockwork spring device drives the transmission gear to rotate; and the transmission gear rotates to drive the fluorescent reagent strip to enter the detection site or be separated from the detection site from the reagent strip insertion opening. According to the fluorescent reagent strip detection device, the damping spring structure is adopted for transmission for scanning detection of the fluorescent reagent strip, the electric quantity required by the whole detection device is small, the cost is greatly reduced, and the fluorescent reagent strip detection device is more suitable for household detection scenes.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of measuring instrument device, specifically, a kind of fluorescent immunoassay instrument device. BACKGROUND

[0002] Electronic measuring device for reading fluorescent immunoassay reagent generally uses stepper motor for signal value acquisition and analysis, its volume is generally larger, and it needs larger power supply to drive motor drive, not suitable for family detection;In recent years, foreign manufacturers have tried to miniaturize the reading instrument, and the detection mode is changed from scanning to fixed detection.For example, the Chinese patent document with publication number CN112740035A discloses an electronic measuring test reader for reading a lateral flow test strip having a development region, the development region includes a test background region and at least one test result line, the electronic lateral flow measuring test reader includes: a cartridge for holding the test strip and a carrier adapted to removably hold the cartridge therein;At least one illumination LED is operatively associated with one or a combination of the cartridge and the carrier to illuminate the test strip;And a light guide includes a window structure of one or a combination of the cartridge and the carrier to guide light emitted or reflected from a selected portion of the development region of the test strip to a sensor, wherein the proportion of at least one test result line is maximized relative to the proportion of the test background region in the selected portion of the development region of the test strip.

[0003] Although the prior art makes the detection device miniaturized, it ignores the chromatographic background influence due to the use of fixed signal acquisition, resulting in false positive of detection results.Therefore, a household detector device capable of automatically conveying reagent strips is needed. UTILITY MODEL CONTENT

[0004] In view of the defects in the prior art, the purpose of the utility model is to provide a fluorescent immunoassay instrument device.

[0005] According to the fluorescent immunoassay instrument device provided by the utility model, it comprises: a detector and a fluorescent reagent strip, and the detector is used for detecting the fluorescent reagent strip;

[0006] The bottom of the fluorescent reagent strip is provided with a toothed structure;

[0007] The detector includes a stage, a reagent strip insertion port, a detection device, a conveying gear and a clockwork device, and the detection device has at least one detection site on the stage;

[0008] The reagent strip insertion port allows the fluorescent reagent strip to enter or come out, the conveying gear is rotatably arranged on the stage and is engaged with the toothed structure at the bottom of the fluorescent reagent strip, the clockwork device drives the conveying gear to rotate, and the conveying gear drives the fluorescent reagent strip to enter the detection site from the reagent strip insertion port or to come out of the detection site.

[0009] Preferably, the clockwork device comprises a rack, a gear and a clockwork ring; the gear is coaxially fixedly connected with the inner end of the clockwork ring, and the outer end of the clockwork ring is fixedly connected with the object table; the rack is engaged with the gear.

[0010] Preferably, the detection device comprises detection windows and a circuit board, and each detection window corresponds to at least one detection site.

[0011] The detection window is provided with at least one illuminating LED.

[0012] Preferably, the reading device comprises a display device or a remote display terminal.

[0013] Preferably, the end of the rack away from the gear exceeds the upper surface of the object table.

[0014] Preferably, the fluorescent reagent strip further comprises a clamping upper cover, the clamping upper cover is connected with the lower bottom, and the clamping upper cover is provided with a detection window and a sample adding hole.

[0015] Preferably, a power supply unit is further comprised for supplying power to the detection device.

[0016] Preferably, the tooth-shaped structure of the fluorescent reagent strip is provided with a protrusion or a groove with a preset inclination angle.

[0017] Preferably, the length of the tooth-shaped structure of the fluorescent reagent strip is longer than that of the detection window.

[0018] Preferably, a rotating shaft is further comprised, and the transmission gear and the gear of the clockwork device are installed on the rotating shaft.

[0019] Compared with the prior art, the utility model has the beneficial effects that:

[0020] 1. The utility model discloses a damping clockwork structure transmission for the scanning detection of the fluorescent reagent strip, which replaces the traditional stepping motor mode, miniaturizes the detection device, does not need a high-power power supply device for driving the motor, only the PCB and / or display screen of the whole detection device need to be powered, the required power is small, and only a dry battery or a button cell can be used.

[0021] 2. The detection card bottom is provided with certain grooves or protrusions in addition to the tooth-shaped structure, which are used for engaging with the clockwork gear, driving the transmission of the reagent card, preventing the reagent card from being inserted in the wrong direction and causing detection errors, etc. DRAWINGS

[0022] Other features, objects, and advantages of the present application will become more apparent from the following detailed description of non-limiting embodiments thereof, when read in conjunction with the accompanying drawings:

[0023] Figure 1 Fig. 1 is a schematic view of the detector of the present application;

[0024] Figure 2 Fig. 2 is a schematic view of the fluorescence immunoassay detector device of the present application;

[0025] Figure 3 Fig. 3 is a schematic view of the fluorescence reagent strip of the present application.

[0026] In the figure, 1 is a detector; 2 is a fluorescence reagent strip; 3 is a rack; 4 is a toothed structure; 5 is a transmission gear; and 6 is a clockwork device. DETAILED DESCRIPTION

[0027] The present application will be described in detail below with specific embodiments. The following embodiments will help those skilled in the art to further understand the present application, but do not limit the present application in any form. It should be pointed out that, for those skilled in the art, without departing from the concept of the present application, a number of changes and improvements can be made. These all belong to the protection scope of the present application.

[0028] Example 1

[0029] A fluorescence immunoassay detector 1 device, comprising: a detector 1 and a fluorescence reagent strip 2, the detector 1 is used for detecting the fluorescence reagent strip 2.

[0030] The detector 1 comprises a stage, a reagent strip insertion port, a detection device, a transmission gear 5 and a clockwork device 6, wherein the detection device is installed on the stage and has at least one detection site; the reagent strip insertion port allows the fluorescence reagent strip 2 to enter or exit, the transmission gear 5 is rotatably arranged on the stage and is engaged with the toothed structure 4 at the bottom of the fluorescence reagent strip 2, the clockwork device 6 drives the transmission gear 5 to rotate, and the transmission gear 5 drives the fluorescence reagent strip 2 to enter or exit the detection site from the reagent strip insertion port. The detection device further comprises a detection window, a circuit board and a reading device, each detection window corresponds to at least one detection site, and the detection window is provided with at least one illuminating LED.

[0031] The detector 1 further comprises a power supply unit for supplying power to the detection device, specifically, for supplying power to the display device and the LED. In a preferred embodiment, the power supply unit can be a dry battery or a button cell.

[0032] In a preferred embodiment, the reading device comprises a display device or a remote display terminal.

[0033] The clockwork device 6 comprises a rack 3, a gear and a clockwork ring; the gear is coaxially fixedly connected with the inner end of the clockwork ring, the outer end of the clockwork ring is fixedly connected with the object table, and the rack 3 is engaged with the gear. The transmission gear 5 and the gear of the clockwork device 6 are installed on a rotating shaft. The end of the rack 3 away from the gear exceeds the upper surface of the object table, facilitating the tightening of the clockwork device 6. The clockwork device 6 is used for transmitting the fluorescent reagent strip 2, which can reduce the cost, does not increase additional power supply, reduces the pressure of the power supply unit, and can miniaturize the fluorescent immunoassay instrument 1.

[0034] The fluorescent reagent strip 2 further comprises a clamping shell upper cover, the clamping shell upper cover is connected with the lower bottom clamping, and the clamping shell upper cover is provided with a detection window and a sample adding hole. The bottom of the fluorescent reagent strip 2 is provided with a toothed structure 4, which is used for engaging with the transmission gear 5 on the detection instrument 1 during detection, so that the fluorescent reagent strip 2 moves to the detection site. The toothed structure 4 is provided with a protrusion or a groove with a preset inclination angle, which is used for engaging with the clockwork gear, driving the reagent card transmission, and preventing the reagent card from being inserted in the wrong direction and causing detection errors.

[0035] In a preferred embodiment, the length of the toothed structure 4 of the fluorescent reagent strip 2 is slightly longer than the detection window, and when the detection is completed, the gear is not engaged, and the reagent card after detection can be directly taken out.

[0036] Working principle:

[0037] The fluorescent reagent strip 2 is placed on the object table, and the end of the toothed structure 4 at the bottom of the fluorescent reagent strip 2 is engaged with the end of the transmission gear 5 away from the detection device. The top end of the rack 3 is pressed until it reaches the preset position, the clockwork device 6 is tightened, and then the rack 3 is released. Under the movement of the clockwork device 6, the transmission gear 5 rotates, thereby driving the fluorescent reagent strip 2 to move horizontally to the detection site. After detecting the fluorescent reagent strip 2, the LED illuminates the fluorescent reagent strip 2, detects the fluorescent reagent strip 2, and sends the detection result to the reading device.

[0038] Example 2

[0039] A household detection device for reading a specific lateral flow fluorescent immunoassay reagent strip, the electronic measurement device comprising a cartridge for loading the fluorescent immunoassay reagent strip and an electronic measurement device; the electronic measurement device comprises a clockwork structure for transmitting the cartridge, which can complete the scanning test of the reagent strip; a PCB, a lighting LED fixedly connected with the circuit board and the device combination associated to illuminate the test strip; and a light guide fixedly connected with the circuit board and the device combination associated to guide the light emitted or reflected from the test strip of the test strip to the sensor.

[0040] The card shell for loading fluorescent immunoassay reagent strip is divided into an upper cover and a lower bottom, the upper cover has an elongated detection window, the lower part has one or two sample wells for dropping the sample to be tested and / or sample diluent; the lower cover has a mounting groove structure inside for fixing the reagent strip, and the bottom has a toothed structure 4 for meshing with the gear of the clockwork structure, when the clockwork gear starts to rotate, it drives the card shell to move, simultaneously drives the LED to irradiate the reagent strip, the light guide receives the emission signal value, after data processing, the result is sent to the display device or APP.

[0041] The damping clockwork gear structure for driving the card shell includes a press switch, a clockwork box, a gear, etc. During detection, the reagent card is inserted, the bottom gear of the reagent card is combined with the clockwork gear; the press switch is pressed, the clockwork is wound, the gear starts to run, drives the card shell to move, simultaneously drives the LED to irradiate the reagent strip, the light guide receives the emission signal value, after data processing, the result is sent to the display device or APP. Because the length of the toothed structure 4 at the bottom of the card shell is slightly longer than the detection window, when the detection is completed, there is no gear engagement, the reagent card after detection can be directly taken out, and the next test is ready.

[0042] The technical scheme of the present application uses the damping clockwork structure to drive the scanning detection of the reagent card, replaces the traditional stepper motor mode, can miniaturize the detection device, at the same time, does not need a large power supply device to drive the motor, only the PCB and / or display screen of the whole detection device need to be powered, the required power is small, only a dry battery or a button cell is needed; at the same time, through the power supply start switch design, only during detection, power is supplied for LED lighting and other purposes, which can prolong the standby time of the detection device; the clockwork device 6 is used to replace the stepper motor, the cost is greatly reduced, and it is more suitable for the scene of home detection.

[0043] In addition to the toothed structure 4 at the bottom of the detection card, a certain groove or protrusion is designed to engage with the clockwork gear, drive the transmission of the reagent card, and also prevent the reagent card from being inserted in the wrong direction, causing detection errors, etc.

[0044] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0045] The specific embodiments of the present application are described above. It needs to be understood that the present application is not limited to the specific embodiments described above, and various changes or modifications can be made by those skilled in the art within the scope of the claims, which does not affect the essential content of the present application. In the case of no conflict, the embodiments of the present application and the features in the embodiments can be combined with each other arbitrarily.

Claims

1. A fluorescence immunoassay instrument apparatus, characterized by, The application relates to a detection instrument (1) and a fluorescent reagent strip (2), wherein the detection instrument (1) is used for detecting the fluorescent reagent strip (2); the bottom of the fluorescent reagent strip (2) is provided with a tooth-shaped structure (4); the detection instrument (1) comprises a carrier table, a reagent strip insertion port, a detection device, a transmission gear (5) and a clockwork device (6), and the detection device has at least one detection site on the carrier table; the reagent strip insertion port allows the fluorescent reagent strip (2) to enter or exit; the transmission gear (5) is rotationally arranged on the carrier table and is engaged with the tooth-shaped structure (4) at the bottom of the fluorescent reagent strip (2); the clockwork device (6) drives the transmission gear (5) to rotate; and the transmission gear (5) drives the fluorescent reagent strip (2) to enter or exit the detection site from the reagent strip insertion port. The clockwork device (6) comprises a rack (3), a gear and a clockwork ring; the gear is coaxially fixedly connected with the inner end of the clockwork ring; the outer end of the clockwork ring is fixedly connected with the carrier table; and the rack (3) is engaged with the gear. The detection device comprises detection windows, a circuit board and a reading device, and each detection window corresponds to at least one detection site; The detection window is provided with at least one illuminating LED. The reading device comprises a display device or a remote display end.

2. The fluorescence immunoassay instrument apparatus of claim 1, wherein, The end of the rack (3) away from the gear exceeds the upper surface of the carrier table.

3. The device for fluorescent immunoassay according to claim 1, wherein The fluorescent reagent strip (2) further comprises a clamping shell upper cover, the clamping shell upper cover is connected with the lower bottom, the clamping shell upper cover is provided with a detection window and a sample adding hole. A power supply unit is further arranged and used for supplying power to the detection device.

4. The device for fluorescent immunoassay according to claim 3, wherein The tooth-shaped structure (4) of the fluorescent reagent strip (2) is provided with a convex or a groove with a preset inclination angle.

5. The device for fluorescent immunoassay according to claim 2, wherein The length of the tooth-shaped structure (4) of the fluorescent reagent strip (2) is longer than that of the detection window.

6. The fluorescence immunoassay instrument apparatus of claim 1, wherein, A rotating shaft is further arranged, and the transmission gear (5) and the gear of the clockwork device (6) are mounted on the rotating shaft.

7. The device for fluorescent immunoassay according to claim 1, wherein ​ 8. The device for fluorescent immunoassay according to claim 1, wherein ​ 9. The device for fluorescent immunoassay according to claim 3, wherein ​ 10. The device for fluorescent immunoassay according to claim 2, wherein ​

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